HK1205200A1 - 多重生物化學測定中的信號編碼和解碼 - Google Patents

多重生物化學測定中的信號編碼和解碼

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Publication number
HK1205200A1
HK1205200A1 HK15105486.3A HK15105486A HK1205200A1 HK 1205200 A1 HK1205200 A1 HK 1205200A1 HK 15105486 A HK15105486 A HK 15105486A HK 1205200 A1 HK1205200 A1 HK 1205200A1
Authority
HK
Hong Kong
Prior art keywords
decoding
signal encoding
biochemical assays
multiplexed biochemical
multiplexed
Prior art date
Application number
HK15105486.3A
Other languages
English (en)
Inventor
Emil P Kartalov
Aditya Rajagopal
Axel Scherer
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48905921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1205200(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of HK1205200A1 publication Critical patent/HK1205200A1/zh

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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6851Quantitative amplification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/20Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10Complex mathematical operations
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10Complex mathematical operations
    • G06F17/11Complex mathematical operations for solving equations, e.g. nonlinear equations, general mathematical optimization problems
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Data Mining & Analysis (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Software Systems (AREA)
  • Public Health (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Epidemiology (AREA)
  • Artificial Intelligence (AREA)
  • Signal Processing (AREA)
  • Databases & Information Systems (AREA)
HK15105486.3A 2012-02-03 2015-06-09 多重生物化學測定中的信號編碼和解碼 HK1205200A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261594480P 2012-02-03 2012-02-03
US201261703093P 2012-09-19 2012-09-19
PCT/US2013/024509 WO2013116780A1 (en) 2012-02-03 2013-02-01 Signal encoding and decoding in multiplexed biochemical assays

Publications (1)

Publication Number Publication Date
HK1205200A1 true HK1205200A1 (zh) 2015-12-11

Family

ID=48905921

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105486.3A HK1205200A1 (zh) 2012-02-03 2015-06-09 多重生物化學測定中的信號編碼和解碼

Country Status (8)

Country Link
US (9) US8838394B2 (zh)
EP (6) EP2809813B1 (zh)
JP (1) JP6255353B2 (zh)
KR (2) KR102145677B1 (zh)
CN (3) CN104271767B (zh)
BR (1) BR112014019168B1 (zh)
HK (1) HK1205200A1 (zh)
WO (1) WO2013116780A1 (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6255353B2 (ja) 2012-02-03 2017-12-27 カリフォルニア インスティチュート オブ テクノロジー 多重生化学アッセイにおける信号エンコードおよびデコード
CN104662172B (zh) 2012-08-03 2018-07-06 加州理工学院 Pcr中具有减少的硬件和要求的多重化和定量
CA2897474A1 (en) 2013-01-24 2014-07-31 California Institute Of Technology Chromophore-based characterization and detection methods
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
KR101789079B1 (ko) 2014-09-22 2017-10-24 건국대학교 산학협력단 마이크로알엔에이 검지를 위한 핵산 다중 접합체 및 그 제조방법
WO2016120396A1 (en) * 2015-01-29 2016-08-04 Instituut Voor Tropische Geneeskunde Combined plasmodium-rna virus detection method
WO2016161325A1 (en) 2015-04-02 2016-10-06 University Of Washington Optical painting and fluorescence-activated sorting of adherent cells
JP6847934B2 (ja) * 2015-10-05 2021-03-24 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill アッセイを多重化する為のデコード方法並びに関連する流体デバイス、キット、及び固体支持体
CN116083543A (zh) 2016-04-01 2023-05-09 克罗玛科德公司 用于工程化信号产生的竞争性探针
EP3465504A4 (en) * 2016-06-02 2020-02-12 Seegene, Inc. METHOD FOR DETECTING A TARGET ANALYTIC IN A SAMPLE USING A DATA SET WITH SIGNAL ALIGNMENT
EP3472354A4 (en) 2016-06-17 2020-01-01 California Institute of Technology NUCLEIC ACID ACTIONS AND RELATED PROCEDURES AND COMPOSITIONS
JP6846636B2 (ja) * 2017-02-28 2021-03-24 パナソニックIpマネジメント株式会社 核酸検出用オリゴヌクレオチド
WO2019006023A1 (en) * 2017-06-28 2019-01-03 ChromaCode, Inc. MULTIPLEXED FLUORIMETRIC MEASUREMENTS WITH DROPLET PCR SYSTEMS
JP2019154246A (ja) * 2018-03-08 2019-09-19 株式会社リコー プローブセット、及びそれを用いた核酸検出方法
WO2019236447A1 (en) * 2018-06-04 2019-12-12 ChromaCode, Inc. Methods for watermarking and identifying chemical compositions
US20200010876A1 (en) * 2018-07-03 2020-01-09 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
EP3821034A4 (en) * 2018-07-11 2022-04-27 Chromacode, Inc. METHODS FOR QUANTIFYING ANALYTES IN MULTIPLEXED BIOCHEMICAL REACTIONS
USD975312S1 (en) 2020-02-14 2023-01-10 Beckman Coulter, Inc. Reagent cartridge

