HK1112248A1 - Affinity purification of polypeptide on protein a matrix - Google Patents

Affinity purification of polypeptide on protein a matrix

Info

Publication number
HK1112248A1
HK1112248A1 HK08107236.1A HK08107236A HK1112248A1 HK 1112248 A1 HK1112248 A1 HK 1112248A1 HK 08107236 A HK08107236 A HK 08107236A HK 1112248 A1 HK1112248 A1 HK 1112248A1
Authority
HK
Hong Kong
Prior art keywords
polypeptide
protein
matrix
affinity purification
affinity
Prior art date
Application number
HK08107236.1A
Other languages
English (en)
Inventor
Greg S Blank
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21859810&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1112248(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of HK1112248A1 publication Critical patent/HK1112248A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/824Immunological separation techniques
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/828Protein A

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK08107236.1A 1996-11-27 2008-06-30 Affinity purification of polypeptide on protein a matrix HK1112248A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3150096P 1996-11-27 1996-11-27

Publications (1)

Publication Number Publication Date
HK1112248A1 true HK1112248A1 (en) 2008-08-29

Family

ID=21859810

Family Applications (2)

Application Number Title Priority Date Filing Date
HK08107236.1A HK1112248A1 (en) 1996-11-27 2008-06-30 Affinity purification of polypeptide on protein a matrix
HK08107458.2A HK1112253A1 (en) 1996-11-27 2008-07-08 Affinity purification of polypeptide on protein a matrix

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK08107458.2A HK1112253A1 (en) 1996-11-27 2008-07-08 Affinity purification of polypeptide on protein a matrix

Country Status (16)

