HK1160795A1 - Muc-1 cytoplasmic domain peptides as inhibitors of cancer muc-1 - Google Patents

Muc-1 cytoplasmic domain peptides as inhibitors of cancer muc-1

Info

Publication number
HK1160795A1
HK1160795A1 HK12101344.7A HK12101344A HK1160795A1 HK 1160795 A1 HK1160795 A1 HK 1160795A1 HK 12101344 A HK12101344 A HK 12101344A HK 1160795 A1 HK1160795 A1 HK 1160795A1
Authority
HK
Hong Kong
Prior art keywords
muc
inhibitors
cancer
cytoplasmic domain
domain peptides
Prior art date
Application number
HK12101344.7A
Other languages
English (en)
Chinese (zh)
Inventor
Donald W Kufe
Surender Kharbanda
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of HK1160795A1 publication Critical patent/HK1160795A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1735—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK12101344.7A 2008-10-17 2012-02-10 Muc-1 cytoplasmic domain peptides as inhibitors of cancer muc-1 HK1160795A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10638008P 2008-10-17 2008-10-17
US17710909P 2009-05-11 2009-05-11
PCT/US2009/061051 WO2010045586A2 (fr) 2008-10-17 2009-10-16 Peptides à domaine cytoplasmique muc-1 en tant qu'inhibiteurs du cancer

Publications (1)

Publication Number Publication Date
HK1160795A1 true HK1160795A1 (en) 2012-08-17

Family

ID=42046194

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12101344.7A HK1160795A1 (en) 2008-10-17 2012-02-10 Muc-1 cytoplasmic domain peptides as inhibitors of cancer muc-1

Country Status (20)

Country Link
US (3) US8524669B2 (fr)
EP (2) EP2352508B1 (fr)
JP (2) JP5657549B2 (fr)
KR (1) KR101689408B1 (fr)
CN (1) CN102245632B (fr)
AU (1) AU2009305550B2 (fr)
BR (1) BRPI0920360A2 (fr)
CA (1) CA2741065C (fr)
DE (1) DE09740811T9 (fr)
DK (1) DK2352508T3 (fr)
ES (1) ES2395028T3 (fr)
HK (1) HK1160795A1 (fr)
IL (1) IL212383A (fr)
MX (1) MX2011004082A (fr)
NZ (1) NZ592537A (fr)
PL (1) PL2352508T3 (fr)
PT (1) PT2352508E (fr)
RU (1) RU2539832C2 (fr)
WO (1) WO2010045586A2 (fr)
ZA (1) ZA201103150B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2741065C (fr) 2008-10-17 2017-04-25 Dana-Farber Cancer Institute, Inc. Peptides a domaine cytoplasmique muc-1 en tant qu'inhibiteurs du cancer
WO2010138740A1 (fr) 2009-05-27 2010-12-02 Dana-Farber Cancer Institute, Inc. Inhibition de l'inflammation au moyen d'antagonistes de muc1
WO2011100688A1 (fr) * 2010-02-12 2011-08-18 Dana-Farber Cancer Institute, Inc. Antagonistes améliorés du muc1
EP2548017A2 (fr) * 2010-03-15 2013-01-23 Genus Oncology, Llc Petites molécules inhibitrices de muc1 et leurs procédés d'identification
US20130231385A1 (en) 2010-05-28 2013-09-05 The Board Of Regents Of The University Of Texas Systems Oligo-benzamide compounds and their use
US8907054B2 (en) * 2011-08-08 2014-12-09 Marquette University Dpy-30 binding peptides
CA2844500C (fr) * 2011-08-17 2022-05-10 Globeimmune, Inc. Compositions immunotherapeutiques de -muc1 de levure et leurs utilisations
CN108434440B (zh) 2011-09-06 2022-08-23 新加坡科技研究局 多肽疫苗
US8754124B2 (en) 2011-11-23 2014-06-17 Board Of Regents, The University Of Texas System Oligo-benzamide compounds and their use in treating cancers
WO2013078288A1 (fr) * 2011-11-23 2013-05-30 The Board Of Regents Of The University Of Texas System Composés d'oligo-benzamides pour une utilisation dans le traitement de cancers
US9044421B2 (en) 2012-03-28 2015-06-02 Genus Oncology, Llc Treating MUC1-expressing cancers with combination therapies
US9572855B2 (en) 2013-03-11 2017-02-21 Dana-Farber Cancer Institute, Inc. Combination anti-estrogen receptor cancer therapy using MUC1 peptides and chemotherapeutics
US9789156B2 (en) 2013-03-11 2017-10-17 Dana-Farber Cancer Institute, Inc. Combination anti-human epidermal growth factor receptor 2 (anti-HER2) cancer therapy using mucin 1 (MUC1) peptides and hemotherapeutics
ES2794088T3 (es) 2014-01-29 2020-11-17 Dana Farber Cancer Inst Inc Anticuerpos contra el dominio extracelular de MUC1-C (MUC1-C/ECD)
CA2888068A1 (fr) 2014-04-15 2015-10-15 The Hospital For Sick Children Peptides antimicrobiens cationiques
EP3542814B1 (fr) 2018-03-21 2022-08-24 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Nouveaux composés à base de peptides destinés à être utilisés dans la prévention, le traitement et/ou la détection du cancer

