HK1178142A1 - Processes for making cyclopropyl amide derivatives and intermediates associated therewith - Google Patents
Processes for making cyclopropyl amide derivatives and intermediates associated therewithInfo
- Publication number
- HK1178142A1 HK1178142A1 HK13105221.5A HK13105221A HK1178142A1 HK 1178142 A1 HK1178142 A1 HK 1178142A1 HK 13105221 A HK13105221 A HK 13105221A HK 1178142 A1 HK1178142 A1 HK 1178142A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- processes
- associated therewith
- amide derivatives
- cyclopropyl amide
- intermediates associated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30558310P | 2010-02-18 | 2010-02-18 | |
PCT/SE2011/050171 WO2011102794A1 (en) | 2010-02-18 | 2011-02-17 | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1178142A1 true HK1178142A1 (en) | 2013-09-06 |
Family
ID=44370080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK13105221.5A HK1178142A1 (en) | 2010-02-18 | 2013-04-30 | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
Country Status (20)
Country | Link |
---|---|
US (2) | US9012452B2 (xx) |
EP (2) | EP2536685B1 (xx) |
JP (3) | JP2013520413A (xx) |
KR (2) | KR20130004296A (xx) |
CN (2) | CN102869651A (xx) |
AR (2) | AR080205A1 (xx) |
AU (2) | AU2011218491C1 (xx) |
BR (2) | BR112012020629A2 (xx) |
CA (2) | CA2790040A1 (xx) |
CL (2) | CL2012002259A1 (xx) |
CO (1) | CO6592109A2 (xx) |
ES (1) | ES2541857T3 (xx) |
HK (1) | HK1178142A1 (xx) |
IL (1) | IL221431A (xx) |
MX (2) | MX2012009473A (xx) |
NZ (2) | NZ601920A (xx) |
RU (2) | RU2012136148A (xx) |
SG (3) | SG183274A1 (xx) |
TW (2) | TWI494301B (xx) |
WO (2) | WO2011102794A1 (xx) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA101809C2 (xx) | 2007-08-22 | 2013-05-13 | Астразенека Аб | Похідні циклопропіламіду$производные циклопропиламида |
TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
ES2541857T3 (es) | 2010-02-18 | 2015-07-27 | Astrazeneca Ab | Procesos para preparar ciclopropilamidas e intermedios asociados con estas |
NZ602108A (en) * | 2010-02-18 | 2014-09-26 | Astrazeneca Ab | Solid forms comprising a cyclopropyl amide derivative |
KR102256770B1 (ko) * | 2013-03-22 | 2021-05-26 | 메르크 파텐트 게엠베하 | 유기 전계발광 소자용 재료의 제조를 위한 합성 빌딩 블록 |
FR3003466B1 (fr) * | 2013-03-22 | 2015-08-07 | Servier Lab | Utilisation du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide pour le traitement des douleurs neuropathiques |
CN103342655A (zh) * | 2013-07-02 | 2013-10-09 | 扬州大学 | 取代乙二酮双苯胺希夫碱合成取代酰胺的新方法 |
Family Cites Families (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL297170A (xx) | 1963-04-04 | 1900-01-01 | ||
NL128365C (xx) | 1963-11-05 | |||
US3449427A (en) | 1965-06-03 | 1969-06-10 | Smithkline Corp | Aminocyclopropane derivatives of 5h-dibenzo(a,d)cycloheptenes |
US3697506A (en) | 1970-08-07 | 1972-10-10 | Pfizer | Crystalline alkali metal salts of {60 -carboxybenzylpenicillin and process therefor |
US3686335A (en) | 1970-12-21 | 1972-08-22 | Smith Kline French Lab | 5-vinyl-5h-di benzo(a,d)cycloheptenes |
US4432987A (en) | 1982-04-23 | 1984-02-21 | Pfizer Inc. | Crystalline benzenesulfonate salts of sultamicillin |
US4547505A (en) | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
