HK1109594A1 - Improved quenching methods for red blood cell inactivation process - Google Patents
Improved quenching methods for red blood cell inactivation processInfo
- Publication number
- HK1109594A1 HK1109594A1 HK08103739.2A HK08103739A HK1109594A1 HK 1109594 A1 HK1109594 A1 HK 1109594A1 HK 08103739 A HK08103739 A HK 08103739A HK 1109594 A1 HK1109594 A1 HK 1109594A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- red blood
- blood cell
- methods
- improved
- quencher
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 210000003743 erythrocyte Anatomy 0.000 title abstract 3
- 238000010791 quenching Methods 0.000 title abstract 3
- 230000000171 quenching effect Effects 0.000 title abstract 3
- 230000002779 inactivation Effects 0.000 title 1
- 125000000524 functional group Chemical group 0.000 abstract 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108010024636 Glutathione Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 glutathione Chemical class 0.000 abstract 1
- 229960003180 glutathione Drugs 0.000 abstract 1
- 230000000415 inactivating effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 238000007086 side reaction Methods 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0215—Disinfecting agents, e.g. antimicrobials for preserving living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62317704P | 2004-10-29 | 2004-10-29 | |
PCT/US2005/039392 WO2006050328A1 (en) | 2004-10-29 | 2005-10-31 | Improved quenching methods for red blood cell inactivation process |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1109594A1 true HK1109594A1 (en) | 2008-06-13 |
Family
ID=35789172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08103739.2A HK1109594A1 (en) | 2004-10-29 | 2008-04-02 | Improved quenching methods for red blood cell inactivation process |
Country Status (13)
Country | Link |
---|---|
US (1) | US7655392B2 (pl) |
EP (1) | EP1838355B1 (pl) |
JP (3) | JP5346468B2 (pl) |
CN (2) | CN101094692A (pl) |
AU (2) | AU2005302256B2 (pl) |
BR (1) | BRPI0518198B8 (pl) |
CA (1) | CA2585621C (pl) |
DK (1) | DK1838355T3 (pl) |
ES (1) | ES2429088T3 (pl) |
HK (1) | HK1109594A1 (pl) |
PL (1) | PL1838355T3 (pl) |
PT (1) | PT1838355E (pl) |
WO (1) | WO2006050328A1 (pl) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU745209B2 (en) * | 1998-01-06 | 2002-03-14 | Cerus Corporation | Methods for quenching pathogen inactivators in biological materials |
US7655392B2 (en) | 2004-10-29 | 2010-02-02 | Cerus Corporation | Quenching methods for red blood cell inactivation process |
ES2636563T3 (es) * | 2008-04-09 | 2017-10-06 | Cerus Corporation | Método de reducción de la deshidratación en una composición de glóbulos rojos |
US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
US7989593B1 (en) | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
US8048856B1 (en) | 2010-06-23 | 2011-11-01 | Billion King, Ltd. | Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition |
US7932356B1 (en) | 2010-06-23 | 2011-04-26 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition |
US8084581B1 (en) | 2011-04-29 | 2011-12-27 | Bing Lou Wong | Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus |
US20130052232A1 (en) | 2011-08-31 | 2013-02-28 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking |
US20160081328A1 (en) * | 2013-05-10 | 2016-03-24 | President And Fellows Of Harvard College | Solutions for Red Blood Cells |
WO2016014854A1 (en) | 2014-07-23 | 2016-01-28 | Cerus Corporation | Methods for preparing platelet products |
WO2016145210A1 (en) | 2015-03-10 | 2016-09-15 | New Health Sciences, Inc. | Oxygen reduction disposable kits, devices and methods of use thereof |
KR20240067253A (ko) | 2015-04-23 | 2024-05-16 | 헤마넥스트 인코포레이티드 | 혐기성 혈액 저장 용기 |
AU2016264327B2 (en) | 2015-05-18 | 2021-12-23 | Hemanext Inc. | Methods for the storage of whole blood, and compositions thereof |
US11096963B2 (en) | 2015-06-26 | 2021-08-24 | Cerus Corporation | Cryoprecipitate compositions and methods of preparation thereof |
