HK1209161A1 - Interrogatory cell-based assays and uses thereof - Google Patents
Interrogatory cell-based assays and uses thereofInfo
- Publication number
- HK1209161A1 HK1209161A1 HK15109778.2A HK15109778A HK1209161A1 HK 1209161 A1 HK1209161 A1 HK 1209161A1 HK 15109778 A HK15109778 A HK 15109778A HK 1209161 A1 HK1209161 A1 HK 1209161A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- based assays
- interrogatory
- cell
- interrogatory cell
- assays
- Prior art date
Links
Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Theoretical Computer Science (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261619326P | 2012-04-02 | 2012-04-02 | |
US201261620305P | 2012-04-04 | 2012-04-04 | |
US201261665631P | 2012-06-28 | 2012-06-28 | |
US201261668617P | 2012-07-06 | 2012-07-06 | |
US201261678590P | 2012-08-01 | 2012-08-01 | |
US201261678596P | 2012-08-01 | 2012-08-01 | |
PCT/US2012/054321 WO2013151577A1 (en) | 2012-04-02 | 2012-09-07 | Interrogatory cell-based assays and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1209161A1 true HK1209161A1 (en) | 2016-03-24 |
Family
ID=49235335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15109778.2A HK1209161A1 (en) | 2012-04-02 | 2015-10-07 | Interrogatory cell-based assays and uses thereof |
Country Status (14)
Country | Link |
---|---|
US (2) | US10061887B2 (es) |
EP (1) | EP2834366A4 (es) |
JP (3) | JP6189926B2 (es) |
KR (2) | KR102149070B1 (es) |
CN (3) | CN108048521B (es) |
AU (2) | AU2012376214B2 (es) |
BR (1) | BR112014024537A2 (es) |
CA (1) | CA2869296A1 (es) |
EA (1) | EA038600B1 (es) |
HK (1) | HK1209161A1 (es) |
IL (1) | IL234920B (es) |
MX (1) | MX357392B (es) |
SG (2) | SG10201608234UA (es) |
WO (1) | WO2013151577A1 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6105491B2 (ja) * | 2011-03-02 | 2017-03-29 | バーグ エルエルシー | 照合性細胞ベースのアッセイ及びその使用 |
EP2668945A1 (de) * | 2012-06-01 | 2013-12-04 | Bayer Technology Services GmbH | Genotyp- bzw. Phänotyp-basierte Arzeimittelformulierungen |
US9449284B2 (en) * | 2012-10-04 | 2016-09-20 | Nec Corporation | Methods and systems for dependency network analysis using a multitask learning graphical lasso objective function |
CN103558354B (zh) * | 2013-11-15 | 2015-07-15 | 南京大学 | 一种基于生物组学整合技术的水体毒性分析方法 |
WO2015196080A1 (en) * | 2014-06-20 | 2015-12-23 | Connecticut Children's Medical Center | Automated cell culture system and corresponding methods |
US10482385B2 (en) * | 2014-09-11 | 2019-11-19 | Berg Llc | Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data |
CN105624275B (zh) * | 2014-11-06 | 2020-03-27 | 上海市东方医院 | Eif4g1在鳞癌诊断和治疗中的应用 |
JP6270221B2 (ja) | 2015-02-13 | 2018-01-31 | 国立研究開発法人産業技術総合研究所 | バイオマーカー探索方法、バイオマーカー探索装置、及びプログラム |
KR101786859B1 (ko) * | 2015-04-30 | 2017-10-17 | 서울대학교산학협력단 | 혈장 내 아밀로이드베타의 농도를 통해 알츠하이머병을 임상학적 및 병리학적으로 모니터링하는 방법 |
US10395759B2 (en) | 2015-05-18 | 2019-08-27 | Regeneron Pharmaceuticals, Inc. | Methods and systems for copy number variant detection |
EP3303579B1 (en) * | 2015-05-28 | 2021-04-07 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Assays to identify genetic elements affecting phenotype |
CN106250717B (zh) * | 2015-06-04 | 2019-03-12 | 徐勇 | 急性髓性白血病的miRNA与转录因子的系统及其构建方法和应用 |
US20160363567A1 (en) * | 2015-06-15 | 2016-12-15 | Lunatech, Llc | Vapor Device For Stressing And Analyzing Compounds |
EP3364188B1 (en) * | 2015-10-14 | 2021-12-01 | Public University Corporation Yokohama City University | Blood biomarker for use in evaluation of effect of drug therapy on kidney cancer |
WO2017214572A1 (en) | 2016-06-10 | 2017-12-14 | The Regents Of The University Of California | Image-based cell sorting systems and methods |
CA3043709A1 (en) | 2016-11-14 | 2018-05-17 | Berg Llc | Methods for treating parkinson's disease |
