HK1133426A1 - Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper- proliferative disorders and diseases associated with angiogenesis - Google Patents
Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper- proliferative disorders and diseases associated with angiogenesisInfo
- Publication number
- HK1133426A1 HK1133426A1 HK09111253.0A HK09111253A HK1133426A1 HK 1133426 A1 HK1133426 A1 HK 1133426A1 HK 09111253 A HK09111253 A HK 09111253A HK 1133426 A1 HK1133426 A1 HK 1133426A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- angiogenesis
- amino
- substituted
- diseases associated
- proliferative disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74169105P | 2005-12-02 | 2005-12-02 | |
PCT/US2006/046081 WO2007064931A2 (en) | 2005-12-02 | 2006-12-01 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1133426A1 true HK1133426A1 (en) | 2010-03-26 |
Family
ID=38092848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09111253.0A HK1133426A1 (en) | 2005-12-02 | 2009-12-01 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper- proliferative disorders and diseases associated with angiogenesis |
Country Status (13)
Country | Link |
---|---|
US (2) | US8143393B2 (xx) |
EP (1) | EP1957485B1 (xx) |
JP (1) | JP5249776B2 (xx) |
KR (2) | KR20130141706A (xx) |
CN (1) | CN101466710B (xx) |
AU (1) | AU2006320440B2 (xx) |
BR (1) | BRPI0619146A2 (xx) |
CA (1) | CA2631741C (xx) |
HK (1) | HK1133426A1 (xx) |
IL (1) | IL191865A0 (xx) |
MX (1) | MX2008007103A (xx) |
WO (1) | WO2007064931A2 (xx) |
ZA (1) | ZA200805695B (xx) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY28931A1 (es) | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
CA2631741C (en) * | 2005-12-02 | 2014-01-28 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
PE20070855A1 (es) | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
US8445687B2 (en) | 2007-09-10 | 2013-05-21 | Cipla Limited | Process for the preparation of a RAF kinase inhibitor and intermediates for use in the process |
JP5678661B2 (ja) * | 2007-09-25 | 2015-03-04 | バイエル ヘルスケア エルエルシー | オーロラキナーゼの阻害による癌の治療に有用なピロロトリアジン誘導体 |
AP3076A (en) | 2008-04-23 | 2014-12-31 | Gilead Sciences Inc | Carba-nucleoside analogs for antiviral treatment |
WO2010002877A2 (en) | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
US8445676B2 (en) * | 2008-10-08 | 2013-05-21 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
AR074830A1 (es) | 2008-12-19 | 2011-02-16 | Cephalon Inc | Pirrolotriazinas como inhibidores de alk y jak2 |
FR2947546B1 (fr) * | 2009-07-03 | 2011-07-01 | Sanofi Aventis | Derives de pyrazoles, leur preparation et leur application en therapeutique |
PL2480559T3 (pl) | 2009-09-21 | 2013-11-29 | Gilead Sciences Inc | Sposoby i związki pośrednie do wytwarzania analogów 11cyjanokarbanukleozydowych |
US8791257B2 (en) | 2010-03-31 | 2014-07-29 | Bristol-Myers Squibb Company | Substituted pyrrolotriazines as protein kinase inhibitors |
PE20130807A1 (es) | 2010-07-19 | 2013-07-27 | Gilead Sciences Inc | Metodos para la preparacion de profarmacos de fosforamidato diastereomericamente puros |
KR101821680B1 (ko) | 2010-07-22 | 2018-01-24 | 길리애드 사이언시즈, 인코포레이티드 | 파라믹소비리대 바이러스 감염을 치료하기 위한 방법 및 화합물 |
FR2965263A1 (fr) | 2010-09-24 | 2012-03-30 | Sanofi Aventis | Derives de thienopyridine nicotinamide, leur preparation et leur application en therapeutique |
FR2965262A1 (fr) | 2010-09-24 | 2012-03-30 | Sanofi Aventis | Derives de nicotinamide, leur preparation et leur application en therapeutique |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
CN103929961A (zh) * | 2011-06-20 | 2014-07-16 | 美国阿尔茨海默病研究所公司 | 化合物及其治疗应用 |
EA023775B1 (ru) * | 2011-07-01 | 2016-07-29 | Байер Интеллектуэль Проперти Гмбх | Гидроксиметиларилзамещенные пирролотриазины в качестве ингибиторов alk1 |
EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
FR2983859B1 (fr) | 2011-12-12 | 2014-01-17 | Sanofi Sa | Derives de 1,3,5-triazine-2-amine, leur preparation et leur application en diagnostique et en therapeutique |
CN104159900B (zh) | 2011-12-15 | 2016-08-24 | 拜耳知识产权有限责任公司 | 取代的苯并噻吩基-吡咯并三嗪及其在癌症治疗中的用途 |
UY34484A (es) | 2011-12-15 | 2013-07-31 | Bayer Ip Gmbh | Benzotienilo-pirrolotriazinas disustituidas y sus usos |
US9475815B2 (en) | 2012-02-23 | 2016-10-25 | Bayer Intelletual Property Gmbh | Substituted benzothienyl-pyrrolotriazines and uses thereof |
PL3176170T3 (pl) | 2012-06-13 | 2019-05-31 | Incyte Holdings Corp | Podstawione związki tricykliczne jako inhibitory fgfr |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
US9242988B2 (en) | 2012-10-17 | 2016-01-26 | Merck Sharp & Dohme Corp. | 2′-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
EP3251674A3 (en) | 2012-11-16 | 2018-02-21 | BioCryst Pharmaceuticals, Inc. | Antiviral azasugar-containing nucleosides |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
PT2986610T (pt) | 2013-04-19 | 2018-03-09 | Incyte Holdings Corp | Heterociclos bicíclicos como inibidores de fgfr |
DK3169671T3 (da) | 2014-07-17 | 2019-09-23 | Sunshine Lake Pharma Co Ltd | 1-(5-(tert.-butyl)isoxazol-3-yl)-3-(4-((phenyl)ethynyl)phenyl)ureaderivater og relaterede forbindelser som flt3-inhibitorer til behandling af kræft |
CN104326985A (zh) * | 2014-09-24 | 2015-02-04 | 安润医药科技(苏州)有限公司 | 利你法尼的制备方法 |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
ES2807785T3 (es) | 2014-10-22 | 2021-02-24 | Bristol Myers Squibb Co | Compuestos de heteroarilamina bicíclicos como inhibidores de pi3k |
US10023576B2 (en) | 2014-10-22 | 2018-07-17 | Bristol-Myers Squibb Company | Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors |
TWI740546B (zh) | 2014-10-29 | 2021-09-21 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
ES2751669T3 (es) | 2015-02-20 | 2020-04-01 | Incyte Corp | Heterociclos bicíclicos como inhibidores FGFR |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
MA52371A (fr) | 2015-09-16 | 2021-09-22 | Gilead Sciences Inc | Méthodes de traitement d'infections dues aux coronaviridae |
WO2017156262A1 (en) | 2016-03-09 | 2017-09-14 | Alios Biopharma, Inc. | Acyclic antivirals |
CR20180516A (es) * | 2016-03-28 | 2019-03-05 | Incyte Corp | Compuestos de iprrolotriazina como inhibidores de tam |
CN107619388A (zh) * | 2016-07-13 | 2018-01-23 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
BR112019012335A2 (pt) * | 2016-12-16 | 2020-03-03 | Cystic Fibrosis Foundation Therapeutics, Inc. | Derivados de heteroarila bicíclica como potenciadores de cftr |
TW201836615A (zh) | 2017-03-14 | 2018-10-16 | 美商基利科學股份有限公司 | 治療貓冠狀病毒感染之方法 |
KR102398659B1 (ko) * | 2017-03-17 | 2022-05-16 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 피롤로트리아진 유도체 |
KR20190141747A (ko) | 2017-05-01 | 2019-12-24 | 길리애드 사이언시즈, 인코포레이티드 | (S)-2-에틸부틸 2-(((S)-(((2R,3S,4R,5R)-5-(4-아미노피롤로[2,1-f] [1,2,4]트리아진-7-일)-5-시아노-3,4-디히드록시테트라히드로푸란-2-일)메톡시)(페녹시) 포스포릴)아미노)프로파노에이트의 결정질 형태 |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
CN111093627B (zh) | 2017-07-11 | 2024-03-08 | 吉利德科学公司 | 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物 |
MX2020003375A (es) | 2017-09-27 | 2020-08-03 | Incyte Corp | Sales de inhibidores de macrofagos asociados a tumores (tam). |
KR20200115550A (ko) | 2018-01-26 | 2020-10-07 | 브리스톨-마이어스 스큅 컴퍼니 | 키나제 억제제로서의 아미노피롤로트리아진 |
US11466004B2 (en) | 2018-05-04 | 2022-10-11 | Incyte Corporation | Solid forms of an FGFR inhibitor and processes for preparing the same |
KR20210018264A (ko) | 2018-05-04 | 2021-02-17 | 인사이트 코포레이션 | Fgfr 억제제의 염 |
US11241438B2 (en) | 2018-06-29 | 2022-02-08 | Incyte Corporation | Formulations of an AXL/MER inhibitor |
WO2020142557A1 (en) | 2018-12-31 | 2020-07-09 | Biomea Fusion, Llc | Irreversible inhibitors of menin-mll interaction |
