HK1205200A1 - Signal encoding and decoding in multiplexed biochemical assays - Google Patents

Signal encoding and decoding in multiplexed biochemical assays

Info

Publication number
HK1205200A1
HK1205200A1 HK15105486.3A HK15105486A HK1205200A1 HK 1205200 A1 HK1205200 A1 HK 1205200A1 HK 15105486 A HK15105486 A HK 15105486A HK 1205200 A1 HK1205200 A1 HK 1205200A1
Authority
HK
Hong Kong
Prior art keywords
decoding
signal encoding
biochemical assays
multiplexed biochemical
multiplexed
Prior art date
Application number
HK15105486.3A
Other languages
English (en)
Chinese (zh)
Inventor
Emil P Kartalov
Aditya Rajagopal
Axel Scherer
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48905921&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1205200(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of HK1205200A1 publication Critical patent/HK1205200A1/xx

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/11—Complex mathematical operations for solving equations, e.g. nonlinear equations, general mathematical optimization problems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Data Mining & Analysis (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Software Systems (AREA)
  • Public Health (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
HK15105486.3A 2012-02-03 2015-06-09 Signal encoding and decoding in multiplexed biochemical assays HK1205200A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261594480P 2012-02-03 2012-02-03
US201261703093P 2012-09-19 2012-09-19
PCT/US2013/024509 WO2013116780A1 (en) 2012-02-03 2013-02-01 Signal encoding and decoding in multiplexed biochemical assays

Publications (1)

Publication Number Publication Date
HK1205200A1 true HK1205200A1 (en) 2015-12-11

Family

ID=48905921

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105486.3A HK1205200A1 (en) 2012-02-03 2015-06-09 Signal encoding and decoding in multiplexed biochemical assays

Country Status (8)

Country Link
US (8) US8838394B2 (ko)
EP (6) EP4361607A2 (ko)
JP (1) JP6255353B2 (ko)
KR (2) KR102145677B1 (ko)
CN (3) CN104271767B (ko)
BR (1) BR112014019168B1 (ko)
HK (1) HK1205200A1 (ko)
WO (1) WO2013116780A1 (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102145677B1 (ko) 2012-02-03 2020-08-18 캘리포니아 인스티튜트 오브 테크놀로지 다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩
US9791372B2 (en) 2012-08-03 2017-10-17 California Institute Of Technology Multiplexing and quantification in PCR with reduced hardware and requirements
EP2948566A4 (en) 2013-01-24 2016-10-05 California Inst Of Techn CHROMOPHORE-BASED CHARACTERIZATION AND DETECTION METHODS
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
KR101789079B1 (ko) 2014-09-22 2017-10-24 건국대학교 산학협력단 마이크로알엔에이 검지를 위한 핵산 다중 접합체 및 그 제조방법
WO2016120396A1 (en) * 2015-01-29 2016-08-04 Instituut Voor Tropische Geneeskunde Combined plasmodium-rna virus detection method
US10429294B2 (en) 2015-04-02 2019-10-01 University Of Washington Optical painting and fluorescence-activated sorting of adherent cells
US11016084B2 (en) * 2015-10-05 2021-05-25 The University Of North Carolina At Chapel Hill Decoding methods for multiplexing assays and associated fluidic devices, kits, and solid supports
EP4219519A3 (en) 2016-04-01 2023-09-13 Chromacode, Inc. Competitive probes for engineering signal generation
KR102385959B1 (ko) * 2016-06-02 2022-04-12 주식회사 씨젠 신호 변화량 데이터 세트를 이용한 샘플 내 타겟 분석물질 검출 방법
US10066263B2 (en) 2016-06-17 2018-09-04 California Institute Of Technology Nucleic acid reactions and related methods and compositions
JP6846636B2 (ja) * 2017-02-28 2021-03-24 パナソニックＩｐマネジメント株式会社 核酸検出用オリゴヌクレオチド
EP4379065A2 (en) * 2017-06-28 2024-06-05 Chromacode, Inc. Multiplexed fluorometric measurements with droplet pcr systems
JP2019154246A (ja) * 2018-03-08 2019-09-19 株式会社リコー プローブセット、及びそれを用いた核酸検出方法
US20210208071A1 (en) * 2018-06-04 2021-07-08 ChromaCode, Inc. Methods for watermarking and identifying chemical compositions
US20200010876A1 (en) * 2018-07-03 2020-01-09 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
CN112805392A (zh) * 2018-07-11 2021-05-14 克罗玛科德公司 多重生化反应中分析物的定量方法
USD975312S1 (en) 2020-02-14 2023-01-10 Beckman Coulter, Inc. Reagent cartridge

