HK1176075A1 - 抗體可變區的糖基化 - Google Patents
抗體可變區的糖基化Info
- Publication number
- HK1176075A1 HK1176075A1 HK13103092.6A HK13103092A HK1176075A1 HK 1176075 A1 HK1176075 A1 HK 1176075A1 HK 13103092 A HK13103092 A HK 13103092A HK 1176075 A1 HK1176075 A1 HK 1176075A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- variable region
- antibody glycosylation
- glycosylation
- antibody
- variable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05027090 | 2005-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1176075A1 true HK1176075A1 (zh) | 2013-07-19 |
Family
ID=37745986
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09106521.6A HK1130066A1 (en) | 2005-12-12 | 2009-07-17 | Antibody glycosylation in the variable region |
HK13103092.6A HK1176075A1 (zh) | 2005-12-12 | 2009-07-17 | 抗體可變區的糖基化 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09106521.6A HK1130066A1 (en) | 2005-12-12 | 2009-07-17 | Antibody glycosylation in the variable region |
Country Status (34)
Country | Link |
---|---|
US (2) | US8906370B2 (zh) |
EP (2) | EP2377886A1 (zh) |
JP (1) | JP5145241B2 (zh) |
KR (2) | KR101401159B1 (zh) |
CN (2) | CN102659943B (zh) |
AR (1) | AR057233A1 (zh) |
AT (1) | ATE517923T1 (zh) |
AU (1) | AU2006326301B2 (zh) |
BR (1) | BRPI0619605B8 (zh) |
CA (1) | CA2632828C (zh) |
CR (1) | CR10000A (zh) |
CY (1) | CY1114783T1 (zh) |
DK (1) | DK1960428T3 (zh) |
DO (1) | DOP2006000278A (zh) |
EC (1) | ECSP088524A (zh) |
ES (1) | ES2368591T3 (zh) |
HK (2) | HK1130066A1 (zh) |
IL (1) | IL191004A (zh) |
JO (1) | JO2824B1 (zh) |
MA (1) | MA30038B1 (zh) |
MY (1) | MY155286A (zh) |
NO (1) | NO346105B1 (zh) |
NZ (1) | NZ568241A (zh) |
PE (3) | PE20100748A1 (zh) |
PL (1) | PL1960428T3 (zh) |
PT (1) | PT1960428E (zh) |
RS (1) | RS52004B (zh) |
RU (1) | RU2438706C2 (zh) |
SI (1) | SI1960428T1 (zh) |
TW (1) | TWI382990B (zh) |
UA (1) | UA99097C2 (zh) |
UY (1) | UY30003A1 (zh) |
WO (1) | WO2007068429A1 (zh) |
ZA (1) | ZA200805038B (zh) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR038568A1 (es) | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
PT1954718E (pt) | 2005-11-30 | 2014-12-16 | Abbvie Inc | Anticorpos anti-globulómeros aβ, suas porções de ligação ao antigénio, correspondentes hibridomas, ácidos nucleicos, vectores, células hospedeiras, métodos de produção dos ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos para uso dos ditos anticorpos |
NZ568241A (en) * | 2005-12-12 | 2011-08-26 | Hoffmann La Roche | Antibodies against amyloid beta 4 with glycosylation in the variable region |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
MX2009006199A (es) * | 2006-12-11 | 2009-06-22 | Hoffmann La Roche | Formulacion parenteral de anticuerpos abeta. |
WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
KR101163295B1 (ko) * | 2007-06-29 | 2012-07-05 | 에프. 호프만-라 로슈 아게 | 향상된 면역글로불린을 생산하는 중쇄 돌연변이체 |
ES2473623T3 (es) * | 2007-08-20 | 2014-07-07 | Glaxo Group Limited | Procedimiento de producción |
AU2008311367B2 (en) | 2007-10-05 | 2014-11-13 | Ac Immune S.A. | Use of anti-amyloid beta antibody in ocular diseases |
CN101896163A (zh) * | 2007-12-21 | 2010-11-24 | 弗·哈夫曼-拉罗切有限公司 | 抗体制剂 |
