IN2014KN01374A - - Google Patents

Info

Publication number
IN2014KN01374A
IN2014KN01374A IN1374KON2014A IN2014KN01374A IN 2014KN01374 A IN2014KN01374 A IN 2014KN01374A IN 1374KON2014 A IN1374KON2014 A IN 1374KON2014A IN 2014KN01374 A IN2014KN01374 A IN 2014KN01374A
Authority
IN
India
Prior art keywords
resistance
cells
identification
generation
cell cultures
Prior art date
Application number
Inventor
Ulrich Elling
Josef Penninger
Jasmin Taubenschmid
Original Assignee
Imba Inst Für Molekulare Biotechnologie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imba Inst Für Molekulare Biotechnologie Gmbh filed Critical Imba Inst Für Molekulare Biotechnologie Gmbh
Publication of IN2014KN01374A publication Critical patent/IN2014KN01374A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)

Abstract

The present invention relates to the generation of stable haploid cell cultures uses of said cells in forward and reverse genetics especially the identification of target genes associated with a modified phenotype and in particular identifying genetic targets associated with toxin resistance especially ricin toxicity resistance and therapeutic uses of target compounds.
IN1374KON2014 2011-11-30 2012-11-30 IN2014KN01374A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11191408.1A EP2599859A1 (en) 2011-11-30 2011-11-30 Haploid cells
US201161565626P 2011-12-01 2011-12-01
PCT/EP2012/074112 WO2013079670A1 (en) 2011-11-30 2012-11-30 Haploid cells

Publications (1)

Publication Number Publication Date
IN2014KN01374A true IN2014KN01374A (en) 2015-10-16

Family

ID=45218335

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1374KON2014 IN2014KN01374A (en) 2011-11-30 2012-11-30

Country Status (11)

Country Link
US (1) US20140342369A1 (en)
EP (2) EP2599859A1 (en)
JP (1) JP2015500637A (en)
KR (1) KR20140101390A (en)
CN (1) CN104024404A (en)
AU (1) AU2012343826A1 (en)
CA (1) CA2856810A1 (en)
IL (1) IL232879A0 (en)
IN (1) IN2014KN01374A (en)
SG (1) SG11201402350QA (en)
WO (1) WO2013079670A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2629285T5 (en) 2011-03-02 2020-07-23 Anton Wutz Mammalian haploid embryonic stem cells
WO2015152146A1 (en) * 2014-03-31 2015-10-08 国立大学法人東京医科歯科大学 Method for culturing haploid embryonic stem cells
CA2993476A1 (en) 2015-07-29 2017-02-02 New York Stem Cell Foundation, Inc. Haploid human embryonic stem cell lines and somatic cell lines and methods of making the same
US11859232B2 (en) 2016-06-19 2024-01-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Screening for chemotherapy resistance in human haploid cells
US11608570B2 (en) 2016-07-29 2023-03-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Targeted in situ protein diversification by site directed DNA cleavage and repair
EP3388530A1 (en) 2017-04-13 2018-10-17 IMBA-Institut für Molekulare Biotechnologie GmbH Nucleic acid modification and identification method
CA3058540A1 (en) 2017-04-13 2018-10-18 Imba - Institut Fur Molekulare Biotechnologie Gmbh Nucleic acid modification and identification method
CN108998410B (en) * 2017-06-07 2020-11-06 中国科学院动物研究所 Use of protein kinase inhibitors to inhibit haploid cell doubling
CN107217042B (en) * 2017-07-31 2020-03-06 江苏东抗生物医药科技有限公司 Genetic engineering cell line for producing afucosylated protein and establishing method thereof
US10626319B1 (en) 2019-05-17 2020-04-21 King Fahd University Of Petroleum And Minerals Methods of inhibiting corrosion with a pyrazine corrosion inhibitor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
EP1092768A1 (en) 1999-10-16 2001-04-18 ARTEMIS Pharmaceuticals GmbH Conditional gene trapping construct for the disruption of genes
AU782846B2 (en) 1999-10-28 2005-09-01 University Of Massachusetts Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues
CA2388510A1 (en) 1999-11-02 2001-05-10 James M. Robl Use of haploid genomes for genetic diagnosis, modification and multiplication
US7074611B2 (en) 2001-04-27 2006-07-11 Gie-Cerbn, Centre Europeen De Recherche En Biologie Et En Medecine (Gie) Method for the stable inversion of DNA sequence by site-specific recombination and DNA vectors and transgenic cells thereof
US7235654B2 (en) 2002-12-09 2007-06-26 Boehringer Ingelheim Pharmaceuticals, Inc. Methods for modulating IKKα activity
DK2457999T3 (en) 2002-12-16 2019-02-11 Technion Res & Dev Foundation CULTIVATION MEDIUM FOR PLURIPOTENT STEM CELLS
EP1662005A1 (en) 2004-11-26 2006-05-31 FrankGen Biotechnologie AG Enhancer-containing gene trap vectors for random and targeted gene trapping
DK1815001T3 (en) 2004-11-26 2011-05-16 Helmholtz Zentrum Muenchen Fallback cartridges for random and targeted conditioned gene inactivation
US20100069251A1 (en) 2006-09-15 2010-03-18 Children's Medical Center Corporation Methods for producing embryonic stem cells from parthenogenetic embryos
US20080299091A1 (en) * 2007-04-06 2008-12-04 International Stem Cell Corporation Patient-specific stem cell lines derived from human parthenogenetic blastocysts
ES2629285T5 (en) * 2011-03-02 2020-07-23 Anton Wutz Mammalian haploid embryonic stem cells