EP3364986B1 (en) | 2015-10-23 | 2023-12-13 | Cerus Corporation | Pathogen-inactivated cryo-poor plasma and methods of use thereof |
IL303240A (en) | 2016-05-27 | 2023-07-01 | Hemanext Inc | Anaerobic blood storage and pathogen inactivation method |
JP2020503512A (ja) * | 2016-12-23 | 2020-01-30 | シーラス コーポレイション | 化合物結合基材を使用して、試験およびスクリーニングするためのシステムおよび方法 |
US20190321407A1 (en) * | 2016-12-31 | 2019-10-24 | Cerus Corporation | Compositions and methods for preparation of red blood cells |
BR112019018273A2 (pt) | 2017-03-03 | 2020-07-14 | Cerus Corporation | kits e métodos para preparação de composições de plaquetas inativadas por patógenos |
KR20200088801A (ko) | 2017-09-20 | 2020-07-23 | 세루스 코포레이션 | 혈소판의 병원체 비활성화를 위한 조성물 및 방법 |
IL275698B2 (en) | 2017-12-29 | 2024-08-01 | Cerus Corp | Systems and methods for treating biological fluids |
CA3107314A1 (en) * | 2018-07-27 | 2020-01-30 | Zata Pharmaceuticals, Inc. | Method for pathogens, microorganisms, and parasites inactivation |
IL281504B2 (en) * | 2018-09-20 | 2024-08-01 | Cerus Corp | Methods and kits for preparing pathogen-neutralized whole blood |
US12011510B2 (en) | 2019-06-22 | 2024-06-18 | Cerus Corporation | Biological fluid treatment systems |
AU2020308035A1 (en) | 2019-06-28 | 2022-02-17 | Cerus Corporation | System and methods for implementing a biological fluid treatment device |
EP4240757A2 (en) | 2020-11-09 | 2023-09-13 | Takeda Pharmaceutical Company Limited | Purification of fviii from plasma using silicon oxide adsorption |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2402665A (en) * | 1942-11-12 | 1946-06-25 | Du Pont | Chemical process |
IT1093275B (it) * | 1978-01-26 | 1985-07-19 | Snam Progetti | Composizione adatta alla purificazione del sangue e suoi impieghi |
US4337269A (en) * | 1979-07-23 | 1982-06-29 | Sutton Laboratories, Inc. | Preservative compositions |
US4727027A (en) * | 1983-05-02 | 1988-02-23 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
US4748120A (en) * | 1983-05-02 | 1988-05-31 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
US5281579A (en) * | 1984-03-23 | 1994-01-25 | Baxter International Inc. | Purified virus-free hemoglobin solutions and method for making same |
US4971760A (en) * | 1986-03-10 | 1990-11-20 | University Of Southern California | Novel method for disinfecting red blood cells, blood platelets, blood plasma, and optical corneas and sclerae |
US4944920A (en) * | 1986-08-01 | 1990-07-31 | University Of Southern California | Novel method to treat blood |
US4920143A (en) | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
US5094960A (en) * | 1988-10-07 | 1992-03-10 | New York Blood Center, Inc. | Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography |
US5055485A (en) * | 1988-12-02 | 1991-10-08 | New York Blood Center, Inc. | Inactivation of viruses in cell- and protein-containing compositions using aryl diol epoxides |
US5587490A (en) * | 1990-04-16 | 1996-12-24 | Credit Managers Association Of California | Method of inactivation of viral and bacterial blood contaminants |
US5418130A (en) * | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
US5120649A (en) * | 1990-05-15 | 1992-06-09 | New York Blood Center, Inc. | Photodynamic inactivation of viruses in blood cell-containing compositions |
US5232844A (en) * | 1990-05-15 | 1993-08-03 | New York Blood Center | Photodynamic inactivation of viruses in cell-containing compositions |
US5658722A (en) * | 1990-05-15 | 1997-08-19 | New York Blood Center, Inc. | Process for the sterilization of biological compositions using UVA1 irradiation |
US5753258A (en) * | 1990-10-19 | 1998-05-19 | University Of Florida | Artificial viral envelopes |
GB9218581D0 (en) * | 1992-09-02 | 1992-10-14 | Pall Corp | Removal of unwanted fluids from processed blood products |
WO1995000631A1 (en) | 1993-06-23 | 1995-01-05 | New York Blood Center, Inc. | System for viral inactivation of blood |
US5591350A (en) * | 1994-04-15 | 1997-01-07 | Pall Corporation | Iodine disinfection method using a gaseous iodine treated porous medium |