Family Cites Families (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE88761T1 (de) 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US6127155A (en) 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
US5618711A (en) 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US5079351A (en) 1986-11-26 1992-01-07 Cetus Corporation Oligonucleotides and kits for detection of htlvi and htlvii viruses by hybridization
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
ES2091976T3 (es) 1991-06-20 1996-11-16 Hoffmann La Roche Metodos perfeccionados para la amplificacion del acido nucleico.
DE69333650T2 (de) 1992-02-19 2006-01-12 The Public Health Research Institute Of The City Of New York, Inc. Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5948360A (en) * 1994-07-11 1999-09-07 Tekmar Company Autosampler with robot arm
EP0807816A4 (en) 1995-02-02 1999-09-22 Chugai Pharmaceutical Co Ltd METHOD FOR EXAMINING A SUBSTANCE BY CONTROLLING THE CHEMILUMINESCENCE DOSE
CN1181720A (zh) * 1995-04-25 1998-05-13 伊萝莉公司 可远程编程的存储器材料及其应用
JP4040087B2 (ja) 1995-05-05 2008-01-30 アプレラ コーポレイション Pcr増幅とハイブリダイゼーションプロービングアッセイとを組み合わせた方法およびそのための試薬
US5882856A (en) 1995-06-07 1999-03-16 Genzyme Corporation Universal primer sequence for multiplex DNA amplification
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US20050112637A1 (en) 1995-09-08 2005-05-26 Chatterjee Deb K. Mutant DNA polymerases and uses thereof
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6007994A (en) 1995-12-22 1999-12-28 Yale University Multiparametric fluorescence in situ hybridization
EP0929694A4 (en) 1996-03-15 2002-05-02 Penn State Res Found DETECTION OF TUMOR-RELATED EXTRACELLULAR NUCLEIC ACID USING PLASMA OR BLOOD SERUM USING NUCLEIC ACID AMPLIFICATION TESTS
US6329179B1 (en) 1996-03-26 2001-12-11 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
DK1179600T3 (da) 1996-06-04 2005-09-05 Univ Utah Res Found Overvågning af hybridisering under PCR
US5834203A (en) 1997-08-25 1998-11-10 Applied Spectral Imaging Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore
IL135593A (en) 1997-10-14 2004-06-01 Luminex Corp Precisely fluorescently painted polymeric microspheres and methods for making and using them
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
WO1999052708A1 (en) 1998-04-13 1999-10-21 Luminex Corporation Liquid labeling with fluorescent microparticles
EP2360271A1 (en) 1998-06-24 2011-08-24 Illumina, Inc. Decoding of array sensors with microspheres
AU762728B2 (en) 1998-07-02 2003-07-03 Gen-Probe Incorporated Molecular torches
US6642062B2 (en) 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
EP1171636A2 (en) 1999-04-22 2002-01-16 Albert Einstein College Of Medicine Of Yeshiva University Assay of gene expression patterns by multi-fluor fish
WO2001007640A2 (en) 1999-07-23 2001-02-01 The Secretary Of State For The Home Department Method for detecting single nucleotide polymorphisms
JP4919568B2 (ja) 1999-10-22 2012-04-18 ピーエイチアールアイ プロパティーズ,インコーポレイテッド 短い配列の変異体を検出するためのアッセイ
US20040053230A1 (en) 2001-03-07 2004-03-18 Schaffer Michael Edward Real time quantitative pcr with intercalating dye for single and multiplex target dna
ES2269365T3 (es) 2000-03-29 2007-04-01 Lgc Limited Baliza de hibridacion y metodo de deteccion y discriminacion rapidas de secuencias.
US6734420B2 (en) * 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
