HK1119168A1 - 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors 2- 1h--4- parp - Google Patents

1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors 2- 1h--4- parp

Info

Publication number
HK1119168A1
HK1119168A1 HK08111033.8A HK08111033A HK1119168A1 HK 1119168 A1 HK1119168 A1 HK 1119168A1 HK 08111033 A HK08111033 A HK 08111033A HK 1119168 A1 HK1119168 A1 HK 1119168A1
Authority
HK
Hong Kong
Prior art keywords
parp
benzimidazole
quaternary carbon
potent
inhibitors
Prior art date
Application number
HK08111033.8A
Other languages
English (en)
Chinese (zh)
Inventor
Guidong Zhu
Jianchun Gong
Virajkumar B Gandhi
Thomas D Penning
Vincent Giranda
Original Assignee
Abbvie Bahamas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Bahamas Ltd filed Critical Abbvie Bahamas Ltd
Publication of HK1119168A1 publication Critical patent/HK1119168A1/xx

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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HK08111033.8A 2005-04-11 2008-10-02 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors 2- 1h--4- parp HK1119168A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67020405P 2005-04-11 2005-04-11
PCT/US2006/013652 WO2006110816A2 (en) 2005-04-11 2006-04-11 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors

Publications (1)

Publication Number Publication Date
HK1119168A1 true HK1119168A1 (en) 2009-02-27

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
HK08111033.8A HK1119168A1 (en) 2005-04-11 2008-10-02 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors 2- 1h--4- parp
HK12107159.8A HK1166465A1 (en) 2005-04-11 2012-07-20 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position as parp inhibitors for use in treating cancer
HK16103730.1A HK1215807A1 (zh) 2005-04-11 2016-04-01 -位上被個季碳原子取代的 -苯並咪唑- -甲酰胺化合物是有效的 抑制劑

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK12107159.8A HK1166465A1 (en) 2005-04-11 2012-07-20 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position as parp inhibitors for use in treating cancer
HK16103730.1A HK1215807A1 (zh) 2005-04-11 2016-04-01 -位上被個季碳原子取代的 -苯並咪唑- -甲酰胺化合物是有效的 抑制劑

Country Status (24)

Country Link
US (1) US7550603B2 (el)
EP (3) EP2420499B1 (el)
JP (1) JP4960342B2 (el)
KR (1) KR101349206B1 (el)
CN (2) CN104961723A (el)
AU (1) AU2006235492B2 (el)
BR (1) BRPI0609121B8 (el)
CA (1) CA2603784C (el)
CY (1) CY1123919T1 (el)
DK (2) DK1869011T3 (el)
ES (2) ES2391832T3 (el)
HK (3) HK1119168A1 (el)
HR (2) HRP20120819T1 (el)
IL (2) IL186303A (el)
ME (2) ME02087B (el)
MX (1) MX2007012593A (el)
NZ (1) NZ561729A (el)
PL (2) PL1869011T3 (el)
PT (2) PT2420234E (el)
RS (2) RS52546B (el)
SI (1) SI2420234T1 (el)
TW (1) TWI375673B (el)
WO (1) WO2006110816A2 (el)
ZA (1) ZA200904501B (el)

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