HK1189027A1 - 高純度質粒 製備物及其製備方法 - Google Patents

高純度質粒 製備物及其製備方法

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Publication number
HK1189027A1
HK1189027A1 HK14101537.2A HK14101537A HK1189027A1 HK 1189027 A1 HK1189027 A1 HK 1189027A1 HK 14101537 A HK14101537 A HK 14101537A HK 1189027 A1 HK1189027 A1 HK 1189027A1
Authority
HK
Hong Kong
Prior art keywords
preparing
processes
highly pure
dna
pure plasmid
Prior art date
Application number
HK14101537.2A
Other languages
English (en)
Inventor
.坦普爾頓
Original Assignee
斯特萊科生物有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 斯特萊科生物有限公司 filed Critical 斯特萊科生物有限公司
Publication of HK1189027A1 publication Critical patent/HK1189027A1/zh

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1017Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/325Reversed phase
    • B01D15/327Reversed phase with hydrophobic interaction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361Ion-exchange
    • B01D15/362Cation-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361Ion-exchange
    • B01D15/363Anion-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804Affinity chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
HK14101537.2A 2008-04-30 2014-02-18 高純度質粒 製備物及其製備方法 HK1189027A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12591608P 2008-04-30 2008-04-30
US12592308P 2008-04-30 2008-04-30

Publications (1)

Publication Number Publication Date
HK1189027A1 true HK1189027A1 (zh) 2014-05-23

Family

ID=41255821

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14101537.2A HK1189027A1 (zh) 2008-04-30 2014-02-18 高純度質粒 製備物及其製備方法

Country Status (11)

Country Link
US (8) US20110020924A1 (zh)
EP (1) EP2283131B1 (zh)
JP (2) JP5693449B2 (zh)
KR (1) KR20110028258A (zh)
CN (2) CN102171341A (zh)
AU (1) AU2009242587B2 (zh)
CA (1) CA2739341A1 (zh)
HK (1) HK1189027A1 (zh)
IL (1) IL209001A (zh)
SG (1) SG2014015010A (zh)
WO (1) WO2009135048A2 (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110020924A1 (en) 2008-04-30 2011-01-27 Gradalis, Inc. Highly pure plasmid dna preparations
US9863006B2 (en) 2011-06-06 2018-01-09 Biocartis Nv Selective lysis of cells by ionic surfactants
JP5899731B2 (ja) * 2011-09-13 2016-04-06 ソニー株式会社 核酸精製方法、核酸抽出方法、及び核酸精製用キット
CA2868154A1 (en) 2012-03-20 2013-09-26 The Research Foundation For The State University Of New York Flocculation of lignocellulosic hydrolyzates
US9556427B2 (en) * 2013-02-27 2017-01-31 Syngenta Participations Ag Methods and compositions for preparation of nucleic acids
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
ES2929099T3 (es) 2014-05-02 2022-11-24 Grace W R & Co Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado
US20170198002A1 (en) * 2014-06-13 2017-07-13 Avantor Performance Materials, Inc. High Purity Low Endotoxin Carbohydrate (HPLE) Compositions, and Methods of Isolation Thereof
JP2018517559A (ja) * 2015-06-05 2018-07-05 ダブリュー・アール・グレース・アンド・カンパニー−コーンW R Grace & Co−Conn 吸着性バイオプロセス清澄化剤並びにその製造及び使用方法
CA3027288A1 (en) * 2016-06-14 2017-12-21 Biogen Ma Inc. Hydrophobic interaction chromatography for purification of oligonucleotides
CN106554956A (zh) * 2016-12-07 2017-04-05 安徽智飞龙科马生物制药有限公司 一种产业化制备BCG‑CpG‑DNA的方法
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
WO2020191251A1 (en) * 2019-03-20 2020-09-24 Anchor Molecular Inc. Method of removing nucleic acids from human plasma
CN111088248B (zh) * 2019-12-23 2020-10-16 广州湾区生物科技有限公司 一种用于提取无内毒素质粒的磁性材料及其使用方法
EP4090380A1 (en) 2020-01-13 2022-11-23 Gradalis, Inc. Methods for treating cancers using gm-csf encoding polynucleotide and additional agents
CN111304193A (zh) * 2020-02-28 2020-06-19 恒瑞源正(上海)生物科技有限公司 一种大规模快速纯化质粒dna的方法
CN111462813B (zh) * 2020-03-18 2020-10-20 华东师范大学 一种基于α螺旋融合两种蛋白质且保持各自亚基活性的蛋白质融合设计方法
CN112960780B (zh) * 2021-03-03 2023-02-03 龙江环保集团股份有限公司 一种生物膜载体的预处理方法及生物法污水处理工艺
CN113265396B (zh) * 2021-05-31 2024-01-09 上海碧博生物医药科技有限公司 大型质粒dna的连续化生产的工艺方法

