ZA200805695B - Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associ-ated with angiogenesis - Google Patents
Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associ-ated with angiogenesisInfo
- Publication number
- ZA200805695B ZA200805695B ZA200805695A ZA200805695A ZA200805695B ZA 200805695 B ZA200805695 B ZA 200805695B ZA 200805695 A ZA200805695 A ZA 200805695A ZA 200805695 A ZA200805695 A ZA 200805695A ZA 200805695 B ZA200805695 B ZA 200805695B
- Authority
- ZA
- South Africa
- Prior art keywords
- ated
- angiogenesis
- amino
- substituted
- proliferative disorders
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74169105P | 2005-12-02 | 2005-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200805695B true ZA200805695B (en) | 2009-07-29 |
Family
ID=38092848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200805695A ZA200805695B (en) | 2005-12-02 | 2008-06-30 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associ-ated with angiogenesis |
Country Status (13)
Country | Link |
---|---|
US (2) | US8143393B2 (xx) |
EP (1) | EP1957485B1 (xx) |
JP (1) | JP5249776B2 (xx) |
KR (2) | KR101461680B1 (xx) |
CN (1) | CN101466710B (xx) |
AU (1) | AU2006320440B2 (xx) |
BR (1) | BRPI0619146A2 (xx) |
CA (1) | CA2631741C (xx) |
HK (1) | HK1133426A1 (xx) |
IL (1) | IL191865A0 (xx) |
MX (1) | MX2008007103A (xx) |
WO (1) | WO2007064931A2 (xx) |
ZA (1) | ZA200805695B (xx) |
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AU2006320440B2 (en) * | 2005-12-02 | 2012-04-05 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
NZ583790A (en) * | 2007-09-10 | 2012-04-27 | Cipla Ltd | Process for the preparation the raf kinase inhibitor sorafenib and intermediates for use in the process |
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US8445676B2 (en) * | 2008-10-08 | 2013-05-21 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
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AU2003265349A1 (en) | 2002-08-02 | 2004-02-23 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
EP1633710A1 (en) * | 2003-06-02 | 2006-03-15 | Abbott Laboratories | Isoindolin-1-one compounds as kinase inhibitors |
US7572914B2 (en) | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
UY28931A1 (es) | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
US7405213B2 (en) | 2005-07-01 | 2008-07-29 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith |
US7514435B2 (en) * | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
AU2006320440B2 (en) | 2005-12-02 | 2012-04-05 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
PE20070855A1 (es) | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
WO2009042543A1 (en) | 2007-09-25 | 2009-04-02 | Bayer Healthcare Llc | Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase |
-
2006
- 2006-12-01 AU AU2006320440A patent/AU2006320440B2/en not_active Ceased
- 2006-12-01 KR KR1020087016135A patent/KR101461680B1/ko active IP Right Grant
- 2006-12-01 WO PCT/US2006/046081 patent/WO2007064931A2/en active Application Filing
- 2006-12-01 MX MX2008007103A patent/MX2008007103A/es active IP Right Grant
- 2006-12-01 KR KR1020137030839A patent/KR20130141706A/ko not_active Application Discontinuation
- 2006-12-01 CA CA2631741A patent/CA2631741C/en active Active
- 2006-12-01 BR BRPI0619146-0A patent/BRPI0619146A2/pt not_active IP Right Cessation
- 2006-12-01 CN CN2006800522645A patent/CN101466710B/zh active Active
- 2006-12-01 US US12/085,880 patent/US8143393B2/en not_active Expired - Fee Related
- 2006-12-01 JP JP2008543506A patent/JP5249776B2/ja active Active
- 2006-12-01 EP EP06838828A patent/EP1957485B1/en active Active
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2008
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- 2008-06-30 ZA ZA200805695A patent/ZA200805695B/xx unknown
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2009
- 2009-09-02 US US12/552,923 patent/US8129379B2/en not_active Expired - Fee Related
- 2009-12-01 HK HK09111253.0A patent/HK1133426A1/xx unknown
Also Published As
Publication number | Publication date |
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JP5249776B2 (ja) | 2013-07-31 |
KR101461680B1 (ko) | 2014-11-19 |
JP2009518303A (ja) | 2009-05-07 |
AU2006320440A1 (en) | 2007-06-07 |
KR20130141706A (ko) | 2013-12-26 |
KR20080075903A (ko) | 2008-08-19 |
EP1957485A4 (en) | 2010-03-10 |
CA2631741A1 (en) | 2007-06-07 |
CN101466710B (zh) | 2013-05-29 |
US20100179125A1 (en) | 2010-07-15 |
HK1133426A1 (en) | 2010-03-26 |
US8129379B2 (en) | 2012-03-06 |
US20100063038A1 (en) | 2010-03-11 |
AU2006320440B2 (en) | 2012-04-05 |
EP1957485A2 (en) | 2008-08-20 |
EP1957485B1 (en) | 2013-02-13 |
CA2631741C (en) | 2014-01-28 |
US8143393B2 (en) | 2012-03-27 |
IL191865A0 (en) | 2008-12-29 |
WO2007064931A2 (en) | 2007-06-07 |
CN101466710A (zh) | 2009-06-24 |
WO2007064931A3 (en) | 2007-07-19 |
BRPI0619146A2 (pt) | 2011-09-13 |
MX2008007103A (es) | 2008-09-12 |
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