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475085A (en) 1991-02-07 1995-12-12 Molecumetics, Ltd. Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
JPH06505486A (ja) 1991-02-07 1994-06-23 モレキュメティクス，リミティド βターンおよびβバルジのコンフォメーション的に制限された模倣物およびそれらを含有するペプチド
US5329028A (en) 1992-08-05 1994-07-12 Genentech, Inc. Carbohydrate-directed cross-linking reagents
HUT71860A (en) 1992-08-27 1996-02-28 Deakin Res Ltd Retro-, inverso-, and retro-inverso synthetic peptide analogues
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US5446128A (en) 1993-06-18 1995-08-29 The Board Of Trustees Of The University Of Illinois Alpha-helix mimetics and methods relating thereto
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
CA2188432C (fr) * 1994-04-22 2011-02-01 Yutaka Kawakami Antigenes du melanome
US5912232A (en) * 1994-09-23 1999-06-15 Board Of Regents Of The University Of Nebraska Anti-inflammatory polypeptide antagonists of human I1-8
US6548643B1 (en) * 1994-11-16 2003-04-15 Austin Research Institute Antigen carbohydrate compounds and their use in immunotherapy
US5597457A (en) 1995-01-23 1997-01-28 The Regents Of The University Of California System and method for forming synthetic protein crystals to determine the conformational structure by crystallography
US5929237A (en) 1995-10-27 1999-07-27 Molecumetics Ltd. Reverse-turn mimetics and methods relating thereto
US5840833A (en) 1995-10-27 1998-11-24 Molecumetics, Ltd Alpha-helix mimetics and methods relating thereto
NO961031D0 (no) * 1996-03-13 1996-03-13 Det Norske Radiumshospital Tum Fremgangsmåte til å drepe uönskede målceller
US6093573A (en) 1997-06-20 2000-07-25 Xoma Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
US20020044943A1 (en) * 1997-09-10 2002-04-18 Longenecker B. Michael MUC-1 as an immunosuppressive therapeutic agent for the treatment of inflammatory and autoimmune conditions
AU767185B2 (en) 1998-03-23 2003-11-06 President And Fellows Of Harvard College Synthesis of compounds and libraries of compounds
WO2000009744A1 (fr) 1998-08-13 2000-02-24 American Home Products Corporation Structure cristalline de gdp-fucose synthetase d'escherichia coli et procedes d'utilisation de celle-ci
JP2002523057A (ja) 1998-08-25 2002-07-30 ザ スクリップス リサーチ インスティテュート タンパク質の機能を予測するための方法およびシステム
US20010047183A1 (en) 2000-04-05 2001-11-29 Salvatore Privitera Surgical device for the collection of soft tissue
EP1159418A2 (fr) 1998-12-11 2001-12-05 Biomira Inc. Antagonistes de la muc-1 et methodes de traitement de troubles immunitaires
US6801860B1 (en) 1999-02-15 2004-10-05 Genetics Institute, Llc Crystal structure of cPLA2 and methods of identifying agonists and antagonists using same
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
AU5298900A (en) 1999-05-26 2000-12-12 Regents Of The University Of California, The Method of determining the three-dimensional shape of a macromolecule
MXPA02001857A (es) * 1999-08-24 2003-07-14 Cellgate Inc Composiciones y metodos para incrementar la entrega de drogas a traves y dentro de tejidos epiteliales.
DK1210430T3 (da) 1999-09-08 2006-11-20 Transgene Sa MUC-1-afledte peptider
WO2001057068A1 (fr) * 2000-02-01 2001-08-09 The Austin Research Institute Antigenes derives de mucine-1 et leur utilisation en immunotherapie
CN1455680A (zh) * 2000-09-11 2003-11-12 达纳-法伯癌症协会有限公司 Muc1胞外域和癌症治疗组合物及方法
AU2001289079A1 (en) 2000-09-13 2002-03-26 Praecis Pharmaceuticals Incorporated Pharmaceutical compositions for sustained drug delivery
EP1958642A1 (fr) * 2000-12-22 2008-08-20 Dana-Farber Cancer Institute Régulation de croissance cellulaire par MUC1
