JP6883046B2 - 長寿命ガドリニウムに基づく腫瘍標的化イメージングおよび治療薬 - Google Patents
長寿命ガドリニウムに基づく腫瘍標的化イメージングおよび治療薬 Download PDFInfo
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Description
本出願は、参照によりその全体が本明細書に組み込まれる、2015年11月6日に出願された米国仮特許出願第62/252,218号の優先権を主張するものである。
該当しない。
この開示は、記載される特定の方法、プロトコル、材料および試薬に限定されず、これらは異なり得ることが理解される。本明細書で使用される用語は、特定の実施形態を説明することだけを目的とし、本発明の範囲を限定することを意図するものではなく、本発明の範囲は後日に出願される非仮出願によってのみ限定される。
特定の態様では、本開示は、対象内または生物学的試料中の癌性腫瘍または腫瘍細胞の医学的検出または検出/画像化のためのガドリニウム標識アルキルホスホコリン類似体の使用を対象とする。他の態様では、本開示は、対象において癌を治療するためのガドリニウム標識アルキルホスホコリン類似体の使用を対象とする。さらに他の態様では、本開示は、ガドリニウム標識アルキルホスホコリン類似体およびそのような化合物を合成する方法を対象とする。
中性子捕捉療法(NCT)は、原発性脳腫瘍および再発性頭頸部癌などの、局所侵襲性悪性腫瘍を治療するための非侵襲的治療法である。NCTでは、最初に、低速中性子を捕捉する高い傾向または断面積(σ)を有する非放射性同位体を含有する腫瘍局在化薬(「捕捉剤」)を患者に注射する。捕捉剤の断面積は、水素、酸素および窒素などの組織中に存在する他の元素の断面積より何倍も大きい。第2段階では、患者に熱外中性子を照射し、熱外中性子は、組織に浸透する際にエネルギーを喪失した後、捕捉剤によって吸収される。その後、捕捉剤は、癌組織を有効に死滅させることができる高エネルギーの荷電粒子を放出する。
開示される化合物は、一般的な広域スペクトルの腫瘍イメージングおよび特徴付けのための最初の長寿命の腫瘍特異的MR造影剤である。さらに、本明細書で開示される長寿命の腫瘍特異的MR造影剤は、化学療法および放射線療法の両方に対する治療応答観測における使用に適しており、MRI誘導体外照射療法のための適切な腫瘍造影剤である。
開示される構造は、アルキルホスホコリン担体骨格を利用する。ひとたび合成されると、薬剤は、腫瘍選択性を保持しつつ薬剤を注射に適したものにする製剤特性を有さなければならない。以下は非限定的な一連のGd−PLE類似体である(さらなる非限定的な例は先に記載されている)。示されている構造は、最終的な造影剤または治療薬を生成するためにガドリニウムイオンがキレート化されるキレート化部分を含む。
化合物1の提案される合成を以下に示す。合成の第1段階は、Org Synth,2008,85,10−14に記載されている手順と同様である。合成はサイクレン(cyclen)から出発し、これをDO3Aトリス−Bnエステルに変換する。次いで、この中間体を塩基およびPd触媒の存在下でNM404と結合させる。最後に、ベンジル保護基を接触水素化によって除去する。
いずれの投与経路も、開示されるGd−PLE類似体を対象に投与するのに適し得る。一実施形態では、開示される類似体は静脈内注射によって対象に投与し得る。別の実施形態では、開示される類似体は、経口、非経口、鼻腔内、舌下、直腸または経皮投与などの他の任意の適切な全身送達によって対象に投与し得る。
(概要:)
実施例1では、放射性金属同位体をキレート化する類似の化合物の合成のためにも使用できる例示的な合成を提供する。
この実施例では、1つの例示的なリン脂質キレート、Gd−DO3A−404を合成するために使用される合成スキームを示す。
この実施例では、MRI造影剤としてGd−DO3A−404を使用して、腫瘍のインビボMRIイメージングの成功を実証する。
この実施例では、Gd−DO3A−404に関連する遊離Gd濃度を定量した。結果は、Gd−DO3A−404が非常に安定であり、キレート化Gd(III)イオンを実質的に保持することを実証する。したがって、画像化および/または治療用途における使用のための腫瘍標的剤としての使用に適する。
この実施例では、Gd−DO3A−404の磁気共鳴緩和特性を特徴付けたが、これは一般的に使用される造影剤の特性と比べて遜色がない。
この実施例2の拡張では、Gd−DO3A−404をMRI造影剤として使用して、2つの異なる側腹部腫瘍型における選択的取り込みおよびインビボMRIイメージングを実証する。
この実施例では、造影剤を投与した後のGd−DO3A−404のインビボ生体内分布を決定した(実施例5参照)。実施例4で述べた実験を行う過程で、生体内分布を観察するために、マウスの腹部においてT1強調スポイル勾配(SPGR)(T1‐weighted spoiled gradient(SPGR))画像も取得した。画像化した腹部横断面には、心筋(図8〜12、上の画像)、肝臓(図8〜12、中央の画像)および腎臓(図8〜12、下の画像)が含まれた。造影剤前(図8)ならびに造影剤投与の1時間後(図9)、24時間後(図10)、4日後(図11)および7日後(図12)の画像が示されている。
この実施例では、腫瘍組織におけるGd−DO3A−404の選択的取り込みおよび保持が、実際に、ガドリニウム金属またはそのキレート剤によってではなく、腫瘍標的リン脂質部分(「404」部分、図1参照)によって促進されることを実証する。したがって、この実施例は、有効な腫瘍標的造影剤が、開示される腫瘍標的リン脂質部分を含む限り、特定のキレート剤を有するものに限定されないことを実証する。
この実施例では、より高い用量で、Gd−DO3A−404が血液脳関門を通過して脳腫瘍組織を成功裏に標的とすることができることを実証する。
この実施例6の拡張では、投与された後のGd−DO3A−404のインビボ生体内分布をさらに調べた。具体的には、Gd−DO3A−404投与の72時間後のA549側腹部担持マウスにおいて組織生体内分布を測定した。ヌード無胸腺マウスを犠死させ、灌流して、組織を収集し、高分解能(磁気セクタ)誘導結合プラズマ質量分析法(SF−ICPMS)によってGdを定量した。n=3匹のマウス。
この実施例では、乳癌組織へのGd−DO3A−404の標的化の成功を実証する。
この実施例では、2つの異なる同所性異種移植モデルにおけるGd−DO3A−404の標的化の成功を実証する。
この実施例では、Gd−DO3A−404および64Cu−DO3A−404の両方の腫瘍標的造影剤としての使用の成功(MRIの場合はGd−DO3A−404、同時PETイメージングの場合は64Cu−DO3A−404)を実証する。
Claims (28)
- 下記式を有する化合物またはその塩。
R1は、1つ以上のガドリニウム(Gd)原子にキレート化されたキレート剤であり、
aは0または1であり、
nは12から30までの整数であり、
mは0または1であり、
Yは−H、−OH、−COOH、−COOX、−OCOXおよび−OXから成る群より選択され、ここでXはアルキルまたはアリールアルキルであり、
R2は、−N+H3、−N+H2Z、−N+HZ2および−N+Z3から成る群より選択され、ここで各々のZは独立してアルキルであり、ならびに
bは1または2であり、
前記キレート剤が、1,4,7,10−テトラアザシクロドデカン−1,4,7−三酢酸(DO3A);1,4,7−トリアザシクロノナン−1,4−二酢酸(NODA);1,4,7−トリアザシクロノナン−1,4,7−三酢酸(NOTA);1,4,7,10−テトラアザシクロドデカン−1,4,7,10−四酢酸(DOTA);1,4,7−トリアザシクロノナン,1−グルタル酸−4,7−二酢酸(NODAGA);1,4,7,10−テトラアザシクロデカン,1−グルタル酸−4,7,10−三酢酸(DOTAGA);1,4,8,11−テトラアザシクロテトラデカン−1,4,8,11−四酢酸(TETA);1,4,8,11−テトラアザビシクロ[6.6.2]ヘキサデカン−4,11−二酢酸(CB−TE2A);ジエチレントリアミン五酢酸(DTPA);2−シクロヘキシルジエチレントリアミン五酢酸(CHX−A”−DTPA);デフェロキサミン(DFO);1,2−[[6−カルボキシピリジン−2−イル]メチルアミノ]エタン(H 2 dedpa);およびDADAから成る群より選択され、
DADAは以下の構造を有する。]
- 前記1つ以上のガドリニウム原子がGd(III)イオンの形態である、請求項1に記載の化合物。
- aが1(脂肪族アリール−アルキル鎖)である、請求項1または請求項2に記載の化合物。
- aが0(脂肪族アルキル鎖)である、請求項1または請求項2に記載の化合物。
- mが1(アシルリン脂質系)である、請求項1または請求項2に記載の化合物。
- nが12から20の間の整数である、請求項5に記載の化合物。
- Yが−OCOX、−COOXまたは−OXである、請求項6に記載の化合物。
- Xが−CH2CH3または−CH3である、請求項7に記載の化合物。
- mが0(アルキルリン脂質系)である、請求項1または請求項2に記載の化合物。
- bが1である、請求項1または請求項2に記載の化合物。
- nが18である、請求項1または請求項2に記載の化合物。
- R2が−N+Z3である、請求項1または請求項2に記載の化合物。
- 各々のZが独立して−CH2CH3または−CH3である、請求項12に記載の化合物。
- 各々のZが−CH3である、請求項13に記載の化合物。
- 請求項1から請求項17のいずれか一項に記載の化合物および薬学的に許容される担体を含有する組成物。
- 癌または癌性細胞の磁気共鳴イメージングにおける使用のための、請求項1から請求項17のいずれか一項に記載の化合物。
- 中性子捕捉療法によって癌を治療する際に使用するための、請求項1から請求項17のいずれか一項に記載の化合物。
- 癌を治療または画像化するための薬剤を製造するのに使用するための、請求項1から請求項17のいずれか一項に記載の化合物。
- 生物学的試料中の1つ以上の癌腫瘍細胞を検出または画像化するための方法であって、
(a)生物学的試料を請求項1から請求項17のいずれか一項に記載の化合物と接触させること;および
(b)ガドリニウムに特徴的な信号を発している生物学的試料内の個々の細胞または領域を同定し、それによって1つ以上の癌腫瘍細胞を検出または画像化すること
を含む方法。 - ガドリニウムに特徴的な信号を発している前記生物学的試料内の個々の細胞または領域を同定する工程が、磁気共鳴イメージング(MRI)によって実施される、請求項22に記載の方法。
- 前記生物学的試料が対象の一部または全部である、請求項22または請求項23に記載の方法。
- 前記生物学的試料が対象から得られる、請求項22から請求項24のいずれか一項に記載の方法。
- 前記対象がヒトである、請求項24または請求項25に記載の方法。
- 前記癌細胞が成人固形腫瘍細胞または小児固形腫瘍細胞である、請求項22から請求項26のいずれか一項に記載の方法。
- 前記癌細胞が、黒色腫細胞、神経芽細胞腫細胞、肺癌細胞、副腎癌細胞、結腸癌細胞、結腸直腸癌細胞、卵巣癌細胞、前立腺癌細胞、肝臓癌細胞、皮下癌細胞、扁平上皮癌細胞、腸癌細胞、網膜芽細胞腫細胞、子宮頸癌細胞、神経膠腫細胞、乳癌細胞、膵臓癌細胞、ユーイング肉腫細胞、横紋筋肉腫細胞、骨肉腫細胞、網膜芽細胞腫細胞、ウィルムス腫瘍細胞および小児脳腫瘍細胞から成る群より選択される、請求項27に記載の方法。
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KR20200088374A (ko) * | 2017-11-10 | 2020-07-22 | 위스콘신 얼럼나이 리서어치 화운데이션 | 면역요법에 대한 항-종양 면역 반응을 유도하기 위해 표적화된 방사선요법(trt)을 이용하는 방법 |
RU2730507C1 (ru) * | 2019-08-27 | 2020-08-24 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Соединение для диагностики опухолей, экспрессирующих псма, и композиция на его основе |
KR102362962B1 (ko) * | 2020-06-12 | 2022-02-16 | (주)미래바이오팜 | 신규한 화합물 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물 |
KR20230050552A (ko) * | 2021-10-07 | 2023-04-17 | (주)퓨쳐켐 | 가돌리늄 화합물 및 이를 포함하는 전립선암의 진단 및 치료용 약학적 조성물 |
WO2023106883A1 (ko) * | 2021-12-10 | 2023-06-15 | (주)에트노바테라퓨틱스 | 신규한 화합물, 이의 제조방법 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물 |
WO2023106616A1 (ko) * | 2021-12-10 | 2023-06-15 | (주)에트노바테라퓨틱스 | 신규한 화합물, 이의 제조방법 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물 |
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US10813998B2 (en) | 2020-10-27 |
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KR102129472B1 (ko) | 2020-07-02 |
EP3370779A1 (en) | 2018-09-12 |
US20230310610A1 (en) | 2023-10-05 |
US11623007B2 (en) | 2023-04-11 |
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