HK1103722A1 - Production method - Google Patents

Production method

Info

Publication number
HK1103722A1
HK1103722A1 HK07107855.2A HK07107855A HK1103722A1 HK 1103722 A1 HK1103722 A1 HK 1103722A1 HK 07107855 A HK07107855 A HK 07107855A HK 1103722 A1 HK1103722 A1 HK 1103722A1
Authority
HK
Hong Kong
Prior art keywords
production method
production
Prior art date
Application number
HK07107855.2A
Other languages
English (en)
Inventor
Mathias Berwe
Christian Thomas
Joachim Rehse
Dirk Grotjohann
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34716548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1103722(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of HK1103722A1 publication Critical patent/HK1103722A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
HK07107855.2A 2004-01-15 2007-07-20 Production method HK1103722A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004002044A DE102004002044A1 (de) 2004-01-15 2004-01-15 Herstellverfahren
PCT/EP2004/014870 WO2005068456A1 (fr) 2004-01-15 2004-12-31 Procede de preparation

Publications (1)

Publication Number Publication Date
HK1103722A1 true HK1103722A1 (en) 2007-12-28

Family

ID=34716548

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07107855.2A HK1103722A1 (en) 2004-01-15 2007-07-20 Production method

Country Status (33)

Country Link
US (1) US7351823B2 (fr)
EP (1) EP1720866B1 (fr)
JP (2) JP5311742B2 (fr)
KR (1) KR20130004257A (fr)
CN (1) CN1906191B (fr)
AR (1) AR047389A1 (fr)
AT (1) ATE518856T1 (fr)
AU (1) AU2004313694B2 (fr)
BR (1) BRPI0418405B8 (fr)
CA (1) CA2553237C (fr)
CY (1) CY1112565T1 (fr)
DE (1) DE102004002044A1 (fr)
DK (1) DK1720866T3 (fr)
EC (1) ECSP066703A (fr)
ES (1) ES2369140T3 (fr)
GT (1) GT200400277A (fr)
HK (1) HK1103722A1 (fr)
HN (1) HN2005000016A (fr)
HR (1) HRP20110796T1 (fr)
IL (1) IL176767A (fr)
MA (1) MA28290A1 (fr)
MY (1) MY138944A (fr)
NO (1) NO335553B1 (fr)
NZ (1) NZ548506A (fr)
PE (1) PE20050763A1 (fr)
PL (1) PL1720866T3 (fr)
PT (1) PT1720866E (fr)
RU (1) RU2383540C2 (fr)
SI (1) SI1720866T1 (fr)
TW (1) TWI340137B (fr)
UY (1) UY28718A1 (fr)
WO (1) WO2005068456A1 (fr)
ZA (1) ZA200605747B (fr)