Family Cites Families (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE88761T1 (de) 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US6127155A (en) 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
US5618711A (en) 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US5079351A (en) 1986-11-26 1992-01-07 Cetus Corporation Oligonucleotides and kits for detection of htlvi and htlvii viruses by hybridization
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
DK0519338T3 (da) 1991-06-20 1996-10-28 Hoffmann La Roche Forbedrede fremgangsmåder til nukleinsyreamplifikation
DE69333650T2 (de) 1992-02-19 2006-01-12 The Public Health Research Institute Of The City Of New York, Inc. Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5948360A (en) * 1994-07-11 1999-09-07 Tekmar Company Autosampler with robot arm
KR100449216B1 (ko) 1995-02-02 2005-01-25 쥬가이 세이야쿠 가부시키가이샤 화학발광량조절에의한피검물질의측정방법
WO1996036436A1 (en) 1995-04-25 1996-11-21 Irori Remotely programmable matrices with memories and uses thereof
JP4040087B2 (ja) 1995-05-05 2008-01-30 アプレラ コーポレイション Ｐｃｒ増幅とハイブリダイゼーションプロービングアッセイとを組み合わせた方法およびそのための試薬
US5882856A (en) 1995-06-07 1999-03-16 Genzyme Corporation Universal primer sequence for multiplex DNA amplification
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US20050112637A1 (en) 1995-09-08 2005-05-26 Chatterjee Deb K. Mutant DNA polymerases and uses thereof
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6007994A (en) 1995-12-22 1999-12-28 Yale University Multiparametric fluorescence in situ hybridization
AU2324997A (en) 1996-03-15 1997-10-01 Penn State Research Foundation, The Detection of extracellular tumor-associated nucleic acid in blood plasma or ser um using nucleic acid amplification assays
PT938320E (pt) 1996-03-26 2010-09-22 Michael S Kopreski Método que permite a utilização de arn extracelular extraído de plasma ou de soro para detectar, monitorizar ou avaliar o cancro
US6174670B1 (en) 1996-06-04 2001-01-16 University Of Utah Research Foundation Monitoring amplification of DNA during PCR
US5834203A (en) 1997-08-25 1998-11-10 Applied Spectral Imaging Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore
AU1080999A (en) 1997-10-14 1999-05-03 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
US6235480B1 (en) * 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
EP1079967A4 (en) 1998-04-13 2003-07-23 Luminex Corp LIQUID MARKING USING FLUORESCENT MICROPARTICLES
EP2045334A1 (en) * 1998-06-24 2009-04-08 Illumina, Inc. Decoding of array sensors with microspheres
EP1092047B1 (en) 1998-07-02 2009-08-26 Gen-Probe Incorporated Molecular torches
US6642062B2 (en) 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
JP2002542793A (ja) 1999-04-22 2002-12-17 ザ アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 多蛍光ｆｉｓｈによる遺伝子発現パターンのアッセイ法
ATE368125T1 (de) 1999-07-23 2007-08-15 Forensic Science Service Ltd Verfahren zur erkennung von einzel-nukleotid- polymorphismen
JP4919568B2 (ja) 1999-10-22 2012-04-18 ピーエイチアールアイ プロパティーズ，インコーポレイテッド 短い配列の変異体を検出するためのアッセイ
US20040053230A1 (en) 2001-03-07 2004-03-18 Schaffer Michael Edward Real time quantitative pcr with intercalating dye for single and multiplex target dna
WO2001073118A2 (en) 2000-03-29 2001-10-04 Lgc (Teddington) Limited Hybridisation beacon and method of rapid sequence detection and discrimination
US6734420B2 (en) 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