Country Link
US (4) US6127526A (xx)
EP (4) EP1897890B1 (xx)
JP (1) JP4031049B2 (xx)
AR (1) AR010073A1 (xx)
AT (4) ATE371673T1 (xx)
AU (1) AU729164B2 (xx)
CA (1) CA2271255C (xx)
DE (4) DE69739673D1 (xx)
DK (4) DK1897890T3 (xx)
ES (4) ES2322299T3 (xx)
HK (2) HK1112248A1 (xx)
IL (1) IL130061A (xx)
PT (4) PT950067E (xx)
SI (4) SI1864999T1 (xx)
WO (1) WO1998023645A1 (xx)
ZA (1) ZA979996B (xx)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
PT950067E (pt) * 1996-11-27 2007-12-06 Genentech Inc Purificação por afinidade de um polipéptido numa matriz de proteína a.
AU760048B2 (en) * 1998-05-06 2003-05-08 Genentech Inc. Protein purification by ion exchange chromatography
US20030086924A1 (en) * 1999-06-25 2003-05-08 Genentech, Inc. Treatment with anti-ErbB2 antibodies
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
AU2001259271A1 (en) * 2000-04-28 2001-11-12 Millennium Pharmaceuticals, Inc. 14094, a novel human trypsin family member and uses thereof
US20020119148A1 (en) 2000-09-01 2002-08-29 Gerritsen Mary E. ErbB4 antagonists
CA2448788C (en) 2001-06-05 2010-08-24 Genetics Institute, Llc. Methods for purifying highly anionic proteins
US7452539B2 (en) * 2001-12-19 2008-11-18 Genentech, Inc. Stabilizing polypeptides which have been exposed to urea
EP1463942B2 (en) * 2001-12-21 2012-06-20 Immunex Corporation Methods for purifying protein
WO2003066662A2 (en) * 2002-02-05 2003-08-14 Genentech, Inc. Protein purification
EP3388452A3 (en) 2002-09-11 2019-02-20 Genentech, Inc. Protein purification
EP2261230B1 (en) 2002-09-11 2017-05-10 Chugai Seiyaku Kabushiki Kaisha Protein purification method
EP1626993B1 (en) * 2003-05-09 2015-03-11 Duke University Cd20-specific antibodies and methods of employing same
SI3095793T1 (sl) * 2003-07-28 2020-07-31 Genentech, Inc. Zmanjšanje izluževanja proteina A med afinitetno kromatografijo proteina A
US20050065136A1 (en) * 2003-08-13 2005-03-24 Roby Russell R. Methods and compositions for the treatment of infertility using dilute hormone solutions
JP2007504144A (ja) 2003-08-26 2007-03-01 ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド ア ボディー コーポレイト セリンプロテアーゼ活性阻害因子、ならびに細菌感染の治療法および組成物におけるその使用方法
US20050165222A1 (en) * 2003-10-15 2005-07-28 Applera Corporation Method of reducing leachate from protein a affinity media
US20050130246A1 (en) * 2003-10-27 2005-06-16 Hossein Salimi-Moosavi Detecting human anti-therapeutic antibodies
CA2544865C (en) 2003-11-05 2019-07-09 Glycart Biotechnology Ag Cd20 antibodies with increased fc receptor binding affinity and effector function
US20050239757A1 (en) * 2004-04-21 2005-10-27 Roby Russell R Hormone treatment of macular degeneration
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
KR20170134771A (ko) 2005-01-21 2017-12-06 제넨테크, 인크. Her 항체의 고정 용량 투여법
MX2007009566A (es) * 2005-02-09 2009-02-16 Genentech Inc Inhibicion de la difusion de la her2 con antagonistas de la metaloproteasa de matriz.
KR101253576B1 (ko) 2005-02-23 2013-04-11 제넨테크, 인크. Her 이량체화 억제제를 이용한 암 환자에서의 질환진행까지의 시간 또는 생존의 연장
US20090247421A1 (en) * 2005-03-23 2009-10-01 Egisto Boschetti Diverse chemical libraries bound to small particles with paramagnetic properties
CA2602951A1 (en) * 2005-03-23 2006-09-28 Bio-Rad Laboratories, Inc. Diverse chemical libraries bound to small particles with paramagnetic properties
JP2006316040A (ja) 2005-05-13 2006-11-24 Genentech Inc Herceptin(登録商標)補助療法
PE20070207A1 (es) * 2005-07-22 2007-03-09 Genentech Inc Tratamiento combinado de los tumores que expresan el her
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
CN102827287B (zh) * 2005-10-31 2015-08-12 昂考梅德药品有限公司 用于诊断和治疗癌症的组合物和方法
AU2006330922B2 (en) 2005-12-20 2012-07-26 Bristol-Myers Squibb Company Compositions and methods for producing a composition
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
CA2636109A1 (en) * 2006-01-06 2007-07-19 Amgen Inc. Methods and systems for isolating target molecules from complex solutions by column-chromatography using eluants containing organic solvents
US8263750B2 (en) * 2006-03-16 2012-09-11 Amgen Inc. Method for purifying a protein using protein-A affinity chromatography using an intermediate wash step
FR2902799B1 (fr) 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
PE20080913A1 (es) * 2006-09-08 2008-08-21 Wyeth Corp Lavado de arginina en la purificacion de proteinas usando cromatografia de afinidad