CN101525660A (zh) * 2000-07-07 2009-09-09 维西根生物技术公司 实时序列测定
US7608683B2 (en) * 2000-08-09 2009-10-27 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
CA2314398A1 (en) * 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
US20020142345A1 (en) 2000-12-22 2002-10-03 Nelsen Anita J. Methods for encoding and decoding complex mixtures in arrayed assays
WO2002100157A2 (en) * 2001-02-21 2002-12-19 Amnis Corporation Method and apparatus for labeling and analyzing cellular components
CA2439402A1 (en) 2001-03-02 2002-09-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Pcr method
WO2009003492A1 (en) 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
US20030148544A1 (en) * 2001-06-28 2003-08-07 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof
AU2002322457A1 (en) * 2001-06-28 2003-03-03 Illumina, Inc. Multiplex decoding of array sensors with microspheres
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
EP1288308A1 (en) 2001-08-28 2003-03-05 Roche Diagnostics GmbH A method for the determination of multiple analytes
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US20030134320A1 (en) 2002-01-15 2003-07-17 Myriad Genetics, Incorporated Method system and computer program product for quality assurance in detecting biochemical markers
EP1426448A1 (en) 2002-12-03 2004-06-09 bioMérieux BV Method for lowering the effects of sequence variations in a diagnostic hybridization assay, probe for use in the assay and assay
CA2525482C (en) 2003-04-04 2015-02-17 F. Hoffmann-La Roche Ag Improved system for multicolor real-time pcr comprising 3 to 6 pairs of forester resonance energy transfer (fret) probes
US7385043B1 (en) 2003-04-30 2008-06-10 The Public Health Research Institute Of The City Of New York, Inc. Homogeneous multiplex screening assays and kits
US7070786B2 (en) 2003-06-06 2006-07-04 Centocor, Inc. RSV proteins, antibodies, compositions, methods and uses
US20050053950A1 (en) 2003-09-08 2005-03-10 Enrique Zudaire Ubani Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons
US20050064435A1 (en) 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
TWI232934B (en) 2003-11-19 2005-05-21 Ind Tech Res Inst A biochip containing splitable reaction confinement and method for producing same and application thereof
CN101076537B (zh) 2003-11-19 2012-07-04 阿莱洛吉克生物科学公司 标记有多个荧光团的寡核苷酸
US7604937B2 (en) 2004-03-24 2009-10-20 Applied Biosystems, Llc Encoding and decoding reactions for determining target polynucleotides
JP4972541B2 (ja) 2004-04-01 2012-07-11 バイオ−ラッド ラボラトリーズ インコーポレーティッド 標識されたプローブおよび3’→5’エキソヌクレアーゼ活性を用いた定量的増幅方法
US7294466B2 (en) 2004-05-07 2007-11-13 Cepheid Multiplexed detection of biological agents
US7575864B2 (en) 2004-05-27 2009-08-18 E.I. Du Pont De Nemours And Company Method for the direct detection of diagnostic RNA
DE102004043870B4 (de) 2004-09-10 2009-11-19 Eppendorf Ag Verfahren zur Erweiterung des dynamischen Erfassungsbereich bei Mikroarrays
WO2006032487A2 (en) 2004-09-24 2006-03-30 Universität Bern Molecular beacons
CA2996947C (en) 2004-10-18 2019-02-26 Brandeis University Primers, probes and methods for nucleic acid amplification
US8133703B2 (en) 2004-10-27 2012-03-13 Ceoheid Closed-system multi-stage nucleic acid amplification reactions
WO2006079049A2 (en) 2005-01-21 2006-07-27 Third Wave Technologies, Inc. Methods and compositions for increased dynamic range detection of nucleic acid molecules
