HK1204608A1 - C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity hiv c-3 - Google Patents

C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity hiv c-3

Info

Publication number
HK1204608A1
HK1204608A1 HK15105069.8A HK15105069A HK1204608A1 HK 1204608 A1 HK1204608 A1 HK 1204608A1 HK 15105069 A HK15105069 A HK 15105069A HK 1204608 A1 HK1204608 A1 HK 1204608A1
Authority
HK
Hong Kong
Prior art keywords
hiv
inhibitory activity
maturation inhibitory
triterpenoids
cycloalkenyl
Prior art date
Application number
HK15105069.8A
Other languages
English (en)
Chinese (zh)
Inventor
Jacob Swidorski
Nicholas A Meanwell
Alicia Regueiro-Ren
Sing-Yuen Sit
Jie Chen
Yan Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48946098&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1204608(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HK1204608A1 publication Critical patent/HK1204608A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK15105069.8A 2012-02-15 2015-05-28 C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity hiv c-3 HK1204608A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261599040P 2012-02-15 2012-02-15
US13/760,726 US8906889B2 (en) 2012-02-15 2013-02-06 C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
PCT/US2013/025897 WO2013123019A1 (en) 2012-02-15 2013-02-13 C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity

Publications (1)

Publication Number Publication Date
HK1204608A1 true HK1204608A1 (en) 2015-11-27

Family

ID=48946098

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105069.8A HK1204608A1 (en) 2012-02-15 2015-05-28 C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity hiv c-3

Country Status (26)

Country Link
US (1) US8906889B2 (es)
EP (1) EP2814834B1 (es)
JP (1) JP6155285B2 (es)
KR (1) KR20140123584A (es)
CN (2) CN106046106A (es)
AR (1) AR089996A1 (es)
AU (1) AU2013221725B2 (es)
BR (1) BR112014019672A8 (es)
CA (1) CA2864656A1 (es)
CL (1) CL2014002141A1 (es)
CO (1) CO7061077A2 (es)
EA (1) EA024361B1 (es)
ES (1) ES2656984T3 (es)
HK (1) HK1204608A1 (es)
IL (1) IL234077A (es)
MX (1) MX2014009235A (es)
MY (1) MY166793A (es)
NZ (1) NZ631408A (es)
PE (1) PE20142315A1 (es)
PH (1) PH12014501816A1 (es)
PT (1) PT2814834T (es)
SG (1) SG11201404748XA (es)
TW (1) TW201336863A (es)
UY (1) UY34627A (es)
WO (1) WO2013123019A1 (es)
ZA (1) ZA201406724B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
SG11201505639SA (en) 2013-02-06 2015-08-28 Bristol Myers Squibb Co C-19 modified triterpenoids with hiv maturation inhibitory activity
SI3129392T1 (sl) * 2014-04-11 2020-11-30 VIIV Healthcare UK(No.4) Limited Triterpenoidi z inhibitorno aktivnostjo maturacije HIV-a, substituirani na položaju 3 z nearomatskim obročem, ki nosi haloalkilni substituent
WO2015195776A1 (en) 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Betulinic acid derivatives with hiv maturation inhibitory activity
KR20170092581A (ko) 2014-11-14 2017-08-11 비브 헬스케어 유케이 (넘버5) 리미티드 Ｃ１７-아릴 치환된 베툴린산 유사체
EP3218389A1 (en) * 2014-11-14 2017-09-20 VIIV Healthcare UK (No.5) Limited Extended betulinic acid analogs
CN107250153A (zh) * 2014-11-14 2017-10-13 Viiv保健英国第五有限公司 氧代羽扇豆烯衍生物
BR112017021936A2 (pt) * 2015-04-14 2018-07-10 Viiv Healthcare Uk No 4 Ltd método para produção de um composto
RU2018105343A (ru) * 2015-07-28 2019-08-28 ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед Производные бетулина для предупреждения или лечения ВИЧ-инфекций
JP2018521107A (ja) 2015-07-28 2018-08-02 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ感染を予防または治療するためのベツイン誘導体
JP2018528231A (ja) 2015-09-24 2018-09-27 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ成熟阻害活性を有する化合物
JP2019502728A (ja) * 2016-01-20 2019-01-31 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ成熟阻害活性を有するルパンのアミン誘導体
AR107512A1 (es) * 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
CN106905264B (zh) * 2017-04-12 2019-06-07 连云港杰瑞药业有限公司 一种合成阿扎拉韦中间体的方法
CN111093673A (zh) * 2017-09-13 2020-05-01 艾蒙有限责任公司 熊果酸吗啉盐和熊果酸二乙醇胺盐
US20210347813A1 (en) 2018-04-24 2021-11-11 Viiv Healthcare Uk (No. 5) Limited Compounds with hiv maturation inhibitory activity
CN109705189B (zh) * 2018-12-29 2020-06-05 中国医学科学院药用植物研究所 具有式i所示结构的三萜衍生物及其制备方法和应用
LT3924361T (lt) 2019-02-11 2023-12-27 Hetero Labs Limited Nauji triterpeno dariniai kaip živ inhibitoriai
WO2020229398A1 (de) 2019-05-14 2020-11-19 Bayer Aktiengesellschaft (1-alkenyl)-substituierte pyrazole und triazole als schädlingsbekämpfungsmittel