SE9402472L (sv) | 1994-07-13 | 1996-01-14 | Forskarpatent I Linkoeping Ab | Modifierade ytor |
US5522385A (en) | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
US5660731A (en) * | 1994-11-08 | 1997-08-26 | Pall Corporation | Filter for separating photoactive agent |
US5691132A (en) * | 1994-11-14 | 1997-11-25 | Cerus Corporation | Method for inactivating pathogens in red cell compositions using quinacrine mustard |
US5637451A (en) * | 1995-03-29 | 1997-06-10 | New York Blood Center, Inc. | Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells |
US6177441B1 (en) * | 1995-06-05 | 2001-01-23 | Cerus Corporation | Treating red blood cell solutions with anti-viral agents |
AU722811B2 (en) | 1995-06-07 | 2000-08-10 | Cerus Corporation | Treating red blood cell solutions with anti-viral agents |
ES2337852T3 (es) | 1995-06-07 | 2010-04-29 | Cerus Corporation | Metodos y dispositivos para la eliminacion de psoralenos de productos sanguineos. |
US20020192632A1 (en) * | 1995-06-07 | 2002-12-19 | Hei Derek J. | Method and devices for the removal of psoralens from blood products |
WO1996039816A1 (en) | 1995-06-07 | 1996-12-19 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants |
US6544727B1 (en) * | 1995-06-07 | 2003-04-08 | Cerus Corporation | Methods and devices for the removal of psoralens from blood products |
WO1997002028A1 (en) | 1995-06-29 | 1997-01-23 | Hemasure, Inc. | Inactivation of pathogens using hydroxymethylamines |
US6114108A (en) | 1995-08-29 | 2000-09-05 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of viral nucleic acids |
US6136586A (en) * | 1995-08-29 | 2000-10-24 | Vi Technologies, Inc. | Methods for the selective modification of viral nucleic acids |
JP2000500137A (ja) | 1995-11-06 | 2000-01-11 | ニューヨーク・ブラッド・センター・インコーポレイテッド | フタロシアニン及び赤色光を用いた赤血球細胞のウイルス不活性化処理 |
AU1085697A (en) | 1995-11-21 | 1997-06-11 | Pall Corporation | Inactivation method and system in biological fluids |
ES2196530T3 (es) | 1997-01-06 | 2003-12-16 | Cerus Corp | Compuestos de ruptura para inactivar patogenos. |
US20010018179A1 (en) * | 1998-01-06 | 2001-08-30 | Derek J. Hei | Batch devices for the reduction of compounds from biological compositions containing cells and methods of use |
US6514987B1 (en) * | 1997-01-06 | 2003-02-04 | Cerus Corporation | Frangible compounds for pathogen inactivation |
US20010009756A1 (en) * | 1998-01-06 | 2001-07-26 | Derek Hei | Flow devices for the reduction of compounds from biological compositions and methods of use |
US6093725A (en) * | 1997-01-06 | 2000-07-25 | Cerus Corporation | Frangible compounds for pathogen inactivation |
US6093564A (en) * | 1997-10-03 | 2000-07-25 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of nucleic acids |
AU745209B2 (en) * | 1998-01-06 | 2002-03-14 | Cerus Corporation | Methods for quenching pathogen inactivators in biological materials |
US6277337B1 (en) * | 1998-07-21 | 2001-08-21 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
US6150109A (en) * | 1999-01-25 | 2000-11-21 | V. I. TECHNOLOGIES, Inc. | Lipophilic quenching of viral inactivating agents |
EP1284743A2 (en) * | 2000-05-31 | 2003-02-26 | Cerus Corporation | Preparation of a pathogen inactivated solution of red blood cells having reduced immunogenicity |
CN100417325C (zh) * | 2000-11-04 | 2008-09-10 | 王祥文 | 卫生灭菌消毒剂 |
CA2434256A1 (en) * | 2000-12-21 | 2003-07-31 | David Cook | Methods for inactivation of pathogens in biological materials |
CN1186099C (zh) * | 2001-12-13 | 2005-01-26 | 孙岩军 | 麻醉机呼吸回路清洗消毒的方法及其操作步骤 |
US7655392B2 (en) | 2004-10-29 | 2010-02-02 | Cerus Corporation | Quenching methods for red blood cell inactivation process |
-
2005
- 2005-10-31 US US11/264,195 patent/US7655392B2/en active Active
- 2005-10-31 CN CNA2005800453138A patent/CN101094692A/zh active Pending
- 2005-10-31 AU AU2005302256A patent/AU2005302256B2/en not_active Ceased
- 2005-10-31 ES ES05821102T patent/ES2429088T3/es active Active
- 2005-10-31 WO PCT/US2005/039392 patent/WO2006050328A1/en active Application Filing