CS244821B2 (en) | 1983-06-16 | 1986-08-14 | Boehringer Ingelheim Ltd | Production method of new substituted phenylalkyl(piperazinyl or homopiperazinyle)-prpylureas or thioureas |
DE3418167A1 (de) | 1984-05-16 | 1985-11-21 | Bayer Ag, 5090 Leverkusen | Verwendung von amiden zur verbesserung der kulturpflanzen-vertraeglichkeit von herbizid wirksamen heteroaryloxyacetamiden |
DE3600288A1 (de) | 1986-01-08 | 1987-07-16 | Bayer Ag | Verwendung von amiden zur verbesserung der kulturpflanzen-vertraeglichkeit von herbizid wirksamen sulfonylharnstoff-derivaten |
DE3618004A1 (de) | 1986-05-28 | 1987-12-03 | Bayer Ag | Verwendung von amiden zur verbesserung der kulturpflanzen-vertraeglichkeit von herbizid wirksamen sulfonyliso(thio)-harnstoff-derivaten |
EP0507863A4 (en) | 1989-12-28 | 1993-07-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
CA2033390A1 (en) | 1989-12-29 | 1991-06-30 | Susumu Nakagawa | 2-(2-cyclopropylpyrrolidin-4-ylthio) carbapenem derivatives |
BR9206396A (pt) | 1991-08-22 | 1994-12-13 | Monsanto Co | Pirazolilsulfoniluréias herbicidas de proteção |
DE4131139A1 (de) | 1991-09-19 | 1993-03-25 | Bayer Ag | Verfahren zur herstellung von 1-fluor-cyclopropan-1-carbonsaeure |
PL184611B1 (pl) | 1993-03-12 | 2002-11-29 | Upjohn Co | Krystaliczny ceftiofur w postaci wolnego kwasu sposób jego wytwarzania oraz kompozycja farmaceutyczna zawierająca krystaliczny ceftiofur w postaci wolnego kwasu |
BR9509760A (pt) | 1994-11-23 | 1998-06-30 | Neurogen Corp | Composto |
US5604253A (en) | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
US5859246A (en) | 1997-01-30 | 1999-01-12 | Neurogen Corporation | 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands |
JP3476203B2 (ja) | 1997-02-24 | 2003-12-10 | ザイモジュネティックス インコーポレイテッド | カルシトニン擬似体 |
US6160134A (en) | 1997-12-24 | 2000-12-12 | Bristol-Myers Squibb Co. | Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines |
CA2319198C (en) | 1998-01-27 | 2011-02-22 | Aventis Pharmaceuticals Products Inc. | Substituted oxoazaheterocyclyl factor xa inhibitors |
US6268367B1 (en) | 1998-02-23 | 2001-07-31 | Zymogenetics, Inc. | Piperazine derivatives for treating bone deficit conditions |
EP1090919A4 (en) | 1998-06-26 | 2002-05-22 | Chugai Pharmaceutical Co Ltd | L-ALPHA-AMINOADIPIC ACID DERIVATIVE IN FINE POWDER, ORAL SOLID PREPARATIONS CONTAINING SAID DERIVATIVE AND BULK POWDER PROCESSING PROCESS |
US6284761B1 (en) | 1999-01-08 | 2001-09-04 | Neurogen Corporation | 1-phenyl-4-(1-[2-aryl]cyclopropyl)methylpiperazines: dopamine receptor ligands |
EP1140879A1 (en) | 1999-01-08 | 2001-10-10 | Neurogen Corporation | 1-phenyl-4-(1- 2-aryl]cyclopropyl) methylpiperazines: dopamine receptor ligands |
GB9913083D0 (en) * | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
US6936602B1 (en) | 1999-06-16 | 2005-08-30 | Takeda Chemical Industries, Ltd. | Benzazepine derivatives, process for the preparation of the same and uses thereof |
AU7715300A (en) | 1999-09-27 | 2001-04-30 | Merck & Co., Inc. | Method of preventing osteoporosis |
EP1248869A2 (en) * | 2000-01-07 | 2002-10-16 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
US6521619B2 (en) * | 2000-06-29 | 2003-02-18 | Icos Corporation | Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents |
WO2002002522A1 (en) | 2000-06-29 | 2002-01-10 | Abbott Laboratories | Aryl phenycyclopropyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents |
AU8066701A (en) | 2000-07-20 | 2002-02-05 | Neurogen Corp | Capsaicin receptor ligands |
US6888012B2 (en) | 2000-12-25 | 2005-05-03 | Ajinomoto Co., Inc. | Process for producing optically active halohydrin compound |
ATE324371T1 (de) * | 2001-02-23 | 2006-05-15 | Merck & Co Inc | N-substituierte heterocyclische nichtaryl- nmda/nr2b-antagonisten |
AU2002344951A1 (en) | 2001-07-02 | 2003-01-21 | Boehringer Ingelheim International Gmbh | Substituted piperazine and diazepanes as histamine h3 receptor agonists |
EP1422228A1 (en) | 2001-08-08 | 2004-05-26 | Takeda Chemical Industries, Ltd. | BENZAZEPINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE |
US7145002B2 (en) | 2001-09-26 | 2006-12-05 | Merck & Co. Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
AU2002363236A1 (en) * | 2001-10-30 | 2003-05-12 | Millennium Pharmaceuticals, Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
US6861432B2 (en) * | 2001-11-23 | 2005-03-01 | Schering Aktiengesellschaft | Piperazine derivatives that destabilize androgen receptors |
EP1487826A4 (en) | 2002-03-22 | 2005-06-29 | Lg Life Sciences Ltd | NOVEL (2S) -N-5- (AMINO (IMINO) METHYL) -2-THIENYLMETHYL-1- (2R) -2 - ((CARBOXYMETHYL) AMINO) -3,3-DIPHENYLPROPANOYL-2-PYRROLIDINECARBOXAMIDE CRYSTALLINE FORMS. nH2O |
AU2003236686A1 (en) | 2002-06-07 | 2003-12-22 | Altana Pharma Ag | 4,5-dihydro-imidazo(4,5,1-j) quinolin-6-ones as parp inhibitors |
US20040077618A1 (en) | 2002-10-22 | 2004-04-22 | Bennani Youssef L. | Cycloalkylamides and their therapeutic applications |
US20040209858A1 (en) | 2002-10-22 | 2004-10-21 | Bennani Youssef L. | Cycloalkylamides and their therapeutic applications |
AU2003284402A1 (en) | 2002-11-15 | 2004-06-15 | Yamanouchi Pharmaceutical Co., Ltd. | Antagonist to melanin-concentrating hormone receptor |
DE60318891T2 (de) | 2002-12-13 | 2009-01-22 | Smithkline Beecham Corp. | Cyclopropylverbindungen als ccr5 antagonisten |
PT1615909E (pt) | 2003-04-23 | 2008-10-30 | Glaxo Group Ltd | Derivados de piperazina e a sua utilização para o tratamento de doenças neurológicas e psiquiátricas |
WO2004098518A2 (en) | 2003-05-01 | 2004-11-18 | Bristol-Myers Squibb Company | Pyrazole-amide compounds useful as kinase inhibitors |
TWI339206B (en) | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
RU2006125441A (ru) | 2003-12-15 | 2008-01-27 | Джапан Тобакко Инк. (Jp) | Производные циклопропана и их фармацевтическое применение |
AU2004321997A1 (en) | 2004-07-06 | 2006-02-09 | Xenon Pharmaceuticals Inc. | Nicotinamide derivatives and their use as therapeutic agents |
AR050865A1 (es) | 2004-09-09 | 2006-11-29 | Sanofi Aventis | Derivados de 2- morfolino-4-pirimidona |
AR051823A1 (es) | 2004-09-29 | 2007-02-14 | Mitsubishi Pharma Corp | Derivados de piridinil-pirimidonas |
ATE387202T1 (de) | 2004-10-15 | 2008-03-15 | Glaxo Group Ltd | Pyrrolidinderivate als histaminrezeptor-liganden |
MX2007007220A (es) | 2004-12-27 | 2007-08-20 | Astrazeneca Ab | Compuestos de pirazolona como agonistas de receptor de glutamato metabotropico para el tratamiento de trastornos neurologicos y psiquiatricos. |