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342832A (en) 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4981591A (en) 1989-04-07 1991-01-01 Cuno, Incorporated Cationic charge modified filter media
US5206161A (en) 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
WO1995006652A1 (en) * 1993-08-30 1995-03-09 Promega Corporation Nucleic acid purification compositions and methods
GB9401603D0 (en) 1994-01-27 1994-03-23 Univ Strathclyde Purification of plant-derived polynucleotides
CA2182388C (en) * 1994-02-07 2007-08-07 Metin Colpan Process for producing endotoxin-free or endotoxin-poor nucleic acids and/or oligonucleotides for gene therapy
ATE181921T1 (de) * 1994-02-07 1999-07-15 Qiagen Gmbh Chromatographische isolierung von nucleinsäuren
MX9603866A (es) * 1994-03-18 1997-03-29 Boehringer Ingelheim Int Procedimiento para el tratamiento de celulas eucarioticas.
US5705628A (en) 1994-09-20 1998-01-06 Whitehead Institute For Biomedical Research DNA purification and isolation using magnetic particles
US5534911A (en) * 1994-11-02 1996-07-09 Levitan; Gutman Virtual personal channel in a television system
US6069230A (en) 1994-11-10 2000-05-30 Promega Corporation High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications
US5758257A (en) * 1994-11-29 1998-05-26 Herz; Frederick System and method for scheduling broadcast of and access to video programs and other data using customer profiles
ES2174068T3 (es) * 1995-04-07 2002-11-01 Betzdearborn Inc Enzima de capaz de degradar exopolisacaridos y uso de la misma.
US6750333B1 (en) * 1996-02-06 2004-06-15 Roche Diagnostics Gmbh Process for preparing purified nucleic acid and the use thereof
US5981735A (en) 1996-02-12 1999-11-09 Cobra Therapeutics Limited Method of plasmid DNA production and purification
US7026468B2 (en) * 1996-07-19 2006-04-11 Valentis, Inc. Process and equipment for plasmid purification
DE19726083A1 (de) * 1997-06-19 1998-12-24 Consortium Elektrochem Ind Mikroorganismen und Verfahren zur fermentativen Herstellung von L-Cystein, L-Cystin, N-Acetyl-Serin oder Thiazolidinderivaten
SE9703532D0 (sv) * 1997-09-30 1997-09-30 Pharmacia Biotech Ab A process for the purification of plasmid DNA
US7041814B1 (en) * 1998-02-18 2006-05-09 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Enterobacter cloacae for diagnostics and therapeutics
US6194562B1 (en) 1998-04-22 2001-02-27 Promega Corporation Endotoxin reduction in nucleic acid purification
EP0964057B1 (en) 1998-05-11 2004-12-22 Tosoh Corporation Method for separating nucleic acids by means of liquid chromatography
US20030064951A1 (en) 1998-11-12 2003-04-03 Valentis, Inc. Methods for purifying nucleic acids
DE19903507A1 (de) 1999-01-29 2000-08-10 Roche Diagnostics Gmbh Verfahren zur Herstellung endotoxinfreier oder an Endotoxin abgereicherter Nukleinsäuren und deren Verwendung
US6617108B1 (en) 1999-07-12 2003-09-09 Technology Licensing Co. Llc Methods and compositions for biotechnical separations using selective precipitation by compaction agents
US20020010145A1 (en) * 1999-07-12 2002-01-24 Willson Richard C. Apparatus, methods and compositions for biotechnical separations
DE10010342A1 (de) * 2000-03-06 2001-09-20 Merck Patent Gmbh Verfahren zur Abreicherung von Endotoxinen
EP1290158B1 (en) * 2000-06-02 2006-12-06 Pall Corporation Processing of plasmid-containing fluids
US6504021B2 (en) 2000-07-05 2003-01-07 Edge Biosystems, Inc. Ion exchange method for DNA purification
PT102491B (pt) 2000-07-10 2003-02-28 Inst Superior Tecnico Processo para producao e purificacao de dna plasmidico
US6579705B2 (en) * 2001-04-04 2003-06-17 Consortium Fur Elektrochemische Industrie Gmbh Process for preparing non-proteinogenic L-amino acids
US20020197637A1 (en) 2001-06-02 2002-12-26 Willson Richard C. Process and compositions for protection of nucleic acids
SE0200543D0 (sv) * 2002-02-21 2002-02-21 Amersham Biosciences Ab Method of separation using aromatic thioether ligands
US6772147B2 (en) * 2002-02-26 2004-08-03 Sony Corporation System and method for effectively implementing a personal channel for interactive television
CA2559368A1 (en) 2004-04-19 2005-10-27 Centelion Method for purifying plasmid dna
CA2615547A1 (en) * 2005-07-21 2007-01-25 Syngenta Participations Ag Fungicidal compositions comprising tebuconazole
EP1984021B1 (en) * 2006-01-19 2016-08-10 Research Corporation Technologies, Inc Viable non-toxic gram negative bacteria
DK2027272T3 (en) 2006-05-24 2016-03-14 Scarab Genomics Llc Plasmid DNA PREPARATIONS AND METHODS FOR THE MANUFACTURE OF SAME
CN101091797B (zh) 2006-06-23 2012-08-01 上海海规生物科技有限公司 去除初纯质粒或蛋白质溶液中内毒素的方法及试剂盒
US8252526B2 (en) * 2006-11-09 2012-08-28 Gradalis, Inc. ShRNA molecules and methods of use thereof
CN101707882A (zh) * 2007-04-17 2010-05-12 伊姆克罗尼责任有限公司 PDGFRβ特异性抑制剂
US9211581B2 (en) 2007-09-21 2015-12-15 Wilson Tool International Inc. Stripper assemblies and components thereof for multi-tool punch assemblies
US20120231537A1 (en) 2008-04-30 2012-09-13 Gradalis, Inc. Highly Pure Plasmid DNA Preparations
US20110020924A1 (en) 2008-04-30 2011-01-27 Gradalis, Inc. Highly pure plasmid dna preparations
US20140093888A1 (en) 2009-04-30 2014-04-03 Gradalis, Inc. Highly pure plasmid dna preparations
US8166038B2 (en) * 2009-06-11 2012-04-24 Kaufman Mark A Intelligent retrieval of digital assets