NZ575328A (en) 2006-09-13 2012-06-29 Abbott Lab Cell culture improvements
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
EP2089429B1 (en) * 2006-10-19 2014-11-26 Janssen Biotech, Inc. Process for preparing unaggregated antibody fc domains
WO2008079302A2 (en) 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) * 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
US7947813B2 (en) 2007-01-22 2011-05-24 Genentech, Inc. Polyelectrolyte precipitation and purification of proteins
AU2008208837A1 (en) * 2007-01-26 2008-07-31 Merck Serono S.A. Purification of Fc-TACT fusion proteins using the oilbody technology
EP2899541A1 (en) 2007-03-02 2015-07-29 Genentech, Inc. Predicting response to a HER dimerisation inhbitor based on low HER3 expression
PL2171090T3 (pl) 2007-06-08 2013-09-30 Genentech Inc Markery ekspresji genów odporności guza na leczenie hamujące HER2
US9551033B2 (en) * 2007-06-08 2017-01-24 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
PL3327026T3 (pl) 2007-07-09 2020-02-28 Genentech, Inc. Zapobieganie redukcji wiązań disiarczkowych podczas rekombinacyjnego wytwarzania polipeptydów
DK2215117T4 (en) 2007-10-30 2018-04-09 Genentech Inc ANTISTO PURIFICATION BY CATION CHANGE CHROMATOGRAPHY
TWI472339B (zh) * 2008-01-30 2015-02-11 Genentech Inc 包含結合至her2結構域ii之抗體及其酸性變異體的組合物
US8999702B2 (en) * 2008-06-11 2015-04-07 Emd Millipore Corporation Stirred tank bioreactor
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
TW201014605A (en) 2008-09-16 2010-04-16 Genentech Inc Methods for treating progressive multiple sclerosis
JP5792621B2 (ja) * 2008-09-26 2015-10-14 オンコメッド ファーマシューティカルズ インコーポレイテッド frizzled結合剤およびその使用
US8551789B2 (en) 2010-04-01 2013-10-08 OncoMed Pharmaceuticals Frizzled-binding agents and their use in screening for WNT inhibitors
AU2009307737B2 (en) 2008-10-20 2015-07-23 Abbvie Inc. Viral inactivation during purification of antibodies
JP5808249B2 (ja) 2008-10-20 2015-11-10 アッヴィ・インコーポレイテッド プロテインaアフィニティークロマトグラフィーを用いる抗体の単離および精製
JP2012511929A (ja) * 2008-12-16 2012-05-31 イー・エム・デイー・ミリポア・コーポレイシヨン 攪拌タンク反応器及び方法
US8846878B1 (en) * 2009-01-23 2014-09-30 Cubrc Corporation Method and device for isolating a protein sample
AR075896A1 (es) 2009-03-20 2011-05-04 Genentech Inc Anticuerpos anti-her (factor de crecimiento epidermico)
SG10201507044PA (en) 2009-05-29 2015-10-29 Hoffmann La Roche Modulators for her2 signaling in her2 expressing patients with gastric cancer
SG178078A1 (en) * 2009-07-24 2012-03-29 Hoffmann La Roche Optimizing the production of antibodies
AR078161A1 (es) 2009-09-11 2011-10-19 Hoffmann La Roche Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
WO2011038894A1 (en) 2009-10-01 2011-04-07 F. Hoffmann-La Roche Ag Protein a chromatography
DK2483305T3 (en) 2009-10-01 2016-10-24 Hoffmann La Roche MULTI-STEP-END FILTERING Immunoglobulin
WO2011060242A2 (en) 2009-11-13 2011-05-19 Talecris Biotherapeutics, Inc. Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto
DK2513134T3 (en) 2009-12-18 2017-12-18 Novartis Ag Washing solution and process for affinity chromatography
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt拮抗劑及治療和篩選方法
JP5981853B2 (ja) 2010-02-18 2016-08-31 ジェネンテック, インコーポレイテッド ニューレグリンアンタゴニスト及び癌の治療におけるそれらの使用
KR101551295B1 (ko) 2010-05-17 2015-09-08 이엠디 밀리포어 코포레이션 생체분자 정제용 자극 반응성 중합체
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
GB201012603D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
EP2643353A1 (en) 2010-11-24 2013-10-02 Novartis AG Multispecific molecules
WO2012082933A1 (en) 2010-12-15 2012-06-21 Baxter International, Inc. Eluate collection using conductivity gradient
EP2655413B1 (en) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
KR102103476B1 (ko) 2011-06-24 2020-04-23 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
KR20140057326A (ko) 2011-08-17 2014-05-12 제넨테크, 인크. 뉴레귤린 항체 및 그의 용도
US20130095172A1 (en) 2011-10-14 2013-04-18 Genentech, Inc. Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
PL2773438T5 (pl) * 2011-11-02 2022-01-17 F.Hoffmann-La Roche Ag Chromatografia przeciążenia i elucji
CN106987620A (zh) 2011-11-30 2017-07-28 霍夫曼-拉罗奇有限公司 癌症中的erbb3突变
EP2788500A1 (en) 2011-12-09 2014-10-15 F.Hoffmann-La Roche Ag Identification of non-responders to her2 inhibitors
KR20140137347A (ko) 2012-01-10 2014-12-02 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