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* Cited by examiner, † Cited by third party
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DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (fr) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention et traitement de troubles thromboemboliques
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
DE102005047564A1 (de) * 2005-10-04 2007-05-31 Bayer Healthcare Ag Amorphe Form von 5-Chlor-N-({(5S)2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl)-methyl)-2-thiophencarboxamid
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
DE102005047558A1 (de) * 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DK1934208T3 (da) * 2005-10-04 2011-07-18 Bayer Schering Pharma Ag Ny polymorf form af 5-chlor-N-({(5S)-2-0x0-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE102006007146A1 (de) 2006-02-16 2007-08-23 Bayer Healthcare Ag Aminoacyl-Prodrugs
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
DE102006051625A1 (de) * 2006-11-02 2008-05-08 Bayer Materialscience Ag Kombinationstherapie substituierter Oxazolidinone
DE102007028407A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
WO2009018807A1 (fr) * 2007-08-06 2009-02-12 Schebo Biotech Ag Oxazolidinones utilisées comme inhibiteurs du facteur xa, procédé pour leur production et leur utilisation thérapeutique
US8706950B2 (en) 2008-03-01 2014-04-22 Kabushiki Kaisha Toshiba Memory system
DE102008028071A1 (de) 2008-06-12 2009-12-17 Bayer Schering Pharma Aktiengesellschaft Neue Cokristall-Verbindung von Rivaroxaban und Malonsäure
US20100168111A1 (en) * 2008-12-31 2010-07-01 Apotex Pharmachem Inc. Polymorphic form of 5 chloro n {[(5s) 2 oxo 3 [4 (3 oxomorpholin 4 yl)phenyl]oxa-zolidin 5 yl]-methyl}thiophene 2 carboxamide
US8435989B2 (en) * 2009-04-28 2013-05-07 Apotex Pharmachem Inc. Processes for the preparation of rivaroxaban and intermediates thereof
US8309547B2 (en) * 2009-04-28 2012-11-13 Apotex Pharmachem Inc. Processes for the preparation of rivaroxaban and intermediates thereof
US7816355B1 (en) 2009-04-28 2010-10-19 Apotex Pharmachem Inc Processes for the preparation of rivaroxaban and intermediates thereof
ES2905760T3 (es) 2009-07-31 2022-04-12 Krka D D Novo Mesto Procedimientos para la cristalización del rivaroxabán
EP2521723A1 (fr) * 2010-01-04 2012-11-14 Enantia, S.L. Procédé de préparation de rivaroxaban et ses intermédiaires
DE102010028362A1 (de) 2010-04-29 2011-11-03 Bayer Schering Pharma Aktiengesellschaft Herstellverfahren
EP2388260A1 (fr) 2010-05-21 2011-11-23 Archimica GmbH Procédé de fabrication pour un inhibiteur d'un facteur de coagulation sanguine
CN102311400A (zh) * 2010-06-29 2012-01-11 翔真生物科技股份有限公司 制备5-左旋-氨甲基-3-芳基-2-恶唑烷酮类的方法
EP2404920A1 (fr) 2010-07-06 2012-01-11 Sandoz AG Form cristalline de Rivaroxaban dihydrate
US20130253187A1 (en) * 2010-09-14 2013-09-26 Medichem, S.A. Process for Determining the Suitability for Distribution of a Batch of Thiophene-2-Carboxamide Derivative
CZ2010714A3 (cs) * 2010-09-30 2012-04-11 Farmak, A. S. Zpusob výroby 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morfolinyl)fenyl]-1,3oxazolidin-5-yl}methyl)-1H-isoindol-1,3(2H)-dionu ve vysoké optické cistote
AU2010362639B2 (en) 2010-10-18 2016-10-27 Apotex Pharmachem Inc. Processes for the preparation of Rivaroxaban and intermediates thereof
GEP20156397B (en) * 2011-05-06 2015-11-10 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Process for the preparation of a rivaroxaban and intermediates formed in said process
WO2012156983A1 (fr) * 2011-05-16 2012-11-22 Symed Labs Limited Procédés pour la préparation de 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phényl]-1,3-oxazolidin-5-yl}méthyl)-2-thiophènecarboxamide
ES2395304B1 (es) 2011-05-20 2014-01-16 Interquim, S.A. Procedimiento de obtención de una tiofen-2-carboxamida.
CN102250076A (zh) * 2011-05-27 2011-11-23 横店集团家园化工有限公司 一种利伐沙班中间体及利伐沙班的制备方法
