JP2015500637A - 一倍体細胞 - Google Patents

一倍体細胞 Download PDF

Info

Publication number
JP2015500637A
JP2015500637A JP2014543917A JP2014543917A JP2015500637A JP 2015500637 A JP2015500637 A JP 2015500637A JP 2014543917 A JP2014543917 A JP 2014543917A JP 2014543917 A JP2014543917 A JP 2014543917A JP 2015500637 A JP2015500637 A JP 2015500637A
Authority
JP
Japan
Prior art keywords
cells
cell
haploid
embryonic stem
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014543917A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015500637A5 (enExample
Inventor
エリンク ウルリッヒ
エリンク ウルリッヒ
ペニンガー ヨーゼフ
ペニンガー ヨーゼフ
タウベンシュミット ヤスミン
タウベンシュミット ヤスミン
Original Assignee
イーエムベーアー−インスティテュート フュール モレクラレ バイオテクロノジー ゲゼルシャフト ミットベシュレンクテル ハフツング
イーエムベーアー−インスティテュート フュール モレクラレ バイオテクロノジー ゲゼルシャフト ミット ベシュレンクテル ハフツング
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イーエムベーアー−インスティテュート フュール モレクラレ バイオテクロノジー ゲゼルシャフト ミットベシュレンクテル ハフツング, イーエムベーアー−インスティテュート フュール モレクラレ バイオテクロノジー ゲゼルシャフト ミット ベシュレンクテル ハフツング filed Critical イーエムベーアー−インスティテュート フュール モレクラレ バイオテクロノジー ゲゼルシャフト ミットベシュレンクテル ハフツング
Publication of JP2015500637A publication Critical patent/JP2015500637A/ja
Publication of JP2015500637A5 publication Critical patent/JP2015500637A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00Use of cells in diagnostics
    • C12N2503/02Drug screening
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
JP2014543917A 2011-11-30 2012-11-30 一倍体細胞 Pending JP2015500637A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11191408.1 2011-11-30
EP11191408.1A EP2599859A1 (en) 2011-11-30 2011-11-30 Haploid cells
US201161565626P 2011-12-01 2011-12-01
US61/565,626 2011-12-01
PCT/EP2012/074112 WO2013079670A1 (en) 2011-11-30 2012-11-30 Haploid cells

Publications (2)

Publication Number Publication Date
JP2015500637A true JP2015500637A (ja) 2015-01-08
JP2015500637A5 JP2015500637A5 (enExample) 2016-01-21

Family

ID=45218335

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014543917A Pending JP2015500637A (ja) 2011-11-30 2012-11-30 一倍体細胞

Country Status (11)

Country Link
US (1) US20140342369A1 (enExample)
EP (2) EP2599859A1 (enExample)
JP (1) JP2015500637A (enExample)
KR (1) KR20140101390A (enExample)
CN (1) CN104024404A (enExample)
AU (1) AU2012343826A1 (enExample)
CA (1) CA2856810A1 (enExample)
IL (1) IL232879A0 (enExample)
IN (1) IN2014KN01374A (enExample)
SG (1) SG11201402350QA (enExample)
WO (1) WO2013079670A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108138138A (zh) * 2015-07-29 2018-06-08 纽约干细胞基金会有限公司 单倍体人胚胎干细胞系和体细胞系及其制备方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9957479B2 (en) 2011-03-02 2018-05-01 Anton Wutz Mammalian haploid embryonic stem cells
WO2015152146A1 (ja) * 2014-03-31 2015-10-08 国立大学法人東京医科歯科大学 1倍体胚性幹細胞の培養方法
WO2017221225A1 (en) * 2016-06-19 2017-12-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Screening for chemotherapy resistance in human haploid cells
JP7026304B2 (ja) 2016-07-29 2022-02-28 マックス-プランク-ゲゼルシャフト ツア フェルデルンク デア ヴィッセンシャフテン エー.ファウ. 部位特異的dna開裂及び修復による標的化原位置タンパク質多様化
EP3388530A1 (en) 2017-04-13 2018-10-17 IMBA-Institut für Molekulare Biotechnologie GmbH Nucleic acid modification and identification method
ES3043187T3 (en) 2017-04-13 2025-11-25 Imba Inst Molekulare Biotech Nucleic acid modification and identification method
CN108998410B (zh) * 2017-06-07 2020-11-06 中国科学院动物研究所 蛋白激酶抑制剂在抑制单倍体细胞二倍化中的用途
CN107217042B (zh) * 2017-07-31 2020-03-06 江苏东抗生物医药科技有限公司 一种生产无岩藻糖基化蛋白的基因工程细胞系及其建立方法
US10626319B1 (en) 2019-05-17 2020-04-21 King Fahd University Of Petroleum And Minerals Methods of inhibiting corrosion with a pyrazine corrosion inhibitor
EP4183873A4 (en) * 2020-07-17 2024-04-24 Tohoku University Trophoblast stem cell-like cells capable of differentiating into placenta-constituting cells, and method for producing same
CN118389411A (zh) * 2024-06-21 2024-07-26 中国科学院昆明动物研究所 一种小鼠双单倍体胚胎干细胞分离建系的方法
CN118370275B (zh) * 2024-06-21 2024-09-06 中国科学院昆明动物研究所 一种产生母源性半克隆小鼠的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
EP1092768A1 (en) 1999-10-16 2001-04-18 ARTEMIS Pharmaceuticals GmbH Conditional gene trapping construct for the disruption of genes
CN100497598C (zh) 1999-10-28 2009-06-10 马萨诸塞大学 多能细胞和细胞系的单雌生殖或单雄生殖产生,及其产生分化细胞和组织的用途
AU1581001A (en) 1999-11-02 2001-05-14 University Of Massachusetts Use of haploid genomes for genetic diagnosis, modification and multiplication
US7074611B2 (en) 2001-04-27 2006-07-11 Gie-Cerbn, Centre Europeen De Recherche En Biologie Et En Medecine (Gie) Method for the stable inversion of DNA sequence by site-specific recombination and DNA vectors and transgenic cells thereof
AU2003297700A1 (en) 2002-12-09 2004-06-30 Boehringer Ingelheim Pharmaceuticals, Inc. METHODS FOR MODULATING IKKAlpha ACTIVITY
HUE028026T2 (en) 2002-12-16 2016-11-28 Technion Res & Dev Foundation Breeding system free of native cells, free of foreign matter for human embryonic stem cells
EP1662005A1 (en) 2004-11-26 2006-05-31 FrankGen Biotechnologie AG Enhancer-containing gene trap vectors for random and targeted gene trapping
DK1815001T3 (da) 2004-11-26 2011-05-16 Helmholtz Zentrum Muenchen Genfældekassetter til tilfældig og målrettet konditioneret geninaktivering
US20100069251A1 (en) 2006-09-15 2010-03-18 Children's Medical Center Corporation Methods for producing embryonic stem cells from parthenogenetic embryos
CN104651299B (zh) * 2007-04-06 2022-07-26 国际干细胞公司 源于人单性生殖胚泡的患者特异性干细胞系
US9957479B2 (en) * 2011-03-02 2018-05-01 Anton Wutz Mammalian haploid embryonic stem cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CELL, (1993), VOL. 73, P. 643-658, JPN6016038516 *
J. EXP. MED., (2008), VOL. 205, NO. 9, P. 2005-2017, JPN6016038513 *
NATURE, (2011), VOL. 479, P. 131-134, JPN6016038509 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108138138A (zh) * 2015-07-29 2018-06-08 纽约干细胞基金会有限公司 单倍体人胚胎干细胞系和体细胞系及其制备方法
JP2018521692A (ja) * 2015-07-29 2018-08-09 ニュー ヨーク ステム セル ファウンデーション,インコーポレイテッド 一倍体ヒト胚性幹細胞株と体細胞株およびこれらを作製する方法
US10961503B2 (en) 2015-07-29 2021-03-30 New York Stem Cell Foundation, Inc. Haploid human embryonic stem cell lines and somatic cell lines and methods of making the same
CN108138138B (zh) * 2015-07-29 2023-11-14 纽约干细胞基金会有限公司 单倍体人胚胎干细胞系和体细胞系及其制备方法
US12091678B2 (en) 2015-07-29 2024-09-17 New York Stem Cell Foundation, Inc. Haploid human embryonic stem cell lines and somatic cell lines and methods of making the same