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413999A (en) 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5869535A (en) 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5962527A (en) 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US7365221B2 (en) 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
MXPA06010592A (es) 2004-03-17 2007-06-12 Panacos Pharmaceuticals Inc Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico.
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
WO2008127364A2 (en) 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
US20110144069A1 (en) 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
WO2009020732A1 (en) 2007-08-03 2009-02-12 Advanced Life Sciences, Inc. Lupane-type triterpenoids modified at 30-position and analogues thereof
AU2008342537A1 (en) * 2008-01-03 2009-07-09 Virochem Pharma Inc. Novel lupane derivatives
CA2714049A1 (en) 2008-02-14 2009-08-20 Virochem Pharma Inc. Novel 17.beta. lupane derivatives
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
CN102858767B (zh) 2009-12-17 2015-08-19 默沙东公司 作为syk抑制剂的氨基嘧啶
ES2612452T3 (es) * 2010-06-04 2017-05-17 VIIV Healthcare UK (No.5) Limited Derivados de ácido betulínico C-3 modificados como inhibidores de la maduración del VIH
EP2576586B1 (en) * 2010-06-04 2015-08-12 Bristol-Myers Squibb Company C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors
CN103140474A (zh) 2010-07-02 2013-06-05 吉里德科学公司 治疗aids的萘-2-基乙酸衍生物
BR112013019419A2 (pt) * 2011-01-31 2019-12-03 Bristol-Myers Squibb Company triterpenoides modificados por c-17 e c-3 com atividade inibitória de maturação de hiv
PT2670764E (pt) * 2011-01-31 2015-11-20 Bristol Myers Squibb Co C-28 aminas de derivados de ácido betulínico c-3 modificado como inibidores de maturação de vih
US8754069B2 (en) * 2011-09-21 2014-06-17 Bristol-Myers Squibb Company Betulinic acid derivatives with antiviral activity
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
SG11201505639SA (en) * 2013-02-06 2015-08-28 Bristol Myers Squibb Co C-19 modified triterpenoids with hiv maturation inhibitory activity

Also Published As

Publication number Publication date
AR089996A1 (es) 2014-10-01
US8906889B2 (en) 2014-12-09
IL234077A0 (en) 2014-09-30
CN104220451A (zh) 2014-12-17
AU2013221725A1 (en) 2014-10-02
SG11201404748XA (en) 2014-09-26
ZA201406724B (en) 2016-08-31
US20130210787A1 (en) 2013-08-15
AU2013221725B2 (en) 2016-10-27
CO7061077A2 (es) 2014-09-19
CL2014002141A1 (es) 2014-10-03
IL234077A (en) 2016-11-30
JP6155285B2 (ja) 2017-06-28
NZ631408A (en) 2015-06-26
BR112014019672A8 (pt) 2017-07-11
CA2864656A1 (en) 2013-08-22
UY34627A (es) 2013-09-02
MY166793A (en) 2018-07-23
BR112014019672A2 (es) 2017-06-20
EP2814834B1 (en) 2017-09-13
MX2014009235A (es) 2014-11-10
WO2013123019A1 (en) 2013-08-22
EA024361B1 (ru) 2016-09-30
ES2656984T3 (es) 2018-03-01
PH12014501816A1 (en) 2014-11-17
CN106046106A (zh) 2016-10-26
JP2015510515A (ja) 2015-04-09
EP2814834A1 (en) 2014-12-24
KR20140123584A (ko) 2014-10-22
PT2814834T (pt) 2017-12-06
PE20142315A1 (es) 2015-01-16
TW201336863A (zh) 2013-09-16
EA201491531A1 (ru) 2014-11-28
CN104220451B (zh) 2016-06-29

Similar Documents

Publication Publication Date Title
HK1204608A1 (en) C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity hiv c-3
ZA201306546B (en) C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
IL240289A0 (en) c19-modified triterpenoids with HIV maturation inhibitory activity
SG11201502885SA (en) Rf pulse edge shaping
IL235465A (en) Biocyclic amines in position c-17 of tritrapenoids as maturation inhibitors of HIV virus
EP2814501A4 (en) MELANOCORTINANALOGA WITH INCREASED EFFECTIVENESS AND TRANSPORTATION OF THEREOF
LT2896218T (lt) Bendraašė garsiakalbio konstrukcija
HK1188365A2 (en) Activity center
EP2679167A4 (en) sonographer
PL2641505T3 (pl) Skrzynka meblowa
GB201211792D0 (en) Photocatalysts
GB201223241D0 (en) Echo suppression
HK1210038A1 (en) Nanoconstructs with pharmacological activity
PL2879805T3 (pl) Układ dyszy
GB201223246D0 (en) Echo suppression
GB2504072B (en) Contra-rotating transmission
EP2813390A4 (en) ARMREST
GB2505784B (en) Furniture
GB201222139D0 (en) Flood-safe fitted kitchen
GB2503440B (en) Cutlery
EP2929195A4 (en) MOUNTING ARRANGEMENT
EP2915320A4 (en) ADVANCED RECALL FUNCTION
AU2012905237A0 (en) Shielding Structure
AU2012905245A0 (en) Mesh
AU2012901220A0 (en) Circular structure