CA2975228C (en) * | 2008-05-02 | 2020-07-21 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
US20120282654A1 (en) * | 2009-04-29 | 2012-11-08 | Schering Corporation | Antibody purification |
US20130116413A1 (en) * | 2009-12-29 | 2013-05-09 | Dr. Reddy's Laboratories, Inc. | Purification of proteins |
CN102781962B (zh) | 2010-03-03 | 2014-12-10 | 阿布林克斯公司 | 双互补位A-β结合多肽 |
MX360403B (es) | 2010-04-15 | 2018-10-31 | Abbvie Inc | Proteinas de union a amiloide beta. |
CN103179981B (zh) | 2010-07-30 | 2017-02-08 | Ac免疫有限公司 | 安全和功能性的人源化抗β‑淀粉样蛋白抗体 |
EP2603524A1 (en) | 2010-08-14 | 2013-06-19 | AbbVie Inc. | Amyloid-beta binding proteins |
WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
IN2014CN03555A (zh) | 2011-10-25 | 2015-07-03 | Onclave Therapeutics Ltd | |
WO2013081946A1 (en) * | 2011-12-02 | 2013-06-06 | Plaxgen, Inc. | Plaque array method and compositions for forming and detecting plaques |
RU2014140137A (ru) | 2012-03-08 | 2016-04-27 | Ф.Хоффманн-Ля Рош Аг | Лекарственный препарат антитела к бета-амилоиду |
TR201909156T4 (tr) * | 2012-08-29 | 2019-07-22 | Hoffmann La Roche | Kan beyin bariyeri mekiği. |
CN102998454A (zh) * | 2012-12-11 | 2013-03-27 | 华中师范大学 | 一种检测生物体内邻苯二甲酸二丁酯相对含量的方法 |
US9587022B2 (en) | 2012-12-18 | 2017-03-07 | The Rockefeller University | Glycan-modified anti-CD4 antibody with improved HIV-1 neutralizing activity |
EP2934589B1 (en) * | 2012-12-18 | 2021-01-13 | The Rockefeller University | Glycan-modified anti-cd4 antibodies for hiv prevention and therapy |
BR112015019341A2 (pt) | 2013-02-13 | 2017-08-22 | Lab Francais Du Fractionnement | Anticorpo anti-tnf-alfa, composição que compreende o anticorpo, método para produzir uma população de anticorpos, células epiteliais da glândula mamária, mamífero não humano transgênico, e, composição de anticorpo anti-tnf monoclonal |
JP6169885B2 (ja) | 2013-05-07 | 2017-07-26 | 株式会社日立製作所 | 精製装置及び精製方法 |
NZ756750A (en) | 2013-09-13 | 2022-05-27 | Genentech Inc | Methods and compositions comprising purified recombinant polypeptides |
ES2915378T3 (es) | 2013-09-13 | 2022-06-22 | Hoffmann La Roche | Procedimientos para detectar y cuantificar una proteína de célula huésped en líneas celulares |
CA2931056C (en) | 2013-11-22 | 2023-02-28 | The University Of Tokyo | Carrier for use in delivering drug, conjugate, composition comprising same, and method for administrating same |
CA2944402A1 (en) | 2014-04-08 | 2015-10-15 | Prothena Biosciences Limited | Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein |
WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
HUE057952T2 (hu) | 2015-06-24 | 2022-06-28 | Hoffmann La Roche | Anti-transzferrin receptor antitestek testreszabott affinitással |
CN116063375A (zh) * | 2015-08-21 | 2023-05-05 | 豪夫迈·罗氏有限公司 | 在亲和层析中减少宿主细胞蛋白的方法 |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
JP6657392B2 (ja) | 2015-10-02 | 2020-03-04 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性抗ヒトcd20/ヒトトランスフェリン受容体抗体及び使用方法 |
EP3155958B1 (en) * | 2015-10-16 | 2021-11-17 | Roche Diabetes Care GmbH | A method for operating a system and a system |
