HK1174326A1 - 3,4,4a,10b-tetrahydr-1h-thiopyrano-[4, 3-c] isoquinoline derivatives 344a10b--1h-[43-c] - Google Patents

3,4,4a,10b-tetrahydr-1h-thiopyrano-[4, 3-c] isoquinoline derivatives 344a10b--1h-[43-c]

Info

Publication number
HK1174326A1
HK1174326A1 HK13101194.7A HK13101194A HK1174326A1 HK 1174326 A1 HK1174326 A1 HK 1174326A1 HK 13101194 A HK13101194 A HK 13101194A HK 1174326 A1 HK1174326 A1 HK 1174326A1
Authority
HK
Hong Kong
Prior art keywords
thiopyrano
tetrahydr
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
HK13101194.7A
Other languages
English (en)
Chinese (zh)
Inventor
Dieter Flockerzi
Thomas Stengel
Alexander Mann
Harald Ohmer
Ulrich Kautz
Steffen Weinbrenner
Stefan Fischer
Christof Zitt
Armin Hatzelmann
Torsten Dunkern
Christian Hesslinger
Thomas Maier
Hermann Tenor
Clemens Braun
Raimund Klzer
Degenhard Marx
Original Assignee
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Gmbh filed Critical Takeda Gmbh
Publication of HK1174326A1 publication Critical patent/HK1174326A1/xx

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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HK13101194.7A 2009-12-18 2013-01-28 3,4,4a,10b-tetrahydr-1h-thiopyrano-[4, 3-c] isoquinoline derivatives 344a10b--1h-[43-c] HK1174326A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09179982 2009-12-18
US31555210P 2010-03-19 2010-03-19
PCT/EP2010/069704 WO2011073231A1 (en) 2009-12-18 2010-12-15 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4, 3-c] ISOQUINOLINE DERIVATIVES

Publications (1)

Publication Number Publication Date
HK1174326A1 true HK1174326A1 (en) 2013-06-07

Family

ID=41718903

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HK13101194.7A HK1174326A1 (en) 2009-12-18 2013-01-28 3,4,4a,10b-tetrahydr-1h-thiopyrano-[4, 3-c] isoquinoline derivatives 344a10b--1h-[43-c]

Country Status (29)

