HK1090422A1 - A system for determining the electrical potential across a membrane - Google Patents

A system for determining the electrical potential across a membrane

Info

Publication number
HK1090422A1
HK1090422A1 HK06107168.5A HK06107168A HK1090422A1 HK 1090422 A1 HK1090422 A1 HK 1090422A1 HK 06107168 A HK06107168 A HK 06107168A HK 1090422 A1 HK1090422 A1 HK 1090422A1
Authority
HK
Hong Kong
Prior art keywords
membrane
energy transfer
face
reagent
potential
Prior art date
Application number
HK06107168.5A
Other languages
English (en)
Chinese (zh)
Inventor
Roger Y Tsien
Jesus E Gonzalez
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23914150&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1090422(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ California filed Critical Univ California
Publication of HK1090422A1 publication Critical patent/HK1090422A1/xx

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/66—Thiobarbituric acids
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
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    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
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    • C07F5/027—Organoboranes and organoborohydrides
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07F9/10—Phosphatides, e.g. lecithin
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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  • Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
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  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Traffic Control Systems (AREA)
  • Measuring Instrument Details And Bridges, And Automatic Balancing Devices (AREA)
  • Image Input (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Measurement Of Current Or Voltage (AREA)
  • Electrostatic Charge, Transfer And Separation In Electrography (AREA)
  • Elimination Of Static Electricity (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK06107168.5A 1995-06-07 2006-06-23 A system for determining the electrical potential across a membrane HK1090422A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/481,977 US5661035A (en) 1995-06-07 1995-06-07 Voltage sensing by fluorescence resonance energy transfer

Publications (1)

Publication Number Publication Date
HK1090422A1 true HK1090422A1 (en) 2006-12-22

Family

ID=23914150

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06107168.5A HK1090422A1 (en) 1995-06-07 2006-06-23 A system for determining the electrical potential across a membrane

Country Status (11)

