SI2271626T1 - Tetrahidrofenantridinoni in tetrahidrociklopentakinolinoni, kot inhibitorji polimerizacije PARP in tubulina - Google Patents
Tetrahidrofenantridinoni in tetrahidrociklopentakinolinoni, kot inhibitorji polimerizacije PARP in tubulinaInfo
- Publication number
- SI2271626T1 SI2271626T1 SI200931124T SI200931124T SI2271626T1 SI 2271626 T1 SI2271626 T1 SI 2271626T1 SI 200931124 T SI200931124 T SI 200931124T SI 200931124 T SI200931124 T SI 200931124T SI 2271626 T1 SI2271626 T1 SI 2271626T1
- Authority
- SI
- Slovenia
- Prior art keywords
- tetrahydrophenanthridinones
- tetrahydrocyclopentaquinolinones
- parp
- polymerization inhibitors
- tubulin polymerization
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08153432 | 2008-03-27 | ||
PCT/EP2009/053598 WO2009118382A1 (en) | 2008-03-27 | 2009-03-26 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors |
EP09725177.1A EP2271626B1 (en) | 2008-03-27 | 2009-03-26 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2271626T1 true SI2271626T1 (sl) | 2015-03-31 |
Family
ID=39665796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200931124T SI2271626T1 (sl) | 2008-03-27 | 2009-03-26 | Tetrahidrofenantridinoni in tetrahidrociklopentakinolinoni, kot inhibitorji polimerizacije PARP in tubulina |
Country Status (15)
Country | Link |
---|---|
US (3) | US8889866B2 (sl) |
EP (1) | EP2271626B1 (sl) |
JP (1) | JP5492183B2 (sl) |
CN (1) | CN101981013B (sl) |
AU (1) | AU2009228943B2 (sl) |
BR (1) | BRPI0909017A2 (sl) |
CA (1) | CA2716726C (sl) |
DK (1) | DK2271626T3 (sl) |
ES (1) | ES2529545T3 (sl) |
HK (1) | HK1151796A1 (sl) |
HR (1) | HRP20150139T1 (sl) |
MX (1) | MX2010010406A (sl) |
RU (1) | RU2490260C2 (sl) |
SI (1) | SI2271626T1 (sl) |
WO (1) | WO2009118382A1 (sl) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2010010406A (es) * | 2008-03-27 | 2010-10-25 | Janssen Pharmaceutica Nv | Tetrahidrofenantridinonas y tetrahidrociclopentaquinolinonas como inhibidores de la polimerizacion de poli(adp-ribosa)polimerasa-1 y tubulina. |
EA022623B1 (ru) | 2010-10-06 | 2016-02-29 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Производные бензимидазола в качестве ингибиторов pi3-киназ |
MX2014000536A (es) | 2011-07-13 | 2014-12-05 | Novartis Ag | Compuestos de 4-piperidinilo para usarse como inhibidores de tanquirasa. |
WO2013012723A1 (en) | 2011-07-13 | 2013-01-24 | Novartis Ag | Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
JP2014520860A (ja) * | 2011-07-13 | 2014-08-25 | ノバルティス アーゲー | タンキラーゼ阻害剤として使用するための4−オキソ−3,5,7,8−テトラヒドロ−4H−ピラノ{4,3−d}ピルミニジニル化合物 |
WO2014085486A2 (en) | 2012-11-30 | 2014-06-05 | Waters Technologies Corporation | Methods and apparatus for the analysis of vitamin d metabolites |
CN103304494B (zh) * | 2013-06-20 | 2015-05-27 | 河北大学 | 茚(1,2-b)喹喔啉-11-酮肟衍生物及其制备方法和用途 |
CN108137598B (zh) | 2015-09-30 | 2021-02-12 | 湖北生物医药产业技术研究院有限公司 | 4H-吡唑并[1,5-α]苯并咪唑类化合物的盐型、晶型及其制备方法和中间体 |
SG11201811393WA (en) * | 2016-06-24 | 2019-01-30 | Univ California | Phthalazine derivatives as inhibitors of parp1, parp2 and/or tubulin useful for the treatment of cancer |
CN109761902B (zh) * | 2017-11-09 | 2022-06-10 | 四川大学 | 6-菲啶酮衍生物及其制备方法和用途 |
JP7372253B2 (ja) * | 2018-04-05 | 2023-10-31 | ノビガ・リサーチ・エービー | 癌の治療における使用のためのチューブリン重合阻害剤とポリ(adp-リボース)ポリメラーゼ(parp)阻害剤との新規組合せ |
