ATE424448T1 - Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten - Google Patents

Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten

Info

Publication number
ATE424448T1
ATE424448T1 AT03774653T AT03774653T ATE424448T1 AT E424448 T1 ATE424448 T1 AT E424448T1 AT 03774653 T AT03774653 T AT 03774653T AT 03774653 T AT03774653 T AT 03774653T AT E424448 T1 ATE424448 T1 AT E424448T1
Authority
AT
Austria
Prior art keywords
methods
antagonists
condition
test methods
calcium channel
Prior art date
Application number
AT03774653T
Other languages
English (en)
Inventor
Menghang Xia
Thomas Connolly
Paul Bennett
Charles Cohen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE424448T1 publication Critical patent/ATE424448T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03774653T 2002-10-10 2003-10-09 Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten ATE424448T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41801702P 2002-10-10 2002-10-10

Publications (1)

Publication Number Publication Date
ATE424448T1 true ATE424448T1 (de) 2009-03-15

Family

ID=32094136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03774653T ATE424448T1 (de) 2002-10-10 2003-10-09 Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten

Country Status (6)

Country Link
US (1) US20060014206A1 (de)
EP (1) EP1560915B1 (de)
AT (1) ATE424448T1 (de)
CA (1) CA2501233A1 (de)
DE (1) DE60326482D1 (de)
WO (1) WO2004033647A2 (de)

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EP1581558A2 (de) * 2003-01-07 2005-10-05 Neuromed Technologies, Inc. Fluoreszenz-basiertes t-typ ionenkanal-testverfahren
WO2006055927A2 (en) * 2004-11-17 2006-05-26 The Cleveland Clinic Foundation Pathogenic gene and protein associated with paroxysmal dyskinesia and epilepsy
EP1919497B1 (de) 2005-07-22 2020-02-12 The Board of Trustees of the Leland Stanford Junior University Lichtaktivierter kationenkanal und dessen verwendung
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
GB0520405D0 (en) * 2005-10-07 2005-11-16 Imp College Innovations Ltd Biological agents and method
KR100716103B1 (ko) 2005-10-28 2007-05-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제의 세포 기반 고효율 검색 방법
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
WO2008101128A1 (en) 2007-02-14 2008-08-21 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
WO2008106694A2 (en) 2007-03-01 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
MY169771A (en) 2008-04-23 2019-05-15 Univ Leland Stanford Junior Systems, methods and compositions for optical stimulation of target cells
WO2009148946A2 (en) 2008-05-29 2009-12-10 The Board Of Trustees Of The Leland Stanford Junior University Cell line, system and method for optical control of secondary messengers
JP2011525130A (ja) 2008-06-17 2011-09-15 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ 光伝送素子を用いた標的細胞の光刺激のための方法、システム、および装置
EP2303405A4 (de) 2008-06-17 2017-12-27 The Board of Trustees of the Leland Stanford Junior University Gerät und verfahren zur kontrolle der zellentwicklung
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
US20100330607A1 (en) * 2009-06-24 2010-12-30 Photoswitch Biosciences, Inc. Photoswitch-enabled ion channel assay system
US20110144028A1 (en) * 2009-12-11 2011-06-16 Vinod Sharma Modulating cellular electrophysiology
WO2011116238A2 (en) 2010-03-17 2011-09-22 The Board Of Trustees Of The Leland Stanford Junior University. Light-sensitive ion-passing molecules
CN106106368A (zh) 2010-11-05 2016-11-16 斯坦福大学托管董事会 光控cns功能障碍
CN106422081B (zh) 2010-11-05 2019-06-21 斯坦福大学托管董事会 用于光遗传学方法的光的上转换
WO2012061679A2 (en) 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
AU2011323235B2 (en) 2010-11-05 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of reward-related behaviors
CN106376525A (zh) 2010-11-05 2017-02-08 斯坦福大学托管董事会 记忆功能的控制和表征
ES2684307T3 (es) 2010-11-05 2018-10-02 The Board Of Trustees Of The Leland Stanford Junior University Proteínas estabilizadas de tipo opsina de función escalonada y métodos de uso de las mismas
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CA2859364C (en) 2011-12-16 2019-05-07 The Board Of Trustees Of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
EP3205374B1 (de) 2012-02-21 2019-03-27 The Board of Trustees of The Leland Stanford Junior University Zusammensetzungen zur behandlung neurogener erkrankungen des beckenbodens
SG11201505206WA (en) * 2013-01-10 2015-07-30 Tau Therapeutics Llc T-type calcium channel inhibitors for treatment of cancer
JP6594854B2 (ja) 2013-03-15 2019-10-23 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 行動状態の光遺伝学的制御方法
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
AU2014260101B2 (en) 2013-04-29 2018-07-26 Humboldt-Universitat Zu Berlin Devices, systems and methods for optogenetic modulation of action potentials in target cells
EP3033427A4 (de) 2013-08-14 2017-05-31 The Board Of Trustees Of The University Of the Leland Stanford Junior University Zusammensetzungen und verfahren zur bekämpfung von schmerzen
WO2016209654A1 (en) 2015-06-22 2016-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
JP7629408B2 (ja) * 2019-03-22 2025-02-13 トゥルイオン ゲーエムベーハー 雄性不妊を判定するためのＣａｔＳｐｅｒ活性試験

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US5043457A (en) * 1990-04-17 1991-08-27 Allergan, Inc. 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents
US5429921A (en) * 1988-04-04 1995-07-04 The Salk Institute Biotechnology/Industrial Assoc. Inc. Assays for agonists and antagonists of recombinant human calcium channels
US5876958A (en) * 1988-04-04 1999-03-02 Sibia Neurosciences, Inc. Assays of cells expressing human calcium channels containing α1 β subunits
US5851824A (en) * 1988-04-04 1998-12-22 Sibia Neurosciences, Inc. Human calcium channel α-1C/α-1D, α-2, β-1, and γsubunits and cells expressing the DNA
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US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US5661035A (en) 1995-06-07 1997-08-26 The Regents Of The University Of California Voltage sensing by fluorescence resonance energy transfer
US6117990A (en) * 1999-04-06 2000-09-12 Synaptic Pharmaceutical Corporation DNA encoding SNORF1 receptor
US6686193B2 (en) * 2000-07-10 2004-02-03 Vertex Pharmaceuticals, Inc. High throughput method and system for screening candidate compounds for activity against target ion channels

Also Published As

Publication number Publication date
EP1560915A2 (de) 2005-08-10
EP1560915A4 (de) 2006-11-15
DE60326482D1 (de) 2009-04-16
EP1560915B1 (de) 2009-03-04
WO2004033647A2 (en) 2004-04-22
US20060014206A1 (en) 2006-01-19
WO2004033647A3 (en) 2004-11-04
CA2501233A1 (en) 2004-04-22

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