HK1090933A1 - 穩定抗體的方法及穩定化溶液狀抗體製劑 - Google Patents

穩定抗體的方法及穩定化溶液狀抗體製劑

Info

Publication number
HK1090933A1
HK1090933A1 HK06112681.3A HK06112681A HK1090933A1 HK 1090933 A1 HK1090933 A1 HK 1090933A1 HK 06112681 A HK06112681 A HK 06112681A HK 1090933 A1 HK1090933 A1 HK 1090933A1
Authority
HK
Hong Kong
Prior art keywords
antibody
stabilizing
stabilized solution
type
preparation
Prior art date
Application number
HK06112681.3A
Other languages
English (en)
Inventor
上野裕司
栢下隆
石原淳
中倉政司
山內恭子
Original Assignee
Kyowa Hakko Kirin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34419308&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1090933(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyowa Hakko Kirin Co Ltd filed Critical Kyowa Hakko Kirin Co Ltd
Publication of HK1090933A1 publication Critical patent/HK1090933A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
HK06112681.3A 2003-10-01 2006-11-17 穩定抗體的方法及穩定化溶液狀抗體製劑 HK1090933A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003343645 2003-10-01
PCT/JP2004/014903 WO2005033143A1 (ja) 2003-10-01 2004-10-01 抗体の安定化方法及び安定化された溶液状抗体製剤

Publications (1)

Publication Number Publication Date
HK1090933A1 true HK1090933A1 (zh) 2007-01-05

Family

ID=34419308

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06112681.3A HK1090933A1 (zh) 2003-10-01 2006-11-17 穩定抗體的方法及穩定化溶液狀抗體製劑

Country Status (16)

Country Link
US (3) US8496930B2 (zh)
EP (2) EP1698640B2 (zh)
JP (1) JP4219932B2 (zh)
KR (1) KR100911091B1 (zh)
CN (1) CN100522998C (zh)
AU (1) AU2004277466C1 (zh)
CA (1) CA2540848C (zh)
CY (1) CY1117215T1 (zh)
DK (1) DK1698640T4 (zh)
ES (1) ES2562912T5 (zh)
HK (1) HK1090933A1 (zh)
HU (1) HUE026793T2 (zh)
PL (1) PL1698640T5 (zh)
PT (1) PT1698640E (zh)
SI (1) SI1698640T2 (zh)
WO (1) WO2005033143A1 (zh)

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AU2007240507B2 (en) * 2006-04-21 2013-07-18 Novartis Ag Antagonist anti-CD40 antibody pharmaceutical compositions
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
AU2008205512B2 (en) * 2007-01-16 2014-06-12 Abbvie Inc. Methods for treating psoriasis
CN101679507A (zh) * 2007-03-29 2010-03-24 艾博特公司 结晶抗人类il-12抗体
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
KR20190045414A (ko) * 2007-11-30 2019-05-02 애브비 바이오테크놀로지 리미티드 단백질 제형 및 이의 제조방법
WO2009117289A2 (en) 2008-03-18 2009-09-24 Abbott Laboratories Methods for treating psoriasis
EP2350649A4 (en) * 2008-11-28 2012-11-14 Abbott Lab STABLE ANTIBODY COMPOSITIONS AND METHODS FOR STABILIZING THE SAME
EP2427211A4 (en) * 2009-05-04 2013-05-01 Abbott Biotech Ltd STABLE FORMULATIONS WITH HIGH PROTEIN CONCENTRATION OF ANTI-TNF-ALPHA HUMAN ANTIBODIES
RU2527337C9 (ru) * 2009-06-04 2014-12-27 Альк Аг Стабилизированная композиция, включающая по крайней мере одно адренергическое соединение
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CN107496917B (zh) 2010-02-26 2021-06-11 诺沃—诺迪斯克有限公司 包含稳定抗体的组合物
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AR083034A1 (es) 2010-09-17 2013-01-30 Baxter Int ESTABILIZACION DE INMUNOGLOBULINAS Y OTRAS PROTEINAS MEDIANTE UNA FORMULACION ACUOSA CON CLORURO DE SODIO A pH ACIDO DEBIL A NEUTRO
MX344727B (es) 2010-11-11 2017-01-05 Abbvie Biotechnology Ltd Formulaciones liquidas de anticuerpos anti-tnf-alfa de alta concentracion mejoradas.
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CN105377237B (zh) * 2013-07-19 2019-04-19 德国赫素制药集团 使免疫反应的调节与生物药品的给药相关的方法和制剂
CN103772505B (zh) * 2013-12-18 2014-10-15 长春博迅生物技术有限责任公司 一种抗体试剂保存液
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JP7104629B2 (ja) * 2016-02-24 2022-07-21 ビステラ， インコーポレイテッド インフルエンザウイルスに対する抗体分子の製剤
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Also Published As

Publication number Publication date
JP4219932B2 (ja) 2009-02-04
CA2540848C (en) 2012-12-11
ES2562912T5 (es) 2020-02-18
HUE026793T2 (en) 2016-07-28
US20070020255A1 (en) 2007-01-25
US20150190507A1 (en) 2015-07-09
AU2004277466B2 (en) 2010-04-01
DK1698640T3 (en) 2016-02-15
US8496930B2 (en) 2013-07-30
US9011850B2 (en) 2015-04-21
AU2004277466C1 (en) 2022-06-23
KR20060089227A (ko) 2006-08-08
DK1698640T4 (da) 2019-09-02
SI1698640T1 (sl) 2016-03-31
EP3006463A1 (en) 2016-04-13
JPWO2005033143A1 (ja) 2007-11-15
SI1698640T2 (sl) 2019-08-30
PT1698640E (pt) 2016-03-31
CY1117215T1 (el) 2017-04-05
CN1856507A (zh) 2006-11-01
CA2540848A1 (en) 2005-04-14
PL1698640T3 (pl) 2016-05-31
EP1698640B2 (en) 2019-06-19
KR100911091B1 (ko) 2009-08-06
US20130280248A1 (en) 2013-10-24
EP1698640B1 (en) 2015-12-30
EP1698640A4 (en) 2008-09-17
PL1698640T5 (pl) 2019-12-31
AU2004277466A1 (en) 2005-04-14
WO2005033143A1 (ja) 2005-04-14
CN100522998C (zh) 2009-08-05
ES2562912T3 (es) 2016-03-09
US10172790B2 (en) 2019-01-08
EP1698640A1 (en) 2006-09-06

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