Country Link
US (1) US9018175B2 (de)
EP (2) EP2813509B1 (de)
JP (1) JP5645961B2 (de)
KR (1) KR20120123313A (de)
CN (1) CN102652136B (de)
AR (1) AR079451A1 (de)
AU (1) AU2010332955B8 (de)
BR (1) BR112012014058A8 (de)
CA (1) CA2784013A1 (de)
CO (1) CO6551705A2 (de)
DK (1) DK2513119T3 (de)
EA (1) EA023212B1 (de)
ES (2) ES2621291T3 (de)
GE (1) GEP20146105B (de)
HK (1) HK1174326A1 (de)
HR (1) HRP20140893T1 (de)
ME (1) ME01914B (de)
MX (1) MX2012006696A (de)
NZ (1) NZ601115A (de)
PL (1) PL2513119T3 (de)
PT (1) PT2513119E (de)
RS (1) RS53544B1 (de)
SG (2) SG196785A1 (de)
SI (1) SI2513119T1 (de)
SM (1) SMT201400185B (de)
TW (1) TWI468411B (de)
UA (1) UA107689C2 (de)
WO (1) WO2011073231A1 (de)
ZA (1) ZA201204135B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110300432A1 (en) 2010-06-07 2011-12-08 Snyder Shawn W Rechargeable, High-Density Electrochemical Device
RU2013142268A (ru) * 2011-02-17 2015-03-27 Сипла Лимитед Фармацевтическая композиция
EP2721036B1 (de) 2011-06-15 2015-07-22 Takeda GmbH Neuartige 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isochinolin-verbindungen
WO2014016548A2 (en) * 2012-07-27 2014-01-30 Cipla Limited Pharmaceutical composition
WO2014090990A1 (en) * 2012-12-13 2014-06-19 Ludwig Aigner Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease
AU2014211755B2 (en) 2013-02-04 2017-07-06 Grunenthal Gmbh 4-amino substituted condensed pyrimidine compounds as PDE4 inhibitors
ES2638850T3 (es) 2013-02-19 2017-10-24 Pfizer Inc. Compuestos de azabenzimidazol como inhibidores de las isoenzimas de la PDE4 para el tratamiento de trastornos del SNC y otros trastornos
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
WO2016020786A1 (en) 2014-08-06 2016-02-11 Pfizer Inc. Imidazopyridazine compounds
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
DE2047465A1 (de) 1970-09-26 1972-03-30 Farbwerke Hoechst AG, vorm Meister Lucius & Bruning, 6000 Frankfurt Neue Oxdiazole und Verfahren zu lh rer Herstellung
CN1003445B (zh) 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物,其制备方法和用途
JPH01213284A (ja) 1988-02-22 1989-08-28 Sankyo Co Ltd チエノピリミジン−2,4−ジオン誘導体
GB8828477D0 (en) 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
ATE111364T1 (de) 1989-05-31 1994-09-15 Fisons Plc Medikament und inhalationsvorrichtung dafür.
GB8921222D0 (en) 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
IE67185B1 (en) 1990-02-02 1996-03-06 Fisons Plc Propellant compositions
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
JPH05505824A (ja) 1990-03-23 1993-08-26 ミネソタ マイニング アンド マニュファクチャリング カンパニー 所定投与量エアロゾル製剤の製造のための可溶性弗素界面活性剤の使用
ATE114112T1 (de) 1990-10-18 1994-12-15 Minnesota Mining & Mfg Aerosolzubereitung, die beclometason 17,21- dipropionat enthält.
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
IL104068A (en) 1991-12-12 1998-10-30 Glaxo Group Ltd Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant
GB9213874D0 (en) 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
GB9306703D0 (en) 1993-03-31 1993-05-26 Fisons Plc Inhalation device
IL111194A (en) 1993-10-08 1998-02-08 Fisons Plc Process for the production of drug patramulations
ES2195189T3 (es) 1996-11-11 2003-12-01 Altana Pharma Ag Benzonaftiridinas como agentes terapeuticos bronquiales.
ES2179490T3 (es) 1997-05-08 2003-01-16 Merck Sharp & Dohme Derivados de 1,2,4-triazolo(3,4-a)ftalazina sustituidos como ligandos de gaba alfa 5.
AU8106598A (en) 1997-06-03 1998-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
CN1150890C (zh) 1998-08-04 2004-05-26 杰格研究股份公司 药用气溶胶制剂
US6397838B1 (en) 1998-12-23 2002-06-04 Battelle Pulmonary Therapeutics, Inc. Pulmonary aerosol delivery device and method
US6454193B1 (en) 1999-04-23 2002-09-24 Battellepharma, Inc. High mass transfer electrosprayer
BR0009993A (pt) 1999-04-23 2002-01-08 Battelle Memorial Institute Pulverizador de aerossol eletrohidrodinâmico direcionalmente controlado, dispositivo para liberar gotìculas de aerossol eletricamente neutras, aparelho para liberar gotìculas de aerossol terapêuticas, processo para liberar gotìculas de aerossol, e, dispositivo para liberar aerossol
ATE312820T1 (de) 1999-10-28 2005-12-15 Trine Pharmaceuticals Inc Pumpeninhibitoren zur freisetzung von medikamenten
WO2001094350A1 (en) 2000-06-07 2001-12-13 Almirall Prodesfarma S.A. 6-phenylpyrrolopyrimidinedione derivatives
AU2001281965A1 (en) 2000-07-14 2002-01-30 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Novel 6-phenylphenanthridines
ES2260299T3 (es) 2000-10-09 2006-11-01 3M Innovative Properties Company Formulaciones medicinales en aerosol.
EP1425029A4 (de) 2001-08-10 2006-06-07 Palatin Technologies Inc Peptidomimetika von biologisch aktiven metallopeptiden
US20030216407A1 (en) 2002-01-31 2003-11-20 Pfizer Inc. Use of PDE5 inhibitors in the treatment of scarring
GB0202254D0 (en) 2002-01-31 2002-03-20 Pfizer Ltd Prevention of scarring
AU2003253165A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidine fused bicyclic metalloproteinase inhibitors
MXPA06012279A (es) 2004-04-23 2007-01-31 Celgene Corp Metodos de uso y composiciones que comprenden moduladores de pde4 para el tratamiento y manejo de la hipertension pulmonar.
JP4960870B2 (ja) 2004-09-08 2012-06-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の3−チア−10−アザ−フェナントレン誘導体
US7838521B2 (en) 2004-09-08 2010-11-23 Nycomed Gmbh 3-oxa-10-aza-phenanthrenes
EP1813603A1 (de) 2004-11-17 2007-08-01 Kissei Pharmaceutical Co., Ltd. Aromatische amidderivate, medizinische zusammensetzungen, die diese enthalten, und medizinische anwendungen der beiden
JP2008532980A (ja) * 2005-03-09 2008-08-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング アミド置換された6−フェニルフェナントリジン
JP5309131B2 (ja) * 2007-04-23 2013-10-09 サノフイ P2y12アンタゴニストとしてのキノリン−カルボキサミド誘導体
EP2721036B1 (de) * 2011-06-15 2015-07-22 Takeda GmbH Neuartige 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isochinolin-verbindungen

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