CN106834105A (zh) * | 2017-02-21 | 2017-06-13 | 齐齐哈尔医学院 | 一种用于表观遗传分析的设备和方法 |
US11636917B2 (en) * | 2017-06-28 | 2023-04-25 | The Regents Of The University Of California | Simulating the metabolic pathway dynamics of an organism |
CN107475346B (zh) * | 2017-08-11 | 2021-08-06 | 北京汉典制药有限公司 | 一种体外筛选糖尿病肾病药物的方法 |
JP6902977B2 (ja) * | 2017-09-22 | 2021-07-14 | 新日本無線株式会社 | 起動回路の故障検出方法 |
AU2018351147A1 (en) * | 2017-10-18 | 2020-05-07 | Venn Biosciences Corporation | Identification and use of biological parameters for diagnosis and treatment monitoring |
JP2021073432A (ja) * | 2018-03-02 | 2021-05-13 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 治療標的である活性化キナーゼのスクリーニング方法 |
JP7176381B2 (ja) * | 2018-12-03 | 2022-11-22 | 富士通株式会社 | 環状分子の構造探索方法、及び構造探索装置、並びにプログラム |
CN109536473A (zh) * | 2018-12-19 | 2019-03-29 | 华中科技大学鄂州工业技术研究院 | 整合多组学数据推测细胞转分化中关键蛋白质激酶的方法 |
US11216742B2 (en) | 2019-03-04 | 2022-01-04 | Iocurrents, Inc. | Data compression and communication using machine learning |
WO2020264379A1 (en) * | 2019-06-26 | 2020-12-30 | Berg Llc | Markers for the diagnosis of prostate cancer |
WO2021183684A1 (en) * | 2020-03-10 | 2021-09-16 | AI:ON Innovations, Inc. | System and methods for mammalian transfer learning |
US11227690B1 (en) * | 2020-09-14 | 2022-01-18 | Opendna Ltd. | Machine learning prediction of therapy response |
CN113035298B (zh) * | 2021-04-02 | 2023-06-20 | 南京信息工程大学 | 递归生成大阶数行限制覆盖阵列的药物临床试验设计方法 |
CN113138249B (zh) * | 2021-04-12 | 2021-11-23 | 北京蛋白质组研究中心 | 基于微孔阵列芯片的微量样本代谢组、蛋白质组和磷酸化蛋白质组多组学分析方法 |
EP4338163A1 (en) * | 2021-05-13 | 2024-03-20 | Scipher Medicine Corporation | Assessing responsiveness to therapy |
CN113943720A (zh) * | 2021-11-03 | 2022-01-18 | 江苏省农业科学院 | 一种绿盲蝽GRK基因、其dsRNA及其合成方法和应用 |
WO2023230268A1 (en) * | 2022-05-27 | 2023-11-30 | Memorial Sloan-Kettering Cancer Center | Systems and methods for metabolite imputation |
CN117417914A (zh) * | 2022-07-18 | 2024-01-19 | 华东师范大学 | 预防和保护脑缺血疾病的标志物及阿司匹林衍生物在预防和保护脑缺血疾病中的应用 |
WO2024081740A1 (en) * | 2022-10-13 | 2024-04-18 | Somalogic Operating Co., Inc. | Systems and methods for validation of proteomic models |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
WO1987002671A1 (en) | 1985-11-01 | 1987-05-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
US6121424A (en) | 1991-11-25 | 2000-09-19 | Enzon, Inc. | Multivalent antigen-binding proteins |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
DE768377T1 (de) | 1988-09-02 | 1998-01-02 | Dyax Corp | Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
AU665190B2 (en) | 1990-07-10 | 1995-12-21 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
ATE164395T1 (de) | 1990-12-03 | 1998-04-15 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
DK1820858T3 (da) | 1991-03-01 | 2009-11-02 | Dyax Corp | Kimært protein omfatende mikroprotein med to eller flere disulfidbindinger og udförelsesformer deraf |
WO1992018619A1 (en) | 1991-04-10 | 1992-10-29 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
US5621083A (en) | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
ATE241426T1 (de) | 1991-11-22 | 2003-06-15 | Affymetrix Inc A Delaware Corp | Verfahren zur herstellung von polymerarrays |
DE69326967T2 (de) | 1992-01-17 | 2000-06-15 | Lakowicz Joseph R | Phasenmodulationsenergieübertragungsfluoroimmunassay |
US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
WO1994016101A2 (en) | 1993-01-07 | 1994-07-21 | Koester Hubert | Dna sequencing by mass spectrometry |
CA2158642A1 (en) | 1993-03-19 | 1994-09-29 | Hubert Koster | Dna sequencing by mass spectrometry via exonuclease degradation |
US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
JP2001521753A (ja) | 1997-10-31 | 2001-11-13 | アフィメトリックス インコーポレイテッド | 成人臓器及び胎児臓器中の発現プロフィール |
US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