WO2006079916A1 (en) | 2005-01-26 | 2006-08-03 | Pharmacia & Upjohn Company Llc | Thieno [2,3-d] pyrimidine compounds as inhibitors of adp-mediated platelets aggregation |
TW200640863A (en) * | 2005-02-15 | 2006-12-01 | Glaxo Group Ltd | Compounds which potentiate glutamate receptor and uses thereof in medicine |
TW200640864A (en) | 2005-02-17 | 2006-12-01 | Astellas Pharma Inc | Pyridyl non-aromatic nitrogenated heterocyclic-1-carboxylate ester derivative |
EP1874780A1 (en) | 2005-03-25 | 2008-01-09 | Pharmacia & Upjohn Company LLC | 4-piperazinylthieno[2,3-d]pyrimidine compounds as platelet aggregation inhibitors |
EP1869051A1 (en) | 2005-03-28 | 2007-12-26 | Pharmacia & Upjohn Company LLC | 4-piperazinylthieno ý2,3-d¨pyrimidine compounds as platelet aggregation inhibitors |
EP1896483A2 (en) | 2005-03-28 | 2008-03-12 | Pharmacia & Upjohn Company LLC | 4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors |
US20080200475A1 (en) | 2005-03-28 | 2008-08-21 | Pfizer Inc. | 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors |
JP2009501235A (ja) | 2005-07-15 | 2009-01-15 | シェーリング コーポレイション | 癌処置において有用なキナゾリン誘導体 |
TW200740779A (en) * | 2005-07-22 | 2007-11-01 | Mitsubishi Pharma Corp | Intermediate compound for synthesizing pharmaceutical agent and production method thereof |
EP1909797A4 (en) | 2005-08-02 | 2013-02-27 | Neurogen Corp | DIPIPERAZINYL KETONE AND RELATED ANALOG |
DE602006013501D1 (de) * | 2005-09-16 | 2010-05-20 | Janssen Pharmaceutica Nv | Cyclopropylamine als modulatoren des histamin-h3-rezeptors |
US8158673B2 (en) | 2005-10-27 | 2012-04-17 | Pfizer Inc. | Histamine-3 receptor antagonists |
MX367916B (es) | 2005-10-31 | 2019-09-11 | Janssen Pharmaceutica N V Star | Procedimientos para la preparacion de derivados de ciclopropilamida. |
CA2633653A1 (en) | 2005-12-21 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
US8119668B2 (en) | 2005-12-23 | 2012-02-21 | Nelson Erik B | Treatment methods employing histamine H3 receptor antagonists, including betahistine |
BRPI0707916A2 (pt) | 2006-01-13 | 2011-05-17 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem e uso destes compostos |
CN101384581B (zh) * | 2006-02-17 | 2013-09-18 | 弗·哈夫曼-拉罗切有限公司 | 作为5ht2/d3调节剂的苯甲酰基-哌啶衍生物 |
EP2004568A4 (en) | 2006-03-01 | 2010-12-01 | Cementech Pty Ltd | MATRIX FOR WALL ELEMENTS AND MANUFACTURING METHOD THEREFOR |
JP2009132621A (ja) | 2006-03-13 | 2009-06-18 | Ajinomoto Co Inc | シクロプロピルアミド化合物の製造方法 |
AU2007231594A1 (en) | 2006-03-23 | 2007-10-04 | Amgen Inc. | 1-phenylsulfonyl-diaza heterocyclic amide compounds and their uses as modulators of hydroxsteroid dehydrogenases |
US7834190B2 (en) | 2006-05-26 | 2010-11-16 | Kaneka Corporation | Process for production of optically active-3-amino-2-hydroxypropionic cyclopropylamide derivatives and salts thereof |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
JP5203360B2 (ja) | 2006-06-23 | 2013-06-05 | アボット・ラボラトリーズ | ヒスタミンh3受容体調節剤としてのシクロプロピルアミン誘導体 |
JP2009541460A (ja) | 2006-07-03 | 2009-11-26 | ベレナギング ヴォー クリスタラク ホガー オンダーヴェイル ヴェーテンザパーリク オンダージーク エン パシェンテンゾーク | ヒスタミンh4受容体と相互作用する縮合二環式化合物 |
GB0615620D0 (en) * | 2006-08-05 | 2006-09-13 | Astrazeneca Ab | A process for the preparation of optically active intermediates |
EP2056828A4 (en) | 2006-08-21 | 2010-06-23 | Merck Sharp & Dohme | SULFONYLATED PIPERAZINES AS CANNABINOID-1 RECEPTOR MODULATORS |
