CO6761397A2 - Métodos para preparar glicoesfingolípidos y usos de los mismos - Google Patents
Métodos para preparar glicoesfingolípidos y usos de los mismosInfo
- Publication number
- CO6761397A2 CO6761397A2 CO13159964A CO13159964A CO6761397A2 CO 6761397 A2 CO6761397 A2 CO 6761397A2 CO 13159964 A CO13159964 A CO 13159964A CO 13159964 A CO13159964 A CO 13159964A CO 6761397 A2 CO6761397 A2 CO 6761397A2
- Authority
- CO
- Colombia
- Prior art keywords
- glycosphingolipids
- methods
- heteroaryl
- aryl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Se proporcionan m¨¦todos para la s¨ªntesis y preparaci¨®n de alfa-glicoesfingol¨ªpidos. Se proporcionan m¨¦todos para la s¨ªntesis de ¦Á-galactosil ceramida, y an¨¢logos y variantes farmac¨¦uticamente activos del mismo. Se proporcionan alfa-glicoesfingol¨ªpidos novedosos, en donde los compuestos son compuestos inmunog¨¦nicos los cuales sirven como ligandos para las c¨¦lulas NKT (T asesinas naturales). Se proporciona un proceso para preparar un compuesto quiral que comprende una forma R o S de un glicoesfingol¨ªpido de la f¨®rmula (I), en donde R1=OH, NH2, NHCOR2, R2 = H o un alquilo, alquenilo, o alquilo terminando en arilo, arilo sustituido, heteroarilo, o heteroarilo sustituido, X=grupo alquilo, R3= OH o H, R4= OH o H, R5= arilo, arilo sustituido, heteroarilo, o heteroarilo sustituido, o una sal farmac¨¦uticamente aceptable del mismo, en donde el compuesto de la f¨®rmula I se prepara mediante (a) desprotegiendo un compuesto de la f¨®rmula (2): con hidr¨®geno bajo cat¨¢lisis de hidrogenaci¨®n.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161430117P | 2011-01-05 | 2011-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6761397A2 true CO6761397A2 (es) | 2013-09-30 |
Family
ID=45688966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO13159964A CO6761397A2 (es) | 2011-01-05 | 2013-07-05 | Métodos para preparar glicoesfingolípidos y usos de los mismos |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9181292B2 (es) |
| EP (1) | EP2661440B1 (es) |
| JP (2) | JP6057300B2 (es) |
| KR (1) | KR102005003B1 (es) |
| CN (1) | CN103748103A (es) |
| AU (2) | AU2012204336C1 (es) |
| BR (1) | BR112013017382B1 (es) |
| CA (1) | CA2854725C (es) |
| CO (1) | CO6761397A2 (es) |
| ES (1) | ES2654382T3 (es) |
| HK (1) | HK1197068A1 (es) |
| IL (1) | IL227333B (es) |
| MX (1) | MX345764B (es) |
| RU (1) | RU2636587C2 (es) |
| WO (1) | WO2012094540A2 (es) |
Families Citing this family (36)
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| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| WO2010009271A2 (en) | 2008-07-15 | 2010-01-21 | Academia Sinica | Glycan arrays on ptfe-like aluminum coated glass slides and related methods |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| DK2568976T3 (en) | 2010-05-10 | 2016-01-11 | Academia Sinica | Zanamivir-phosphonate congener with the anti-influenza activity, and determining the sensitivity oseltamivir in influenza viruses |
| RU2636587C2 (ru) * | 2011-01-05 | 2017-11-24 | Нэшнл Тайвэн Юниверсити | Способы получения гликосфинголипидов и их применение |
