HK1156073A1 - 製造培養皮膚裝置的個方法 - Google Patents
製造培養皮膚裝置的個方法Info
- Publication number
- HK1156073A1 HK1156073A1 HK11110337.8A HK11110337A HK1156073A1 HK 1156073 A1 HK1156073 A1 HK 1156073A1 HK 11110337 A HK11110337 A HK 11110337A HK 1156073 A1 HK1156073 A1 HK 1156073A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- matrix
- cultured
- producing
- cells
- dermal cells
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/10—Hair or skin implants
- A61F2/105—Skin implants, e.g. artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
- C12N5/0698—Skin equivalents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
- C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Prostheses (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/092,237 US7741116B2 (en) | 2002-03-06 | 2002-03-06 | Surgical device for skin therapy or testing |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1156073A1 true HK1156073A1 (zh) | 2012-06-01 |
Family
ID=27804165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11110337.8A HK1156073A1 (zh) | 2002-03-06 | 2011-09-30 | 製造培養皮膚裝置的個方法 |
Country Status (11)
Country | Link |
---|---|
US (4) | US7741116B2 (zh) |
EP (3) | EP1483373B1 (zh) |
JP (3) | JP4555576B2 (zh) |
AT (1) | ATE431400T1 (zh) |
AU (1) | AU2003217907A1 (zh) |
CA (1) | CA2478107C (zh) |
DE (1) | DE60327603D1 (zh) |
DK (1) | DK1483373T3 (zh) |
ES (1) | ES2326873T3 (zh) |
HK (1) | HK1156073A1 (zh) |
WO (1) | WO2003076604A2 (zh) |
Families Citing this family (42)
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US7741116B2 (en) * | 2002-03-06 | 2010-06-22 | University Of Cincinnati | Surgical device for skin therapy or testing |
JP2005270477A (ja) * | 2004-03-26 | 2005-10-06 | Kazutaka Soejima | 細胞含有人工真皮及びその調製方法 |
DE102004039537A1 (de) * | 2004-08-13 | 2006-02-23 | Phenion Gmbh & Co. Kg | Vernetzte Kollagenmatrix zur Herstellung eines Hautäquivalentes |
JP4951868B2 (ja) * | 2005-03-18 | 2012-06-13 | 凸版印刷株式会社 | 薄膜トランジスタの製造方法 |
US9259445B2 (en) | 2006-06-07 | 2016-02-16 | Universidad Tecnica Federico Santa Maria | Integrated implant system (IIS) biocompatible, biodegradable and bioactive, comprising a biocompatible sterile porous polymeric matrix and a gel, integrating in situ the tridimensional matrix structure |
EP2152359A2 (en) | 2007-05-25 | 2010-02-17 | Compex Medical S.A. | Wound healing electrode set |
WO2009020650A2 (en) * | 2007-08-08 | 2009-02-12 | Pervasis Therapeutics, Inc. | Materials and methods for treating and managing wounds and the effects of trauma |
EP2238447B1 (en) * | 2008-01-10 | 2015-02-25 | L'Oreal, S.A. | Immune system modeling devices and methods |
DE102009022351A1 (de) * | 2009-05-15 | 2010-11-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Modulares Produktionssystem zur automatischen Herstellung von dreidimensionalen Gewebestrukturen |
DE102010023156B4 (de) * | 2010-06-02 | 2012-07-05 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | In vitro-Testsystem für virale Infektionen |
ES2885523T3 (es) | 2011-11-23 | 2021-12-14 | Therapeuticsmd Inc | Formulaciones y terapias de reposición hormonal de combinación naturales |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
ITPD20120390A1 (it) * | 2012-12-19 | 2014-06-20 | Univ Degli Studi Trieste | Dispositivo comprendente una matrice biocompatibile e cellule endoteliali impiegabile nel trattamento di lesioni cutanee |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10772767B2 (en) | 2013-06-28 | 2020-09-15 | 3M Innovative Properties Company | Fibrin-coated wound dressing |
CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
EP3199622A4 (en) * | 2014-09-23 | 2018-08-08 | The University of Tokyo | Three-dimensional artificial tissue, method for producing the same, three-dimensional artificial tissue perfusion device, and drug evaluation method using three-dimensional artificial tissue |
CN104667352B (zh) * | 2015-02-03 | 2016-11-09 | 济南磐升生物技术有限公司 | 一种带有真皮细胞的组织工程表皮的制备方法 |
CN104548209B (zh) * | 2015-02-03 | 2017-01-25 | 苏州磐升生物技术有限公司 | 一种组织工程表皮及其制备方法 |
ES2625768T3 (es) * | 2015-03-26 | 2017-07-20 | Université De Bordeaux | Método de reconstrucción de piel |
JP2018518190A (ja) * | 2015-06-25 | 2018-07-12 | オークランド ユニサービシズ リミテッド | 組織を培養する装置及び方法 |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
JP6933855B2 (ja) * | 2016-01-20 | 2021-09-08 | 国立大学法人 東京大学 | 人工皮膚組織の製造方法、人工皮膚組織灌流デバイス、人工皮膚組織を用いた薬剤評価方法 |
AU2017239645A1 (en) | 2016-04-01 | 2018-10-18 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
KR101908030B1 (ko) * | 2016-06-17 | 2018-10-15 | 울산대학교 산학협력단 | 상처 또는 궤양치료를 위한 3차원 세포시트 및 이의 제조방법 |
