DK1404319T3 - Hidtil ukendte metalloporphyriner og anvendelsen deraf som radiosensibilisatorer til strålebehandling - Google Patents

Hidtil ukendte metalloporphyriner og anvendelsen deraf som radiosensibilisatorer til strålebehandling

Info

Publication number
DK1404319T3
DK1404319T3 DK02737384T DK02737384T DK1404319T3 DK 1404319 T3 DK1404319 T3 DK 1404319T3 DK 02737384 T DK02737384 T DK 02737384T DK 02737384 T DK02737384 T DK 02737384T DK 1404319 T3 DK1404319 T3 DK 1404319T3
Authority
DK
Denmark
Prior art keywords
radiosensitizers
lporophyrins
radiation therapy
new metal
present
Prior art date
Application number
DK02737384T
Other languages
English (en)
Inventor
Michiko Miura
Daniel N Slatkin
Original Assignee
Brookhaven Science Ass Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/874,203 external-priority patent/US6566517B2/en
Application filed by Brookhaven Science Ass Llc filed Critical Brookhaven Science Ass Llc
Application granted granted Critical
Publication of DK1404319T3 publication Critical patent/DK1404319T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Radiation-Therapy Devices (AREA)
DK02737384T 2001-06-06 2002-06-05 Hidtil ukendte metalloporphyriner og anvendelsen deraf som radiosensibilisatorer til strålebehandling DK1404319T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/874,203 US6566517B2 (en) 2001-06-06 2001-06-06 Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy
US10/117,010 US6759403B2 (en) 2001-06-06 2002-04-05 Metalloporphyrins and their uses as radiosensitizers for radiation therapy

Publications (1)

Publication Number Publication Date
DK1404319T3 true DK1404319T3 (da) 2006-07-31

Family

ID=26814828

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02737384T DK1404319T3 (da) 2001-06-06 2002-06-05 Hidtil ukendte metalloporphyriner og anvendelsen deraf som radiosensibilisatorer til strålebehandling

Country Status (14)

Country Link
EP (1) EP1404319B1 (da)
JP (1) JP4247110B2 (da)
CN (1) CN1279907C (da)
AT (1) ATE320808T1 (da)
AU (1) AU2002310314B2 (da)
CA (1) CA2449316A1 (da)
DE (1) DE60210074T2 (da)
DK (1) DK1404319T3 (da)
ES (1) ES2257554T3 (da)
GB (1) GB2393123B (da)
HK (1) HK1078472A1 (da)
PT (1) PT1404319E (da)
RU (1) RU2310447C2 (da)
WO (1) WO2002098417A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2044961B1 (en) * 2004-03-02 2013-07-17 Cellectar, Inc. Phospholipid analogues for the treatment of pancreatic, ovarian and colon cancers, melanomas, gliomas, and carcinosarcomas
US6989443B2 (en) * 2004-06-28 2006-01-24 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
GB0415663D0 (en) 2004-07-13 2004-08-18 Psimei Pharmaceuticals Plc Compound
GB0427589D0 (en) * 2004-12-16 2005-01-19 Psimei Pharmaceuticals Plc Process for the preparation of a substituted porphyrin
EP1704870A1 (en) 2005-03-25 2006-09-27 Nipro Corporation Use of iron compounds as radiosensitizers
US8287839B2 (en) * 2006-12-04 2012-10-16 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
JP5745415B2 (ja) * 2009-09-17 2015-07-08 国立大学法人九州大学 ポルフィリン化合物
US9040687B2 (en) * 2010-01-22 2015-05-26 Council Of Scientific And Idustrial Research Process for the preparaton of novel porphyrin derivatives and their use as PDT agents and fluorescence probes
WO2013130150A2 (en) * 2011-12-02 2013-09-06 The Regents Of The University Of Colorado, A Body Corporate Metalloporphyrin neurological treatments
BR112014025702B1 (pt) * 2012-04-15 2022-10-11 Sherri Ann Mcfarland Compostos de tiofeno fotodinâmicos a base de metal e seus usos
GB201212409D0 (en) * 2012-07-12 2012-08-22 Morex Dev Partners Llp Cancer treatment
CA2907356C (en) 2013-03-15 2022-07-12 Sherri Ann MCFARLAND Metal-based coordination complexes as photodynamic compounds and their use
RU2551539C2 (ru) * 2013-08-01 2015-05-27 Федеральное Государственное Бюджетное Учреждение Науки Институт Биохимической Физики Им. Н.М. Эмануэля Российской Академии Наук (Ибхф Ран) Способ получения борированных порфиринов
RU2533267C1 (ru) * 2013-10-07 2014-11-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Тихоокеанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ТГМУ Минздрава России) Способ фотон-захватной терапии опухолей
JP6731730B2 (ja) * 2015-01-07 2020-07-29 東京都公立大学法人 抗酸化機能を有するエピジェネティクコントロールキャリアによる慢性閉塞性肺疾患（ｃｏｐｄ）治療
RU2615770C1 (ru) * 2015-12-21 2017-04-11 Общество с ограниченной ответственностью "Пермская химическая компания" Борированные производные фторированных бактериохлоринов и их металлокомплексов, обладающие противоопухолевой активностью
CN109748914B (zh) * 2018-12-29 2021-05-25 上海珂臻医药科技有限公司 吡啶并嘧啶类化合物及其应用
RU2702294C1 (ru) * 2019-01-18 2019-10-07 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук ("Томский НИМЦ") Способ радионуклидной диагностики операбельного рака молочной железы с гиперэкспрессией Her2/neu
CN111053902A (zh) * 2019-12-26 2020-04-24 深圳市纳诺艾医疗科技有限公司 一种携带共振原子的放疗或化疗药物及其应用
CN112442095B (zh) * 2020-12-01 2022-07-22 上海科黛生物科技有限公司 一种维生素b12的精制方法及所得产品的应用
CN113061260B (zh) * 2021-03-19 2022-04-29 暨南大学 一种稀土金属卟啉框架材料及其制备方法与应用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959356A (en) * 1989-05-26 1990-09-25 The United States Of America As Represented By The United States Department Of Energy Porphyrins for boron neutron capture therapy

Also Published As

Publication number Publication date
PT1404319E (pt) 2006-08-31
AU2002310314B2 (en) 2006-07-27
EP1404319A4 (en) 2005-03-23
CN1279907C (zh) 2006-10-18
GB2393123A (en) 2004-03-24
ES2257554T3 (es) 2006-08-01
ATE320808T1 (de) 2006-04-15
DE60210074T2 (de) 2006-10-19
JP4247110B2 (ja) 2009-04-02
GB0400163D0 (en) 2004-02-11
RU2003138076A (ru) 2005-05-27
DE60210074D1 (de) 2006-05-11
GB2393123B (en) 2005-01-12
WO2002098417A1 (en) 2002-12-12
EP1404319A1 (en) 2004-04-07
JP2005504012A (ja) 2005-02-10
RU2310447C2 (ru) 2007-11-20
CA2449316A1 (en) 2002-12-12
EP1404319B1 (en) 2006-03-22
HK1078472A1 (en) 2006-03-17
CN1620289A (zh) 2005-05-25

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