IN2014KN01374A - - Google Patents

Info

Publication number
IN2014KN01374A
IN2014KN01374A IN1374KON2014A IN2014KN01374A IN 2014KN01374 A IN2014KN01374 A IN 2014KN01374A IN 1374KON2014 A IN1374KON2014 A IN 1374KON2014A IN 2014KN01374 A IN2014KN01374 A IN 2014KN01374A
Authority
IN
India
Prior art keywords
resistance
cells
identification
generation
cell cultures
Prior art date
Application number
Inventor
Ulrich Elling
Josef Penninger
Jasmin Taubenschmid
Original Assignee
Imba Inst Für Molekulare Biotechnologie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imba Inst Für Molekulare Biotechnologie Gmbh filed Critical Imba Inst Für Molekulare Biotechnologie Gmbh
Publication of IN2014KN01374A publication Critical patent/IN2014KN01374A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)

Abstract

The present invention relates to the generation of stable haploid cell cultures uses of said cells in forward and reverse genetics especially the identification of target genes associated with a modified phenotype and in particular identifying genetic targets associated with toxin resistance especially ricin toxicity resistance and therapeutic uses of target compounds.
IN1374KON2014 2011-11-30 2012-11-30 IN2014KN01374A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11191408.1A EP2599859A1 (en) 2011-11-30 2011-11-30 Haploid cells
US201161565626P 2011-12-01 2011-12-01
PCT/EP2012/074112 WO2013079670A1 (en) 2011-11-30 2012-11-30 Haploid cells

Publications (1)

Publication Number Publication Date
IN2014KN01374A true IN2014KN01374A (en) 2015-10-16

Family

ID=45218335

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1374KON2014 IN2014KN01374A (en) 2011-11-30 2012-11-30

Country Status (11)

Country Link
US (1) US20140342369A1 (en)
EP (2) EP2599859A1 (en)
JP (1) JP2015500637A (en)
KR (1) KR20140101390A (en)
CN (1) CN104024404A (en)
AU (1) AU2012343826A1 (en)
CA (1) CA2856810A1 (en)
IL (1) IL232879A0 (en)
IN (1) IN2014KN01374A (en)
SG (1) SG11201402350QA (en)
WO (1) WO2013079670A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9957479B2 (en) 2011-03-02 2018-05-01 Anton Wutz Mammalian haploid embryonic stem cells
WO2015152146A1 (en) * 2014-03-31 2015-10-08 国立大学法人東京医科歯科大学 Method for culturing haploid embryonic stem cells
CA2993476A1 (en) * 2015-07-29 2017-02-02 New York Stem Cell Foundation, Inc. Haploid human embryonic stem cell lines and somatic cell lines and methods of making the same
WO2017221225A1 (en) * 2016-06-19 2017-12-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Screening for chemotherapy resistance in human haploid cells
JP7026304B2 (en) 2016-07-29 2022-02-28 マックス－プランク－ゲゼルシャフト ツア フェルデルンク デア ヴィッセンシャフテン エー．ファウ． Targeted in-situ protein diversification through site-specific DNA cleavage and repair
EP3388530A1 (en) 2017-04-13 2018-10-17 IMBA-Institut für Molekulare Biotechnologie GmbH Nucleic acid modification and identification method
ES3043187T3 (en) 2017-04-13 2025-11-25 Imba Inst Molekulare Biotech Nucleic acid modification and identification method
CN108998410B (en) * 2017-06-07 2020-11-06 中国科学院动物研究所 Use of protein kinase inhibitors in inhibiting the diploidy of haploid cells
CN107217042B (en) * 2017-07-31 2020-03-06 江苏东抗生物医药科技有限公司 Genetic engineering cell line for producing afucosylated protein and establishing method thereof
US10626319B1 (en) 2019-05-17 2020-04-21 King Fahd University Of Petroleum And Minerals Methods of inhibiting corrosion with a pyrazine corrosion inhibitor
EP4183873A4 (en) * 2020-07-17 2024-04-24 Tohoku University TROPHOBLAST STEM CELL-LIKE CELLS FOR DIFFERENTIATION INTO PLACENTA-CONSTITUTING CELLS AND METHODS FOR THE PRODUCTION THEREOF
CN118389411A (en) * 2024-06-21 2024-07-26 中国科学院昆明动物研究所 Method for separating and establishing line of double haploid embryonic stem cells of mice
CN118370275B (en) * 2024-06-21 2024-09-06 中国科学院昆明动物研究所 Method for producing maternal half-cloned mice

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
EP1092768A1 (en) 1999-10-16 2001-04-18 ARTEMIS Pharmaceuticals GmbH Conditional gene trapping construct for the disruption of genes
CN100497598C (en) 1999-10-28 2009-06-10 马萨诸塞大学 Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues
AU1581001A (en) 1999-11-02 2001-05-14 University Of Massachusetts Use of haploid genomes for genetic diagnosis, modification and multiplication
US7074611B2 (en) 2001-04-27 2006-07-11 Gie-Cerbn, Centre Europeen De Recherche En Biologie Et En Medecine (Gie) Method for the stable inversion of DNA sequence by site-specific recombination and DNA vectors and transgenic cells thereof
AU2003297700A1 (en) 2002-12-09 2004-06-30 Boehringer Ingelheim Pharmaceuticals, Inc. METHODS FOR MODULATING IKKAlpha ACTIVITY
HUE028026T2 (en) 2002-12-16 2016-11-28 Technion Res & Dev Foundation Feeder-free, xeno-free culture system for human embryonic stem cells
EP1662005A1 (en) 2004-11-26 2006-05-31 FrankGen Biotechnologie AG Enhancer-containing gene trap vectors for random and targeted gene trapping
DK1815001T3 (en) 2004-11-26 2011-05-16 Helmholtz Zentrum Muenchen Fallback cartridges for random and targeted conditioned gene inactivation
US20100069251A1 (en) 2006-09-15 2010-03-18 Children's Medical Center Corporation Methods for producing embryonic stem cells from parthenogenetic embryos
CN104651299B (en) * 2007-04-06 2022-07-26 国际干细胞公司 Patient-specific stem cell lines derived from human parthenogenetic blastocysts
US9957479B2 (en) * 2011-03-02 2018-05-01 Anton Wutz Mammalian haploid embryonic stem cells

Also Published As

Publication number Publication date
EP2785832A1 (en) 2014-10-08
IL232879A0 (en) 2014-07-31
US20140342369A1 (en) 2014-11-20
AU2012343826A1 (en) 2014-06-12
KR20140101390A (en) 2014-08-19
CA2856810A1 (en) 2013-06-06
SG11201402350QA (en) 2014-06-27
CN104024404A (en) 2014-09-03
WO2013079670A1 (en) 2013-06-06
JP2015500637A (en) 2015-01-08
EP2599859A1 (en) 2013-06-05

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