Also Published As

Publication number Publication date
EP2785832A1 (en) 2014-10-08
IL232879A0 (en) 2014-07-31
US20140342369A1 (en) 2014-11-20
AU2012343826A1 (en) 2014-06-12
KR20140101390A (ko) 2014-08-19
CA2856810A1 (en) 2013-06-06
SG11201402350QA (en) 2014-06-27
CN104024404A (zh) 2014-09-03
WO2013079670A1 (en) 2013-06-06
IN2014KN01374A (enExample) 2015-10-16
EP2599859A1 (en) 2013-06-05

Similar Documents

Publication Publication Date Title
JP2015500637A (ja) 一倍体細胞
US20230015276A1 (en) Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation
US20130011380A1 (en) Use of Cytidine Deaminase-Related Agents to Promote Demethylation and Cell Reprogramming
JP2020532291A (ja) 二段階相同組換え修復によるスカーレスゲノム編集
JP6948650B2 (ja) 一倍体ヒト胚性幹細胞株と体細胞株およびこれらを作製する方法
IL293946A (en) Engineered cells for therapy
WO2013159103A1 (en) Programming and reprogramming of cells
WO2011133288A9 (en) Microrna induction of pluripotential stem cells and uses thereof
JP2021520215A (ja) リプログラミングベクター
CN105051188A (zh) 新颖方法
JP2021509577A (ja) Crispr活性化による人工多能性細胞の生成
JP2021520781A (ja) 体細胞リプログラミングおよびインプリンティングのモジュレートのための組成物および方法
CN118973388A (zh) 胚胎干细胞的基因编辑方法
JP7369416B2 (ja) ナイーブ型多能性幹細胞の製造方法、幹細胞のナイーブ化方法および保存方法
Mattei Dissecting the embryonic and extraembryonic requirements for DNA methylation in mice
CA3220168A1 (en) Methods to prevent rapid silencing of genes in pluripotent stem cells
Kearns Generation of Pharyngeal Foregut Endoderm from Pluripotent Stem Cells
Alcaine Colet Identification and characterization of the molecular pathways regulating the cell cycle-linked pluripotency exit
Bartoccetti et al. Dynamics of Tet1 and Oct4 gene activation identify temporally distinct late stages in reprogramming of induced pluripotency.
Vargas Induced pluripotent stem cell models of Kleefstra syndrome
Amlani Post-Transcriptional Regulations of Id1 in Senescence and Pluripotency
Borkent Roadblocks and Facilitators of Reprogramming to Pluripotency
Li PRMT5 is an essential survival factor for ground state pluripotency and primordial germ cells: From primordial germ cell differentiation in vitro to mammalian germline in vivo
Blij Specification and regulation of mammalian extraembryonic and pluripotent embryonic lineages in vivo and in vitro
Chen Enhanced maintenance of genetic integrity in induced pluripotent stem cells

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140731

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140710

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151125

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151125

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161011

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170110

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170208

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20170208

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170801

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180731