EP1368460B1 (en) * 2000-07-07 2007-10-31 Visigen Biotechnologies, Inc. Real-time sequence determination
US7608683B2 (en) * 2000-08-09 2009-10-27 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
CA2314398A1 (en) 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
US20020142345A1 (en) 2000-12-22 2002-10-03 Nelsen Anita J. Methods for encoding and decoding complex mixtures in arrayed assays
US20020146734A1 (en) * 2001-02-21 2002-10-10 Amnis Corporation Method and apparatus for labeling and analyzing cellular components
JP4808365B2 (ja) 2001-03-02 2011-11-02 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション Ｐｃｒ法
CA2450725A1 (en) * 2001-06-28 2003-01-09 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof
WO2003002979A2 (en) * 2001-06-28 2003-01-09 Illumina, Inc. Multiplex decoding of array sensors with microspheres
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
EP1288308A1 (en) 2001-08-28 2003-03-05 Roche Diagnostics GmbH A method for the determination of multiple analytes
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US20030134320A1 (en) 2002-01-15 2003-07-17 Myriad Genetics, Incorporated Method system and computer program product for quality assurance in detecting biochemical markers
EP1426448A1 (en) 2002-12-03 2004-06-09 bioMérieux BV Method for lowering the effects of sequence variations in a diagnostic hybridization assay, probe for use in the assay and assay
EP2284278A1 (en) * 2003-04-04 2011-02-16 Roche Diagnostics GmbH Improved system for multi color real time PCR
US7385043B1 (en) 2003-04-30 2008-06-10 The Public Health Research Institute Of The City Of New York, Inc. Homogeneous multiplex screening assays and kits
US7070786B2 (en) 2003-06-06 2006-07-04 Centocor, Inc. RSV proteins, antibodies, compositions, methods and uses
US20050053950A1 (en) 2003-09-08 2005-03-10 Enrique Zudaire Ubani Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons
US20050064435A1 (en) 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
TWI232934B (en) 2003-11-19 2005-05-21 Ind Tech Res Inst A biochip containing splitable reaction confinement and method for producing same and application thereof
US7667024B2 (en) 2003-11-19 2010-02-23 Allelogic Biosciences Corp. Oligonucleotides labeled with a plurality of fluorophores
US7601821B2 (en) * 2004-03-24 2009-10-13 Applied Biosystems, Llc Encoding and decoding reactions for determining target molecules
AU2005230833B2 (en) 2004-04-01 2011-04-14 Bio-Rad Laboratories, Inc. Quantitative amplification with a labeled probe and 3' to 5' exonuclease activity
US7294466B2 (en) 2004-05-07 2007-11-13 Cepheid Multiplexed detection of biological agents
US7575864B2 (en) 2004-05-27 2009-08-18 E.I. Du Pont De Nemours And Company Method for the direct detection of diagnostic RNA
DE102004043870B4 (de) 2004-09-10 2009-11-19 Eppendorf Ag Verfahren zur Erweiterung des dynamischen Erfassungsbereich bei Mikroarrays
EP1799853A2 (en) 2004-09-24 2007-06-27 Universität Bern Molecular beacons
ES2359322T3 (es) 2004-10-18 2011-05-20 Brandeis University Procedimiento para la amplificación de ácidos nucleicos.
CA2587085C (en) 2004-10-27 2017-08-08 Cepheid Closed-system multi-stage nucleic acid amplification reactions
WO2006079049A2 (en) 2005-01-21 2006-07-27 Third Wave Technologies, Inc. Methods and compositions for increased dynamic range detection of nucleic acid molecules