TW200828371A (en) | 2006-09-21 | 2008-07-01 | Matsushita Electric Ind Co Ltd | Chip-type filter |
DE102006056526A1 (de) | 2006-11-30 | 2008-06-05 | Archimica Gmbh | Verfahren zur stereoselektiven Synthese von chiralen Epoxiden durch ADH-Reduktion von alpha-Abgangsgruppen-substituierten Ketonen und Cyclisierung |
US7737149B2 (en) * | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
WO2008147864A2 (en) | 2007-05-22 | 2008-12-04 | Xenon Pharmaceuticals Inc. | Methods of using piperazine compounds in treating sodium channel-mediated diseases or conditions |
US8030495B2 (en) | 2007-05-23 | 2011-10-04 | Coleman Paul J | Cyclopropyl pyrrolidine orexin receptor antagonists |
WO2008151957A1 (en) | 2007-06-11 | 2008-12-18 | F. Hoffmann-La Roche Ag | Cyclohexyl derivatives |
UA101809C2 (xx) * | 2007-08-22 | 2013-05-13 | Астразенека Аб | Похідні циклопропіламіду$производные циклопропиламида |
JP5362729B2 (ja) * | 2007-10-04 | 2013-12-11 | エフ.ホフマン−ラ ロシュ アーゲー | シクロプロピルアリールアミド誘導体及びその使用 |
PE20091313A1 (es) * | 2008-01-15 | 2009-09-03 | Lilly Co Eli | (r)-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida cristalina |
DE102008049371A1 (de) | 2008-03-06 | 2009-09-10 | Mühlbauer Ag | Einrichtung mit einem RFID-Transponder in einem elektrisch leitfähigen Gegenstand und Herstellungsverfahren hierfür |
JP2011525478A (ja) * | 2008-03-20 | 2011-09-22 | フォレスト・ラボラトリーズ・ホールディングス・リミテッド | ステアロイル−CoAデサチュラーゼの阻害剤としての新規ピペラジン誘導体 |
CA2721303C (en) * | 2008-05-08 | 2016-06-28 | Evotec Ag | Azetidines and cyclobutanes as histamine h3 receptor antagonists |
CN102137836B (zh) | 2008-07-28 | 2015-08-26 | 赛丹思科大学 | 用于治疗代谢疾病的化合物 |
CN101462980B (zh) * | 2009-01-05 | 2013-01-09 | 扬州天辰精细化工有限公司 | 2,6—二氟苯甲酰胺的工业化生产方法 |
TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
ES2541857T3 (es) * | 2010-02-18 | 2015-07-27 | Astrazeneca Ab | Procesos para preparar ciclopropilamidas e intermedios asociados con estas |
NZ602108A (en) | 2010-02-18 | 2014-09-26 | Astrazeneca Ab | Solid forms comprising a cyclopropyl amide derivative |
-
2011
- 2011-02-17 ES ES11744974.4T patent/ES2541857T3/es active Active
- 2011-02-17 TW TW100105300A patent/TWI494301B/zh not_active IP Right Cessation
- 2011-02-17 NZ NZ60192011A patent/NZ601920A/en not_active IP Right Cessation
- 2011-02-17 TW TW100105296A patent/TWI520945B/zh not_active IP Right Cessation
- 2011-02-17 BR BR112012020629A patent/BR112012020629A2/pt not_active IP Right Cessation
- 2011-02-17 RU RU2012136148/04A patent/RU2012136148A/ru not_active Application Discontinuation
- 2011-02-17 MX MX2012009473A patent/MX2012009473A/es active IP Right Grant
- 2011-02-17 US US13/579,605 patent/US9012452B2/en not_active Expired - Fee Related
- 2011-02-17 EP EP20110744974 patent/EP2536685B1/en not_active Not-in-force
- 2011-02-17 SG SG2012059473A patent/SG183274A1/en unknown
- 2011-02-17 WO PCT/SE2011/050171 patent/WO2011102794A1/en active Application Filing
- 2011-02-17 EP EP11744975.1A patent/EP2536702A4/en not_active Withdrawn
- 2011-02-17 KR KR20127024174A patent/KR20130004296A/ko not_active Application Discontinuation
- 2011-02-17 CN CN2011800196365A patent/CN102869651A/zh active Pending
- 2011-02-17 JP JP2012553849A patent/JP2013520413A/ja not_active Ceased
