HK1100774A1 - 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp- ribose) polymerase inhibitors - Google Patents
7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp- ribose) polymerase inhibitorsInfo
- Publication number
- HK1100774A1 HK1100774A1 HK07105886.9A HK07105886A HK1100774A1 HK 1100774 A1 HK1100774 A1 HK 1100774A1 HK 07105886 A HK07105886 A HK 07105886A HK 1100774 A1 HK1100774 A1 HK 1100774A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- quinoxalinones
- quinolinones
- adp
- ribose
- poly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03078650 | 2003-11-20 | ||
PCT/EP2004/013162 WO2005054209A1 (en) | 2003-11-20 | 2004-11-18 | 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1100774A1 true HK1100774A1 (en) | 2007-09-28 |
Family
ID=34639291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07105886.9A HK1100774A1 (en) | 2003-11-20 | 2007-06-04 | 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp- ribose) polymerase inhibitors |
Country Status (19)
Country | Link |
---|---|
US (2) | US7928104B2 (ja) |
EP (1) | EP1709011B1 (ja) |
JP (1) | JP4864717B2 (ja) |
KR (1) | KR101118644B1 (ja) |
CN (1) | CN1882549B (ja) |
AU (1) | AU2004295057B2 (ja) |
BR (1) | BRPI0416817A (ja) |
CA (1) | CA2546002C (ja) |
EA (1) | EA011211B1 (ja) |
ES (1) | ES2551027T3 (ja) |
HK (1) | HK1100774A1 (ja) |
IL (1) | IL175756A (ja) |
MX (1) | MXPA06005686A (ja) |
NO (1) | NO337252B1 (ja) |
NZ (1) | NZ546990A (ja) |
SG (1) | SG150534A1 (ja) |
UA (1) | UA91002C2 (ja) |
WO (1) | WO2005054209A1 (ja) |
ZA (1) | ZA200604076B (ja) |
Families Citing this family (33)
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JP4864718B2 (ja) * | 2003-11-20 | 2012-02-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ポリ(adp−リボース)ポリメラーゼ阻害剤としての6−アルケニルおよび6−フェニルアルキル置換2−キノリノンおよび2−キノキサリノン |
SG150533A1 (en) | 2003-11-20 | 2009-03-30 | Janssen Pharmaceutica Nv | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2- quinoxalinones as poly(adp-ribose) polymerase inhibitors |
NZ546990A (en) * | 2003-11-20 | 2010-03-26 | Janssen Pharmaceutica Nv | 7-Phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors |
UA89618C2 (ru) * | 2003-12-05 | 2010-02-25 | Янссен Фармацевтика Н.В. | 6-замещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли(адф-рибоза)полимеразы |
DK1711181T3 (da) * | 2004-01-23 | 2010-02-01 | Janssen Pharmaceutica Nv | Quinolin-derivater og anvendelse af disse som mycobakterielle inhibitorer |
MXPA06014541A (es) | 2004-06-30 | 2007-03-23 | Janssen Pharmaceutica Nv | Derivados de quinazolindiona como inhibidores de la poli(adp-ribosa) polimerasa. |
CA2568835C (en) | 2004-06-30 | 2014-05-27 | Janssen Pharmaceutica N.V. | Quinazolinone derivatives as parp inhibitors |
AU2005259189B2 (en) * | 2004-06-30 | 2011-04-21 | Janssen Pharmaceutica N.V. | Phthalazine derivatives as PARP inhibitors |
JP5177429B2 (ja) | 2005-07-18 | 2013-04-03 | バイパー サイエンシズ,インコーポレイティド | 癌の治療 |
JO2952B1 (en) * | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
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CA2678248C (en) * | 2007-03-08 | 2016-06-28 | Janssen Pharmaceutica Nv | Quinolinone derivatives as parp and tank inhibitors |
US8404713B2 (en) * | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
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BR112014014529A2 (pt) | 2011-12-13 | 2019-09-24 | Buck Inst For Res On Aging | métodos para melhorar terapias médicas |
US20150064137A1 (en) | 2012-04-17 | 2015-03-05 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
CN108138177B9 (zh) | 2015-07-23 | 2021-08-13 | 法国居里学院 | Dbait分子与PARP抑制剂的组合用于治疗癌症的用途 |
GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
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US8546368B2 (en) | 2006-02-15 | 2013-10-01 | Abbvie Inc. | Pyrazoloquinolones are potent PARP inhibitors |
US8198448B2 (en) | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
US8466150B2 (en) | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
CA2678248C (en) | 2007-03-08 | 2016-06-28 | Janssen Pharmaceutica Nv | Quinolinone derivatives as parp and tank inhibitors |
US8153633B2 (en) | 2007-06-25 | 2012-04-10 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
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2004
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- 2004-11-18 CN CN2004800342874A patent/CN1882549B/zh not_active Expired - Fee Related
- 2004-11-18 EP EP04819600.0A patent/EP1709011B1/en active Active
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- 2004-11-18 EA EA200601007A patent/EA011211B1/ru not_active IP Right Cessation
- 2004-11-18 WO PCT/EP2004/013162 patent/WO2005054209A1/en active Application Filing
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- 2004-11-18 ES ES04819600.0T patent/ES2551027T3/es active Active
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- 2004-11-18 JP JP2006540337A patent/JP4864717B2/ja not_active Expired - Fee Related
- 2004-11-18 SG SG200901198-2A patent/SG150534A1/en unknown
- 2004-11-18 UA UAA200603547A patent/UA91002C2/ru unknown
- 2004-11-18 MX MXPA06005686A patent/MXPA06005686A/es active IP Right Grant
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- 2006-05-19 ZA ZA200604076A patent/ZA200604076B/en unknown
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Also Published As
Publication number | Publication date |
---|---|
NZ546990A (en) | 2010-03-26 |
KR101118644B1 (ko) | 2012-03-06 |
US7928104B2 (en) | 2011-04-19 |
JP2007513087A (ja) | 2007-05-24 |
ZA200604076B (en) | 2007-09-26 |
NO20062892L (no) | 2006-08-09 |
SG150534A1 (en) | 2009-03-30 |
US20110230492A1 (en) | 2011-09-22 |
NO337252B1 (no) | 2016-02-22 |
UA91002C2 (ru) | 2010-06-25 |
ES2551027T3 (es) | 2015-11-13 |
KR20060111532A (ko) | 2006-10-27 |
CN1882549A (zh) | 2006-12-20 |
EP1709011B1 (en) | 2015-07-29 |
EA200601007A1 (ru) | 2006-10-27 |
WO2005054209A1 (en) | 2005-06-16 |
JP4864717B2 (ja) | 2012-02-01 |
CA2546002A1 (en) | 2005-06-16 |
US8524714B2 (en) | 2013-09-03 |
US20080249099A1 (en) | 2008-10-09 |
IL175756A (en) | 2013-03-24 |
AU2004295057B2 (en) | 2010-11-25 |
EP1709011A1 (en) | 2006-10-11 |
CA2546002C (en) | 2012-09-18 |
MXPA06005686A (es) | 2006-08-17 |
EA011211B1 (ru) | 2009-02-27 |
AU2004295057A1 (en) | 2005-06-16 |
CN1882549B (zh) | 2011-02-23 |
BRPI0416817A (pt) | 2007-03-06 |
IL175756A0 (en) | 2006-09-05 |
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