| EP2811831B1 (en) * | 2012-02-07 | 2018-04-11 | The Regents Of The University Of California | Glycosphingolipids for use in modulating immune responses |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| JP6302909B2 (ja) | 2012-08-18 | 2018-03-28 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | シアリダーゼの同定および画像化のための細胞透過性プローブ |
| CA2883168A1 (en) | 2012-08-21 | 2014-02-27 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
| EP2727929A1 (en) * | 2012-10-30 | 2014-05-07 | Wittycell | Method of preparation of alpha galactosyl ceramides compounds |
| US10086054B2 (en) | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
| WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
| CA2923579C (en) | 2013-09-06 | 2023-09-05 | Academia Sinica | Human inkt cell activation using glycolipids with altered glycosyl groups |
| CA2937123A1 (en) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| CN106415244B (zh) | 2014-03-27 | 2020-04-24 | 中央研究院 | 反应性标记化合物及其用途 |
| EP3149036A4 (en) | 2014-05-27 | 2017-12-27 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| TWI717319B (zh) | 2014-05-27 | 2021-02-01 | 中央研究院 | 得自類桿菌屬之岩藻糖苷酶及其用途 |
| EP4116329A1 (en) | 2014-05-27 | 2023-01-11 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
| TWI732738B (zh) | 2014-05-28 | 2021-07-11 | 中央研究院 | 抗TNF-α醣抗體及其用途 |
| CA2960712A1 (en) * | 2014-09-08 | 2016-03-17 | Academia Sinica | Human inkt cell activation using glycolipids |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| CA2972072A1 (en) | 2015-01-24 | 2016-07-28 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| US10723750B2 (en) * | 2015-11-13 | 2020-07-28 | La Jolla Institute For Allergy And Immunology | Sphingamide compounds and methods for binding iNKT cells |
| CA3005084A1 (en) | 2015-12-11 | 2017-06-15 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
| WO2017116979A1 (en) | 2015-12-29 | 2017-07-06 | Opko Diagnostics, Llc | Fluid collection device and related methods |
| CA3016170A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
| CA3034057A1 (en) | 2016-08-22 | 2018-03-01 | CHO Pharma Inc. | Antibodies, binding fragments, and methods of use |
| EP3771948A1 (fr) | 2019-07-31 | 2021-02-03 | Omega SA | Cadran pour piece d`horlogerie |
| CN110835361A (zh) * | 2019-10-21 | 2020-02-25 | 山东大学 | 一类唾液酸糖基给体及其制备方法和应用 |
| WO2021142581A1 (zh) * | 2020-01-13 | 2021-07-22 | 郑州市御合源生物科技有限公司 | 一种糖苷化合物及其制备方法和应用 |
| CN114805454B (zh) * | 2021-01-21 | 2023-07-18 | 中国科学院生态环境研究中心 | α-半乳糖神经酰胺类化合物及其制备方法和用途 |
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| JPH0676429B2 (ja) * | 1987-03-09 | 1994-09-28 | 理化学研究所 | ラクト系列スフィンゴ糖脂質の合成法 |
| JP2588729B2 (ja) * | 1987-10-05 | 1997-03-12 | 塩野義製薬株式会社 | スフィンゴシン誘導体 |
| EP0666268B1 (en) | 1992-10-22 | 2000-04-19 | Kirin Beer Kabushiki Kaisha | Novel sphingoglycolipid and use thereof |
| CA2142153A1 (en) * | 1994-03-04 | 1995-09-05 | Jacques Banville | Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors |
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| US7923013B2 (en) | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
| EP2007783B1 (en) * | 2006-04-03 | 2018-07-11 | Technion Research & Development Foundation Ltd. | Novel aminoglycosides and uses thereof in the treatment of genetic disorders |
| US8420607B2 (en) | 2006-06-30 | 2013-04-16 | University Of Georgia Research Foundation, Inc. | Anthrax carbohydrates, synthesis and uses thereof |