CA3125353A1 (en) | 2018-12-31 | 2020-07-09 | Biomea Fusion, Llc | Inhibitors of menin-mll interaction |
CN109928976A (zh) * | 2019-02-26 | 2019-06-25 | 泰州亿腾景昂药业有限公司 | 一种工业化生产eoc317的方法 |
WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
CN112552302B (zh) | 2019-09-26 | 2022-05-13 | 深圳市塔吉瑞生物医药有限公司 | 取代的芳香稠合环衍生物及其组合物及用途 |
PE20221085A1 (es) | 2019-10-14 | 2022-07-05 | Incyte Corp | Heterociclos biciclicos como inhibidores de fgfr |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
CN110845502A (zh) * | 2019-11-25 | 2020-02-28 | 成都傲飞生物化学品有限责任公司 | 一种7-溴吡咯并[2,1-f][1,2,4]噻嗪-4-胺的制备方法 |
CA3162010A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
TWI789695B (zh) | 2020-01-27 | 2023-01-11 | 美商基利科學股份有限公司 | 治療sars cov-2感染之方法 |
CN113248507A (zh) * | 2020-02-09 | 2021-08-13 | 上海茂晟康慧科技有限公司 | 瑞德西韦关键中间体7-卤代吡咯并[1,2-f][1,2,4]三嗪-4-胺的合成方法 |
CN111233870A (zh) * | 2020-03-11 | 2020-06-05 | 中国科学技术大学 | 用于快速制备瑞德西韦药物中间体的方法 |
TWI785528B (zh) | 2020-03-12 | 2022-12-01 | 美商基利科學股份有限公司 | 1’-氰基核苷之製備方法 |
WO2021207049A1 (en) | 2020-04-06 | 2021-10-14 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
CA3179226A1 (en) | 2020-05-29 | 2021-12-02 | Tomas Cihlar | Remdesivir treatment methods |
US11939347B2 (en) | 2020-06-24 | 2024-03-26 | Gilead Sciences, Inc. | 1′-cyano nucleoside analogs and uses thereof |
KR20230057411A (ko) | 2020-08-27 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스 감염 치료를 위한 화합물 및 방법 |
EP4352059A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
CN113480548B (zh) * | 2021-08-03 | 2023-09-22 | 山东三牧新材料科技有限公司 | 一种4-氨基吡咯并[2,1-f][1,2,4]三嗪的制备方法 |
CN114773312B (zh) * | 2021-10-29 | 2024-03-26 | 北京鑫诺康桥药物研究有限公司 | 一种盐酸阿罗洛尔中间体的制备工艺 |
EP4320128A1 (en) | 2022-03-02 | 2024-02-14 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
PL204437B1 (pl) | 1999-05-21 | 2010-01-29 | Bristol Myers Squibb Co | Pochodna pirolotriazyny i jej zastosowanie oraz kompozycja farmaceutyczna i jej zastosowanie |
AU7491400A (en) * | 1999-09-17 | 2001-04-17 | Abbott Gmbh & Co. Kg | Kinase inhibitors as therapeutic agents |
IL148718A0 (en) * | 1999-09-17 | 2002-09-12 | Abbott Gmbh & Co Kg | Pyrazolopyrimidines as therapeutic agents |
US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US7427623B2 (en) * | 2001-09-11 | 2008-09-23 | Smithkline Beecham Corporation | 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof |
TW200300350A (en) | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
US20030199525A1 (en) * | 2002-03-21 | 2003-10-23 | Hirst Gavin C. | Kinase inhibitors |
US20030225273A1 (en) * | 2002-03-21 | 2003-12-04 | Michaelides Michael R. | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors |
TWI272271B (en) | 2002-07-19 | 2007-02-01 | Bristol Myers Squibb Co | Process for preparing certain pyrrolotriazine compounds |
TWI329112B (en) | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
EP1543009A4 (en) | 2002-08-02 | 2007-08-08 | Bristol Myers Squibb Co | Pyrrolotriazine KINASE INHIBITORS |
WO2004108672A1 (en) * | 2003-06-02 | 2004-12-16 | Abbott Laboratories | Isoindolin-1-one compounds as kinase inhibitors |
US7572914B2 (en) * | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
UY28931A1 (es) | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
US7405213B2 (en) * | 2005-07-01 | 2008-07-29 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith |
US7514435B2 (en) | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
PE20070855A1 (es) * | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
CA2631741C (en) * | 2005-12-02 | 2014-01-28 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
JP5678661B2 (ja) * | 2007-09-25 | 2015-03-04 | バイエル ヘルスケア エルエルシー | オーロラキナーゼの阻害による癌の治療に有用なピロロトリアジン誘導体 |
-
2006
- 2006-12-01 CA CA2631741A patent/CA2631741C/en active Active