MA52486B1 (fr) * | 2018-04-30 | 2023-04-28 | Ribon Therapeutics Inc | Pyridazinones utilisés en tant qu'inhibiteurs de parp7 |
CN108707147A (zh) * | 2018-06-20 | 2018-10-26 | 桑文军 | 一种新型微管蛋白抑制剂及其在抗肿瘤药物中的应用 |
AR120338A1 (es) | 2019-10-30 | 2022-02-09 | Ribon Therapeutics Inc | Piridazinonas como inhibidores de parp7 |
US11939335B2 (en) | 2022-05-17 | 2024-03-26 | 858 Therapeutics, Inc. | Substituted imidazo[1,2-a]quinazolines and imidazo [1,2-a]pyrido[4,3-e]pyrimidines as inhibitors of PARG |
WO2023224998A1 (en) * | 2022-05-17 | 2023-11-23 | 858 Therapeutics, Inc. | Inhibitors of parg |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB732581A (en) | 1952-01-18 | 1955-06-29 | Ciba Ltd | Manufacture of hydrazine compounds |
DE1006423B (de) | 1952-01-18 | 1957-04-18 | Ciba Geigy | Verfahren zur Herstellung von Hydrazinophthalazinen |
US3274194A (en) | 1963-03-29 | 1966-09-20 | Miles Lab | Quinazolinedione derivatives |
GB1062357A (en) | 1965-03-23 | 1967-03-22 | Pfizer & Co C | Quinazolone derivatives |
GB1293565A (en) | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
US3919425A (en) | 1971-04-09 | 1975-11-11 | Miles Lab | Method of producing vasodilation using certain 3-substituted-quinazoline derivatives |
BE792206A (sl) | 1971-12-02 | 1973-06-01 | Byk Gulden Lomberg Chem Fab | |
US3879393A (en) | 1973-06-18 | 1975-04-22 | Miles Lab | Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones |
FR2436781A1 (fr) | 1978-09-19 | 1980-04-18 | Berri Balzac | Derives d'amino-3 (1h,3h) quinazolinedione-2,4, leur procede de preparation et leurs applications en therapeutique |
US4335127A (en) | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
JPS5976082A (ja) | 1982-10-23 | 1984-04-28 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
JPS60120872A (ja) | 1983-12-01 | 1985-06-28 | Kyowa Hakko Kogyo Co Ltd | 新規なヘテロ環状化合物及び強心剤 |
PL147465B1 (en) | 1984-03-26 | 1989-06-30 | Janssen Pharmaceutica Nv | Method of obtaining novel pyridazionoamine compounds |
US5001125A (en) | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
DK623586A (da) | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
US5231184A (en) | 1987-11-23 | 1993-07-27 | Janssen Pharmaceutica N.V. | Pridazinamine derivatives |
US5177075A (en) | 1988-08-19 | 1993-01-05 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
CA2002864C (en) | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
GB8827822D0 (en) | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
US5374637A (en) | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
EP0391462A1 (en) | 1989-04-05 | 1990-10-10 | Janssen Pharmaceutica N.V. | Synergistic compositions containing ketanserin |
US5160727A (en) | 1990-02-13 | 1992-11-03 | Warner-Lambert Company | Tumor cell sensitization method using quinazolinedione derivatives |
IE913473A1 (en) | 1990-10-15 | 1992-04-22 | Fujisawa Pharmaceutical Co | Quinazoline derivatives and their preparation |
DK0637306T3 (da) | 1992-04-23 | 2001-07-30 | Merrell Pharma Inc | 4-Imidomethyl-1-[2'-phenyl-2'-oxoethyl]-piperidiner som serotonin-5HT2-antagonister, deres fremstilling og anvendelse til terapi |
TW294595B (sl) | 1992-11-20 | 1997-01-01 | Janssen Pharmaceutica Nv | |
CA2118117A1 (en) | 1993-02-18 | 1994-08-19 | Shigeki Fujiwara | Adenosine uptake inhibitor |