Also Published As

Publication number Publication date
JP2011519560A (ja) 2011-07-14
JP6038972B2 (ja) 2016-12-07
US8647857B2 (en) 2014-02-11
AU2009242587A1 (en) 2009-11-05
CN103255130B (zh) 2015-12-23
IL209001A (en) 2016-10-31
SG2014015010A (en) 2014-05-29
US20140349389A1 (en) 2014-11-27
JP5693449B2 (ja) 2015-04-01
US8460908B2 (en) 2013-06-11
US20090275122A1 (en) 2009-11-05
EP2283131A4 (en) 2011-08-10
US8524475B1 (en) 2013-09-03
EP2283131A2 (en) 2011-02-16
US20100075404A1 (en) 2010-03-25
KR20110028258A (ko) 2011-03-17
WO2009135048A2 (en) 2009-11-05
US20110020924A1 (en) 2011-01-27
WO2009135048A3 (en) 2009-12-23
JP2015128428A (ja) 2015-07-16
CN102171341A (zh) 2011-08-31
US20090275088A1 (en) 2009-11-05
AU2009242587B2 (en) 2015-05-28
US20130210118A1 (en) 2013-08-15
US20130309752A1 (en) 2013-11-21
US8969068B2 (en) 2015-03-03
IL209001A0 (en) 2011-01-31
US8735119B2 (en) 2014-05-27
US20150132843A1 (en) 2015-05-14
CN103255130A (zh) 2013-08-21
CA2739341A1 (en) 2009-11-05
EP2283131B1 (en) 2016-08-10

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200429