WO2013148315A1 (en) 2012-03-27 2013-10-03 Genentech, Inc. Diagnosis and treatments relating to her3 inhibitors
EP2647709B1 (en) * 2012-04-05 2016-02-24 F. Hoffmann-La Roche AG Amine compounds for the selective preparation of biological samples
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
WO2013177118A2 (en) * 2012-05-21 2013-11-28 Abbvie Inc. Novel purification of non-human antibodies using protein a affinity chromatography
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
CA2883272A1 (en) 2012-09-02 2014-03-06 Abbvie Inc. Methods to control protein heterogeneity
SG11201404684RA (en) 2012-09-17 2014-10-30 Grace W R & Co Functionalized particulate support material and methods of making and using the same
PL2812091T3 (pl) 2012-09-17 2021-07-19 W.R. Grace & Co. - Conn. Podłoża chromatograficzne i urządzenia
JP2015536933A (ja) 2012-10-23 2015-12-24 オンコメッド ファーマシューティカルズ インコーポレイテッド Wnt経路結合剤を用いて神経内分泌腫瘍を処置する方法
KR102291355B1 (ko) 2012-11-30 2021-08-19 에프. 호프만-라 로슈 아게 Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법
WO2014121196A1 (en) 2013-02-04 2014-08-07 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a wnt pathway inhibitor
MX2015012114A (es) 2013-03-08 2016-01-12 Genzyme Corp Fabricacion continua integrada de principios activos proteinicos terapeuticos.
CA2905010A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
CA3071678A1 (en) 2013-04-16 2014-10-23 Genentech,Inc. Pertuzumab variants and evaluation thereof
WO2014192877A1 (ja) * 2013-05-29 2014-12-04 Jsr株式会社 洗浄用組成物、タンパク質精製方法、及びタンパク質
JP6141524B2 (ja) * 2013-07-12 2017-06-07 メルク パテント ゲーエムベーハー 活性炭を用いた標的タンパク質含有サンプルからのフラグメントの除去
PL3044323T3 (pl) 2013-09-13 2022-06-27 F.Hoffmann-La Roche Ag Sposoby wykrywania i ilościowego oznaczania białka komórki gospodarza w liniach komórkowych
NZ756750A (en) * 2013-09-13 2022-05-27 Genentech Inc Methods and compositions comprising purified recombinant polypeptides
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
CN105407905B (zh) 2014-01-03 2020-03-03 生物辐射实验室股份有限公司 蛋白a洗脱产物中杂质的去除
US11229896B2 (en) 2014-01-16 2022-01-25 W.R. Grace & Co.—Conn. Affinity chromatography media and chromatography devices
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
SG10201809411PA (en) 2014-04-25 2018-11-29 Genentech Inc Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab
PL3137209T3 (pl) 2014-05-02 2023-01-02 W.R. Grace & Co. - Conn. Funkcjonalizowany materiał nośnikowy i sposoby wytwarzania oraz stosowania funkcjonalizowanego materiału nośnikowego
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
CN107614015A (zh) 2015-05-30 2018-01-19 豪夫迈·罗氏有限公司 治疗her2阳性局部晚期或先前未治疗的转移性乳腺癌的方法
JP2018517559A (ja) 2015-06-05 2018-07-05 ダブリュー・アール・グレース・アンド・カンパニー−コーンW R Grace & Co−Conn 吸着性バイオプロセス清澄化剤並びにその製造及び使用方法
WO2017087280A1 (en) 2015-11-16 2017-05-26 Genentech, Inc. Methods of treating her2-positive cancer
WO2017194554A1 (en) 2016-05-10 2017-11-16 Inserm (Institut National De La Sante Et De La Recherche Medicale) Combinations therapies for the treatment of cancer
CN109311949B (zh) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 储存分离基质的方法
EP3455241B1 (en) 2016-05-11 2022-02-23 Cytiva BioProcess R&D AB Method of cleaning and/or sanitizing a separation matrix
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
WO2017194597A1 (en) 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Separation matrix
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
WO2018045587A1 (zh) * 2016-09-12 2018-03-15 广东东阳光药业有限公司 一种抗vegf类单克隆抗体的纯化方法
EP3534948A1 (en) 2016-11-04 2019-09-11 Genentech, Inc. Treatment of her2-positive breast cancer
CN110099926A (zh) 2016-12-28 2019-08-06 豪夫迈·罗氏有限公司 晚期her2表达性癌症的治疗
CR20190376A (es) 2017-01-17 2019-11-20 Genentech Inc Formulaciones de anticuerpos de her2 subcutáneas
EP3589661B1 (en) 2017-03-02 2023-11-01 Genentech, Inc. Adjuvant treatment of her2-positive breast cancer
TW201902509A (zh) 2017-04-24 2019-01-16 美商建南德克公司 Erbb2/her2突變
ES2887046T3 (es) 2017-08-17 2021-12-21 Just Evotec Biologics Inc Método de purificación de proteína glicosilada a partir de galectinas de las células hospedadoras y otros contaminantes
JP2021536353A (ja) 2018-08-31 2021-12-27 ジェンザイム・コーポレーション 無菌クロマトグラフィー樹脂および製造方法におけるその使用
SG11202110947RA (en) 2019-04-02 2021-10-28 Bondwell Tech Inc Functionalized ubx protein materials for enhanced purification of antibodies