US6270867B1 (en) * | 1993-06-24 | 2001-08-07 | Pechiney Plastic Packaging, Inc. | Structures of polymers made from single site catalysts |
GB9404485D0 (en) | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
TW445263B (en) | 1996-02-29 | 2001-07-11 | Janssen Pharmaceutica Nv | Novel esters of 1,4-disubstituted piperidine derivatives |
JPH107572A (ja) | 1996-06-17 | 1998-01-13 | Sumitomo Pharmaceut Co Ltd | 腫瘍壊死因子産生阻害剤 |
EP0927192B1 (de) | 1996-09-10 | 2004-05-12 | Boehringer Ingelheim Pharma GmbH & Co.KG | Abgewandelte aminosäuren, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
TW460464B (en) * | 1996-11-25 | 2001-10-21 | Nippon Kayaku Kk | Novel phenanthridinium derivative having an anti-tumor activity and pharmaceutical composition containing the same |
CA2291630A1 (en) | 1997-05-30 | 1998-12-03 | Tetsutaro Niizato | Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same |
JPH10330377A (ja) | 1997-06-02 | 1998-12-15 | Kyowa Hakko Kogyo Co Ltd | ピペリジン誘導体 |
US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
US20030069231A1 (en) | 1999-10-12 | 2003-04-10 | Klaus Rudolf | Modified aminoacids, pharmaceuticals containing these compounds and method for their production |
EP1026160A4 (en) | 1997-09-16 | 2003-01-22 | Takeda Chemical Industries Ltd | CONNECTIONS WITH NITROGEN-CONDENSED RINGS, METHOD FOR THEIR PRODUCTION AND MEDICINES |
US6133277A (en) | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
JP2000191659A (ja) | 1999-01-04 | 2000-07-11 | Sumitomo Pharmaceut Co Ltd | 腫瘍壊死因子産生阻害剤 |
JP4676062B2 (ja) | 1999-01-29 | 2011-04-27 | アボット・ラボラトリーズ | ニコチン性アセチルコリン受容体リガンドとしてのジアザ2環式誘導体 |
US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
ATE400558T1 (de) | 2000-10-02 | 2008-07-15 | Janssen Pharmaceutica Nv | Metabotropische glutamatrezeptor-antagonisten |
ITMI20002358A1 (it) | 2000-10-31 | 2002-05-01 | Flavio Moroni | Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi |
AUPR201600A0 (en) | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
JP2002284699A (ja) | 2001-03-28 | 2002-10-03 | Sumitomo Pharmaceut Co Ltd | 視細胞変性疾患治療剤 |
JPWO2002094790A1 (ja) | 2001-05-23 | 2004-09-09 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
US6924284B2 (en) | 2001-08-15 | 2005-08-02 | Icos Corporation | PARP inhibitors |
WO2003039460A2 (en) | 2001-11-07 | 2003-05-15 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
AUPR975601A0 (en) | 2001-12-24 | 2002-01-31 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivatives |
AUPS137402A0 (en) * | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
CA2479109C (en) | 2002-03-29 | 2011-08-02 | Janssen Pharmaceutica N.V. | Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands |
US7119111B2 (en) | 2002-05-29 | 2006-10-10 | Amgen, Inc. | 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use |
AR043059A1 (es) | 2002-11-12 | 2005-07-13 | Bayer Pharmaceuticals Corp | Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos |
US20050075364A1 (en) | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
US7855207B2 (en) | 2003-11-20 | 2010-12-21 | Janssen Pharmaceutica, Nv | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adpribose) polymerase inhibitors |
JP4864718B2 (ja) * | 2003-11-20 | 2012-02-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ポリ(adp−リボース)ポリメラーゼ阻害剤としての6−アルケニルおよび6−フェニルアルキル置換2−キノリノンおよび2−キノキサリノン |