US8168602B2 (en) * 2005-02-17 2012-05-01 Dana-Farber Cancer Institute, Inc. Compositions, kits and methods for identification, assessment, prevention and therapy of cancer
US7709249B2 (en) 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
AU2005333512A1 (en) 2005-06-16 2006-12-28 Biotools Biotechnological & Medical Laboratories, S.A. Nucleic acid detection method involving the direct generation of a measurable signal
US8067208B2 (en) 2005-06-30 2011-11-29 Roche Molecular Systems, Inc. Probes and methods for hepatitis C virus typing using multidimensional probe analysis
PL1937834T3 (pl) 2005-09-01 2014-11-28 Mtpcr Pty Ltd Sposoby wzmacniania, kwantyfikacji i identyfikacji kwasów nukleinowych
US7553955B2 (en) 2005-09-01 2009-06-30 The Trustees Of The University Of Pennsylvania Molecular beacons, methods and kits for detecting DNA damage response
CN1936019B (zh) * 2005-10-18 2013-01-30 厦门大学 用于多重实时核酸扩增检测的探针编码方法
ES2402939T3 (es) 2005-12-23 2013-05-10 Nanostring Technologies, Inc. Composiciones que comprenden macromoléculas inmovilizadas y orientadas y métodos para su preparación
ES2374788T3 (es) 2005-12-23 2012-02-22 Nanostring Technologies, Inc. Nanoinformadores y métodos para su producción y uso.
US9133506B2 (en) 2006-01-10 2015-09-15 Applied Spectral Imaging Ltd. Methods and systems for analyzing biological samples
US8455184B2 (en) 2006-04-18 2013-06-04 The United States Of America As Represented By The Secretary Of The Air Force Differential multiplexing with pattern recognition
CA2649725A1 (en) * 2006-04-19 2007-10-25 Applera Corporation Reagents, methods, and libraries for gel-free bead-based sequencing
JP5081232B2 (ja) 2006-05-22 2012-11-28 ナノストリング テクノロジーズ, インコーポレイテッド ナノレポーターを分析するためのシステムおよび方法
CA2653454A1 (en) 2006-05-23 2007-11-29 Molecular Detection, Inc. Ambient temperature stable kits for molecular diagnostics
WO2008002882A2 (en) 2006-06-26 2008-01-03 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
WO2008005248A2 (en) * 2006-06-30 2008-01-10 Canon U.S. Life Sciences, Inc. Real-time pcr in micro-channels
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
WO2008036614A1 (en) * 2006-09-18 2008-03-27 California Institute Of Technology Apparatus for detecting target molecules and related methods
WO2008054595A2 (en) 2006-09-28 2008-05-08 The Regents Of The University Of California Drug controlled molecular tags
WO2008052774A2 (en) 2006-10-31 2008-05-08 Noxxon Pharma Ag Methods for detection of a single- or double-stranded nucleic acid molecule
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
AU2007325037B2 (en) 2006-11-30 2012-09-20 Gen-Probe Incorporated Quantitative method employing adjustment of pre-defined master calibration curves
EP2857526B1 (en) 2006-12-13 2016-08-17 Luminex Corporation Systems and methods for multiplex analysis of PCR in real time
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
WO2008109636A1 (en) 2007-03-05 2008-09-12 University Of Utah Research Foundation Methods and compositions related to nucleic acid detection
WO2008118998A2 (en) 2007-03-27 2008-10-02 Primera Biosystems Inc. Method for multiplex detection and quantitation of nucleic acids
US8415102B2 (en) 2007-04-10 2013-04-09 Nanostring Technologies, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
EP2193356B1 (en) 2007-08-29 2014-07-23 Eppendorf Ag Device and method for radiometric measurement of a plurality of samples