Country Link
US (2) US5661035A (de)
EP (3) EP0834074B2 (de)
JP (2) JP4033899B2 (de)
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Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
US6596522B2 (en) * 1997-05-08 2003-07-22 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US6342379B1 (en) 1995-06-07 2002-01-29 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US5661035A (en) * 1995-06-07 1997-08-26 The Regents Of The University Of California Voltage sensing by fluorescence resonance energy transfer
US5945526A (en) 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US7388092B2 (en) 1996-05-03 2008-06-17 Applera Corporation Oligonucleotides and analogs labeled with energy transfer dyes
US6593135B2 (en) * 1996-08-16 2003-07-15 The State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Long wavelength engineered fluorescent proteins
AT405103B (de) * 1996-10-16 1999-05-25 Avl Verbrennungskraft Messtech Sensorschicht zur quantitativen bestimmung zumindest einer chemischen komponente einer gasförmigen oder flüssigen probe
FR2756633B1 (fr) * 1996-11-29 1999-01-15 Centre Nat Rech Scient Methode de detection in vitro du potentiel transmembranaire mitochondrial
US6342345B1 (en) 1997-04-02 2002-01-29 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by reporter subunit complementation
FR2764387B1 (fr) * 1997-06-05 1999-07-23 Centre Nat Rech Scient Utilisation d'une proteine fluorescente pour la detection d'interactions entre une proteine cible et son ligand
US6214563B1 (en) 1997-08-01 2001-04-10 Aurora Biosciences Corporation Photon reducing agents for reducing undesired light emission in assays
US6221612B1 (en) 1997-08-01 2001-04-24 Aurora Biosciences Corporation Photon reducing agents for use in fluorescence assays
US6200762B1 (en) 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
US6348322B1 (en) * 1997-10-17 2002-02-19 Duke University Method of screening for specific binding interactions
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
EP1053253A4 (de) * 1998-02-05 2004-09-29 Merck & Co Inc Neue dns-sequenzen, die für einen gaba b-rezeptor kodieren.
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
AU4188599A (en) * 1998-05-15 1999-12-06 Geron Corporation Method and apparatus for detecting hazardous agents
US5998146A (en) * 1998-07-17 1999-12-07 Wallac Oy Homogeneous luminescence assay method based on energy transfer
DE69907962T2 (de) * 1998-12-14 2004-05-19 Vertex Pharmaceuticals (San Diego) Llc, San Diego Optische molekularsensoren für cytochrome p-450 aktivität
US6420130B1 (en) * 1998-12-14 2002-07-16 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
US8148110B2 (en) 1999-03-15 2012-04-03 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by β-lactamase reporter fragment complementation
US6285909B1 (en) 1999-05-27 2001-09-04 Cardiac Pacemakers, Inc. Preserving patient specific data in implantable pulse generator systems
US6662039B2 (en) * 1999-06-18 2003-12-09 The Trustees Of Columbia University In The City Of New York Optical probing of neuronal connections with fluorescent indicators
EP1210596A2 (de) * 1999-06-22 2002-06-05 Mitokor Verfahren zur untersuchung subzellulärer zustände mit hilfe von energietransfer
US6323039B1 (en) 1999-06-22 2001-11-27 Mitokor Compositions and methods for assaying subcellular conditions and processes using energy transfer
WO2001005828A1 (en) * 1999-07-20 2001-01-25 Merck & Co., Inc. Novel human calcium sensitive potassium channel subunits
US6358684B1 (en) 1999-08-27 2002-03-19 Pe Corporation UV excitable fluorescent energy transfer dyes
EP1081495B1 (de) * 1999-09-01 2004-03-10 Invitrogen Corporation Photon Dämpfer für Fluoreszenzassays
US6468763B1 (en) 1999-09-29 2002-10-22 Caliper Technologies Corp. Optical detection of transmembrane potential changes
CA2385618A1 (en) * 1999-10-08 2001-04-19 Caliper Technologies Corporation Use of nernstein voltage sensitive dyes in measuring transmembrane voltage
US6740466B1 (en) * 1999-11-15 2004-05-25 Fuji Photo Film Co., Ltd. Photopolymerizable composition and recording material using the same
GB0003069D0 (en) * 2000-02-11 2000-03-29 Cambridge Drug Discovery Ltd Improved assay
US6287758B1 (en) * 2000-03-23 2001-09-11 Axiom Biotechnologies, Inc. Methods of registering trans-membrane electric potentials
JP2004500119A (ja) * 2000-03-31 2004-01-08 メルク　エンド　カムパニー　インコーポレーテッド デルマセンター・ヴァリァビリスｇａｂａ依存性塩素イオンチャンネル
DK1303757T3 (da) * 2000-07-10 2007-02-05 Vertex Pharma San Diego Llc Ionkanal-assayfremgangsmåder
US7615356B2 (en) 2000-07-10 2009-11-10 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
JP5603850B2 (ja) * 2000-07-10 2014-10-08 ヴァーテックス ファーマシューティカルズ （サンディエゴ）エルエルシー イオンチャネルアッセイ法
US6686193B2 (en) 2000-07-10 2004-02-03 Vertex Pharmaceuticals, Inc. High throughput method and system for screening candidate compounds for activity against target ion channels
WO2002042842A2 (en) * 2000-11-22 2002-05-30 Allergan, Inc. A high-throughput screen for identifying channel blockers that selectively distinguish transient from persistent sodium channels
