HK1151796A1 - Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors - Google Patents

Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors

Info

Publication number
HK1151796A1
HK1151796A1 HK11105902.3A HK11105902A HK1151796A1 HK 1151796 A1 HK1151796 A1 HK 1151796A1 HK 11105902 A HK11105902 A HK 11105902A HK 1151796 A1 HK1151796 A1 HK 1151796A1
Authority
HK
Hong Kong
Prior art keywords
tetrahydrophenanthridinones
tetrahydrocyclopentaquinolinones
parp
polymerization inhibitors
tubulin polymerization
Prior art date
Application number
HK11105902.3A
Other languages
English (en)
Inventor
Patrick Rene Angibaud
Laurence Anne Mevellec
Bruno Roux
Pierre-Henri Storck
Christophe Meyer
Jorge Eduardo Vialard
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1151796A1 publication Critical patent/HK1151796A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK11105902.3A 2008-03-27 2011-06-10 Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors HK1151796A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08153432 2008-03-27
PCT/EP2009/053598 WO2009118382A1 (en) 2008-03-27 2009-03-26 Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors

Publications (1)

Publication Number Publication Date
HK1151796A1 true HK1151796A1 (en) 2012-02-10

Family

ID=39665796

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11105902.3A HK1151796A1 (en) 2008-03-27 2011-06-10 Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors

Country Status (15)

Country Link
US (3) US8889866B2 (sl)
EP (1) EP2271626B1 (sl)
JP (1) JP5492183B2 (sl)
CN (1) CN101981013B (sl)
AU (1) AU2009228943B2 (sl)
BR (1) BRPI0909017A2 (sl)
CA (1) CA2716726C (sl)
DK (1) DK2271626T3 (sl)
ES (1) ES2529545T3 (sl)
HK (1) HK1151796A1 (sl)
HR (1) HRP20150139T1 (sl)
MX (1) MX2010010406A (sl)
RU (1) RU2490260C2 (sl)
SI (1) SI2271626T1 (sl)
WO (1) WO2009118382A1 (sl)

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Publication number Priority date Publication date Assignee Title
US8889866B2 (en) * 2008-03-27 2014-11-18 Janssen Pharmaceutica, Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
NZ608069A (en) 2010-10-06 2014-06-27 Glaxosmithkline Llc Benzimidazole derivatives as pi3 kinase inhibitors
US9181266B2 (en) 2011-07-13 2015-11-10 Novartis Ag 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
CN103797006B (zh) 2011-07-13 2016-01-27 诺华股份有限公司 用作端锚聚合酶抑制剂的4-哌啶基化合物
WO2013010092A1 (en) * 2011-07-13 2013-01-17 Novartis Ag 4-oxo-3,5,7,8-tetrahydro-4h-pyrano {4,3-d} pyrminidinyl compounds for use as tankyrase inhibitors
WO2014085486A2 (en) 2012-11-30 2014-06-05 Waters Technologies Corporation Methods and apparatus for the analysis of vitamin d metabolites
CN103304494B (zh) * 2013-06-20 2015-05-27 河北大学 茚(1,2-b)喹喔啉-11-酮肟衍生物及其制备方法和用途
CN108137598B (zh) * 2015-09-30 2021-02-12 湖北生物医药产业技术研究院有限公司 4H-吡唑并[1,5-α]苯并咪唑类化合物的盐型、晶型及其制备方法和中间体
ES2964531T3 (es) * 2016-06-24 2024-04-08 Univ California Derivados de ftalazina como inhibidores de PARP1, PARP2 y/o tubulina útiles para el tratamiento del cáncer
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CN111936143A (zh) * 2018-04-05 2020-11-13 诺维嘉研究公司 用于治疗癌症的微管蛋白聚合抑制剂和聚(adp-核糖)聚合酶(parp)抑制剂的新型联用药品
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CN108707147A (zh) * 2018-06-20 2018-10-26 桑文军 一种新型微管蛋白抑制剂及其在抗肿瘤药物中的应用
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WO2023224998A1 (en) * 2022-05-17 2023-11-23 858 Therapeutics, Inc. Inhibitors of parg

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Also Published As

Publication number Publication date
AU2009228943B2 (en) 2013-04-04
RU2010143857A (ru) 2012-05-10
CN101981013A (zh) 2011-02-23
US9150540B2 (en) 2015-10-06
MX2010010406A (es) 2010-10-25
HRP20150139T1 (hr) 2015-05-22
EP2271626B1 (en) 2014-11-26
WO2009118382A1 (en) 2009-10-01
ES2529545T3 (es) 2015-02-23
AU2009228943A1 (en) 2009-10-01
CN101981013B (zh) 2013-05-29
JP2011515450A (ja) 2011-05-19
US20150038521A1 (en) 2015-02-05
SI2271626T1 (sl) 2015-03-31
DK2271626T3 (en) 2015-02-23
CA2716726A1 (en) 2009-10-01
US20110263622A1 (en) 2011-10-27
BRPI0909017A2 (pt) 2020-11-10
US8889866B2 (en) 2014-11-18
RU2490260C2 (ru) 2013-08-20
CA2716726C (en) 2017-01-24
EP2271626A1 (en) 2011-01-12
US9598396B2 (en) 2017-03-21
JP5492183B2 (ja) 2014-05-14
US20150353526A1 (en) 2015-12-10

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