CN102827154B (zh) * 2011-06-14 2015-04-22 上海科胜药物研发有限公司 一种合成利伐沙班中间体4-{4-[(5s)-5-(氨基甲基)-2-氧代-1,3-恶唑烷-3-基]苯基}吗啉-3-酮的方法
US20140378682A1 (en) 2011-09-08 2014-12-25 Cadila Healthcare Limited Processes and intermediates for preparing rivaroxaban
WO2013053739A1 (fr) 2011-10-10 2013-04-18 Laboratorios Lesvi, S. L. Procédé de préparation d'inhibiteurs du facteur xa
WO2013121436A2 (fr) * 2012-02-06 2013-08-22 Megafine Pharma (P) Ltd Procédé de préparation de rivaroxaban et de ses intermédiaires
CZ2012114A3 (cs) * 2012-02-17 2013-02-20 Zentiva, K.S. Zpusob prípravy rivaroxabanu zalozený na úspore 1,1´ -karbonyldiimidazolu
CN103288814B (zh) 2012-02-24 2016-07-06 国药集团国瑞药业有限公司 一种利伐沙班中间体的制备方法
CN102659756A (zh) * 2012-04-01 2012-09-12 南京哈柏医药科技有限公司 5-氯-2-酰氯噻吩的合成方法
EP2834235A1 (fr) 2012-04-06 2015-02-11 Indiana University Research and Technology Corporation Procédés de préparation du rivaroxaban
CN104487436B (zh) 2012-05-02 2017-05-24 信谊实验室有限公司 使用中间产物制备利伐沙班的改良方法
CN102757424B (zh) * 2012-07-09 2014-10-15 云南大学 2-苄基取代苯并呋喃—咪唑盐类化合物及其制备方法
CN102746288B (zh) * 2012-07-24 2015-04-08 常州制药厂有限公司 一种抗凝血药及其关键中间体的制备方法
WO2014020458A1 (fr) * 2012-08-01 2014-02-06 Alembic Pharmaceuticals Limited Procédé amélioré de préparation du rivaroxaban
CN102786516B (zh) * 2012-08-21 2014-10-01 湖南师范大学 一种利伐沙班的合成方法
CN103833724A (zh) * 2012-11-20 2014-06-04 上海医药工业研究院 一种5-氯噻吩-2-甲酰氯的制备方法
CN103864771A (zh) * 2012-12-13 2014-06-18 北京京卫信康医药科技发展有限公司 一种利伐沙班的制备方法
CN103864772A (zh) * 2012-12-13 2014-06-18 北京京卫信康医药科技发展有限公司 一种利伐沙班及其中间体的制备方法
EP3309158B1 (fr) 2012-12-21 2022-03-16 Krka, tovarna zdravil, d.d. Forme cristalline k du rivaroxaban et procédé de préparation
WO2014102820A2 (fr) 2012-12-26 2014-07-03 Wanbury Ltd. Intermédiaire du rivaroxaban et sa préparation
US9359341B2 (en) 2012-12-26 2016-06-07 Wanbury Ltd. Aldehyde derivative of substitute oxazolidinones
WO2014155259A2 (fr) 2013-03-25 2014-10-02 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Procédé pour la préparation de rivaroxaban
CN104109158A (zh) * 2013-04-16 2014-10-22 上海医药工业研究院 一种纯化利伐沙班的方法
CN103275061A (zh) * 2013-06-04 2013-09-04 上海同昌生物医药科技有限公司 一种生产5-氯噻吩-2-羧酸的方法
CN103351385A (zh) * 2013-06-28 2013-10-16 浙江燎原药业有限公司 一种利伐沙班中间体的制备方法
CN103709116B (zh) * 2013-12-10 2015-09-23 四川大学 一种4-(4-烷氧羰氨基)苯基-3-吗啉酮的制备方法
CN103724336B (zh) * 2013-12-24 2015-10-21 悦康药业集团有限公司 一种新型抗凝血药物的合成方法
IN2014MU00072A (fr) 2014-01-08 2015-08-21 Wockhardt Ltd
WO2015111076A2 (fr) 2014-01-23 2015-07-30 Symed Labs Limited Procédés améliorés pour la préparation d'une modification cristalline i de rivaroxaban à haute pureté
CN105085370B (zh) * 2014-04-22 2017-04-12 北大方正集团有限公司 (s)‑1‑卤代‑2‑[2‑(1,3‑二氧异吲哚)基]乙基氯甲酸酯及其制备方法
CN105693746B (zh) * 2014-06-14 2018-09-14 广东东阳光药业有限公司 噁唑烷酮类化合物的制备方法及其中间体
CN104086539A (zh) * 2014-07-17 2014-10-08 天津炜捷制药有限公司 一种利伐沙班的制备方法
CN104211693B (zh) * 2014-08-07 2017-02-22 成都百裕制药股份有限公司 一种利伐沙班晶型及其制备方法与用途
CN104211694A (zh) * 2014-08-14 2014-12-17 广东东阳光药业有限公司 一种改进的制备Xa因子抑制剂的方法
WO2016030669A1 (fr) * 2014-08-25 2016-03-03 Cipla Limited Procédé de préparation du rivaroxaban
US10040786B2 (en) 2014-10-22 2018-08-07 Zaklady Farmaceutyczne Polphamra Sa Process for preparing a polymorph of rivaroxaban
CN104807934B (zh) * 2015-04-30 2017-01-18 成都百裕制药股份有限公司 异吲哚二酮类化合物的正相高效液相色谱检测方法
CN105130976A (zh) * 2015-08-26 2015-12-09 浙江车头制药股份有限公司 一种利伐沙班中间体的合成方法
CN105440028B (zh) * 2015-12-07 2018-03-13 石家庄康贺威药业有限公司 一种利伐沙班化合物及其制备方法
CN106008490B (zh) * 2016-01-11 2019-01-04 南京生命能科技开发有限公司 一种利伐沙班的新晶体及其制备方法
CN106977507A (zh) * 2017-04-21 2017-07-25 上海华源医药科技发展有限公司 一种利伐沙班的制备方法
CN109553611A (zh) * 2017-09-23 2019-04-02 齐鲁制药有限公司 利伐沙班中间体的制备方法和用途
CN111699184B (zh) * 2018-02-26 2023-05-23 住友化学株式会社 噁唑烷酮化合物的制造方法
JP7339754B2 (ja) * 2019-03-27 2023-09-06 ダイト株式会社 中間体の製造方法
CN112521380A (zh) * 2020-12-14 2021-03-19 哈尔滨珍宝制药有限公司 一种利伐沙班中间体a的合成方法及其在制备利伐沙班中的应用
AU2022280865A1 (en) * 2021-05-28 2023-11-09 Merck Sharp & Dohme Llc Synthesis of btk inhibitor and intermediates thereof
EP4201933A1 (fr) * 2021-12-23 2023-06-28 Zaklady Farmaceutyczne Polpharma S.A. Processus de cristallisation de rivaroxaban