KR20180088828A (ko) | 2015-11-09 | 2018-08-07 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아밀로이드 베타에서의 n-말단 에피토프 및 이에 형태적으로-선택적인 항체 |
US10774120B2 (en) | 2015-11-09 | 2020-09-15 | The University Of British Columbia | Anti-amyloid beta antibodies binding to a cyclic amyloid beta peptide |
US10759837B2 (en) | 2015-11-09 | 2020-09-01 | The University Of British Columbia | Anti-amyloid beta antibodies binding to a cyclic amyloid beta peptide |
US10792477B2 (en) * | 2016-02-08 | 2020-10-06 | Orbusneich Medical Pte. Ltd. | Drug eluting balloon |
EP3427183A1 (en) * | 2016-03-10 | 2019-01-16 | Genomic Vision | Method of curvilinear signal detection and analysis and associated platform |
EP3448874A4 (en) * | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
TWI798751B (zh) | 2016-07-01 | 2023-04-11 | 美商美國禮來大藥廠 | 抗-N3pGlu類澱粉β肽抗體及其用途 |
CA3031135A1 (en) | 2016-07-18 | 2018-01-25 | The University Of British Columbia | Antibodies to amyloid beta |
US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
JPWO2018221244A1 (ja) * | 2017-05-30 | 2019-11-21 | 森永乳業株式会社 | 脳機能改善用組成物 |
WO2019014768A1 (en) | 2017-07-18 | 2019-01-24 | The University Of British Columbia | ANTI-BETA-AMYLOID ANTIBODY |
CN108048477A (zh) * | 2017-12-15 | 2018-05-18 | 南京理工大学 | 基于大肠杆菌表达系统的制备多肽的方法 |
EP3778875A1 (en) | 2019-08-14 | 2021-02-17 | MaxiVax SA | Immortalized myoblast cell lines and uses thereof |
EP4185612A1 (en) | 2020-07-23 | 2023-05-31 | Othair Prothena Limited | Anti-abeta antibodies |
MX2023005581A (es) | 2020-11-16 | 2023-05-29 | Hoffmann La Roche | Glucoformas de fab ricas en manosa. |
TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
CN114591429B (zh) * | 2022-05-07 | 2022-08-09 | 北京第一生物化学药业有限公司 | 结合β-淀粉样蛋白的抗体及其用途 |
WO2024157085A1 (en) | 2023-01-26 | 2024-08-02 | Othair Prothena Limited | Methods of treating neurological disorders with anti-abeta antibodies |
CN117783359A (zh) * | 2023-12-28 | 2024-03-29 | 中国计量科学研究院 | 一种基于串联质谱的转基因蛋白多靶同检方法 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4666829A (en) | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US5811310A (en) | 1986-09-30 | 1998-09-22 | Albert Einstein College Of Medicine Of Yeshiva Univ. | The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
CA1339014C (en) | 1987-10-08 | 1997-03-25 | Ronald E. Majocha | Antibodies to a4 amyloid peptide |
JP2780507B2 (ja) | 1991-03-29 | 1998-07-30 | 松下電器産業株式会社 | 内燃機関用フィルタ再生装置 |
US5955317A (en) | 1993-01-25 | 1999-09-21 | Takeda Chemical Industries, Ltd. | Antibodies to β-amyloids or their derivatives and use thereof |
US5750349A (en) | 1993-01-25 | 1998-05-12 | Takeda Chemical Industries Ltd. | Antibodies to β-amyloids or their derivatives and use thereof |
US5443953A (en) * | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
GB9416007D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
US5688651A (en) | 1994-12-16 | 1997-11-18 | Ramot University Authority For Applied Research And Development Ltd. | Prevention of protein aggregation |
AU5976996A (en) * | 1995-06-06 | 1996-12-24 | Stemcell Therapeutics L.L.C. | Glycoprotein gp105 on bl3 hematopoietic stem cells |
CA2229043C (en) | 1995-08-18 | 2016-06-07 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