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3627063A1 (de) * 1986-08-09 1988-02-11 Diagen Inst Molekularbio Verfahren zur abtrennung und reinigung von biopolymeren durch affinitaetschromatographie
US4801687A (en) * 1986-10-27 1989-01-31 Bioprobe International, Inc. Monoclonal antibody purification process using protein A
US5100034A (en) * 1990-04-16 1992-03-31 Bethlehem Steel Corporation Molten metal slide gate valve
US5200471A (en) * 1990-11-05 1993-04-06 Minnesota Mining And Manufacturing Company Biomolecules covalently immobilized with a high bound specific biological activity and method of preparing same
US5233456A (en) * 1991-12-20 1993-08-03 Texas Instruments Incorporated Resonant mirror and method of manufacture
JPH05262799A (ja) * 1992-03-23 1993-10-12 Ngk Insulators Ltd 抗体の精製方法
JPH08503698A (ja) * 1992-10-02 1996-04-23 ザ ゼネラル ホスピタル コーポレーション アミノ酸模倣物を溶出試薬として用いる親和精製方法
US5451660A (en) * 1993-12-13 1995-09-19 Genentech, Inc. Method for purifying polypeptides
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5600998A (en) * 1995-02-10 1997-02-11 Dean, Jr.; William R. Level sensor offset mounting mechanism
US5731168A (en) * 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
PT950067E (pt) * 1996-11-27 2007-12-06 Genentech Inc Purificação por afinidade de um polipéptido numa matriz de proteína a.

