HK1210476A1 - 弱分配層析的方法 - Google Patents

弱分配層析的方法

Info

Publication number
HK1210476A1
HK1210476A1 HK15111155.1A HK15111155A HK1210476A1 HK 1210476 A1 HK1210476 A1 HK 1210476A1 HK 15111155 A HK15111155 A HK 15111155A HK 1210476 A1 HK1210476 A1 HK 1210476A1
Authority
HK
Hong Kong
Prior art keywords
weak partitioning
partitioning chromatography
chromatography
weak
partitioning
Prior art date
Application number
HK15111155.1A
Other languages
English (en)
Inventor
Paul Brown
Jon Coffman
Ranganathan Godavarti
Tim Iskra
Brian D Kelley
Suresh Vunnum
Shujun Sun
Tianning Yu
James Edward Booth
Mary Beth Switzer
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36992346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1210476(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of HK1210476A1 publication Critical patent/HK1210476A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30—Partition chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
HK15111155.1A 2005-03-11 2015-11-12 弱分配層析的方法 HK1210476A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66043705P 2005-03-11 2005-03-11

Publications (1)

Publication Number Publication Date
HK1210476A1 true HK1210476A1 (zh) 2016-04-22

Family

ID=36992346

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15111155.1A HK1210476A1 (zh) 2005-03-11 2015-11-12 弱分配層析的方法

Country Status (21)

Country Link
US (3) US8067182B2 (zh)
EP (1) EP1869065B1 (zh)
JP (1) JP5199063B2 (zh)
KR (2) KR101660575B1 (zh)
CN (2) CN104610422A (zh)
AU (1) AU2006223180B2 (zh)
BR (1) BRPI0608584B8 (zh)
CA (1) CA2601062C (zh)
CR (1) CR9377A (zh)
DK (1) DK1869065T3 (zh)
ES (1) ES2797480T3 (zh)
HK (1) HK1210476A1 (zh)
HU (1) HUE049797T2 (zh)
IL (1) IL185687A (zh)
MX (1) MX2007011129A (zh)
NO (1) NO20074443L (zh)
PL (1) PL1869065T3 (zh)
PT (1) PT1869065T (zh)
RU (1) RU2457214C2 (zh)
SI (1) SI1869065T1 (zh)
WO (1) WO2006099308A2 (zh)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE049797T2 (hu) * 2005-03-11 2020-10-28 Wyeth Llc Gyenge megoszlási kromatográfiás eljárás
EP2069387A4 (en) * 2006-06-14 2011-02-02 Glaxosmithkline Llc METHODS OF PURIFYING ANTIBODIES USING HYDROXYAPATITE CERAMIC
KR101770312B1 (ko) 2006-08-28 2017-08-22 아레스 트레이딩 에스.에이. Ｆｃ­함유 단백질을 정제하는 방법
MX2009002576A (es) * 2006-09-08 2009-03-20 Wyeth Corp Lavado de arginina en purificacion de proteina utilizando cromatografia de afinidad.
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
KR20090074040A (ko) 2006-09-13 2009-07-03 아보트 러보러터리즈 세포 배양의 개선
ES2538986T3 (es) * 2006-11-08 2015-06-25 Wyeth Llc Medios diseñados racionalmente para un cultivo celular
ES2666170T3 (es) * 2007-10-30 2018-05-03 Genentech, Inc. Purificación de anticuerpos mediante cromatografía de intercambio catiónico
WO2009092010A1 (en) 2008-01-18 2009-07-23 Gagnon Peter S Enhanced purification of phosphorylated and non-phosphorylated biomolecules by apatite chromatography
LT2848625T (lt) 2008-08-14 2019-10-10 Genentech, Inc. Priemaišų pašalinimo būdai, panaudojant reziduojančio baltymo pakeitimą jonų mainų membraninės chromatografijos pagalba
WO2010030222A1 (en) * 2008-09-12 2010-03-18 Ge Healthcare Bio-Sciences Ab Enhanced protein aggregate removal with multimodal anion exchangers in the presence of protein-excluded zwitterions
US20100069617A1 (en) * 2008-09-12 2010-03-18 Ge Healthcare Bio-Sciences Ab Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions
SG10201702951RA (en) 2008-10-20 2017-06-29 Abbvie Inc Viral inactivation during purification of antibodies
SG10201702922VA (en) 2008-10-20 2017-06-29 Abbvie Inc Isolation and purification of antibodies using protein a affinity chromatography
MX345226B (es) 2008-10-29 2017-01-20 Ablynx Nv Formulaciones de moleculas de union a antigeno de dominio sencillo.
RU2553214C2 (ru) 2008-10-29 2015-06-10 Аблинкс Н.В. Способы очистки однодоменных антигенсвязывающих молекул
EP2379108B1 (en) * 2008-12-22 2014-06-25 F. Hoffmann-La Roche AG Immunoglobulin purification
PT3272764T (pt) * 2009-12-18 2024-04-24 Novartis Ag Método para cromatografia de afinidade
CA2787009C (en) 2010-01-15 2018-04-03 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
CN102905718A (zh) * 2010-05-25 2013-01-30 弗·哈夫曼-拉罗切有限公司 纯化多肽的方法
WO2011162210A1 (ja) * 2010-06-21 2011-12-29 協和発酵キリン株式会社 アミノ酸を利用したタンパク質の精製方法
GB201012603D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
US9428546B2 (en) 2010-07-30 2016-08-30 Pfizer Inc. Tandem purification of proteins
US8895707B2 (en) 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
EP2640483A1 (en) 2010-11-15 2013-09-25 Biogen Idec Inc. Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography
US9592540B2 (en) 2011-02-02 2017-03-14 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US10221210B2 (en) 2011-07-20 2019-03-05 Zepteon, Incorporated Polypeptide separation methods
CA2854330A1 (en) * 2011-11-02 2013-05-10 Genentech, Inc. Overload and elute chromatography
SG10201701224UA (en) 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode
US9505833B2 (en) 2012-04-20 2016-11-29 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
US9815695B2 (en) 2012-05-30 2017-11-14 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
CN104507955A (zh) * 2012-05-31 2015-04-08 新加坡科技研究局 采用具有多形式官能性的颗粒对免疫球蛋白g制备物的色谱纯化
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
US9206390B2 (en) 2012-09-02 2015-12-08 Abbvie, Inc. Methods to control protein heterogeneity
US20150328563A1 (en) 2012-12-14 2015-11-19 Ge Healthcare Bio-Sciences Ab Method for Cleaning of Packed Bed Chromatography Columns
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
EP4026596A1 (en) * 2013-03-14 2022-07-13 Amgen, Inc Removal of leaked affinity purification ligand
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
TWI670279B (zh) * 2013-03-15 2019-09-01 美商艾爾德生物製藥股份有限公司 抗體純化及純度監測
TWI596107B (zh) * 2013-06-25 2017-08-21 卡地拉保健有限公司 單株抗體之新穎純化方法
NZ756750A (en) 2013-09-13 2022-05-27 Genentech Inc Methods and compositions comprising purified recombinant polypeptides
JP6546178B2 (ja) 2013-09-13 2019-07-17 ジェネンテック， インコーポレイテッド 細胞株中の宿主細胞タンパク質及び組換えポリペプチド産物を検出及び定量化するための組成物並びに方法
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
KR101891522B1 (ko) 2013-12-12 2018-08-24 이엠디 밀리포어 코포레이션 아크릴아미드 함유 필터를 사용한 단백질 분리
EP3157551B1 (en) 2014-06-23 2023-02-15 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
CN105392569B (zh) 2014-06-23 2019-08-20 生物辐射实验室股份有限公司 磷灰石预处理
MX2019000898A (es) 2016-07-25 2019-07-01 Cephalon Inc Amortiguador de lavado de cromatografia de afinidad.
US11155575B2 (en) 2018-03-21 2021-10-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
JP6951051B2 (ja) * 2018-05-24 2021-10-20 ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 吸着剤の生産方法
US20220267369A1 (en) * 2018-07-25 2022-08-25 Merck Sharp & Dohme Corp. Methods of separating host cell lipases from a production protein in chromatographic processes
WO2020172658A1 (en) 2019-02-24 2020-08-27 Bristol-Myers Squibb Company Methods of isolating a protein
US20220387906A1 (en) 2019-03-21 2022-12-08 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
AU2021213153A1 (en) * 2020-01-29 2022-08-04 Merck Sharp & Dohme Llc Methods of separating host cell lipases from an anti-LAG3 antibody production
WO2022066928A2 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
CA3193107A1 (en) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Process for preparing extracellular vesicles
TW202323268A (zh) 2021-08-23 2023-06-16 美商建南德克公司 用於抗體藥物結合物之流通陽離子交換層析純化製程