US20100297633A1 (en) 2007-09-20 2010-11-25 Molecular Plant Breeding Nominees Ltd Method of amplifying nucleic acid
WO2009081967A1 (ja) 2007-12-26 2009-07-02 Arkray, Inc. 標的核酸配列の増幅方法およびそれに用いるプローブ
EP2336358A1 (en) 2008-05-06 2011-06-22 QIAGEN GmbH Simultaneous detection of multiple nucleic acid sequences in a reaction
NZ590341A (en) * 2008-06-25 2012-07-27 Baylor Res Inst Blood transcriptional signature of mycobacterium tuberculosis infection
GB0812862D0 (en) 2008-07-14 2008-08-20 Lumora Ltd Nucleic acid amplification
ES2396044T3 (es) 2008-07-31 2013-02-18 Oxitec Limited Amplificación y detección de múltiplex
WO2010017543A1 (en) 2008-08-08 2010-02-11 Smiths Detection Inc. Detection algorithm for pcr assay
JP5836803B2 (ja) 2008-08-14 2015-12-24 ナノストリング テクノロジーズ, インコーポレイテッド 安定したナノレポーター
US9921154B2 (en) 2011-03-18 2018-03-20 Bio-Rad Laboratories, Inc. Multiplexed digital assays
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
CN102232118B (zh) 2008-12-01 2015-07-08 恰根有限公司 用于核酸检测的新型荧光染料组合物
US9534255B2 (en) 2008-12-17 2017-01-03 Life Technologies Corporation Methods, compositions, and kits for detecting allelic variants
US8361738B2 (en) * 2009-03-06 2013-01-29 California Institute Of Technology Methods for quantitative target detection and related devices and systems
US8039215B2 (en) 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
CN101570782B (zh) * 2009-03-20 2012-01-11 曹际娟 乳制品中8种致病菌检测试剂盒及其检测方法
FI20095514A0 (fi) 2009-05-07 2009-05-07 Expression Analytics Oy Menetelmä, laitteisto ja tietokoneohjelmatuote PCR-tuotteiden kvantifioimiseksi
EP2430187A2 (en) 2009-05-12 2012-03-21 Abacus Diagnostica OY Method for detecting nucleic acids
WO2010135917A1 (zh) 2009-05-26 2010-12-02 厦门大学 一种检测核酸序列变异的方法
CN102449166B (zh) 2009-05-26 2013-12-04 厦门大学 一种单管检测多个单核苷酸变异或单核苷酸多态性的方法
EP2280080A1 (en) 2009-07-31 2011-02-02 Qiagen GmbH Method of normalized quantification of nucleic acids using anchor oligonucleotides and adapter oligonucleotides
PT3375891T (pt) 2009-09-10 2020-05-11 Diasorin S P A Métodos e dispositivos para compensação de diafonia espectral em amplificação de ácido nucleico multiplex
WO2011037306A1 (en) 2009-09-24 2011-03-31 Seegene, Inc. Detection of target nucleic acid sequences by cyclic exonucleolytic reactions
US8962251B2 (en) 2009-10-08 2015-02-24 Medical Service Consultation International, Llc Methods and compositions for identifying sulfur and iron modifying bacteria
JP5954876B2 (ja) 2009-10-13 2016-07-20 ナノストリング テクノロジーズ, インコーポレイテッド ナノレポーターによるタンパク質の検出
US9752187B2 (en) 2009-12-11 2017-09-05 Nucleix Categorization of DNA samples
US9220743B2 (en) 2010-01-22 2015-12-29 Nuovo Biologics, Llc Pan-antiviral peptides for protein kinase inhibition
CA2785529C (en) 2010-02-11 2019-01-08 Nanostring Technologies, Inc. Compositions and methods for the detection of small rnas
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US8535889B2 (en) 2010-02-12 2013-09-17 Raindance Technologies, Inc. Digital analyte analysis
WO2011116088A2 (en) 2010-03-16 2011-09-22 Nanostring Technologies, Inc. Compositions and methods for the detection of genomic features
EP2572001A2 (en) 2010-05-19 2013-03-27 QIAGEN Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
CA2802741C (en) 2010-06-30 2020-07-07 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