US7118862B2 (en) * 2001-04-18 2006-10-10 Dana-Farber Cancer Institute, Inc. Induction of apoptosis by cellular stress
WO2003017032A2 (fr) 2001-08-14 2003-02-27 Dana-Farber Cancer Institute, Inc. Methodes informatisees d'identification de molecules
US7247297B2 (en) * 2001-09-14 2007-07-24 The University Of Chicago Use of DF3/MUC1 regulated expression in gene therapy
US20050089957A1 (en) * 2001-10-19 2005-04-28 Audrey Goddard Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders
JP2004137207A (ja) * 2002-10-18 2004-05-13 Keio Gijuku 細胞毒性を抑制する蛋白質
US20060188513A1 (en) * 2002-11-07 2006-08-24 Cadd Gary G Novel inhibin-related multiple antigenic peptide compositions that enhance production performance in avians
US20040176282A1 (en) * 2003-01-09 2004-09-09 Brian Dalby Cellular delivery and activation of polypeptide-nucleic acid complexes
US7696306B2 (en) * 2003-07-11 2010-04-13 Board of Agents of the University of Nebraska Compositions and methods for preventing or treating cancer
WO2005042573A1 (fr) * 2003-10-24 2005-05-12 Dana-Farber Cancer Institute, Inc. Modulation de l'interaction de muc1 avec des ligands de muc1
EP1538164A1 (fr) 2003-12-04 2005-06-08 Vectron Therapeutics AG Production et utilisation de péptides RGD
JP4721903B2 (ja) * 2004-01-29 2011-07-13 大日本住友製薬株式会社 新規腫瘍抗原蛋白質及びその利用
EP1720910A4 (fr) * 2004-02-17 2007-11-21 Cancervax Corp Procede et composition d'inhibition de l'angiogenese
JP2007523214A (ja) * 2004-02-23 2007-08-16 ジェンザイム コーポレイション デスレセプターリガンド誘導アポトーシスのｍｕｃ１アンタゴニスト増強方法
EP1725580B1 (fr) * 2004-03-17 2009-01-28 AplaGen GmbH Transformation isosterique
WO2005101021A1 (fr) 2004-04-13 2005-10-27 Bayer Healthcare Ag Diagnostics et therapeutiques pour maladies associees au recepteur adrenergique alpha-1d (adra1d) couple a une proteine g
US20070207209A1 (en) * 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
US7931904B2 (en) * 2005-02-15 2011-04-26 Dana Farber Cancer Institute, Inc. Modulation of MUC1 activity
CN104017083A (zh) * 2005-04-15 2014-09-03 亚利桑那癌症治疗公司 用于治疗转移性癌症的治疗肽
EP1910840A2 (fr) * 2005-05-26 2008-04-16 Dana-Farber Cancer Institute, Inc. Modulation de résistance aux anti-oestrogènes dépendante de la muc1
US7612181B2 (en) * 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EP1946113A4 (fr) * 2005-08-22 2010-03-10 Dana Farber Cancer Inst Inc Localisation mitochondriale de muc1
GB0519303D0 (en) * 2005-09-21 2005-11-02 Oxford Biomedica Ltd Chemo-immunotherapy method
JPWO2007119515A1 (ja) * 2006-03-28 2009-08-27 昇志 佐藤 新規腫瘍抗原ペプチド
WO2008097840A2 (fr) * 2007-02-02 2008-08-14 Dana-Farber Cancer Institute, Inc. Méthodes et compositions associées à la régulation de muc1 par hsf1 et stat3
US7871784B2 (en) * 2007-02-02 2011-01-18 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proapoptotic proteins
US8012695B2 (en) * 2007-02-14 2011-09-06 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to promoter regulation by MUC1 and KLF proteins
ES2430067T3 (es) 2007-03-28 2013-11-18 President And Fellows Of Harvard College Polipéptidos cosidos
CA2741065C (fr) 2008-10-17 2017-04-25 Dana-Farber Cancer Institute, Inc. Peptides a domaine cytoplasmique muc-1 en tant qu'inhibiteurs du cancer
WO2010138740A1 (fr) 2009-05-27 2010-12-02 Dana-Farber Cancer Institute, Inc. Inhibition de l'inflammation au moyen d'antagonistes de muc1
WO2011100688A1 (fr) 2010-02-12 2011-08-18 Dana-Farber Cancer Institute, Inc. Antagonistes améliorés du muc1
EP2548017A2 (fr) * 2010-03-15 2013-01-23 Genus Oncology, Llc Petites molécules inhibitrices de muc1 et leurs procédés d'identification

