RU2636587C2 - Способы получения гликосфинголипидов и их применение - Google Patents
Способы получения гликосфинголипидов и их применение Download PDFInfo
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- RU2636587C2 RU2636587C2 RU2013136531A RU2013136531A RU2636587C2 RU 2636587 C2 RU2636587 C2 RU 2636587C2 RU 2013136531 A RU2013136531 A RU 2013136531A RU 2013136531 A RU2013136531 A RU 2013136531A RU 2636587 C2 RU2636587 C2 RU 2636587C2
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- JLYXXMFPNIAWKQ-UHFFFAOYSA-N γ Benzene hexachloride Chemical compound ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 1
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- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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| PCT/US2012/020388 WO2012094540A2 (en) | 2011-01-05 | 2012-01-05 | Methods for preparation of glycosphingolipids and uses thereof |
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| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| JP5986745B2 (ja) | 2008-07-15 | 2016-09-06 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | Ｐｔｆｅ様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法 |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| CN103068378B (zh) | 2010-05-10 | 2016-07-06 | 中央研究院 | 具有抗流感活性的扎那米韦膦酸酯同类物及其制备方法 |
| HK1197068A1 (en) * | 2011-01-05 | 2015-01-02 | 台湾大学 | Methods for preparation of glycosphingolipids and uses thereof |
| EP2811831B1 (en) * | 2012-02-07 | 2018-04-11 | The Regents Of The University Of California | Glycosphingolipids for use in modulating immune responses |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| WO2014031498A1 (en) | 2012-08-18 | 2014-02-27 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| WO2014031762A1 (en) | 2012-08-21 | 2014-02-27 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
| EP2727929A1 (en) * | 2012-10-30 | 2014-05-07 | Wittycell | Method of preparation of alpha galactosyl ceramides compounds |
| EP3013365B1 (en) | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2 antigens and use thereof |
| WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
| US9782476B2 (en) * | 2013-09-06 | 2017-10-10 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| CA2937123A1 (en) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| WO2015148915A1 (en) | 2014-03-27 | 2015-10-01 | Academia Sinica | Reactive labelling compounds and uses thereof |
| KR20170003720A (ko) | 2014-05-27 | 2017-01-09 | 아카데미아 시니카 | 항-ｃｄ20 글리코항체 및 이의 용도 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| CA2950423A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| KR102512592B1 (ko) | 2014-05-27 | 2023-03-21 | 아카데미아 시니카 | 항-ｈｅｒ2 글리코항체 및 이의 용도 |
| CN106714829A (zh) | 2014-05-28 | 2017-05-24 | 中央研究院 | 抗TNF‑α醣抗体及其用途 |
| CA2960712A1 (en) * | 2014-09-08 | 2016-03-17 | Academia Sinica | Human inkt cell activation using glycolipids |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| AU2015378564A1 (en) | 2015-01-24 | 2017-07-13 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| EP3374028B1 (en) * | 2015-11-13 | 2021-05-26 | La Jolla Institute for Allergy and Immunology | Sphingamide compounds and methods for binding inkt cells |
| CA3005084A1 (en) | 2015-12-11 | 2017-06-15 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
| JP6956719B2 (ja) | 2015-12-29 | 2021-11-02 | オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーＯｐｋｏ Ｄｉａｇｎｏｓｔｉｃｓ，Ｌｌｃ | 流体の収集のための物品 |
| WO2017156192A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
| EP3500594A4 (en) | 2016-08-22 | 2020-03-11 | Cho Pharma Inc. | ANTIBODIES, BINDING FRAGMENTS AND METHOD FOR USE |
| WO2019053142A1 (en) * | 2017-09-13 | 2019-03-21 | Abivax | ABX196 FOR USE IN THE TREATMENT OF BLADDER CANCER |
| CN110835361A (zh) * | 2019-10-21 | 2020-02-25 | 山东大学 | 一类唾液酸糖基给体及其制备方法和应用 |
| WO2021142581A1 (zh) * | 2020-01-13 | 2021-07-22 | 郑州市御合源生物科技有限公司 | 一种糖苷化合物及其制备方法和应用 |
| EP4274541A1 (en) * | 2021-01-06 | 2023-11-15 | Evonik Operations GmbH | Hydroxy-substituted sphingolipids |
| CN114805454B (zh) * | 2021-01-21 | 2023-07-18 | 中国科学院生态环境研究中心 | α-半乳糖神经酰胺类化合物及其制备方法和用途 |
| CN117222414A (zh) | 2021-03-01 | 2023-12-12 | 脱落性治疗公司 | 用于激活恒定自然杀伤t-细胞的化合物和用于消除炎性衰老细胞的方法 |
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| WO2008128062A1 (en) * | 2007-04-13 | 2008-10-23 | The Rockefeller University | Glycolipids and analogues thereof as antigens for nk t cells |
| RU2340622C2 (ru) * | 2002-12-12 | 2008-12-10 | Санофи-Авентис Дойчланд Гмбх | Новые ароматические фторгликозидные производные, содержащие эти соединения лекарственные средства, и их применение |
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| JPH0676429B2 (ja) * | 1987-03-09 | 1994-09-28 | 理化学研究所 | ラクト系列スフィンゴ糖脂質の合成法 |
| JP2588729B2 (ja) * | 1987-10-05 | 1997-03-12 | 塩野義製薬株式会社 | スフィンゴシン誘導体 |
| EP0666268B1 (en) | 1992-10-22 | 2000-04-19 | Kirin Beer Kabushiki Kaisha | Novel sphingoglycolipid and use thereof |
| CA2142153A1 (en) * | 1994-03-04 | 1995-09-05 | Jacques Banville | Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors |
| JPH11269189A (ja) * | 1998-03-19 | 1999-10-05 | Nissin Food Prod Co Ltd | 免疫調節作用を有する化合物 |
| CN1405172A (zh) * | 2001-08-13 | 2003-03-26 | 青岛海洋大学 | 一种乳糖胺脂及其制备方法和应用 |
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| US8420607B2 (en) | 2006-06-30 | 2013-04-16 | University Of Georgia Research Foundation, Inc. | Anthrax carbohydrates, synthesis and uses thereof |
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| KR100868959B1 (ko) | 2006-12-30 | 2008-11-17 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
| JP2010523724A (ja) | 2007-04-13 | 2010-07-15 | アカデミア シニカ | α−ガラクトシルセラミド類似体およびそれらの免疫療法剤としての使用 |
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| HK1197068A1 (en) * | 2011-01-05 | 2015-01-02 | 台湾大学 | Methods for preparation of glycosphingolipids and uses thereof |
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| RU2340622C2 (ru) * | 2002-12-12 | 2008-12-10 | Санофи-Авентис Дойчланд Гмбх | Новые ароматические фторгликозидные производные, содержащие эти соединения лекарственные средства, и их применение |
| WO2008128062A1 (en) * | 2007-04-13 | 2008-10-23 | The Rockefeller University | Glycolipids and analogues thereof as antigens for nk t cells |
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| CN103748103A (zh) | 2014-04-23 |
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| WO2012094540A2 (en) | 2012-07-12 |
| AU2012204336A1 (en) | 2013-08-22 |
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