HK1197068A1 - Methods for preparation of glycosphingolipids and uses thereof - Google Patents

Methods for preparation of glycosphingolipids and uses thereof Download PDF

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Publication number
HK1197068A1
HK1197068A1 HK14110574.7A HK14110574A HK1197068A1 HK 1197068 A1 HK1197068 A1 HK 1197068A1 HK 14110574 A HK14110574 A HK 14110574A HK 1197068 A1 HK1197068 A1 HK 1197068A1
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HK
Hong Kong
Prior art keywords
compound
formula
prepared
nmr
synthesis
Prior art date
Application number
HK14110574.7A
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English (en)
Chinese (zh)
Inventor
梁碧惠
Original Assignee
台湾大学
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Publication date
Application filed by 台湾大学 filed Critical 台湾大学
Publication of HK1197068A1 publication Critical patent/HK1197068A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK14110574.7A 2011-01-05 2012-01-05 Methods for preparation of glycosphingolipids and uses thereof HK1197068A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430117P 2011-01-05 2011-01-05
US61/430,117 2011-01-05
PCT/US2012/020388 WO2012094540A2 (en) 2011-01-05 2012-01-05 Methods for preparation of glycosphingolipids and uses thereof

Publications (1)

Publication Number Publication Date
HK1197068A1 true HK1197068A1 (en) 2015-01-02

Family

ID=45688966

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14110574.7A HK1197068A1 (en) 2011-01-05 2012-01-05 Methods for preparation of glycosphingolipids and uses thereof

Country Status (15)

Country Link
US (2) US9181292B2 (https=)
EP (1) EP2661440B1 (https=)
JP (2) JP6057300B2 (https=)
KR (1) KR102005003B1 (https=)
CN (1) CN103748103A (https=)
AU (2) AU2012204336C1 (https=)
BR (1) BR112013017382B1 (https=)
CA (1) CA2854725C (https=)
CO (1) CO6761397A2 (https=)
ES (1) ES2654382T3 (https=)
HK (1) HK1197068A1 (https=)
IL (1) IL227333B (https=)
MX (1) MX345764B (https=)
RU (1) RU2636587C2 (https=)
WO (1) WO2012094540A2 (https=)

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US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10338069B2 (en) 2010-04-12 2019-07-02 Academia Sinica Glycan arrays for high throughput screening of viruses
CN103068378B (zh) 2010-05-10 2016-07-06 中央研究院 具有抗流感活性的扎那米韦膦酸酯同类物及其制备方法
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EP2811831B1 (en) * 2012-02-07 2018-04-11 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
WO2014031498A1 (en) 2012-08-18 2014-02-27 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
WO2014031762A1 (en) 2012-08-21 2014-02-27 Academia Sinica Benzocyclooctyne compounds and uses thereof
EP2727929A1 (en) * 2012-10-30 2014-05-07 Wittycell Method of preparation of alpha galactosyl ceramides compounds
EP3013365B1 (en) 2013-06-26 2019-06-05 Academia Sinica Rm2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
US9782476B2 (en) * 2013-09-06 2017-10-10 Academia Sinica Human iNKT cell activation using glycolipids with altered glycosyl groups
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
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WO2015148915A1 (en) 2014-03-27 2015-10-01 Academia Sinica Reactive labelling compounds and uses thereof
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US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
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KR102512592B1 (ko) 2014-05-27 2023-03-21 아카데미아 시니카 항-ｈｅｒ2 글리코항체 및 이의 용도
CN106714829A (zh) 2014-05-28 2017-05-24 中央研究院 抗TNF‑α醣抗体及其用途
CA2960712A1 (en) * 2014-09-08 2016-03-17 Academia Sinica Human inkt cell activation using glycolipids
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
AU2015378564A1 (en) 2015-01-24 2017-07-13 Academia Sinica Novel glycan conjugates and methods of use thereof
EP3374028B1 (en) * 2015-11-13 2021-05-26 La Jolla Institute for Allergy and Immunology Sphingamide compounds and methods for binding inkt cells
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
JP6956719B2 (ja) 2015-12-29 2021-11-02 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーＯｐｋｏ Ｄｉａｇｎｏｓｔｉｃｓ，Ｌｌｃ 流体の収集のための物品
WO2017156192A1 (en) 2016-03-08 2017-09-14 Academia Sinica Methods for modular synthesis of n-glycans and arrays thereof
EP3500594A4 (en) 2016-08-22 2020-03-11 Cho Pharma Inc. ANTIBODIES, BINDING FRAGMENTS AND METHOD FOR USE
WO2019053142A1 (en) * 2017-09-13 2019-03-21 Abivax ABX196 FOR USE IN THE TREATMENT OF BLADDER CANCER
CN110835361A (zh) * 2019-10-21 2020-02-25 山东大学 一类唾液酸糖基给体及其制备方法和应用
WO2021142581A1 (zh) * 2020-01-13 2021-07-22 郑州市御合源生物科技有限公司 一种糖苷化合物及其制备方法和应用
EP4274541A1 (en) * 2021-01-06 2023-11-15 Evonik Operations GmbH Hydroxy-substituted sphingolipids
CN114805454B (zh) * 2021-01-21 2023-07-18 中国科学院生态环境研究中心 α-半乳糖神经酰胺类化合物及其制备方法和用途
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Also Published As

Publication number Publication date
IL227333A0 (en) 2013-09-30
JP6259887B2 (ja) 2018-01-10
IL227333B (en) 2018-01-31
KR102005003B1 (ko) 2019-07-29
KR20140036147A (ko) 2014-03-25
CA2854725C (en) 2019-10-22
JP6057300B2 (ja) 2017-01-11
JP2014504593A (ja) 2014-02-24
JP2017061481A (ja) 2017-03-30
CO6761397A2 (es) 2013-09-30
ES2654382T3 (es) 2018-02-13
MX2013007888A (es) 2014-09-11
US20120178705A1 (en) 2012-07-12
AU2017206277B2 (en) 2019-05-02
US20160229881A1 (en) 2016-08-11
EP2661440B1 (en) 2017-09-27
AU2017206277A1 (en) 2017-08-10
US10654880B2 (en) 2020-05-19
MX345764B (es) 2017-02-15
WO2012094540A3 (en) 2012-08-30
EP2661440A2 (en) 2013-11-13
RU2636587C2 (ru) 2017-11-24
US9181292B2 (en) 2015-11-10
CN103748103A (zh) 2014-04-23
RU2013136531A (ru) 2015-02-10
BR112013017382B1 (pt) 2021-03-16
CA2854725A1 (en) 2013-07-12
BR112013017382A2 (pt) 2016-10-04
AU2012204336C1 (en) 2017-08-03
AU2012204336B2 (en) 2017-05-04
WO2012094540A2 (en) 2012-07-12
AU2012204336A1 (en) 2013-08-22

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