- 2011-02-17 SG SG10201501226VA patent/SG10201501226VA/en unknown
- 2011-02-17 AR ARP110100486 patent/AR080205A1/es unknown
- 2011-02-17 AU AU2011218491A patent/AU2011218491C1/en not_active Ceased
- 2011-02-17 SG SG2012055240A patent/SG182732A1/en unknown
- 2011-02-17 CN CN201180019632.7A patent/CN103168027B/zh not_active Expired - Fee Related
- 2011-02-17 WO PCT/SE2011/050172 patent/WO2011102795A1/en active Application Filing
- 2011-02-17 KR KR20127021548A patent/KR20130002316A/ko not_active Application Discontinuation
- 2011-02-17 JP JP2012553850A patent/JP2013520414A/ja active Pending
- 2011-02-17 BR BR112012020782A patent/BR112012020782A2/pt not_active IP Right Cessation
- 2011-02-17 US US13/029,362 patent/US20110201623A1/en not_active Abandoned
- 2011-02-17 CA CA 2790040 patent/CA2790040A1/en not_active Abandoned
- 2011-02-17 AU AU2011218492A patent/AU2011218492B2/en not_active Ceased
- 2011-02-17 AR ARP110100485 patent/AR080204A1/es unknown
- 2011-02-17 MX MX2012009480A patent/MX336333B/es unknown
- 2011-02-17 NZ NZ60211011A patent/NZ602110A/en not_active IP Right Cessation
- 2011-02-17 CA CA 2788444 patent/CA2788444A1/en not_active Abandoned
- 2011-02-17 RU RU2012139082/04A patent/RU2012139082A/ru not_active Application Discontinuation
-
2012
- 2012-08-13 IL IL221431A patent/IL221431A/en not_active IP Right Cessation
- 2012-08-16 CL CL2012002259A patent/CL2012002259A1/es unknown
- 2012-08-17 CL CL2012002286A patent/CL2012002286A1/es unknown
- 2012-08-17 CO CO12140266A patent/CO6592109A2/es unknown
-
2013
- 2013-04-30 HK HK13105221.5A patent/HK1178142A1/xx not_active IP Right Cessation
-
2015
- 2015-08-14 JP JP2015160029A patent/JP2016006103A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20170961T1 (hr) | Postupak dobivanja karbamoilpiridonskih derivata i međuprodukata | |
GB201006340D0 (en) | Synthesis method and intermediates | |
EP2640730A4 (en) | METHODS FOR PREPARING EVEROLIMUS AND INTERMEDIATES THEREOF | |
ZA201108502B (en) | Processes and intermediates | |
ZA201302670B (en) | Process for the manufacture of degarelix and its intermediates | |
SI2632934T1 (sl) | Proces za izdelavo degareliksa in njegovih intermediatov | |
PL2627656T3 (pl) | Sposób wytwarzania dihydropterydynonów i ich produktów pośrednich | |
EP2526099A4 (en) | IMPROVED METHOD FOR THE MANUFACTURE OF AMID INTERMEDIATE PRODUCTS AND ITS APPLICATION | |
HK1178142A1 (en) | Processes for making cyclopropyl amide derivatives and intermediates associated therewith | |
IL221441A0 (en) | Process for preparing entecavir and its intermediates | |
EP2630143A4 (en) | PROCESS FOR THE PRODUCTION OF RIVAROXABAN AND INTERMEDIATE PRODUCTS THEREOF | |
IL223067A0 (en) | Processes and intermediates | |
IL221430A0 (en) | Solid forms comprising a cyclopropyl amide derivative | |
IL229426A0 (en) | processes and intermediates | |
GB201117416D0 (en) | Processes and intermediates | |
GB201010223D0 (en) | Method of printing | |
IL243320A0 (en) | Intermediates of teroarylpiperidine and piperazine derivatives | |
GB201017214D0 (en) | Processes and intermediates | |
GB201017117D0 (en) | Processes and intermediates | |
GB201017059D0 (en) | Processes and intermediates |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20190223 |