| CN101012254A (zh) * | 2006-08-29 | 2007-08-08 | 中国海洋大学 | 一种α－半乳糖鞘糖脂的2’－OH衍生物及其制备方法 |
| KR100868959B1 (ko) * | 2006-12-30 | 2008-11-17 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
| WO2008128207A1 (en) | 2007-04-13 | 2008-10-23 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
| US20090137793A1 (en) | 2007-11-19 | 2009-05-28 | Academia Sinica | Disaccharide compounds |
| ES2611206T3 (es) | 2008-05-16 | 2017-05-05 | Galecto Biotech Ab | Derivados de di-(3-deoxi-3-1H-1,2,3-triazol-1-il)-beta-D-galacto-iranosil)sulfano como inhibidores de galectina-3 |
| US7928077B2 (en) | 2008-07-11 | 2011-04-19 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
| RU2636587C2 (ru) | 2011-01-05 | 2017-11-24 | Нэшнл Тайвэн Юниверсити | Способы получения гликосфинголипидов и их применение |
-
2012
- 2012-01-05 RU RU2013136531A patent/RU2636587C2/ru active
- 2012-01-05 BR BR112013017382-3A patent/BR112013017382B1/pt active IP Right Grant
- 2012-01-05 CN CN201280011839.4A patent/CN103748103A/zh active Pending
- 2012-01-05 WO PCT/US2012/020388 patent/WO2012094540A2/en active Application Filing
- 2012-01-05 EP EP12704939.3A patent/EP2661440B1/en active Active
- 2012-01-05 JP JP2013548554A patent/JP6057300B2/ja active Active
- 2012-01-05 KR KR1020137020635A patent/KR102005003B1/ko active IP Right Grant
- 2012-01-05 ES ES12704939.3T patent/ES2654382T3/es active Active
- 2012-01-05 CA CA2854725A patent/CA2854725C/en active Active
- 2012-01-05 MX MX2013007888A patent/MX345764B/es active IP Right Grant
- 2012-01-05 US US13/344,557 patent/US9181292B2/en active Active
- 2012-01-05 AU AU2012204336A patent/AU2012204336C1/en active Active
-
2013
- 2013-07-04 IL IL227333A patent/IL227333B/en active IP Right Grant
- 2013-07-05 CO CO13159964A patent/CO6761397A2/es unknown
-
2014
- 2014-10-23 HK HK14110574.7A patent/HK1197068A1/xx unknown
-
2015
- 2015-10-07 US US14/877,897 patent/US10654880B2/en active Active
-
2016
- 2016-10-25 JP JP2016209071A patent/JP6259887B2/ja active Active
-
2017
- 2017-07-21 AU AU2017206277A patent/AU2017206277B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017206277A1 (en) | 2017-08-10 |
| WO2012094540A2 (en) | 2012-07-12 |
| JP2014504593A (ja) | 2014-02-24 |
| US9181292B2 (en) | 2015-11-10 |
| AU2012204336A1 (en) | 2013-08-22 |
| EP2661440B1 (en) | 2017-09-27 |
| KR102005003B1 (ko) | 2019-07-29 |
| US10654880B2 (en) | 2020-05-19 |
| BR112013017382A2 (pt) | 2016-10-04 |
| MX2013007888A (es) | 2014-09-11 |
| EP2661440A2 (en) | 2013-11-13 |
| CA2854725C (en) | 2019-10-22 |
| AU2012204336B2 (en) | 2017-05-04 |
| JP6259887B2 (ja) | 2018-01-10 |
| MX345764B (es) | 2017-02-15 |
| AU2012204336C1 (en) | 2017-08-03 |
| ES2654382T3 (es) | 2018-02-13 |
| JP6057300B2 (ja) | 2017-01-11 |
| RU2636587C2 (ru) | 2017-11-24 |
| AU2017206277B2 (en) | 2019-05-02 |
| HK1197068A1 (en) | 2015-01-02 |
| WO2012094540A3 (en) | 2012-08-30 |
| IL227333B (en) | 2018-01-31 |
| KR20140036147A (ko) | 2014-03-25 |
| CA2854725A1 (en) | 2013-07-12 |
| US20120178705A1 (en) | 2012-07-12 |
| JP2017061481A (ja) | 2017-03-30 |
| CN103748103A (zh) | 2014-04-23 |
| BR112013017382B1 (pt) | 2021-03-16 |
| IL227333A0 (en) | 2013-09-30 |
| RU2013136531A (ru) | 2015-02-10 |
| US20160229881A1 (en) | 2016-08-11 |
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