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US20030211575A1 (en) * 2001-02-07 2003-11-13 Swartz Kenton J. Constituitively open voltage-gated kand methods for discovering modulators thereof
US7005511B2 (en) 2001-02-26 2006-02-28 The Regents Of The University Of California Fluorescent protein variants and methods for making same
US20060029955A1 (en) 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US20040146849A1 (en) * 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
US20050196746A1 (en) * 2001-03-24 2005-09-08 Jia Xu High-density ion transport measurement biochip devices and methods
EP1372828A4 (de) * 2001-03-24 2008-10-29 Aviva Biosciences Corp Biochips mit ionentransporterfassungsstrukturen und verwendungsverfahren
US20050058990A1 (en) * 2001-03-24 2005-03-17 Antonio Guia Biochip devices for ion transport measurement, methods of manufacture, and methods of use
WO2002101364A1 (en) * 2001-06-09 2002-12-19 Glsynthesis Inc. Lipid structures and uses thereof
DE10130172A1 (de) * 2001-06-22 2003-01-09 Evotec Ag Fluoreszenz-Farbstoffderivate
FR2826666B1 (fr) * 2001-07-02 2004-07-02 Novaleads Procede de selection d'agents bio-actifs par couplage de luminescence et systeme cellulaire vivant pour la mise en oeuvre de ce procede
WO2003006103A2 (en) * 2001-07-12 2003-01-23 Merck & Co., Inc. Electrical field stimulation of eukaryotic cells
US7361478B2 (en) 2001-11-20 2008-04-22 Allergan, Inc. High-throughput screen for identifying selective persistent sodium channels channel blockers
US20030186860A1 (en) * 2002-03-29 2003-10-02 Welsh Michael J. Novel compositions and methods for modulating the acid-sensing ion channel (ASIC)
US20070197583A1 (en) * 2002-03-29 2007-08-23 Welsh Michael J Novel compositions and methods for modulation of the acid-sensing ion channel (ASIC) for the treatment of anxiety and drug addiction
US20050181464A1 (en) * 2002-04-04 2005-08-18 Affinium Pharmaceuticals, Inc. Novel purified polypeptides from bacteria
EP1501924A4 (de) * 2002-05-04 2006-05-24 Aviva Biosciences Corp Vorrichtung mit strukturen nachweisendem ionentransport und verwendungsverfahren
US20030228566A1 (en) * 2002-06-11 2003-12-11 Biotechplex Corporation Method of and apparatus for screening for drug candidates
US7427489B1 (en) * 2002-06-17 2008-09-23 The Scripps Research Institute Screening assay to identify modulators of the sleep/wake cycle
ATE424448T1 (de) * 2002-10-10 2009-03-15 Merck & Co Inc Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten
US20050037364A1 (en) 2003-08-13 2005-02-17 International Business Machines Corporation Techniques for recording signals
US7060723B2 (en) 2003-08-29 2006-06-13 Allergan, Inc. Treating neurological disorders using selective antagonists of persistent sodium current
US7125908B2 (en) * 2003-08-29 2006-10-24 Allergan, Inc. Treating pain using selective antagonists of persistent sodium current
US8329390B2 (en) * 2004-10-21 2012-12-11 Anaspec Incorporated Detection of transmembrane potentials using N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonols
JP2008524633A (ja) 2004-12-21 2008-07-10 セダーズ−シナイ メディカル センター イオン流束分析による薬物スクリーニングおよび特徴付けのための方法
FR2890174B1 (fr) * 2005-08-30 2009-04-24 Cis Bio Internat Sa Procede pour la mise en evidence d'un processus biologique par mesure d'un fret
DE602006012072D1 (de) * 2005-10-12 2010-03-18 Allergan Inc Tests der molekularen oder subzellulären interaktivität unter verwendung von depolarisierung nach resonanzenergietransfer (daret)
US20070254276A1 (en) * 2006-04-26 2007-11-01 Seng Enterprises Ltd. Method and system for measuring membrane potential based on fluorescence polarization
US20110098309A1 (en) * 2007-07-12 2011-04-28 Acumen Pharmaceuticals, Inc. Methods of inhibiting the formation of amyloid-beta diffusable ligands using acylhydrazide compounds
US8962677B2 (en) 2007-07-12 2015-02-24 Acumen Pharmaceuticals, Inc. Methods of restoring cognitive ability using non-peptidic compounds
US9006283B2 (en) * 2007-07-12 2015-04-14 Acumen Pharmaceuticals, Inc. Methods of modifying amyloid β oligomers using non-peptidic compounds
CA2749108C (en) 2008-01-18 2017-06-27 Visen Medical, Inc. Intramolecularly-quenched fluorescent imaging agents
US20090291150A1 (en) * 2008-05-21 2009-11-26 University Of Iowa Research Foundation Method and compositions for treating and preventing seizures by modulating acid-sensing ion channel activity
US8962341B2 (en) 2008-12-12 2015-02-24 The Commonwealth Medical College Cell-based detection of APF through its interaction with CKAP4 for diagnosis of interstitial cystitis
WO2010117420A2 (en) * 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
US9222043B2 (en) * 2009-09-22 2015-12-29 Authentix, Inc. Dipyrromethenes and azadipyrromethenes as markers for petroleum products
US9207237B2 (en) 2010-08-23 2015-12-08 President And Fellows Of Harvard College Systems, methods, and workflows for optogenetics analysis
