JP2015500637A5 - - Google Patents

Info

Publication number

JP2015500637A5

JP2015500637A5 JP2014543917A JP2014543917A JP2015500637A5 JP 2015500637 A5 JP2015500637 A5 JP 2015500637A5 JP 2014543917 A JP2014543917 A JP 2014543917A JP 2014543917 A JP2014543917 A JP 2014543917A JP 2015500637 A5 JP2015500637 A5 JP 2015500637A5

Authority

JP

Japan

Prior art keywords

cells

cell

haploid

embryonic stem

toxin

Prior art date

2012-11-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 210000004027 cell Anatomy 0.000 claims 57
• 238000000034 method Methods 0.000 claims 37
• 210000001671 embryonic stem cell Anatomy 0.000 claims 18
• 238000004113 cell culture Methods 0.000 claims 12
• 210000002459 blastocyst Anatomy 0.000 claims 11
• 108090000623 proteins and genes Proteins 0.000 claims 11
• 210000003783 haploid cell Anatomy 0.000 claims 10
• 231100000765 toxin Toxicity 0.000 claims 9
• 239000003053 toxin Substances 0.000 claims 9
• 108700012359 toxins Proteins 0.000 claims 9
• 210000000287 oocyte Anatomy 0.000 claims 8
• 210000000472 morula Anatomy 0.000 claims 6
• 238000012258 culturing Methods 0.000 claims 5
• 231100000710 AB5 toxin Toxicity 0.000 claims 4
• 230000035772 mutation Effects 0.000 claims 4
• 241000124008 Mammalia Species 0.000 claims 3
• 210000002308 embryonic cell Anatomy 0.000 claims 3
• 108020004414 DNA Proteins 0.000 claims 2
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
• -1 Nanog Proteins 0.000 claims 2
• 108010039491 Ricin Proteins 0.000 claims 2
• 210000000349 chromosome Anatomy 0.000 claims 2
• 230000018109 developmental process Effects 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 210000004962 mammalian cell Anatomy 0.000 claims 2
• 230000001776 parthenogenetic effect Effects 0.000 claims 2
• 230000002062 proliferating effect Effects 0.000 claims 2
• 210000002993 trophoblast Anatomy 0.000 claims 2
• LAQPKDLYOBZWBT-NYLDSJSYSA-N (2s,4s,5r,6r)-5-acetamido-2-{[(2s,3r,4s,5s,6r)-2-{[(2r,3r,4r,5r)-5-acetamido-1,2-dihydroxy-6-oxo-4-{[(2s,3s,4r,5s,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-6-[(1r,2r)-1,2,3-trihydrox Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]([C@@H](NC(C)=O)C=O)[C@@H]([C@H](O)CO)O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 LAQPKDLYOBZWBT-NYLDSJSYSA-N 0.000 claims 1
• 101150028074 2 gene Proteins 0.000 claims 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
• 101100239628 Danio rerio myca gene Proteins 0.000 claims 1
• 101100411708 Danio rerio rarga gene Proteins 0.000 claims 1
• 206010012335 Dependence Diseases 0.000 claims 1
• 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 claims 1
• 101150087304 Fut9 gene Proteins 0.000 claims 1
• 230000010190 G1 phase Effects 0.000 claims 1
• 230000010337 G2 phase Effects 0.000 claims 1
• 101150020887 Gpr107 gene Proteins 0.000 claims 1
• 101150072501 Klf2 gene Proteins 0.000 claims 1
• 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 1
• 241000023320 Luma <angiosperm> Species 0.000 claims 1
• 101150044148 MID1 gene Proteins 0.000 claims 1
• 101100218432 Mus musculus B4galnt3 gene Proteins 0.000 claims 1
• 101100496858 Mus musculus Colec12 gene Proteins 0.000 claims 1
• 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 1
• 101710150336 Protein Rex Proteins 0.000 claims 1
• 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims 1
• 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 230000022131 cell cycle Effects 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 230000004069 differentiation Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
• 238000010363 gene targeting Methods 0.000 claims 1
• 239000003966 growth inhibitor Substances 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims 1
• 230000008186 parthenogenesis Effects 0.000 claims 1
• 231100000614 poison Toxicity 0.000 claims 1
• 239000002574 poison Substances 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 230000032537 response to toxin Effects 0.000 claims 1
• 238000012216 screening Methods 0.000 claims 1
• 229910001631 strontium chloride Inorganic materials 0.000 claims 1
• AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims 1
• 230000004083 survival effect Effects 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 229940124598 therapeutic candidate Drugs 0.000 claims 1