BRPI0518198A - métodos de interrupção melhorados para processos de inativação de células hemácias - Google Patents

métodos de interrupção melhorados para processos de inativação de células hemácias

Info

Publication number
BRPI0518198A
BRPI0518198A BRPI0518198-4A BRPI0518198A BRPI0518198A BR PI0518198 A BRPI0518198 A BR PI0518198A BR PI0518198 A BRPI0518198 A BR PI0518198A BR PI0518198 A BRPI0518198 A BR PI0518198A
Authority
BR
Brazil
Prior art keywords
methods
red blood
blood cell
improved
improved interruption
Prior art date
Application number
BRPI0518198-4A
Other languages
English (en)
Inventor
Adonis Stassinopoulos
Original Assignee
Cerus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerus Corp filed Critical Cerus Corp
Publication of BRPI0518198A publication Critical patent/BRPI0518198A/pt
Publication of BRPI0518198B1 publication Critical patent/BRPI0518198B1/pt
Publication of BRPI0518198B8 publication Critical patent/BRPI0518198B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0215—Disinfecting agents, e.g. antimicrobials for preserving living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

MéTODOS DE INTERRUPçãO MELHORADOS PARA PROCESSOS DE INATIVAçãO DE CéLULAS HEMáCIAS. A presente invenção refere-se a métodos para a interrupção melhorada de reações secundárias indesejáveis no tratamento de uma composições de células hemácias que são fornecidos com um composto inativador de patógeno compreendendo um ligante que se liga a ácidos nucléícos e um grupo funcional o qual é, ou o qual é capaz de formar um grupo eletrofílíco. Em algumas modalidades, os métodos melhorados usam uma concentração adequadamente alta de supressor que compreende um grupo funcional nucleofilico que é capaz de reagir covalentemente com o grupo eletrofilíco, em que o tratamento ocorre em uma faixa de pH desejada para fornecer supressão suficiente. Supressores preferidos para uso em alguns dos métodos incluem tióis, tais como glutationa, os quais tenham sido adequadamente neu- tralizados de forma que a adição a uma composição de células hemácias resulte na concentração desejada de supressor em uma faixa de pH desejável de 6,8 a 8,5.
BRPI0518198A 2004-10-29 2005-10-31 método ex vivo para tratar uma composição de células hemácias para inativar um patógeno, se presente, bem como composição e kit BRPI0518198B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62317704P 2004-10-29 2004-10-29
PCT/US2005/039392 WO2006050328A1 (en) 2004-10-29 2005-10-31 Improved quenching methods for red blood cell inactivation process

Publications (3)

Publication Number Publication Date
BRPI0518198A true BRPI0518198A (pt) 2008-11-04
BRPI0518198B1 BRPI0518198B1 (pt) 2018-11-21
BRPI0518198B8 BRPI0518198B8 (pt) 2021-06-22

Family

ID=35789172

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518198A BRPI0518198B8 (pt) 2004-10-29 2005-10-31 método ex vivo para tratar uma composição de células hemácias para inativar um patógeno, se presente, bem como composição e kit

Country Status (13)

Country Link
US (1) US7655392B2 (pt)
EP (1) EP1838355B1 (pt)
JP (3) JP5346468B2 (pt)
CN (2) CN103961731B (pt)
AU (2) AU2005302256B2 (pt)
BR (1) BRPI0518198B8 (pt)
CA (1) CA2585621C (pt)
DK (1) DK1838355T3 (pt)
ES (1) ES2429088T3 (pt)
HK (1) HK1109594A1 (pt)
PL (1) PL1838355T3 (pt)
PT (1) PT1838355E (pt)
WO (1) WO2006050328A1 (pt)

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CN102046006B (zh) * 2008-04-09 2014-09-24 塞鲁斯公司 用于红细胞病原体灭活的改进猝灭方法
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KR20190017747A (ko) * 2016-05-27 2019-02-20 뉴 헬스 사이언시즈 인코포레이티드 혐기성 혈액 저장 및 병원체 불활성화 방법
US20190369087A1 (en) * 2016-12-23 2019-12-05 Cerus Corporation Systems and methods for testing and screening using compound bound substrates
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US11235090B2 (en) 2017-03-03 2022-02-01 Cerus Corporation Kits and methods for preparing pathogen-inactivated platelet compositions
CN111655696A (zh) 2017-09-20 2020-09-11 塞鲁斯公司 用于血小板的病原体灭活的组合物和方法
CN116571191A (zh) 2017-12-29 2023-08-11 塞鲁斯公司 用于处理生物流体的系统和方法
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CA3143732A1 (en) 2019-06-28 2020-12-30 Cerus Corporation System and methods for implementing a biological fluid treatment device
CN116322920A (zh) 2020-11-09 2023-06-23 武田药品工业株式会社 使用氧化硅吸附从血浆中纯化fviii

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Also Published As

Publication number Publication date
BRPI0518198B1 (pt) 2018-11-21
JP2012107068A (ja) 2012-06-07
CA2585621C (en) 2015-12-15
CN103961731A (zh) 2014-08-06
EP1838355A1 (en) 2007-10-03
AU2011201554A1 (en) 2011-04-28
JP2008518952A (ja) 2008-06-05
JP5346468B2 (ja) 2013-11-20
AU2005302256A1 (en) 2006-05-11
DK1838355T3 (da) 2013-10-28
AU2011201554B2 (en) 2012-04-26
PT1838355E (pt) 2013-11-07
JP2013256537A (ja) 2013-12-26
HK1109594A1 (en) 2008-06-13
PL1838355T3 (pl) 2014-01-31
US20060115466A1 (en) 2006-06-01
CA2585621A1 (en) 2006-05-11
WO2006050328A1 (en) 2006-05-11
US7655392B2 (en) 2010-02-02
AU2005302256B2 (en) 2011-01-20
CN101094692A (zh) 2007-12-26
EP1838355B1 (en) 2013-08-14
JP5718840B2 (ja) 2015-05-13
CN103961731B (zh) 2017-01-18
BRPI0518198B8 (pt) 2021-06-22
ES2429088T3 (es) 2013-11-13

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
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