CN103168236B (zh) 2010-08-23 2016-01-20 哈佛大学管理委员会 用于膜电位测定的光遗传学探针
WO2013130808A1 (en) 2012-02-29 2013-09-06 D.E. Shaw Research, Llc Methods for screening voltage gated proteins
US9682970B2 (en) 2012-06-29 2017-06-20 Biotium, Inc. Fluorescent compounds and uses thereof
KR101933620B1 (ko) * 2012-09-18 2018-12-28 삼성전자주식회사 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법
US10175174B2 (en) 2012-12-11 2019-01-08 Ge Healthcare Bio-Sciences Corp. Photoactivated chemical bleaching of dyes
WO2014189145A1 (ja) 2013-05-23 2014-11-27 学校法人慶應義塾 光第二高調波発生化合物、光第二高調波発生色素組成物及び細胞検査方法
US8962779B2 (en) 2013-07-16 2015-02-24 Dow Global Technologies Llc Method of forming polyaryl polymers
US9410016B2 (en) 2013-07-16 2016-08-09 Dow Global Technologies Llc Aromatic polyacetals and articles comprising them
US8933239B1 (en) 2013-07-16 2015-01-13 Dow Global Technologies Llc Bis(aryl)acetal compounds
US9063420B2 (en) 2013-07-16 2015-06-23 Rohm And Haas Electronic Materials Llc Photoresist composition, coated substrate, and method of forming electronic device
US9518103B2 (en) 2014-06-18 2016-12-13 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
CN104357045B (zh) * 2014-11-05 2016-06-01 北京化工大学 具有极酸/极碱开关响应的螺吡喃小分子荧光探针的合成方法及其应用
US10077463B2 (en) 2015-01-15 2018-09-18 President And Fellows Of Harvard College Optical selection of cells
JP6782716B2 (ja) * 2015-06-25 2020-11-11 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗体またはリガンドの結合および機能を明らかにするための細胞ベースアッセイ法
WO2018217266A1 (en) 2017-03-02 2018-11-29 Akita Innovations Llc Voltage sensitive dyes
WO2019212946A1 (en) 2018-04-30 2019-11-07 Ribon Therapeutics Inc. Screening methods for parp modulators
EP3823674A4 (de) 2018-07-18 2022-12-28 Manzanita Pharmaceuticals, Inc. Konjugate zur abgabe eines krebsmittels an nervenzellen, verwendungsverfahren und verfahren zu deren herstellung
RU197959U1 (ru) * 2020-01-28 2020-06-09 Федеральное государственное бюджетное образовательное учреждение высшего образования "МИРЭА - Российский технологический университет" Устройство для исследования компонент вещества с помощью микроволновой плазмы методами оптической и ямр спектроскопии
WO2022008720A1 (en) * 2020-07-10 2022-01-13 Life & Brain Gmbh Novel hybrid optical voltage sensors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1597482B2 (de) * 1967-09-22 1977-03-24 Agfa-Gevaert Ag, 5090 Leverkusen Lichtempfindliches photographisches aufzeichnungsmaterial mit lichthofschutz- oder filterfarbstoffen
JPS59218956A (ja) * 1983-05-27 1984-12-10 Fujirebio Inc 膜融合測定方法
DK487784A (da) * 1983-10-13 1985-04-14 Univ Georgia Immunoassay
US4647531A (en) * 1984-02-06 1987-03-03 Ortho Diagnostic Systems, Inc. Generalized cytometry instrument and methods of use
US4861727A (en) * 1986-09-08 1989-08-29 C. R. Bard, Inc. Luminescent oxygen sensor based on a lanthanide complex
US4900934A (en) * 1987-07-15 1990-02-13 University Of Utah Apparatus for simultaneous visualization and measurement of fluorescence from fluorescent dye-treated cell preparations and solutions
AT393035B (de) * 1989-04-25 1991-07-25 Avl Verbrennungskraft Messtech Verfahren zur quantitativen bestimmung zumindest eines chemischen parameters eines probenmediums
US5169788A (en) * 1989-06-09 1992-12-08 New England Deaconess Hospital Corporation Methods of measuring membrane potential using j-aggregate forming dyes
DK0429907T3 (da) * 1989-11-21 1994-10-03 Bayer Ag Optisk biosensor
US5244813A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
DE4121426A1 (de) * 1991-06-28 1993-01-14 Basf Ag Chemischer sensor
CA2087412A1 (en) * 1992-01-17 1993-07-18 Joseph R. Lakowicz Ph and pco2 sensing by luminescent lifetimes and energy transfer
WO1995008637A1 (en) * 1993-09-21 1995-03-30 Washington State University Research Foundation Immunoassay comprising ligand-conjugated, ion channel receptor immobilized in lipid film
GB9406464D0 (en) * 1994-03-31 1994-05-25 British Tech Group Assay for determining biochemical changes at phospholipid bilayer membrane surfaces
US5661035A (en) * 1995-06-07 1997-08-26 The Regents Of The University Of California Voltage sensing by fluorescence resonance energy transfer

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WO1996041166A2 (en) 1996-12-19
DK0834074T4 (da) 2005-12-12
ATE304706T1 (de) 2005-09-15
EP0834074B2 (de) 2005-11-16
EP1610126B1 (de) 2014-04-30
WO1996041166A3 (en) 1997-05-15
DE69605041T2 (de) 2000-03-16
EP0977035A2 (de) 2000-02-02
JP4033899B2 (ja) 2008-01-16
AU716130B2 (en) 2000-02-17
EP0977035B2 (de) 2010-07-21
US5661035A (en) 1997-08-26
US6107066A (en) 2000-08-22
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CA2223927C (en) 2004-04-06
EP1610126A1 (de) 2005-12-28
ATE186400T1 (de) 1999-11-15
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DK0834074T3 (da) 2000-04-03
DE69635193D1 (de) 2005-10-20
DE69635193T3 (de) 2011-03-10
DE69605041D1 (de) 1999-12-09
ES2140870T5 (es) 2006-04-16
CA2223927A1 (en) 1996-12-19
AU6264396A (en) 1996-12-30
EP0834074B1 (de) 1999-11-03
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