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
DE10300111A1 (de) * 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid

Also Published As

Publication number Publication date
KR20130004257A (ko) 2013-01-09
RU2006129341A (ru) 2008-02-20
MY138944A (en) 2009-08-28
TWI340137B (en) 2011-04-11
HRP20110796T1 (hr) 2011-12-31
HN2005000016A (es) 2009-06-01
ECSP066703A (es) 2006-10-31
DK1720866T3 (da) 2011-11-21
NZ548506A (en) 2009-06-26
ZA200605747B (en) 2007-10-31
SI1720866T1 (sl) 2012-01-31
RU2383540C2 (ru) 2010-03-10
IL176767A0 (en) 2006-10-31
CA2553237A1 (fr) 2005-07-28
JP2012097106A (ja) 2012-05-24
ES2369140T3 (es) 2011-11-25
BRPI0418405B1 (pt) 2018-03-13
MA28290A1 (fr) 2006-11-01
NO20063677L (no) 2006-10-11
BRPI0418405A (pt) 2007-05-15
CY1112565T1 (el) 2016-02-10
AU2004313694A1 (en) 2005-07-28
ATE518856T1 (de) 2011-08-15
CA2553237C (fr) 2012-04-17
DE102004002044A1 (de) 2005-08-04
TW200604195A (en) 2006-02-01
WO2005068456A1 (fr) 2005-07-28
CN1906191A (zh) 2007-01-31
GT200400277A (es) 2005-08-18
IL176767A (en) 2011-04-28
BRPI0418405B8 (pt) 2021-05-25
US20050182055A1 (en) 2005-08-18
UY28718A1 (es) 2005-08-31
CN1906191B (zh) 2010-05-26
US7351823B2 (en) 2008-04-01
JP5311742B2 (ja) 2013-10-09
NO335553B1 (no) 2014-12-29
AU2004313694B2 (en) 2011-06-02
EP1720866B1 (fr) 2011-08-03
PT1720866E (pt) 2011-10-12
PE20050763A1 (es) 2005-12-02
PL1720866T3 (pl) 2012-01-31
AR047389A1 (es) 2006-01-18
JP2007517816A (ja) 2007-07-05
EP1720866A1 (fr) 2006-11-15

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