HK1130186A1 - Phospholipid analogue for the in vivo diagnosis of cancers - Google Patents

Phospholipid analogue for the in vivo diagnosis of cancers

Info

Publication number
HK1130186A1
HK1130186A1 HK09109089.4A HK09109089A HK1130186A1 HK 1130186 A1 HK1130186 A1 HK 1130186A1 HK 09109089 A HK09109089 A HK 09109089A HK 1130186 A1 HK1130186 A1 HK 1130186A1
Authority
HK
Hong Kong
Prior art keywords
cancers
vivo diagnosis
phospholipid analogue
phospholipid
analogue
Prior art date
Application number
HK09109089.4A
Other languages
English (en)
Chinese (zh)
Inventor
Jamey Weichert
Marc Longino
Anatoly Pinchuk
Original Assignee
Cellectar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectar Inc filed Critical Cellectar Inc
Publication of HK1130186A1 publication Critical patent/HK1130186A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0489Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0404Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0408Phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005Compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK09109089.4A 2004-03-02 2009-09-30 Phospholipid analogue for the in vivo diagnosis of cancers HK1130186A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52116604P 2004-03-02 2004-03-02

Publications (1)

Publication Number Publication Date
HK1130186A1 true HK1130186A1 (en) 2009-12-24

Family

ID=34919310

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09109089.4A HK1130186A1 (en) 2004-03-02 2009-09-30 Phospholipid analogue for the in vivo diagnosis of cancers

Country Status (17)

Country Link
US (3) US8535641B2 (ja)
EP (3) EP2044960B1 (ja)
JP (7) JP2007528374A (ja)
KR (1) KR20070015518A (ja)
CN (1) CN1929869B (ja)
AT (1) ATE437657T1 (ja)
AU (1) AU2005219412A1 (ja)
BR (1) BRPI0508425A (ja)
CA (1) CA2557698A1 (ja)
DE (1) DE602005015687D1 (ja)
DK (1) DK1729824T3 (ja)
ES (3) ES2430065T3 (ja)
HK (1) HK1130186A1 (ja)
IL (1) IL177645A0 (ja)
MX (1) MXPA06009681A (ja)
WO (1) WO2005084716A2 (ja)
ZA (1) ZA200607042B (ja)

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US20080075660A1 (en) * 2006-08-15 2008-03-27 Cellectar, Llc Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications
US7893286B2 (en) 2007-06-01 2011-02-22 Cellectar, Inc. Method for the synthesis of phospholipid ethers
WO2008150439A1 (en) 2007-06-01 2008-12-11 Cellectar, Inc. Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use
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WO2010132428A1 (en) * 2009-05-11 2010-11-18 Cellectar, Inc. Fluorescent phospholipid ether compounds, compositions, and methods of use
US8871181B2 (en) 2009-05-11 2014-10-28 Cellectar, Inc. Fluorescent phospholipid ether compounds, compositions, and methods of use
US7811548B1 (en) 2009-05-11 2010-10-12 Cellectar, Inc. Fluorescent phospholipid ether compounds and compositions
ES2799411T3 (es) * 2009-06-12 2020-12-17 Cellectar Inc Compuestos alquilfosfolipídicos para el tratamiento de cáncer y obtención de imágenes y detección de células madre cancerosas
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PT3229810T (pt) 2014-11-17 2020-08-27 Cellectar Biosciences Inc Análogos de éter fosfolipídico como veículos de medicamentos direcionados para o cancro
JP6883046B2 (ja) 2015-11-06 2021-06-02 ウイスコンシン アラムナイ リサーチ ファウンデーシヨンWisconsin Alumni Research Foundation 長寿命ガドリニウムに基づく腫瘍標的化イメージングおよび治療薬
NZ749272A (en) * 2016-06-14 2023-01-27 Cellectar Biosciences Inc Phospholipid ether analogs for the identification and isolation of circulating tumor cells
US11147823B2 (en) * 2016-07-13 2021-10-19 Wisconsin Alumni Research Foundation Phospholipid ether analogs for imaging and targeted treatment of pediatric solid tumors
US11633506B2 (en) 2016-07-18 2023-04-25 Wisconsin Alumni Research Foundation Using targeted radiotherapy (TRT) to drive anti-tumor immune response to immunotherapies
EP3484513B1 (en) * 2016-07-18 2023-06-07 Wisconsin Alumni Research Foundation Radiohalogenated agents for combined cancer therapy
CA3031776C (en) * 2016-07-25 2024-02-20 Wisconsin Alumni Research Foundation Targeted radiotherapy chelates for in situ immune modulated cancer vaccination
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EP3579870A4 (en) 2017-02-07 2020-12-30 Seattle Children's Hospital (DBA Seattle Children's Research Institute) PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS
JP7178355B2 (ja) 2017-02-28 2022-11-25 エンドサイト・インコーポレイテッド Car t細胞療法のための組成物および方法
KR20200088374A (ko) * 2017-11-10 2020-07-22 위스콘신 얼럼나이 리서어치 화운데이션 면역요법에 대한 항-종양 면역 반응을 유도하기 위해 표적화된 방사선요법(trt)을 이용하는 방법
US20190184040A1 (en) * 2017-12-15 2019-06-20 Wisconsin Alumni Research Foundation Targeted Macrocyclic Agents for Dual Modality PET and MRI Imaging of Cancer
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US20200354477A1 (en) * 2018-02-06 2020-11-12 Seattle Children's Hospital (dba Seattle Children's Research Institute) Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
WO2021072300A1 (en) * 2019-10-10 2021-04-15 Cellectar Biosciences, Inc. Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy

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Also Published As

Publication number Publication date
US9550002B2 (en) 2017-01-24
WO2005084716A2 (en) 2005-09-15
JP2017002060A (ja) 2017-01-05
JP2013040201A (ja) 2013-02-28
EP2044960B1 (en) 2013-11-20
EP1729824B1 (en) 2009-07-29
US20150093330A1 (en) 2015-04-02
JP6342818B2 (ja) 2018-06-13
JP2017173339A (ja) 2017-09-28
CN1929869B (zh) 2010-11-24
EP2044961B1 (en) 2013-07-17
ES2440257T3 (es) 2014-01-28
CA2557698A1 (en) 2005-09-15
WO2005084716A3 (en) 2006-06-01
EP2044960A2 (en) 2009-04-08
ATE437657T1 (de) 2009-08-15
MXPA06009681A (es) 2007-03-15
US20140023587A1 (en) 2014-01-23
US8535641B2 (en) 2013-09-17
US20050196339A1 (en) 2005-09-08
JP6228080B2 (ja) 2017-11-08
AU2005219412A1 (en) 2005-09-15
EP2044961A2 (en) 2009-04-08
US8877159B2 (en) 2014-11-04
CN1929869A (zh) 2007-03-14
DE602005015687D1 (de) 2009-09-10
EP2044961A3 (en) 2009-08-12
JP2012097113A (ja) 2012-05-24
JP2007528374A (ja) 2007-10-11
ES2430065T3 (es) 2013-11-18
JP2014210803A (ja) 2014-11-13
EP2044960A3 (en) 2009-11-04
ZA200607042B (en) 2007-12-27
KR20070015518A (ko) 2007-02-05
JP6453818B2 (ja) 2019-01-16
DK1729824T3 (da) 2009-11-02
BRPI0508425A (pt) 2007-07-24
IL177645A0 (en) 2006-12-31
JP2015071642A (ja) 2015-04-16
ES2330951T3 (es) 2009-12-17
EP1729824A2 (en) 2006-12-13

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