HK1136214A1 - Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy 124- - Google Patents

Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy 124-

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Publication number
HK1136214A1
HK1136214A1 HK10103079.6A HK10103079A HK1136214A1 HK 1136214 A1 HK1136214 A1 HK 1136214A1 HK 10103079 A HK10103079 A HK 10103079A HK 1136214 A1 HK1136214 A1 HK 1136214A1
Authority
HK
Hong Kong
Prior art keywords
oxadiazole
dosing
methods
nonsense mutation
orally active
Prior art date
Application number
HK10103079.6A
Other languages
English (en)
Chinese (zh)
Inventor
薩米特‧海拉華特
藍登‧米勒
Original Assignee
醫療公司
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39102963&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1136214(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 醫療公司 filed Critical 醫療公司
Publication of HK1136214A1 publication Critical patent/HK1136214A1/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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HK10103079.6A 2006-10-12 2010-03-24 Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy 124- HK1136214A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85145006P 2006-10-12 2006-10-12
PCT/US2007/021921 WO2008045566A1 (en) 2006-10-12 2007-10-11 Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy

Publications (1)

Publication Number Publication Date
HK1136214A1 true HK1136214A1 (en) 2010-06-25

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HK10103079.6A HK1136214A1 (en) 2006-10-12 2010-03-24 Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy 124-
HK12111647.0A HK1170690A1 (zh) 2006-10-12 2012-11-16 給用口服活性 -噁二唑進行無義突變抑制治療的方法

Family Applications After (1)

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HK12111647.0A HK1170690A1 (zh) 2006-10-12 2012-11-16 給用口服活性 -噁二唑進行無義突變抑制治療的方法

Country Status (24)

Country Link
US (7) US9226919B2 (es)
EP (2) EP2460520B1 (es)
JP (4) JP2010506840A (es)
KR (4) KR20170100072A (es)
CN (2) CN103211766B (es)
AU (1) AU2007308067B2 (es)
BR (2) BRPI0719276A2 (es)
CA (1) CA2675518C (es)
CL (1) CL2007002923A1 (es)
DK (1) DK2073805T3 (es)
ES (1) ES2538359T3 (es)
HK (2) HK1136214A1 (es)
HR (1) HRP20150590T1 (es)
IL (2) IL198147A (es)
MX (1) MX2009003909A (es)
NO (1) NO342061B1 (es)
PE (4) PE20160947A1 (es)
PL (1) PL2073805T3 (es)
PT (1) PT2073805E (es)
RS (1) RS54025B1 (es)
RU (1) RU2462247C2 (es)
SI (1) SI2073805T1 (es)
TW (1) TWI405570B (es)
WO (1) WO2008045566A1 (es)

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UA84420C2 (ru) 2003-04-11 2008-10-27 ПиТиСи ТЕРАПЬЮТИКС, ИНК. СОЕДИНЕНИЯ 1,2,4-ОКСАДИАЗОЛБЕНЗОЙНОЙ КИСЛОТЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ (ВАРИАНТЫ) И ПРИМЕНЕНИЕ СОЕДИНЕНИЙ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, СВЯЗАННОГО С ПРЕЖДЕВРЕМЕННОЙ ТЕРМИНАЦИЕЙ ТРАНСЛЯЦИИ ИЛИ НОНСЕНС-ОБУСЛОВЛЕННЫМ УМЕНЬШЕНИЕМ мРНК
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WO2016136745A1 (ja) 2015-02-25 2016-09-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 キノリン誘導体の苦味抑制方法
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WO2019101709A1 (en) 2017-11-23 2019-05-31 Universita' Degli Studi Di Palermo Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations
KR102378381B1 (ko) * 2021-08-23 2022-03-24 라이보텍(주) 넌센스-매개 mRNA 분해를 억제하기 위한 화합물
US20240156805A1 (en) * 2021-02-16 2024-05-16 Ribotech Co., Ltd. Compound for inhibiting nonsense-mediated mrna decay
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KR102665711B1 (ko) * 2021-12-21 2024-05-14 재단법인 아산사회복지재단 Ras 활성도를 이용한 신경섬유종증 치료제에 대한 감수성 예측용 바이오마커 조성물 및 Ras 활성 억제제를 포함하는 신경섬유종증 예방 또는 치료용 약학적 조성물

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PE20080982A1 (es) 2008-07-19
TW200820968A (en) 2008-05-16
KR20150064244A (ko) 2015-06-10
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BR122019020961B1 (pt) 2021-03-09
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SI2073805T1 (sl) 2015-10-30
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US20190099405A1 (en) 2019-04-04
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JP2016029078A (ja) 2016-03-03
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US20160101087A1 (en) 2016-04-14
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