- 2006-12-01 AU AU2006320440A patent/AU2006320440B2/en not_active Ceased
- 2006-12-01 WO PCT/US2006/046081 patent/WO2007064931A2/en active Application Filing
- 2006-12-01 EP EP06838828A patent/EP1957485B1/en active Active
- 2006-12-01 KR KR1020137030839A patent/KR20130141706A/ko not_active Application Discontinuation
- 2006-12-01 KR KR1020087016135A patent/KR101461680B1/ko active IP Right Grant
- 2006-12-01 BR BRPI0619146-0A patent/BRPI0619146A2/pt not_active IP Right Cessation
- 2006-12-01 CN CN2006800522645A patent/CN101466710B/zh active Active
- 2006-12-01 JP JP2008543506A patent/JP5249776B2/ja active Active
- 2006-12-01 US US12/085,880 patent/US8143393B2/en not_active Expired - Fee Related
- 2006-12-01 MX MX2008007103A patent/MX2008007103A/es active IP Right Grant
-
2008
- 2008-06-01 IL IL191865A patent/IL191865A0/en unknown
- 2008-06-30 ZA ZA200805695A patent/ZA200805695B/xx unknown
-
2009
- 2009-09-02 US US12/552,923 patent/US8129379B2/en not_active Expired - Fee Related
- 2009-12-01 HK HK09111253.0A patent/HK1133426A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP5249776B2 (ja) | 2013-07-31 |
JP2009518303A (ja) | 2009-05-07 |
EP1957485A2 (en) | 2008-08-20 |
CA2631741A1 (en) | 2007-06-07 |
EP1957485B1 (en) | 2013-02-13 |
US20100179125A1 (en) | 2010-07-15 |
US8143393B2 (en) | 2012-03-27 |
MX2008007103A (es) | 2008-09-12 |
AU2006320440B2 (en) | 2012-04-05 |
BRPI0619146A2 (pt) | 2011-09-13 |
WO2007064931A3 (en) | 2007-07-19 |
KR20080075903A (ko) | 2008-08-19 |
CA2631741C (en) | 2014-01-28 |
AU2006320440A1 (en) | 2007-06-07 |
CN101466710A (zh) | 2009-06-24 |
US8129379B2 (en) | 2012-03-06 |
CN101466710B (zh) | 2013-05-29 |
ZA200805695B (en) | 2009-07-29 |
IL191865A0 (en) | 2008-12-29 |
US20100063038A1 (en) | 2010-03-11 |
KR101461680B1 (ko) | 2014-11-19 |
KR20130141706A (ko) | 2013-12-26 |
WO2007064931A2 (en) | 2007-06-07 |
EP1957485A4 (en) | 2010-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL191864A0 (en) | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | |
HK1133426A1 (en) | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper- proliferative disorders and diseases associated with angiogenesis | |
IL201537A0 (en) | Heteroaryl substituted pyarzole derivatives useful for treating hyper- proliferative disorders and diseases associated with angiogenesis | |
PH12006502386B1 (en) | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | |
SI2096919T1 (sl) | Substituirani derivati 2,3-dihidroimidazo(1,2-C)kinazolina, uporabni za zdravljenje hiperproliferativnih motenj in bolezni, povezanih z angiogenezo | |
ZA200710713B (en) | Methods for preventing and treating metabolic disorders and new pyrazole-o-glycoside derivatives | |
IL208607A0 (en) | Improved nanobodiestm for the treatment of aggregation-mediated disorders | |
ZA200801888B (en) | Derivatives of 4-piperazin-1-1-YL-4-benzo [B] thiophene suitable for the treatment of CNS disorders | |
IL189578A0 (en) | Pyridine derivatives and their use in the treatment of psychotic disorders | |
ZA200706791B (en) | Isoxazole combretasin derivatives for the treatment of disorders | |
HRP20130558T1 (hr) | Derivat 17-hidroksi-17-pentafluoretil-estra-4,9(10)-dien-11-arila, postupci za njegovu proizvodnju i njegova uporaba za lijeäśenje bolesti | |
EP2244721A4 (en) | Sulfone substituted 2,3-dihydroimidazo ý1,2-c¨quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis | |
EP2323649A4 (en) | TREATMENT OF VARIOUS DISORDERS WITH 7,8-DIHYDROXY FLAVONE AND ITS DERIVATIVES | |
HK1146221A1 (en) | Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders | |
EP1898921A4 (en) | COMPOSITIONS AND METHODS FOR TREATING SLEEP DISORDERS | |
IL197695A0 (en) | 3-amino-pyridine derivatives for the treatment of metabolic disorders | |
ZA200801548B (en) | Pyridine derivatives and their use in the treatment of psychotic disorders |