PL1698640T3 - Sposób stabilizacji przeciwciała i stabilizowany preparat przeciwciała w postaci roztworu - Google Patents

Sposób stabilizacji przeciwciała i stabilizowany preparat przeciwciała w postaci roztworu

Info

Publication number
PL1698640T3
PL1698640T3 PL04773700T PL04773700T PL1698640T3 PL 1698640 T3 PL1698640 T3 PL 1698640T3 PL 04773700 T PL04773700 T PL 04773700T PL 04773700 T PL04773700 T PL 04773700T PL 1698640 T3 PL1698640 T3 PL 1698640T3
Authority
PL
Poland
Prior art keywords
antibody
stabilizing
stabilized solution
type
preparation
Prior art date
Application number
PL04773700T
Other languages
English (en)
Other versions
PL1698640T5 (pl
Inventor
Yuji Ueno
Takashi Kayashita
Atsushi Ishihara
Masashi Nakakura
Kyoko Yamauchi
Original Assignee
Kyowa Hakko Kirin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34419308&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1698640(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyowa Hakko Kirin Co Ltd filed Critical Kyowa Hakko Kirin Co Ltd
Publication of PL1698640T3 publication Critical patent/PL1698640T3/pl
Publication of PL1698640T5 publication Critical patent/PL1698640T5/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
PL04773700T 2003-10-01 2004-10-01 Sposób stabilizacji przeciwciała i stabilizowany preparat przeciwciała w postaci roztworu PL1698640T5 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003343645 2003-10-01
PCT/JP2004/014903 WO2005033143A1 (ja) 2003-10-01 2004-10-01 抗体の安定化方法及び安定化された溶液状抗体製剤
EP04773700.2A EP1698640B2 (en) 2003-10-01 2004-10-01 Method of stabilizing antibody and stabilized solution-type antibody preparation

Publications (2)

Publication Number Publication Date
PL1698640T3 true PL1698640T3 (pl) 2016-05-31
PL1698640T5 PL1698640T5 (pl) 2019-12-31

Family

ID=34419308

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04773700T PL1698640T5 (pl) 2003-10-01 2004-10-01 Sposób stabilizacji przeciwciała i stabilizowany preparat przeciwciała w postaci roztworu

Country Status (15)

Country Link
US (3) US8496930B2 (pl)
EP (2) EP3006463A1 (pl)
JP (1) JP4219932B2 (pl)
KR (1) KR100911091B1 (pl)
CN (1) CN100522998C (pl)
AU (1) AU2004277466C1 (pl)
CA (1) CA2540848C (pl)
CY (1) CY1117215T1 (pl)
DK (1) DK1698640T4 (pl)
ES (1) ES2562912T5 (pl)
HU (1) HUE026793T2 (pl)
PL (1) PL1698640T5 (pl)
PT (1) PT1698640E (pl)
SI (1) SI1698640T2 (pl)
WO (1) WO2005033143A1 (pl)