US6763307B2 (en) * | 2000-03-06 | 2004-07-13 | Bioseek, Inc. | Patient classification |
WO2002072871A2 (en) | 2001-03-13 | 2002-09-19 | Ashni Naturaceuticals, Inc. | Method for association of genomic and proteomic pathways associated with physiological or pathophysiological processes |
US8000949B2 (en) * | 2001-06-18 | 2011-08-16 | Genego, Inc. | Methods for identification of novel protein drug targets and biomarkers utilizing functional networks |
US7393656B2 (en) * | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
AU2002304965A1 (en) | 2002-05-24 | 2003-12-12 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
EP1540505B1 (en) | 2002-08-29 | 2008-06-18 | Gene Network Sciences, Inc. | Systems and methods for inferring biological networks |
US20070104688A1 (en) | 2003-02-13 | 2007-05-10 | City Of Hope | Small interfering RNA mediated transcriptional gene silencing in mammalian cells |
JP4288345B2 (ja) * | 2003-06-19 | 2009-07-01 | 独立行政法人産業技術総合研究所 | 新規てんかんモデル動物 |
EP1512970A1 (en) * | 2003-09-05 | 2005-03-09 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Method for determining the impact of a multicomponent mixture on the biological profile of a disease |
JPWO2005035780A1 (ja) | 2003-10-14 | 2006-12-21 | 株式会社セルフリーサイエンス | 指標物質の新規スクリーニング方法 |
US8185367B2 (en) | 2004-04-30 | 2012-05-22 | Merck Sharp & Dohme Corp. | Systems and methods for reconstructing gene networks in segregating populations |
EP1607898A3 (en) | 2004-05-18 | 2006-03-29 | Neal E. Solomon | A bioinformatics system for functional proteomics modelling |
US20100316629A1 (en) | 2004-09-01 | 2010-12-16 | Shaughnessy Jr John D | Use of gene expression profiling to predict survival in cancer patient |
WO2006054991A1 (en) * | 2004-11-17 | 2006-05-26 | Immunivest Corporation | Magnetic enrichment of circulating cells, fragments and debris for enabling hts proteomics and genomics in disease detection |
EP1842147A2 (en) * | 2005-01-24 | 2007-10-10 | The Board of Trustees of The Leland Stanford Junior University | Method for modeling cell signaling systems by means of bayesian networks |
US20090132171A1 (en) | 2005-05-31 | 2009-05-21 | Jcl Bioassay Corporation | Screening Method for Specific Protein in Proteome Comprehensive Analysis |
US7906116B2 (en) * | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
CA2622852A1 (en) | 2005-09-30 | 2007-04-12 | Universiteit Maastricht | Tumor angiogenesis associated genes and a method for their identification |
WO2008060620A2 (en) * | 2006-11-15 | 2008-05-22 | Gene Network Sciences, Inc. | Systems and methods for modeling and analyzing networks |
JP2009050171A (ja) * | 2007-08-23 | 2009-03-12 | Toyobo Co Ltd | 表面プラズモン共鳴による基板上におけるリン酸化の検出方法 |
CA3146103A1 (en) | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
CA2732658A1 (en) * | 2008-08-15 | 2010-02-18 | Merrimack Pharmaceuticals, Inc. | Methods and systems for predicting response of cells to a therapeutic agent |
GB2512153B (en) * | 2008-11-17 | 2014-11-12 | Veracyte Inc | Methods and compositions of molecular profiling for disease diagnostics |
BRPI1010648A2 (pt) * | 2009-05-11 | 2016-03-15 | Berg Biosystems Llc | métodos para o diagnóstico de distúrbios oncológicos usando transferidores epimetabólicos, moléculas intracelulares multidimensionais ou influenciadores ambientais |
EP2600154A4 (en) | 2010-03-31 | 2014-06-11 | Univ Kumamoto Nat Univ Corp | METHOD FOR PRODUCING DATA SET FOR INTEGRATED PROTEOMIC, INTEGRATED PROTEASE METHOD USING THE DATA SET FOR INTEGRATED PROTEOME, THAT IS PRODUCED BY THE PRODUCTION METHOD, AND METHOD FOR IDENTIFYING, BY ITS USE, THE SUBSTANCE THAT IN THE ORIGIN |
JP6105491B2 (ja) | 2011-03-02 | 2017-03-29 | バーグ エルエルシー | 照合性細胞ベースのアッセイ及びその使用 |
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