EP1855727A2 (en) * 2005-02-17 2007-11-21 Dana-Farber Cancer Institute, Inc. Compositions, kits and methods for identification, assessment, prevention and therapy of cancer
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7709249B2 (en) 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
EP1892302A1 (en) 2005-06-16 2008-02-27 BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. Nucleic acid detection method involving the direct generation of a measurable signal
US7465561B2 (en) 2005-06-30 2008-12-16 Roche Molecular Systems, Inc. Probes and methods for hepatitis C virus typing using single probe analysis
US7553955B2 (en) * 2005-09-01 2009-06-30 The Trustees Of The University Of Pennsylvania Molecular beacons, methods and kits for detecting DNA damage response
ES2494922T3 (es) 2005-09-01 2014-09-16 Ausdiagnostics Pty Ltd. Métodos para la amplificación, cuantificación e identificación de ácidos nucleicos
CN1936019B (zh) * 2005-10-18 2013-01-30 厦门大学 用于多重实时核酸扩增检测的探针编码方法
US8986926B2 (en) 2005-12-23 2015-03-24 Nanostring Technologies, Inc. Compositions comprising oriented, immobilized macromolecules and methods for their preparation
ATE525482T1 (de) 2005-12-23 2011-10-15 Nanostring Technologies Inc Nanoreporter und verfahren zu deren herstellung und verwendung
US9133506B2 (en) 2006-01-10 2015-09-15 Applied Spectral Imaging Ltd. Methods and systems for analyzing biological samples
US8455184B2 (en) 2006-04-18 2013-06-04 The United States Of America As Represented By The Secretary Of The Air Force Differential multiplexing with pattern recognition
CN101495654A (zh) 2006-04-19 2009-07-29 阿普里拉股份有限公司 无凝胶珠基测序的试剂、方法和文库
ES2620398T3 (es) 2006-05-22 2017-06-28 Nanostring Technologies, Inc. Sistemas y métodos para analizar nanoindicadores
EP2021508B1 (en) 2006-05-23 2012-04-25 Molecular Detection, Inc. Ambient temperature stable kits for molecular diagnostics
WO2008002882A2 (en) 2006-06-26 2008-01-03 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
WO2008005248A2 (en) * 2006-06-30 2008-01-10 Canon U.S. Life Sciences, Inc. Real-time pcr in micro-channels
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
WO2008036614A1 (en) 2006-09-18 2008-03-27 California Institute Of Technology Apparatus for detecting target molecules and related methods
WO2008054595A2 (en) 2006-09-28 2008-05-08 The Regents Of The University Of California Drug controlled molecular tags
WO2008052774A2 (en) 2006-10-31 2008-05-08 Noxxon Pharma Ag Methods for detection of a single- or double-stranded nucleic acid molecule
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
JP2010511390A (ja) 2006-11-30 2010-04-15 ジェン−プロウブ インコーポレイテッド 予め規定されたマスター検量線の調整を使用する定量方法
JP5479910B2 (ja) 2006-12-13 2014-04-23 ルミネックス コーポレーション Ｐｃｒのリアルタイムでの多重分析のためのシステムおよび方法
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
EP2132334A4 (en) 2007-03-05 2010-07-28 Univ Utah Res Found METHODS AND COMPOSITIONS ASSOCIATED WITH DETECTION OF NUCLEIC ACIDS
WO2008118998A2 (en) 2007-03-27 2008-10-02 Primera Biosystems Inc. Method for multiplex detection and quantitation of nucleic acids
US8415102B2 (en) 2007-04-10 2013-04-09 Nanostring Technologies, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
EP3023436A1 (en) 2007-07-03 2016-05-25 Dako Denmark A/S Improved methods for generation, labeling and use of mhc multimers
EP2193356B1 (en) 2007-08-29 2014-07-23 Eppendorf Ag Device and method for radiometric measurement of a plurality of samples