Also Published As

Publication number Publication date
EP1900751B1 (en) 2009-12-09
EP1897890A1 (en) 2008-03-12
ES2322299T3 (es) 2009-06-18
JP4031049B2 (ja) 2008-01-09
DE69739673D1 (de) 2009-12-31
HK1112253A1 (en) 2008-08-29
PT950067E (pt) 2007-12-06
ES2337091T3 (es) 2010-04-20
DK1900751T3 (da) 2010-04-19
DE69739320D1 (de) 2009-04-30
US20040106180A1 (en) 2004-06-03
EP1864999A1 (en) 2007-12-12
DK1897890T3 (da) 2010-04-06
US20020032317A1 (en) 2002-03-14
SI0950067T1 (sl) 2007-12-31
ATE449111T1 (de) 2009-12-15
ZA979996B (en) 1999-05-06
IL130061A (en) 2001-09-13
US6127526A (en) 2000-10-03
AU5243698A (en) 1998-06-22
SI1897890T1 (sl) 2010-03-31
SI1900751T1 (sl) 2010-03-31
EP0950067B1 (en) 2007-08-29
PT1864999E (pt) 2009-06-25
AU729164B2 (en) 2001-01-25
DE69738075T2 (de) 2008-05-21
IL130061A0 (en) 2000-02-29
PT1900751E (pt) 2010-02-23
US6797814B2 (en) 2004-09-28
CA2271255C (en) 2011-06-14
DE69738075D1 (de) 2007-10-11
EP1897890B1 (en) 2009-11-18
EP1864999B1 (en) 2009-03-18
AR010073A1 (es) 2000-05-17
EP0950067A1 (en) 1999-10-20
ATE371673T1 (de) 2007-09-15
ES2335365T3 (es) 2010-03-25
ATE425990T1 (de) 2009-04-15
CA2271255A1 (en) 1998-06-04
PT1897890E (pt) 2010-02-23
JP2001504838A (ja) 2001-04-10
EP1900751A1 (en) 2008-03-19
WO1998023645A1 (en) 1998-06-04
ATE451391T1 (de) 2009-12-15
DK0950067T3 (da) 2007-12-27
SI1864999T1 (sl) 2009-08-31
ES2293661T3 (es) 2008-03-16
DK1864999T3 (da) 2009-06-29
DE69739698D1 (de) 2010-01-21
US6333398B1 (en) 2001-12-25

Similar Documents

Publication Publication Date Title
HK1112253A1 (en) Affinity purification of polypeptide on protein a matrix
AU4234997A (en) Secreted proteins and polynucleotides encoding them
AU3381797A (en) Secreted proteins and polynucleotides encoding them
HUP9900323A2 (hu) Bakteriofág endoszialidáz aktivitással rendelkező rekombináns fehérje
AU3890797A (en) Secreted proteins and polynucleotides encoding them
EP1080182A4 (en) AMINO ACID MODIFIED POLYPEPTIDES
AU5706198A (en) Secreted proteins and polynucleotides encoding them
AU3810097A (en) Secreted proteins and polynucleotides encoding them
AU1101199A (en) Secreted proteins and polynucleotides encoding them
AU1417899A (en) Secreted proteins and polynucleotides encoding them
AU3398797A (en) Polynucleotides encoding secreted proteins
AU2459397A (en) Secreted proteins and polynucleotides encoding them
CZ135099A3 (cs) Nalfa-2-(4-Nitrofenylsulfonyl)ethoxykarbonylované aminokyseliny
AU5256298A (en) Secreted proteins and polynucleotides encoding them
AU5516498A (en) Secreted proteins and polynucleotides encoding them
AU3986497A (en) Secreted proteins and polynucleotides encoding them
AU3721397A (en) Secreted proteins and polynucleotides encoding them
AU3597097A (en) Secreted proteins and polynucleotides encoding them
AU2723397A (en) Polynucleotides encoding secreted proteins
AU2476297A (en) Polypeptide having beta-fructofuranosidase activity
AU5202498A (en) Secreted proteins and polynucleotides encoding them
AU4746397A (en) Secreted proteins and polynucleotides encoding them
AU1390299A (en) Secreted proteins and polynucleotides encoding them
AU4670297A (en) Secreted proteins and polynucleotides encoding them
AU5004097A (en) Secreted proteins and polynucleotides encoding them

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20171028