WO2005054209A1 (en) | 2003-11-20 | 2005-06-16 | Janssen Pharmaceutica N.V. | 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors |
EP2277865B1 (en) | 2003-12-03 | 2014-11-12 | YM BioSciences Australia Pty Ltd | Phenyl-substituted 6-ring nitrogen-heterocycles as microtubule polymerisation inhibitors |
NZ547193A (en) | 2003-12-05 | 2010-03-26 | Janssen Pharmaceutica Nv | 6-Substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
CA2548273C (en) | 2003-12-10 | 2013-04-16 | Janssen Pharmaceutica N.V. | Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
PE20060285A1 (es) | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
DE102004023332A1 (de) | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
JP4991527B2 (ja) | 2004-06-01 | 2012-08-01 | ユニバーシティ オブ バージニア パテント ファンデーション | 二つの部分からなる低分子量の癌および血管新生の抑制剤 |
JP4969443B2 (ja) | 2004-06-30 | 2012-07-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Parp阻害剤としてのキナゾリノン誘導体 |
SG154432A1 (en) * | 2004-06-30 | 2009-08-28 | Janssen Pharmaceutica Nv | Quinazolinedione derivatives as parp inhibitors |
EP1771175B1 (en) | 2004-06-30 | 2015-12-23 | Janssen Pharmaceutica NV | Phthalazine derivatives as parp inhibitors |
WO2006091246A1 (en) * | 2004-11-01 | 2006-08-31 | University Of Southern California | Novel compounds for treatment of cancer and disorders associated with angiogenesis function |
NZ560712A (en) | 2005-02-17 | 2010-12-24 | Synta Pharmaceuticals Corp | (3,4,5-trisubstituted-phenyl)isoxazole combretastin derivatives for the treatment of disorders |
CA2607727A1 (en) | 2005-04-28 | 2006-11-09 | Mitsubishi Tanabe Pharma Corporation | Cyanopyridine derivative and use thereof as medicine |
CN101316592A (zh) | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
CN101316822A (zh) * | 2005-09-30 | 2008-12-03 | 詹森药业有限公司 | 作为RXR激动剂用于治疗异常脂肪血症、高胆固醇血症和糖尿病的1,2,3,5-四氢-环戊烯并[c]喹啉-4-酮衍生物 |
JP5315060B2 (ja) | 2006-02-03 | 2013-10-16 | バイオノミックス リミテッド | 置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用 |
TW200811173A (en) | 2006-02-15 | 2008-03-01 | Abbott Lab | Pyrazoloquinolones are potent PART inhibitors |
US8198448B2 (en) | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
US8466150B2 (en) | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
ATE542799T1 (de) | 2007-03-08 | 2012-02-15 | Janssen Pharmaceutica Nv | Chinolinonderivate als parp und tank-inhibitoren |
AU2008269128B2 (en) | 2007-06-25 | 2012-08-02 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
MX2010010406A (es) * | 2008-03-27 | 2010-10-25 | Janssen Pharmaceutica Nv | Tetrahidrofenantridinonas y tetrahidrociclopentaquinolinonas como inhibidores de la polimerizacion de poli(adp-ribosa)polimerasa-1 y tubulina. |
-
2009
- 2009-03-26 MX MX2010010406A patent/MX2010010406A/es active IP Right Grant
- 2009-03-26 ES ES09725177.1T patent/ES2529545T3/es active Active
- 2009-03-26 RU RU2010143857/04A patent/RU2490260C2/ru active
- 2009-03-26 US US12/934,753 patent/US8889866B2/en active Active
- 2009-03-26 BR BRPI0909017-7A patent/BRPI0909017A2/pt not_active Application Discontinuation
- 2009-03-26 DK DK09725177.1T patent/DK2271626T3/en active
- 2009-03-26 CN CN2009801123862A patent/CN101981013B/zh active Active