US8877464B2 (en) 2010-07-29 2014-11-04 Roche Molecular Systems, Inc. Qualitative and quantitative detection of microbial nucleic acids
EP2633080B1 (en) 2010-10-29 2018-12-05 President and Fellows of Harvard College Method of detecting targets using fluorescently labelled nucleic acid nanotube probes
EP2665995B1 (en) 2011-01-20 2018-08-29 University of Washington through its Center for Commercialization Methods and systems for performing digital measurements
WO2012106428A2 (en) 2011-02-03 2012-08-09 University Of Florida Research Foundation, Inc. Detection methods for target dna
EP2686449B1 (en) 2011-03-18 2020-11-18 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
WO2012129115A2 (en) 2011-03-18 2012-09-27 University Of South Florida Materials and methods for profiling micrornas
WO2012135340A2 (en) 2011-03-28 2012-10-04 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
EP2723897A4 (en) 2011-06-24 2015-03-18 Nanostring Technologies Inc MULTIVARIATED DIAGNOSTIC ASSAYS AND METHODS OF USE THEREOF
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8858623B2 (en) 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
CA2859761C (en) * 2011-12-22 2023-06-20 President And Fellows Of Harvard College Compositions and methods for analyte detection
JP6255353B2 (ja) 2012-02-03 2017-12-27 カリフォルニア インスティチュート オブ テクノロジー 多重生化学アッセイにおける信号エンコードおよびデコード
RU2671707C2 (ru) 2012-06-27 2018-11-06 Рутгерс, Дзе Стейт Юниверсити Оф Нью-Джерси Экспресс-анализы активации т-клеток, основанные на измерении рнк с использованием проточной цитометрии
CN104662172B (zh) 2012-08-03 2018-07-06 加州理工学院 Pcr中具有减少的硬件和要求的多重化和定量
GB201218909D0 (en) 2012-10-22 2012-12-05 Univ Singapore Assay for the parallel detection of biological material based on PCR
CA2897474A1 (en) 2013-01-24 2014-07-31 California Institute Of Technology Chromophore-based characterization and detection methods
EP3640347A3 (en) 2013-03-12 2020-07-29 Life Technologies Corporation Universal reporter-based genotyping methods and materials
EP2873740A1 (en) 2013-11-19 2015-05-20 Oncodiag Methods for the surveillance, diagnosis and screening of bladder cancer
US9670530B2 (en) 2014-01-30 2017-06-06 Illumina, Inc. Haplotype resolved genome sequencing
WO2015147370A1 (en) 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
WO2015169947A1 (en) 2014-05-09 2015-11-12 Lifecodexx Ag Detection of dna that originates from a specific cell-type and related methods
KR102502087B1 (ko) 2015-03-25 2023-02-20 더 제너럴 하스피탈 코포레이션 혈액 샘플 내의 순환 종양 세포의 디지털 분석
JP2019513345A (ja) 2016-02-10 2019-05-30 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 核酸の検知
WO2018081178A1 (en) 2016-10-24 2018-05-03 Two Pore Guys, Inc. Fractional abundance of polynucleotide sequences in a sample
CN116083543A (zh) 2016-04-01 2023-05-09 克罗玛科德公司 用于工程化信号产生的竞争性探针
EP3472354A4 (en) 2016-06-17 2020-01-01 California Institute of Technology NUCLEIC ACID ACTIONS AND RELATED PROCEDURES AND COMPOSITIONS
WO2019006023A1 (en) 2017-06-28 2019-01-03 ChromaCode, Inc. MULTIPLEXED FLUORIMETRIC MEASUREMENTS WITH DROPLET PCR SYSTEMS
US20190112636A1 (en) 2017-10-16 2019-04-18 ChromaCode, Inc. Methods and compositions for nucleic acid detection
WO2019169043A1 (en) 2018-02-28 2019-09-06 ChromaCode, Inc. Molecular targets for fetal nucleic acid analysis
US20200010876A1 (en) 2018-07-03 2020-01-09 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays

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