AU2008301233A1 (en) 2007-09-20 2009-03-26 Molecular Plant Breeding Nominees Ltd Method of amplifying nucleic acid
WO2009081967A1 (ja) 2007-12-26 2009-07-02 Arkray, Inc. 標的核酸配列の増幅方法およびそれに用いるプローブ
EP2116614A1 (en) 2008-05-06 2009-11-11 Qiagen GmbH Simultaneous detection of multiple nucleic acid sequences in a reaction
EP2300823A4 (en) * 2008-06-25 2012-03-14 Baylor Res Inst TRANSCRIPTIONAL SIGNATURE OF BLOOD DURING INFECTION WITH MYCOBACTERIUM TUBERCULOSIS
GB0812862D0 (en) 2008-07-14 2008-08-20 Lumora Ltd Nucleic acid amplification
CN102171366B (zh) 2008-07-31 2014-11-26 奥西泰克有限公司 多重扩增与检测
BRPI0917434A2 (pt) 2008-08-08 2015-12-01 Smiths Detection Inc algoritmo de detecçao para ensaio de pcr
ES2684317T3 (es) 2008-08-14 2018-10-02 Nanostring Technologies, Inc Nanoinformadores estables
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9921154B2 (en) 2011-03-18 2018-03-20 Bio-Rad Laboratories, Inc. Multiplexed digital assays
EP2370596B1 (en) 2008-12-01 2017-06-07 QIAGEN GmbH Novel combination of fluorescent dyes for the detection of nucleic acids
CA2747026A1 (en) 2008-12-17 2010-07-08 Life Technologies Corporation Methods, compositions, and kits for detecting allelic variants
US8361738B2 (en) * 2009-03-06 2013-01-29 California Institute Of Technology Methods for quantitative target detection and related devices and systems
US8039215B2 (en) 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
CN101570782B (zh) * 2009-03-20 2012-01-11 曹际娟 乳制品中8种致病菌检测试剂盒及其检测方法
FI20095514A0 (fi) 2009-05-07 2009-05-07 Expression Analytics Oy Menetelmä, laitteisto ja tietokoneohjelmatuote PCR-tuotteiden kvantifioimiseksi
EP2430187A2 (en) 2009-05-12 2012-03-21 Abacus Diagnostica OY Method for detecting nucleic acids
US8691504B2 (en) 2009-05-26 2014-04-08 Xiamen University Method for detecting variations in nucleic acid sequences
CN102449166B (zh) 2009-05-26 2013-12-04 厦门大学 一种单管检测多个单核苷酸变异或单核苷酸多态性的方法
EP2280080A1 (en) 2009-07-31 2011-02-02 Qiagen GmbH Method of normalized quantification of nucleic acids using anchor oligonucleotides and adapter oligonucleotides
PT3375890T (pt) 2009-09-10 2020-04-23 Diasorin S P A Métodos e dispositivos para determinação de uma correcção de diafonia em amplificação de ácido nucleico
EP2480689A4 (en) 2009-09-24 2013-05-15 Seegene Inc DETECTION OF TARGET NUCLEIC ACID SEQUENCES USING CYCLIC EXONUCLEOLYTIC REACTIONS
US8962251B2 (en) 2009-10-08 2015-02-24 Medical Service Consultation International, Llc Methods and compositions for identifying sulfur and iron modifying bacteria
AU2010306862B2 (en) 2009-10-13 2015-08-27 Nanostring Technologies, Inc. Protein detection via nanoreporters
US9752187B2 (en) 2009-12-11 2017-09-05 Nucleix Categorization of DNA samples
US9220743B2 (en) 2010-01-22 2015-12-29 Nuovo Biologics, Llc Pan-antiviral peptides for protein kinase inhibition
CA2785529C (en) 2010-02-11 2019-01-08 Nanostring Technologies, Inc. Compositions and methods for the detection of small rnas
WO2011100604A2 (en) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
WO2011116088A2 (en) 2010-03-16 2011-09-22 Nanostring Technologies, Inc. Compositions and methods for the detection of genomic features
US9422593B2 (en) 2010-05-19 2016-08-23 Qiagen Gaithresburg, Inc Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
EP2588629B1 (en) 2010-06-30 2017-05-17 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