Also Published As

Publication number Publication date
JP2015500637A (en) 2015-01-08
EP2785832A1 (en) 2014-10-08
AU2012343826A1 (en) 2014-06-12
CA2856810A1 (en) 2013-06-06
IL232879A0 (en) 2014-07-31
EP2599859A1 (en) 2013-06-05
US20140342369A1 (en) 2014-11-20
SG11201402350QA (en) 2014-06-27
KR20140101390A (en) 2014-08-19
CN104024404A (en) 2014-09-03
WO2013079670A1 (en) 2013-06-06

Similar Documents

Publication Publication Date Title
IN2014KN01374A (en)
MY183741A (en) Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
NZ627373A (en) Genes involved in noscapine production
MX2014012994A (en) Nuclease-mediated targeting with large targeting vectors.
IL252045B (en) An isolated nucleic acid, an expression vector and a cultured cell comprising the isolated nucleic acid
EA024121B9 (en) Endoribonuclease compositions and methods of use thereof
MX2019010226A (en) Lipid nanoparticle compositions and methods for mrna delivery.
EP2545182A4 (en) Polynucleotide molecules for gene regulation in plants
SG10201809901SA (en) Generating Pluripotent Cells De Novo
HK1188466A1 (en) Plant derived cell culture material
NZ628549A (en) Novel class of glyphosate resistance genes
PH12015500213A1 (en) Production of fmdv-resistant livestock by allele substitution
MX2011011508A (en) Gene vector.
IN2014DN10996A (en)
MX2023003672A (en) Compositions and methods for inhibiting gene expression of alpha-1 antitrypsin.
MX2013007689A (en) Nucleic acid molecules that confer resistance to coleopteran pests.
ZA201202814B (en) Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis
MX356625B (en) Oligonucleotides for making a change in the sequence of a target rna molecule present in a living cell.
MX2014000301A (en) Methods of increasing yield and stress tolerance in a plant.
WO2012142116A3 (en) Identification and use of krp mutants in wheat
IN2015KN00073A (en)
MY191390A (en) Methods and compositions for increasing efficiency of increased efficiency of targeted gene modification using oligonucleotide-mediated gene repair
MX368901B (en) Interfering with hd-zip transcription factor repression of gene expression to produce plants with enhanced traits.
EP2707479A4 (en) Use of zscan4 and zscan4-dependent genes for direct reprogramming of somatic cells
IN2012DN01604A (en)