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029583A (en) 1975-02-28 1977-06-14 Purdue Research Foundation Chromatographic supports and methods and apparatus for preparing the same
JPS63126826A (ja) * 1986-11-14 1988-05-30 Asahi Chem Ind Co Ltd プラスミノ−ゲン活性化因子誘導物質
EP0391934A1 (en) * 1987-10-23 1990-10-17 Schering Corporation Method of purifying protein
US5451662A (en) 1987-10-23 1995-09-19 Schering Corporation Method of purifying protein
US4983722A (en) 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
EP0365858B1 (en) 1988-10-26 1994-11-30 American Cyanamid Company Process for reducing the aggregate content of growth hormone-like materials
GB9022547D0 (en) 1990-10-17 1990-11-28 Wellcome Found Purified immunoglobulin
US5264555A (en) 1992-07-14 1993-11-23 Enzon, Inc. Process for hemoglobin extraction and purification
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
CA2106612C (en) 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
EP0701566A1 (en) * 1994-04-01 1996-03-20 Unisyn Technologies, Inc. High salt binding buffer for immunoglobulin purification with a synthetic affinity ligand
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
RU2094077C1 (ru) * 1996-07-23 1997-10-27 Акционерное общество закрытого типа "Фосфосорб" Хроматографический способ выделения альфа-фетопротеина
TW505655B (en) 1997-10-14 2002-10-11 Tanox Inc Enhanced aggregate removal from bulk-biologicals using ion exchange chromatography
US6504013B1 (en) 2000-02-01 2003-01-07 Idexx Laboratories, Inc. Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody
WO2000015260A1 (en) 1998-09-16 2000-03-23 Tanox, Inc. Anti-ige gene therapy
AU777203B2 (en) * 1998-12-30 2004-10-07 Hans Olof Johansson Separation method utilizing liquid-liquid partition
US7122641B2 (en) 2001-12-21 2006-10-17 Immunex Corporation Methods for purifying protein
AU2004215653B2 (en) 2003-02-28 2011-03-17 Lonza Biologics Plc. Antibody purification by protein A and ion exchange chromatography
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
JP4496168B2 (ja) * 2003-07-28 2010-07-07 株式会社リバース・プロテオミクス研究所 非特異的物質の除去方法
DE602004026343D1 (de) 2003-10-24 2010-05-12 Amgen Inc Verfahren zur aufreinigung von proteinen in einer durchflussfraktion aus der chromatographie mit hydrophoben wechselwirkungen
EP2336172B1 (en) 2003-10-27 2014-12-10 Wyeth LLC Removal of high molecular weight aggregates using hydroxyapatite chromatography
HUE049797T2 (hu) * 2005-03-11 2020-10-28 Wyeth Llc Gyenge megoszlási kromatográfiás eljárás

Also Published As

Publication number Publication date
SI1869065T1 (sl) 2020-08-31
US20070054390A1 (en) 2007-03-08
EP1869065A4 (en) 2012-07-04
US8067182B2 (en) 2011-11-29
RU2007132851A (ru) 2009-04-20
JP2008533473A (ja) 2008-08-21
CR9377A (es) 2008-02-21
NO20074443L (no) 2007-09-27
MX2007011129A (es) 2007-11-06
EP1869065B1 (en) 2020-05-06
KR101660575B1 (ko) 2016-09-27
US20070060741A1 (en) 2007-03-15
IL185687A0 (en) 2008-01-06
CA2601062C (en) 2016-08-02
CN104610422A (zh) 2015-05-13
PL1869065T3 (pl) 2020-09-21
WO2006099308A2 (en) 2006-09-21
EP1869065A2 (en) 2007-12-26
US20120138537A1 (en) 2012-06-07
US9144755B2 (en) 2015-09-29
KR101482791B1 (ko) 2015-01-21
WO2006099308A3 (en) 2007-10-25
KR20130128020A (ko) 2013-11-25
HUE049797T2 (hu) 2020-10-28
IL185687A (en) 2015-05-31
RU2457214C2 (ru) 2012-07-27
DK1869065T3 (da) 2020-06-08
AU2006223180A1 (en) 2006-09-21
BRPI0608584B1 (pt) 2018-02-06
ES2797480T3 (es) 2020-12-02
BRPI0608584B8 (pt) 2021-05-25
AU2006223180B2 (en) 2011-11-24
PT1869065T (pt) 2020-06-18
KR20070121667A (ko) 2007-12-27
BRPI0608584A2 (pt) 2010-01-19
JP5199063B2 (ja) 2013-05-15
CN101175765A (zh) 2008-05-07
CA2601062A1 (en) 2006-09-21

Similar Documents

Publication Publication Date Title
HK1210476A1 (zh) 弱分配層析的方法
ZA200805297B (en) Method of using ß-hydroxy-ß-methylbutyrate
EP1933309A4 (en) SEARCH PROCESS
SG123650A1 (en) Yield analysis method
EP1951394A4 (en) CHROMATOGRAPHY PROCEDURES USING HALF-SYNTHETIC HEPARIN LIGANDS
GB0400270D0 (en) A method of authorisation
GB0511639D0 (en) Prediction method
GB0509898D0 (en) Analysis method
IL208214A0 (en) Methods for making 4-tetrazolyl-4-phenylpiperidine compounds
GB2421949B (en) Method of analyzing a protein
GB0418529D0 (en) Method for analysing
EP1846854A4 (en) METHOD FOR ANALYZING A PRODUCT
GB0522644D0 (en) New method for antagonisation of anticoagulants
EP1892301A4 (en) METHOD FOR EVALUATING A CONNECTION BY RSK1
GB0511461D0 (en) A method of analysis
GB0501725D0 (en) A method of analysis
IL185801A0 (en) Hydrocodone polymorphs
ZA200609731B (en) A method of construction
GB0414809D0 (en) Analytical method
GB0500240D0 (en) New analytical method
GB0511185D0 (en) Method of analysis
GB0510145D0 (en) Method of analysis
GB0502164D0 (en) A method of providing a flanged component
GB0512448D0 (en) Improved seismic method
GB0515150D0 (en) A method of sensing