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CN100522998C (zh) * 2003-10-01 2009-08-05 协和发酵麒麟株式会社 抗体的稳定化方法和被稳定的溶液状抗体制剂
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WO2007016562A2 (en) * 2005-07-29 2007-02-08 Amgen Inc. Formulations that inhibit protein aggregation
MX2008013508A (es) * 2006-04-21 2008-10-31 Novartis Ag Composiciones farmaceuticas de anticuerpos antagonistas anti-cd40.
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CA2681752A1 (en) * 2007-03-29 2008-10-09 Abbott Laboratories Crystalline anti-human 1l-12 antibodies
TWI543768B (zh) * 2007-11-30 2016-08-01 艾伯維生物技術有限責任公司 蛋白質調配物及製造其之方法
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
EP2274333A4 (en) * 2008-03-18 2011-06-15 Abbott Lab PROCESS FOR TREATING PSORIASIS
WO2010062896A1 (en) * 2008-11-28 2010-06-03 Abbott Laboratories Stable antibody compositions and methods for stabilizing same
MX2011011772A (es) * 2009-05-04 2012-02-08 Abbott Biotech Ltd Formulaicones estables de anticuerpos humanos anti-tnf-alfa con alta concentracion de proteina.
RU2527680C2 (ru) 2009-06-04 2014-09-10 Альк Аг Стабилизированная композиция, содержащая по меньшей мере одно адренергическое соединение
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BR112012021576A2 (pt) 2010-02-26 2016-10-25 Novo Nordisk As composições estáveis contendo anticorpo.
HUE047173T2 (hu) 2010-03-01 2020-04-28 Bayer Healthcare Llc Optimalizált monoklonális ellenanyagok szöveti faktor útvonal inhibitor (TFPI) ellen
RU2012153786A (ru) 2010-05-28 2014-07-10 Ново Нордиск А/С Стабильные многодозовые композиции, содержащие антитело и консервант
CA2810731A1 (en) * 2010-09-17 2012-03-22 Baxter International Inc. Stabilization of immunoglobulins and other proteins through aqueous formulation with sodium chloride at weak acidic to neutral ph
SG190069A1 (en) 2010-11-11 2013-06-28 Abbvie Biotechnology Ltd IMPROVED HIGH CONCENTRATION ANTI-TNFa ANTIBODY LIQUID FORMULATIONS
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
US8613919B1 (en) 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations
US8883979B2 (en) 2012-08-31 2014-11-11 Bayer Healthcare Llc Anti-prolactin receptor antibody formulations
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
JP6527697B2 (ja) 2013-01-28 2019-06-05 国立大学法人 熊本大学 タンパク質を安定化させたゲル状製剤
US20160151484A1 (en) * 2013-07-19 2016-06-02 Hexal Ag Methods and formulations which allow the modulation of immune responses related to the administration of a biopharmaceutical drug
CN103772505B (zh) * 2013-12-18 2014-10-15 长春博迅生物技术有限责任公司 一种抗体试剂保存液
WO2017083627A1 (en) 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN109195629A (zh) * 2016-02-24 2019-01-11 威特拉公司 流行性感冒抗体分子制剂
WO2017170626A1 (ja) * 2016-03-30 2017-10-05 千寿製薬株式会社 水性液剤
KR102735988B1 (ko) 2019-02-18 2024-12-03 일라이 릴리 앤드 캄파니 치료 항체 제제
EP3930757A1 (en) 2019-03-01 2022-01-05 President And Fellows Of Harvard College Methods and compositions for protein delivery
CN113924147A (zh) 2019-03-25 2022-01-11 威特拉公司 用于治疗和预防流感的组合物和方法
CN114746439A (zh) * 2019-10-11 2022-07-12 雷迪博士实验室有限公司 整合蛋白抗体的稳定制剂
JP2024518169A (ja) * 2021-05-05 2024-04-25 アイ２オー セラピューティクス，インク． 炎症性疾患および自己免疫疾患を処置するためのイオン性液体製剤
EP4429704A4 (en) 2021-11-10 2025-11-05 I2O Therapeutics Inc IONIC LIQUID COMPOSITIONS

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Also Published As

Publication number Publication date
EP1698640A4 (en) 2008-09-17
DK1698640T4 (da) 2019-09-02
EP1698640A1 (en) 2006-09-06
US10172790B2 (en) 2019-01-08
AU2004277466B2 (en) 2010-04-01
ES2562912T5 (es) 2020-02-18
HUE026793T2 (en) 2016-07-28
US8496930B2 (en) 2013-07-30
ES2562912T3 (es) 2016-03-09
EP1698640B1 (en) 2015-12-30
HK1090933A1 (en) 2007-01-05
AU2004277466C1 (en) 2022-06-23
US9011850B2 (en) 2015-04-21
CA2540848A1 (en) 2005-04-14
KR20060089227A (ko) 2006-08-08
EP3006463A1 (en) 2016-04-13
CA2540848C (en) 2012-12-11
SI1698640T1 (sl) 2016-03-31
PL1698640T5 (pl) 2019-12-31
KR100911091B1 (ko) 2009-08-06
PT1698640E (pt) 2016-03-31
US20150190507A1 (en) 2015-07-09
US20070020255A1 (en) 2007-01-25
DK1698640T3 (en) 2016-02-15
CY1117215T1 (el) 2017-04-05
SI1698640T2 (sl) 2019-08-30
AU2004277466A1 (en) 2005-04-14
JPWO2005033143A1 (ja) 2007-11-15
US20130280248A1 (en) 2013-10-24
EP1698640B2 (en) 2019-06-19
CN100522998C (zh) 2009-08-05
WO2005033143A1 (ja) 2005-04-14
CN1856507A (zh) 2006-11-01
JP4219932B2 (ja) 2009-02-04

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