PT1161449E (pt) * | 1999-03-04 | 2007-10-12 | Praecis Pharm Inc | Moduladores de agregação do péptido beta-amilóide compreendendo d-aminoácidos |
DK1409654T3 (da) | 1999-06-16 | 2008-12-08 | Boston Biomedical Res Inst | Immunologisk styring af beta-amyloid-niveauer in vivo |
EP1209969A2 (en) | 1999-08-31 | 2002-06-05 | RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. | Peptides and substances, methods and devices using same for diagnosing and treating neurodegenerative disorders |
US20020094335A1 (en) | 1999-11-29 | 2002-07-18 | Robert Chalifour | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases |
AU784312B2 (en) | 1999-11-29 | 2006-03-09 | Bellus Health (International) Limited | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases |
EP1125905A1 (en) | 2000-02-16 | 2001-08-22 | Pepscan Systems B.V. | Segment synthesis |
SK288711B6 (sk) | 2000-02-24 | 2019-11-05 | Univ Washington | Humanizovaná protilátka, jej fragment a ich použitie, polynukleová kyselina, expresný vektor, bunka a farmaceutický prostriedok |
CA2313828A1 (en) | 2000-08-01 | 2002-02-01 | Institut De Recherches Cliniques De Montreal/Ircm | Post-translational processing of .beta.-secretase (bace): the pro-and transmembrane/cytosolic domains affect its cellular activity and amyloid a.beta. production |
TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
WO2002064734A2 (en) | 2000-12-19 | 2002-08-22 | Palatin Technologies, Inc. | Identification of target-specific folding sites in peptides and proteins |
DE60230736D1 (de) | 2001-04-30 | 2009-02-26 | Lilly Co Eli | HUMANISIERTE ANTIKÖRPER DIE DAS BETA-AMYLOID PEPTID ERKENNEN& x9; |
DE60229051D1 (de) | 2001-04-30 | 2008-11-06 | Lilly Co Eli | Humanisierte antikörper |
EP1944040B1 (en) * | 2001-08-17 | 2012-08-01 | Washington University | Assay method for Alzheimer's disease |
WO2003016466A2 (en) | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | ANTI-Aβ ANTIBODIES |
AR038568A1 (es) * | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
BR0315157A (pt) | 2002-10-09 | 2005-08-09 | Rinat Neuroscience Corp | Métodos de tratar doença de alzheimer empregando-se anticorpos direcionados contra peptìdeo beta amilóide e composições deste |
DE10303974A1 (de) * | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
NZ568241A (en) * | 2005-12-12 | 2011-08-26 | Hoffmann La Roche | Antibodies against amyloid beta 4 with glycosylation in the variable region |
MX2009006199A (es) * | 2006-12-11 | 2009-06-22 | Hoffmann La Roche | Formulacion parenteral de anticuerpos abeta. |
-
2006
- 2006-12-11 NZ NZ568241A patent/NZ568241A/en unknown
- 2006-12-11 PT PT06829502T patent/PT1960428E/pt unknown
- 2006-12-11 MY MYPI20081349A patent/MY155286A/en unknown
- 2006-12-11 BR BRPI0619605A patent/BRPI0619605B8/pt active IP Right Grant
- 2006-12-11 SI SI200631096T patent/SI1960428T1/sl unknown
- 2006-12-11 DO DO2006000278A patent/DOP2006000278A/es unknown
- 2006-12-11 TW TW095146304A patent/TWI382990B/zh active
- 2006-12-11 KR KR1020127010552A patent/KR101401159B1/ko active IP Right Grant
- 2006-12-11 DK DK06829502.1T patent/DK1960428T3/da active
