BR112017021936A2 - método para produção de um composto - Google Patents
método para produção de um compostoInfo
- Publication number
- BR112017021936A2 BR112017021936A2 BR112017021936A BR112017021936A BR112017021936A2 BR 112017021936 A2 BR112017021936 A2 BR 112017021936A2 BR 112017021936 A BR112017021936 A BR 112017021936A BR 112017021936 A BR112017021936 A BR 112017021936A BR 112017021936 A2 BR112017021936 A2 BR 112017021936A2
- Authority
- BR
- Brazil
- Prior art keywords
- producing
- compound
- betulin
- presented
- starting material
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Abstract
um método para produção do composto inibidor de maturação de hiv é apresentado usando betulina como material inicial e utilizando técnicas do rearranjo de lossen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562147237P | 2015-04-14 | 2015-04-14 | |
PCT/US2016/027504 WO2016168447A1 (en) | 2015-04-14 | 2016-04-14 | Methods of producing an hiv maturation inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017021936A2 true BR112017021936A2 (pt) | 2018-07-10 |
Family
ID=55802544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017021936A BR112017021936A2 (pt) | 2015-04-14 | 2016-04-14 | método para produção de um composto |
Country Status (10)
Country | Link |
---|---|
US (2) | US10221208B2 (pt) |
EP (1) | EP3283467A1 (pt) |
JP (1) | JP2018512433A (pt) |
KR (1) | KR20170135970A (pt) |
CN (1) | CN107428798A (pt) |
AU (2) | AU2016248068B2 (pt) |
BR (1) | BR112017021936A2 (pt) |
CA (2) | CA2981056A1 (pt) |
RU (1) | RU2017134461A (pt) |
WO (2) | WO2016168447A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10221208B2 (en) * | 2015-04-14 | 2019-03-05 | ViiV Healthcare UK (No.4) Limited | Methods of producing an HIV maturation inhibitor |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
BR112013019419A2 (pt) | 2011-01-31 | 2019-12-03 | Bristol-Myers Squibb Company | triterpenoides modificados por c-17 e c-3 com atividade inibitória de maturação de hiv |
DK2670764T3 (en) * | 2011-01-31 | 2015-12-07 | Bristol Myers Squibb Co | C-28 AMINES OF MODIFIED C-3-BETULIN ACID DERIVATIVES AS ANTI-HUMIDITY INHIBITORS |
AU2012312485B2 (en) * | 2011-09-21 | 2016-09-01 | VIIV Healthcare UK (No.5) Limited | Novel betulinic acid derivatives with antiviral activity |
US8906889B2 (en) * | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
US8889854B2 (en) * | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
US20150320081A1 (en) | 2012-07-18 | 2015-11-12 | Danisco Us Inc. | Melt-delayed granule |
KR20150121712A (ko) * | 2013-02-25 | 2015-10-29 | 브리스톨-마이어스 스큅 컴퍼니 | Hiv의 치료에 유용한 c-3 알킬 및 알케닐 개질된 베툴린산 유도체 |
US10221208B2 (en) * | 2015-04-14 | 2019-03-05 | ViiV Healthcare UK (No.4) Limited | Methods of producing an HIV maturation inhibitor |
-
2016
- 2016-04-14 US US15/563,635 patent/US10221208B2/en not_active Expired - Fee Related
- 2016-04-14 AU AU2016248068A patent/AU2016248068B2/en not_active Ceased
- 2016-04-14 EP EP16718821.8A patent/EP3283467A1/en not_active Withdrawn
- 2016-04-14 JP JP2017553403A patent/JP2018512433A/ja active Pending
- 2016-04-14 KR KR1020177032822A patent/KR20170135970A/ko unknown
- 2016-04-14 CA CA2981056A patent/CA2981056A1/en not_active Abandoned
- 2016-04-14 BR BR112017021936A patent/BR112017021936A2/pt not_active Application Discontinuation
- 2016-04-14 US US15/563,659 patent/US20180094019A1/en not_active Abandoned
- 2016-04-14 CN CN201680021849.4A patent/CN107428798A/zh active Pending
- 2016-04-14 RU RU2017134461A patent/RU2017134461A/ru not_active Application Discontinuation
- 2016-04-14 WO PCT/US2016/027504 patent/WO2016168447A1/en active Application Filing
- 2016-04-14 CA CA2981081A patent/CA2981081A1/en not_active Abandoned
- 2016-04-14 AU AU2016248235A patent/AU2016248235A1/en not_active Abandoned
- 2016-04-14 WO PCT/US2016/027535 patent/WO2016168462A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20180072691A1 (en) | 2018-03-15 |
EP3283467A1 (en) | 2018-02-21 |
WO2016168462A1 (en) | 2016-10-20 |
AU2016248068B2 (en) | 2018-07-26 |
KR20170135970A (ko) | 2017-12-08 |
CA2981081A1 (en) | 2016-10-20 |
JP2018512433A (ja) | 2018-05-17 |
US20180094019A1 (en) | 2018-04-05 |
WO2016168447A1 (en) | 2016-10-20 |
CA2981056A1 (en) | 2016-10-20 |
RU2017134461A (ru) | 2019-05-14 |
AU2016248068A1 (en) | 2017-10-19 |
US10221208B2 (en) | 2019-03-05 |
AU2016248235A1 (en) | 2017-10-19 |
CN107428798A (zh) | 2017-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |