PT1404319E - Novas metaloporfirinas e suas utilizacoes como radiossensibilizadores para terapia de radiacao - Google Patents

Novas metaloporfirinas e suas utilizacoes como radiossensibilizadores para terapia de radiacao

Info

Publication number
PT1404319E
PT1404319E PT02737384T PT02737384T PT1404319E PT 1404319 E PT1404319 E PT 1404319E PT 02737384 T PT02737384 T PT 02737384T PT 02737384 T PT02737384 T PT 02737384T PT 1404319 E PT1404319 E PT 1404319E
Authority
PT
Portugal
Prior art keywords
radiosensensibilizers
metaloporrhinees
new
radiation therapy
radiosensitizers
Prior art date
Application number
PT02737384T
Other languages
English (en)
Inventor
Miura Michiko
Daniel N Slatkin
Original Assignee
Brookhaven Science Ass Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/874,203 external-priority patent/US6566517B2/en
Application filed by Brookhaven Science Ass Llc filed Critical Brookhaven Science Ass Llc
Publication of PT1404319E publication Critical patent/PT1404319E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Radiation-Therapy Devices (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT02737384T 2001-06-06 2002-06-05 Novas metaloporfirinas e suas utilizacoes como radiossensibilizadores para terapia de radiacao PT1404319E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/874,203 US6566517B2 (en) 2001-06-06 2001-06-06 Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy
US10/117,010 US6759403B2 (en) 2001-06-06 2002-04-05 Metalloporphyrins and their uses as radiosensitizers for radiation therapy

Publications (1)

Publication Number Publication Date
PT1404319E true PT1404319E (pt) 2006-08-31

Family

ID=26814828

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02737384T PT1404319E (pt) 2001-06-06 2002-06-05 Novas metaloporfirinas e suas utilizacoes como radiossensibilizadores para terapia de radiacao

Country Status (14)

Country Link
EP (1) EP1404319B1 (pt)
JP (1) JP4247110B2 (pt)
CN (1) CN1279907C (pt)
AT (1) ATE320808T1 (pt)
AU (1) AU2002310314B2 (pt)
CA (1) CA2449316A1 (pt)
DE (1) DE60210074T2 (pt)
DK (1) DK1404319T3 (pt)
ES (1) ES2257554T3 (pt)
GB (1) GB2393123B (pt)
HK (1) HK1078472A1 (pt)
PT (1) PT1404319E (pt)
RU (1) RU2310447C2 (pt)
WO (1) WO2002098417A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005084716A2 (en) * 2004-03-02 2005-09-15 Cellectar, Llc Phospholipid analogs for diagnosis and treatment of cancer
US6989443B2 (en) * 2004-06-28 2006-01-24 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
GB0415663D0 (en) * 2004-07-13 2004-08-18 Psimei Pharmaceuticals Plc Compound
GB0427589D0 (en) * 2004-12-16 2005-01-19 Psimei Pharmaceuticals Plc Process for the preparation of a substituted porphyrin
US20060217291A1 (en) 2005-03-25 2006-09-28 Ichiro Hirotsu Radiosensitizer
US8287839B2 (en) * 2006-12-04 2012-10-16 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
JP5745415B2 (ja) * 2009-09-17 2015-07-08 国立大学法人九州大学 ポルフィリン化合物
US9040687B2 (en) * 2010-01-22 2015-05-26 Council Of Scientific And Idustrial Research Process for the preparaton of novel porphyrin derivatives and their use as PDT agents and fluorescence probes
KR20140109386A (ko) * 2011-12-02 2014-09-15 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 금속포르피린 신경 치료
BR112014025702B1 (pt) * 2012-04-15 2022-10-11 Sherri Ann Mcfarland Compostos de tiofeno fotodinâmicos a base de metal e seus usos
GB201212409D0 (en) * 2012-07-12 2012-08-22 Morex Dev Partners Llp Cancer treatment
EP2976347B1 (en) 2013-03-15 2022-01-19 McFarland, Sherri Ann Metal-based coordination complexes as photodynamic compounds and their use
RU2551539C2 (ru) * 2013-08-01 2015-05-27 Федеральное Государственное Бюджетное Учреждение Науки Институт Биохимической Физики Им. Н.М. Эмануэля Российской Академии Наук (Ибхф Ран) Способ получения борированных порфиринов
RU2533267C1 (ru) * 2013-10-07 2014-11-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Тихоокеанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ТГМУ Минздрава России) Способ фотон-захватной терапии опухолей
JP6731730B2 (ja) * 2015-01-07 2020-07-29 東京都公立大学法人 抗酸化機能を有するエピジェネティクコントロールキャリアによる慢性閉塞性肺疾患（ｃｏｐｄ）治療
RU2615770C1 (ru) * 2015-12-21 2017-04-11 Общество с ограниченной ответственностью "Пермская химическая компания" Борированные производные фторированных бактериохлоринов и их металлокомплексов, обладающие противоопухолевой активностью
CN109748914B (zh) * 2018-12-29 2021-05-25 上海珂臻医药科技有限公司 吡啶并嘧啶类化合物及其应用
RU2702294C1 (ru) * 2019-01-18 2019-10-07 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук ("Томский НИМЦ") Способ радионуклидной диагностики операбельного рака молочной железы с гиперэкспрессией Her2/neu
CN111053902A (zh) * 2019-12-26 2020-04-24 深圳市纳诺艾医疗科技有限公司 一种携带共振原子的放疗或化疗药物及其应用
CN112442095B (zh) * 2020-12-01 2022-07-22 上海科黛生物科技有限公司 一种维生素b12的精制方法及所得产品的应用
CN113061260B (zh) * 2021-03-19 2022-04-29 暨南大学 一种稀土金属卟啉框架材料及其制备方法与应用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959356A (en) * 1989-05-26 1990-09-25 The United States Of America As Represented By The United States Department Of Energy Porphyrins for boron neutron capture therapy

Also Published As

Publication number Publication date
GB2393123A (en) 2004-03-24
GB2393123B (en) 2005-01-12
DK1404319T3 (da) 2006-07-31
DE60210074T2 (de) 2006-10-19
RU2003138076A (ru) 2005-05-27
JP2005504012A (ja) 2005-02-10
EP1404319A1 (en) 2004-04-07
HK1078472A1 (en) 2006-03-17
ES2257554T3 (es) 2006-08-01
WO2002098417A1 (en) 2002-12-12
RU2310447C2 (ru) 2007-11-20
CA2449316A1 (en) 2002-12-12
GB0400163D0 (en) 2004-02-11
EP1404319A4 (en) 2005-03-23
AU2002310314B2 (en) 2006-07-27
JP4247110B2 (ja) 2009-04-02
CN1279907C (zh) 2006-10-18
CN1620289A (zh) 2005-05-25
DE60210074D1 (de) 2006-05-11
EP1404319B1 (en) 2006-03-22
ATE320808T1 (de) 2006-04-15

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