- 2009-03-26 WO PCT/EP2009/053598 patent/WO2009118382A1/en active Application Filing
- 2009-03-26 EP EP09725177.1A patent/EP2271626B1/en active Active
- 2009-03-26 SI SI200931124T patent/SI2271626T1/sl unknown
- 2009-03-26 AU AU2009228943A patent/AU2009228943B2/en not_active Ceased
- 2009-03-26 JP JP2011501234A patent/JP5492183B2/ja active Active
- 2009-03-26 CA CA2716726A patent/CA2716726C/en active Active
-
2011
- 2011-06-10 HK HK11105902.3A patent/HK1151796A1/xx not_active IP Right Cessation
-
2014
- 2014-10-14 US US14/513,814 patent/US9150540B2/en active Active
-
2015
- 2015-02-04 HR HRP20150139TT patent/HRP20150139T1/hr unknown
- 2015-08-18 US US14/829,493 patent/US9598396B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US8889866B2 (en) | 2014-11-18 |
CA2716726C (en) | 2017-01-24 |
AU2009228943B2 (en) | 2013-04-04 |
RU2490260C2 (ru) | 2013-08-20 |
US9150540B2 (en) | 2015-10-06 |
EP2271626A1 (en) | 2011-01-12 |
US20150038521A1 (en) | 2015-02-05 |
ES2529545T3 (es) | 2015-02-23 |
US9598396B2 (en) | 2017-03-21 |
US20110263622A1 (en) | 2011-10-27 |
RU2010143857A (ru) | 2012-05-10 |
CN101981013A (zh) | 2011-02-23 |
CA2716726A1 (en) | 2009-10-01 |
AU2009228943A1 (en) | 2009-10-01 |
JP2011515450A (ja) | 2011-05-19 |
MX2010010406A (es) | 2010-10-25 |
CN101981013B (zh) | 2013-05-29 |
WO2009118382A1 (en) | 2009-10-01 |
HRP20150139T1 (hr) | 2015-05-22 |
BRPI0909017A2 (pt) | 2020-11-10 |
DK2271626T3 (en) | 2015-02-23 |
US20150353526A1 (en) | 2015-12-10 |
HK1151796A1 (en) | 2012-02-10 |
EP2271626B1 (en) | 2014-11-26 |
JP5492183B2 (ja) | 2014-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1151796A1 (en) | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors | |
HK1161583A1 (en) | Deacetylase inhibitors and uses thereof | |
IL211549A0 (en) | Aminotriazolopyridines and their use as kinase inhibitors | |
HK1196358A1 (en) | Substituted pyridin-2-ones and pyridazin-3-ones -2--3- | |
ZA201404552B (en) | Benzoxepin pi3k inhibitor compound and use thereof | |
EP2344481A4 (en) | VIRUS AND FUNGI | |
IL209267A0 (en) | Combinations comprising methotrexate and dhodh inhibitors | |
ZA201100211B (en) | Kinase inhibitors and methods of use | |
EP2200977A4 (en) | F1F0-ATPASE INHIBITOR AND ASSOCIATED METHODS | |
IL213625A0 (en) | Combinations comprising methotrexate and dhodh inhibitors | |
IL212755A0 (en) | Pyrazinopyrazines and derivatives as kinase inhibitors | |
IL208483A (en) | 2 limk inhibitors and preparations containing them | |
DK2358710T3 (da) | AKT- og P70-S6-kinaseinhibitorer | |
HRP20171390T1 (hr) | Inhibitor tolerancije na analgetike | |
IL223202A0 (en) | Substituted isoquinolines and their use as tubulin polymerization inhibitors | |
GB0918601D0 (en) | Decahydro-1H-Indenoquinolinone and decahydro-3H-cyclopenaphenanthridinone CYP17 inhibitors | |
EP2379076A4 (en) | PHOSPHODIESTERASE HEMMER AND ITS USES | |
ZA201102837B (en) | Phosphodiestarase inhibitors | |
IL215552A0 (en) | Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3- carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors | |
IL214333A0 (en) | Carbamoylphosphonates as inhibitors and uses thereof | |
TWI366394B (en) | Synchronnization devices and methods | |
GB201019387D0 (en) | Inhibitors | |
GB0805693D0 (en) | Combinations of P13-delta and P13-gamma kinase inhibitor compounds |