CA3084053A1 (en) * | 2017-12-07 | 2019-06-13 | Wake Forest University Health Sciences | Multi-layer skin constructs and methods of making and using the same |
JP6990139B2 (ja) * | 2018-03-30 | 2022-02-03 | 株式会社 ジャパン・ティッシュ・エンジニアリング | 移植材料の製造方法 |
IT201800010390A1 (it) * | 2018-11-16 | 2020-05-16 | Diego Furlan | Dispositivo medico monouso per la medicazione di lesioni della pelle di un paziente e relativi procedimenti di preparazione e utilizzazione |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
EP3875124A1 (fr) * | 2020-03-02 | 2021-09-08 | Urgo Recherche Innovation Et Developpement | Procede d'obtention d'un tissu dermo-epidermique pre-vascularise |
US20240042095A1 (en) * | 2020-12-21 | 2024-02-08 | L&C Bio Co., Ltd. | Composition for treating wound comprising dermal tissue-derived extracellular matrix and method for preparing same |
CN113201481B (zh) * | 2021-04-19 | 2023-10-13 | 清华大学深圳国际研究生院 | 皮肤微球及其制备方法和应用 |
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DE69933579D1 (de) * | 1998-11-09 | 2006-11-23 | Consorzio Per La Gestione Del | Serum-freies medium für chondrozyt-ähnliche zellen |
JP4214434B2 (ja) * | 1998-11-12 | 2009-01-28 | 東洋紡績株式会社 | 培養皮膚、その製造方法及び用途 |
US6733530B1 (en) | 1999-08-02 | 2004-05-11 | Eric Sun-Yin Chan | Material and method for engraftment of a composite biocompatible skin graft on the neodermis of artificial skin |
JP4074043B2 (ja) * | 2000-03-27 | 2008-04-09 | 株式会社資生堂 | 皮膚基底膜形成促進剤、人工皮膚形成促進剤及び人工皮膚の製造方法 |
US7553664B2 (en) | 2000-05-31 | 2009-06-30 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Three-dimensional skin model |
CN1363398A (zh) | 2002-01-16 | 2002-08-14 | 吉林大学 | 以壳多糖或其衍生物为基质网架的复层人工皮肤 |
US7741116B2 (en) * | 2002-03-06 | 2010-06-22 | University Of Cincinnati | Surgical device for skin therapy or testing |
US9184902B2 (en) | 2012-04-25 | 2015-11-10 | Nec Laboratories America, Inc. | Interference cancellation for full-duplex communications |
-
2002
- 2002-03-06 US US10/092,237 patent/US7741116B2/en not_active Expired - Lifetime
-
2003
- 2003-03-03 WO PCT/US2003/006584 patent/WO2003076604A2/en active Application Filing
- 2003-03-03 CA CA2478107A patent/CA2478107C/en not_active Expired - Fee Related
- 2003-03-03 DK DK03713880T patent/DK1483373T3/da active
- 2003-03-03 EP EP03713880A patent/EP1483373B1/en not_active Expired - Lifetime
- 2003-03-03 DE DE60327603T patent/DE60327603D1/de not_active Expired - Lifetime
- 2003-03-03 AT AT03713880T patent/ATE431400T1/de not_active IP Right Cessation
- 2003-03-03 EP EP09004333.2A patent/EP2075330B1/en not_active Expired - Lifetime
- 2003-03-03 EP EP10012359.5A patent/EP2302035B1/en not_active Expired - Lifetime
- 2003-03-03 ES ES03713880T patent/ES2326873T3/es not_active Expired - Lifetime
- 2003-03-03 AU AU2003217907A patent/AU2003217907A1/en not_active Abandoned
- 2003-03-03 JP JP2003574811A patent/JP4555576B2/ja not_active Expired - Lifetime
-
2008
- 2008-04-09 JP JP2008101712A patent/JP5535446B2/ja not_active Expired - Lifetime
-
2010
- 2010-06-18 US US12/818,302 patent/US8450108B2/en not_active Expired - Lifetime
-
2011
- 2011-05-20 JP JP2011113424A patent/JP5689023B2/ja not_active Expired - Fee Related
- 2011-09-30 HK HK11110337.8A patent/HK1156073A1/zh not_active IP Right Cessation
-
2013
- 2013-05-24 US US13/901,728 patent/US8765468B2/en not_active Expired - Lifetime
-
2014
- 2014-06-09 US US14/299,480 patent/US9089417B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2075330A1 (en) | 2009-07-01 |
DE60327603D1 (de) | 2009-06-25 |
WO2003076604A3 (en) | 2004-03-04 |
ES2326873T3 (es) | 2009-10-21 |
JP2005518910A (ja) | 2005-06-30 |
EP2302035A3 (en) | 2011-06-01 |
AU2003217907A1 (en) | 2003-09-22 |
EP1483373B1 (en) | 2009-05-13 |
US7741116B2 (en) | 2010-06-22 |
CA2478107A1 (en) | 2003-09-18 |
DK1483373T3 (da) | 2009-09-07 |
JP5689023B2 (ja) | 2015-03-25 |
JP5535446B2 (ja) | 2014-07-02 |
EP2302035B1 (en) | 2016-05-11 |
US8765468B2 (en) | 2014-07-01 |
JP2008200520A (ja) | 2008-09-04 |
JP4555576B2 (ja) | 2010-10-06 |
EP2302035A2 (en) | 2011-03-30 |
US20100254955A1 (en) | 2010-10-07 |
JP2011172592A (ja) | 2011-09-08 |
EP2075330B1 (en) | 2016-05-11 |
US20130259919A1 (en) | 2013-10-03 |
EP1483373A2 (en) | 2004-12-08 |
US20030170892A1 (en) | 2003-09-11 |
US20140287020A1 (en) | 2014-09-25 |
US8450108B2 (en) | 2013-05-28 |
CA2478107C (en) | 2014-05-13 |
US9089417B2 (en) | 2015-07-28 |
ATE431400T1 (de) | 2009-05-15 |
WO2003076604A2 (en) | 2003-09-18 |
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