- 2006-12-11 PE PE2010000560A patent/PE20100748A1/es active IP Right Grant
- 2006-12-11 CN CN201210137369.8A patent/CN102659943B/zh active Active
- 2006-12-11 PL PL06829502T patent/PL1960428T3/pl unknown
- 2006-12-11 EP EP11169488A patent/EP2377886A1/en not_active Withdrawn
- 2006-12-11 US US12/086,309 patent/US8906370B2/en active Active
- 2006-12-11 JO JO2006444A patent/JO2824B1/en active
- 2006-12-11 PE PE2006001587A patent/PE20071002A1/es not_active Application Discontinuation
- 2006-12-11 ES ES06829502T patent/ES2368591T3/es active Active
- 2006-12-11 JP JP2008543748A patent/JP5145241B2/ja active Active
- 2006-12-11 AT AT06829502T patent/ATE517923T1/de active
- 2006-12-11 NO NO20082874A patent/NO346105B1/no unknown
- 2006-12-11 UY UY30003A patent/UY30003A1/es unknown
- 2006-12-11 PE PE2010000354A patent/PE20100684A1/es not_active Application Discontinuation
- 2006-12-11 CN CN2006800463079A patent/CN101351476B/zh active Active
- 2006-12-11 KR KR1020087012289A patent/KR20080077132A/ko active Search and Examination
- 2006-12-11 EP EP06829502A patent/EP1960428B1/en active Active
- 2006-12-11 AR ARP060105433A patent/AR057233A1/es unknown
- 2006-12-11 RS RS20110401A patent/RS52004B/en unknown
- 2006-12-11 UA UAA200808791A patent/UA99097C2/ru unknown
- 2006-12-11 AU AU2006326301A patent/AU2006326301B2/en active Active
- 2006-12-11 RU RU2008128138/10A patent/RU2438706C2/ru active
- 2006-12-11 WO PCT/EP2006/011914 patent/WO2007068429A1/en active Application Filing
- 2006-12-11 CA CA2632828A patent/CA2632828C/en active Active
-
2008
- 2008-04-27 IL IL191004A patent/IL191004A/en active IP Right Grant
- 2008-05-20 CR CR10000A patent/CR10000A/es unknown
- 2008-06-09 MA MA31014A patent/MA30038B1/fr unknown
- 2008-06-10 ZA ZA200805038A patent/ZA200805038B/xx unknown
- 2008-06-10 EC EC2008008524A patent/ECSP088524A/es unknown
-
2009
- 2009-07-17 HK HK09106521.6A patent/HK1130066A1/xx unknown
- 2009-07-17 HK HK13103092.6A patent/HK1176075A1/zh unknown
-
2011
- 2011-09-16 CY CY20111100899T patent/CY1114783T1/el unknown
-
2014
- 2014-11-07 US US14/536,262 patent/US9272031B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1130066A1 (en) | Antibody glycosylation in the variable region | |
HK1218126A1 (zh) | 抗體 | |
IL187106A (en) | Sclerostin binds antibody | |
IL190472A0 (en) | Anti-glypican-3 antibody | |
IL185366A0 (en) | Antibody | |
IL187316A0 (en) | Anti-interleukin 2 antibodies | |
IL186500A0 (en) | Protein glycosylation | |
GB0502992D0 (en) | The ballcaster | |
GB0523899D0 (en) | The one | |
GB0511610D0 (en) | The motor-roll-off | |
PL376079A1 (pl) | Piec akumulacyjny obiektu | |
GB0516424D0 (en) | Improvement in the lamp | |
GB0526162D0 (en) | The gift | |
GB0500400D0 (en) | Antibody | |
GB0502412D0 (en) | The sproke | |
GB0506202D0 (en) | The uni-tray | |
GB0511228D0 (en) | The cat-lock | |
GB0500175D0 (en) | The astrocelesphere | |
GB0517209D0 (en) | The wayfinder | |
GB0519318D0 (en) | The wheelbox | |
GB0521054D0 (en) | The chew-it-bar | |
GB0521243D0 (en) | The grapler | |
GB0524595D0 (en) | The guillospade | |
GB0524920D0 (en) | The clipstrip |