Also Published As

Publication number Publication date
ZA201103150B (en) 2014-12-23
EP2352508A2 (fr) 2011-08-10
WO2010045586A3 (fr) 2011-01-13
KR101689408B1 (ko) 2016-12-23
MX2011004082A (es) 2011-10-14
CN102245632A (zh) 2011-11-16
US8957185B2 (en) 2015-02-17
US20150152152A1 (en) 2015-06-04
JP2012505922A (ja) 2012-03-08
BRPI0920360A2 (pt) 2021-03-02
ES2395028T1 (es) 2013-02-07
IL212383A (en) 2017-10-31
EP2727601B1 (fr) 2018-06-13
NZ592537A (en) 2012-07-27
AU2009305550A1 (en) 2010-04-22
WO2010045586A8 (fr) 2011-08-04
CA2741065C (fr) 2017-04-25
DK2352508T3 (da) 2014-04-28
KR20110093801A (ko) 2011-08-18
RU2011119606A (ru) 2012-11-27
EP2727601A1 (fr) 2014-05-07
JP5657549B2 (ja) 2015-01-21
DE09740811T1 (de) 2012-03-22
JP6030622B2 (ja) 2016-11-24
EP2352508B1 (fr) 2014-04-02
PT2352508E (pt) 2014-05-26
US20100125055A1 (en) 2010-05-20
RU2539832C2 (ru) 2015-01-27
ES2395028T3 (es) 2014-05-30
WO2010045586A2 (fr) 2010-04-22
US8524669B2 (en) 2013-09-03
CN102245632B (zh) 2018-10-12
IL212383A0 (en) 2011-06-30
US9546201B2 (en) 2017-01-17
CA2741065A1 (fr) 2010-04-22
US20120172312A1 (en) 2012-07-05
DE09740811T9 (de) 2013-10-31
JP2015096513A (ja) 2015-05-21
PL2352508T3 (pl) 2014-09-30
AU2009305550B2 (en) 2014-06-12

Similar Documents

Publication Publication Date Title
HK1160795A1 (en) Muc-1 cytoplasmic domain peptides as inhibitors of cancer muc-1
HK1223272A1 (zh) 程序性壞死的小分子抑制劑
GB2471987B (en) Anti-tumoural effects of cannabinoid combinations
GB2478072B (en) Anti-tumoural effects of cannabinoid combinations
GB2478074B (en) Anti-tumoural effects of cannabinoid combinations
EP2297174A4 (fr) Synthèse inédite d'inhibiteurs à base de galactoside
HK1245114A1 (zh) 癌症的抑制
HK1156306A1 (en) Substituted dihydropyrazolones as inhibitors of hif-prolyl-4-hydroxylases hif--4-
IL208719A0 (en) Inhibitors of protein kinases
EP2318395A4 (fr) Inhibiteurs d'iap
SI2373157T1 (sl) Disperzije, ki vsebujejo inhibitorje hidroksifenilpiruvat-dioksigenaze
ZA201100898B (en) Novel inhibitors
GB0820309D0 (en) Detection of cancer
ZA201004765B (en) Inhibitors of iap
GB0811091D0 (en) CYP26 Inhibitors
ZA201102837B (en) Phosphodiestarase inhibitors
EP2337868A4 (fr) Détection de tumeurs de la granulosa
PL2306995T3 (pl) Właściwości przeciwnowotworowe inhibitorów proteazy zmodyfikowanych NO
PT2411376E (pt) Inibidores de nf-kb
EP2346829A4 (fr) Inhibiteurs de la stat3
GB0808286D0 (en) Inhibitors of HSP90
GB201019387D0 (en) Inhibitors
GB0816125D0 (en) Novel inhibitors
GB0803895D0 (en) Inhibitors of glyoxalase
AU2008900280A0 (en) Endocytosis inhibitors