US8877464B2 (en) 2010-07-29 2014-11-04 Roche Molecular Systems, Inc. Qualitative and quantitative detection of microbial nucleic acids
US10024796B2 (en) 2010-10-29 2018-07-17 President And Fellows Of Harvard College Nucleic acid nanostructure barcode probes
WO2012100198A2 (en) 2011-01-20 2012-07-26 University Of Washington Through Its Center For Commercialization Methods and systems for performing digital measurements
US20150140554A1 (en) 2011-02-03 2015-05-21 Richard O. Snyder Detection Methods for Target DNA
WO2012129115A2 (en) 2011-03-18 2012-09-27 University Of South Florida Materials and methods for profiling micrornas
WO2012129187A1 (en) 2011-03-18 2012-09-27 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
WO2012135340A2 (en) 2011-03-28 2012-10-04 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
EP2723897A4 (en) 2011-06-24 2015-03-18 Nanostring Technologies Inc MULTIVARIATED DIAGNOSTIC ASSAYS AND METHODS OF USE THEREOF
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8858623B2 (en) 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
ES2953308T3 (es) * 2011-12-22 2023-11-10 Harvard College Composiciones y métodos para la detección de analitos
KR102145677B1 (ko) * 2012-02-03 2020-08-18 캘리포니아 인스티튜트 오브 테크놀로지 다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩
CA2877933A1 (en) 2012-06-27 2014-01-03 Yuri Bushkin Rapid assays for t-cell activation by rna measurements using flow cytometry
US9791372B2 (en) 2012-08-03 2017-10-17 California Institute Of Technology Multiplexing and quantification in PCR with reduced hardware and requirements
GB201218909D0 (en) 2012-10-22 2012-12-05 Univ Singapore Assay for the parallel detection of biological material based on PCR
EP2948566A4 (en) 2013-01-24 2016-10-05 California Inst Of Techn CHROMOPHORE-BASED CHARACTERIZATION AND DETECTION METHODS
WO2014165210A2 (en) 2013-03-12 2014-10-09 Life Technologies Corporation Universal reporter-based genotyping methods and materials
EP2873740A1 (en) 2013-11-19 2015-05-20 Oncodiag Methods for the surveillance, diagnosis and screening of bladder cancer
US9670530B2 (en) 2014-01-30 2017-06-06 Illumina, Inc. Haplotype resolved genome sequencing
WO2015147370A1 (en) 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
MA39951A (fr) 2014-05-09 2017-03-15 Lifecodexx Ag Détection de l'adn provenant d'un type spécifique de cellule et méthodes associées
EP3274476B1 (en) 2015-03-25 2023-06-07 The General Hospital Corporation Digital analysis of circulating tumor cells in blood samples
CN109072205A (zh) 2016-02-10 2018-12-21 密歇根大学董事会 核酸的检测
WO2018081178A1 (en) 2016-10-24 2018-05-03 Two Pore Guys, Inc. Fractional abundance of polynucleotide sequences in a sample
EP4219519A3 (en) 2016-04-01 2023-09-13 Chromacode, Inc. Competitive probes for engineering signal generation
US10066263B2 (en) 2016-06-17 2018-09-04 California Institute Of Technology Nucleic acid reactions and related methods and compositions
EP4379065A2 (en) 2017-06-28 2024-06-05 Chromacode, Inc. Multiplexed fluorometric measurements with droplet pcr systems
US20190112636A1 (en) 2017-10-16 2019-04-18 ChromaCode, Inc. Methods and compositions for nucleic acid detection
CN112041460A (zh) 2018-02-28 2020-12-04 克罗玛科德公司 用于胎儿核酸分析的分子靶标
US20200010876A1 (en) 2018-07-03 2020-01-09 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays

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US8838394B2 (en) 2014-09-16
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