- 2005-10-31 BR BRPI0518198A patent/BRPI0518198B8/pt not_active IP Right Cessation
- 2005-10-31 JP JP2007539281A patent/JP5346468B2/ja active Active
- 2005-10-31 PT PT58211020T patent/PT1838355E/pt unknown
- 2005-10-31 CN CN201410112134.2A patent/CN103961731B/zh active Active
- 2005-10-31 CA CA2585621A patent/CA2585621C/en active Active
- 2005-10-31 EP EP05821102.0A patent/EP1838355B1/en active Active
- 2005-10-31 DK DK05821102.0T patent/DK1838355T3/da active
- 2005-10-31 PL PL05821102T patent/PL1838355T3/pl unknown
-
2008
- 2008-04-02 HK HK08103739.2A patent/HK1109594A1/xx unknown
-
2011
- 2011-04-06 AU AU2011201554A patent/AU2011201554B2/en not_active Ceased
-
2012
- 2012-03-07 JP JP2012050837A patent/JP5718840B2/ja active Active
-
2013
- 2013-09-27 JP JP2013200906A patent/JP2013256537A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1838355A1 (en) | 2007-10-03 |
CN103961731B (zh) | 2017-01-18 |
ES2429088T3 (es) | 2013-11-13 |
AU2005302256B2 (en) | 2011-01-20 |
PL1838355T3 (pl) | 2014-01-31 |
DK1838355T3 (da) | 2013-10-28 |
EP1838355B1 (en) | 2013-08-14 |
US7655392B2 (en) | 2010-02-02 |
JP5346468B2 (ja) | 2013-11-20 |
JP5718840B2 (ja) | 2015-05-13 |
WO2006050328A1 (en) | 2006-05-11 |
BRPI0518198B1 (pt) | 2018-11-21 |
CA2585621A1 (en) | 2006-05-11 |
CN103961731A (zh) | 2014-08-06 |
CN101094692A (zh) | 2007-12-26 |
JP2008518952A (ja) | 2008-06-05 |
PT1838355E (pt) | 2013-11-07 |
AU2011201554B2 (en) | 2012-04-26 |
BRPI0518198A (pt) | 2008-11-04 |
BRPI0518198B8 (pt) | 2021-06-22 |
CA2585621C (en) | 2015-12-15 |
JP2013256537A (ja) | 2013-12-26 |
AU2005302256A1 (en) | 2006-05-11 |
AU2011201554A1 (en) | 2011-04-28 |
US20060115466A1 (en) | 2006-06-01 |
JP2012107068A (ja) | 2012-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1109594A1 (en) | Improved quenching methods for red blood cell inactivation process | |
DE69826521D1 (de) | Verfahren zum quenchen von pathogen-inaktivatoren in biologischen materialien | |
ATE541053T1 (de) | Verfahren und zusammensetzungen zur behandlung von nichtkleinzelligem lungenkrebs | |
GB2397818A (en) | Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid | |
WO2005078097A3 (en) | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING MULTIFUNCTIONAL SHORT INTERFERING NUCLEIC ACID (Multifunctional siNA) | |
EA200300947A1 (ru) | Арил и гетероарил мочевины в качестве ингибиторов chk1 для использования в качестве радиосенсибилизаторов и химиосенсибилизаторов | |
WO2004092405A3 (en) | Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof | |
TNSN06059A1 (en) | Use of polypeptides of the cupredoxin family in cancer therapy | |
WO2003000707A3 (en) | Antisense modulation of superoxide dismutase 1, soluble expression | |
WO2002020500A3 (en) | Materials and methods to potentiate cancer treatment | |
WO2005030254A3 (en) | Conjugates for photodynamic therapy | |
GB0417487D0 (en) | Organic compound | |
WO2005062977A3 (en) | Prostate cancer specific internalizing human antibodies | |
ATE415962T1 (de) | Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs | |
WO2004106495A3 (en) | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer | |
WO2001079164A3 (en) | N-substituted dithiocarbamates for the treatment of biological disorders | |
WO2004087965A3 (en) | Statistical analysis of regulatory factor binding sites of differentially expressed genes | |
HK1078593A1 (en) | Antibody against a tumor-specific antigen as target | |
DE602005026811D1 (de) | Verfahren zur inhibierung von tumorzellwachstum mit foxm1 sirns | |
WO2003030725A3 (en) | Pancreatic cancer diagnosis and therapies | |
WO2004009112A8 (en) | Use of urease for inhibiting cancer cell growth | |
WO2004024062A3 (en) | Platinum complexes as antitumor agents in combination with biochemical modulation | |
KOMEYLIZADEH | Does nature prefer heterocycles? | |
WO2003076610A3 (fr) | Variants de kallikrein-2 et kallikrein-3 humaines et leurs utilisations | |
UA93538C2 (en) | Aurora kinase modulators and method of use |