ATE424448T1 - Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten - Google Patents

Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten

Info

Publication number
ATE424448T1
ATE424448T1 AT03774653T AT03774653T ATE424448T1 AT E424448 T1 ATE424448 T1 AT E424448T1 AT 03774653 T AT03774653 T AT 03774653T AT 03774653 T AT03774653 T AT 03774653T AT E424448 T1 ATE424448 T1 AT E424448T1
Authority
AT
Austria
Prior art keywords
methods
antagonists
condition
test methods
calcium channel
Prior art date
Application number
AT03774653T
Other languages
English (en)
Inventor
Menghang Xia
Thomas Connolly
Paul Bennett
Charles Cohen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE424448T1 publication Critical patent/ATE424448T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03774653T 2002-10-10 2003-10-09 Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten ATE424448T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41801702P 2002-10-10 2002-10-10

Publications (1)

Publication Number Publication Date
ATE424448T1 true ATE424448T1 (de) 2009-03-15

Family

ID=32094136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03774653T ATE424448T1 (de) 2002-10-10 2003-10-09 Testverfahren für zustandsabhängige calciumkanal- agonisten/-antagonisten

Country Status (6)

Country Link
US (1) US20060014206A1 (de)
EP (1) EP1560915B1 (de)
AT (1) ATE424448T1 (de)
CA (1) CA2501233A1 (de)
DE (1) DE60326482D1 (de)
WO (1) WO2004033647A2 (de)

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US7270949B2 (en) * 2003-01-07 2007-09-18 Neuromed Pharmaceuticals Ltd. Fluorescence based T-type channel assay
WO2006055927A2 (en) * 2004-11-17 2006-05-26 The Cleveland Clinic Foundation Pathogenic gene and protein associated with paroxysmal dyskinesia and epilepsy
US10052497B2 (en) 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US20090093403A1 (en) 2007-03-01 2009-04-09 Feng Zhang Systems, methods and compositions for optical stimulation of target cells
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9238150B2 (en) 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
JP2009502140A (ja) 2005-07-22 2009-01-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 光活性化陽イオンチャネルおよびその使用
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
GB0520405D0 (en) * 2005-10-07 2005-11-16 Imp College Innovations Ltd Biological agents and method
KR100716103B1 (ko) 2005-10-28 2007-05-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제의 세포 기반 고효율 검색 방법
US8398692B2 (en) 2007-01-10 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US8401609B2 (en) 2007-02-14 2013-03-19 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
US10035027B2 (en) 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
ES2701349T3 (es) 2008-04-23 2019-02-21 Univ Leland Stanford Junior Sistemas, métodos y composiciones para la estimulación óptica de células diana
EP2294208B1 (de) 2008-05-29 2013-05-08 The Board of Trustees of The Leland Stanford Junior University Zelllinie, system und verfahren zur optischen steuerung von sekundären botenstoffen
JP2011525130A (ja) 2008-06-17 2011-09-15 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ 光伝送素子を用いた標的細胞の光刺激のための方法、システム、および装置
EP2303405A4 (de) 2008-06-17 2017-12-27 The Board of Trustees of the Leland Stanford Junior University Gerät und verfahren zur kontrolle der zellentwicklung
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
US20100330607A1 (en) * 2009-06-24 2010-12-30 Photoswitch Biosciences, Inc. Photoswitch-enabled ion channel assay system
US20110144028A1 (en) * 2009-12-11 2011-06-16 Vinod Sharma Modulating cellular electrophysiology
EP3399024A1 (de) 2010-03-17 2018-11-07 The Board of Trustees of The Leland Stanford Junior University Lichtempfindliche ionendurchgangsmoleküle
US10568307B2 (en) 2010-11-05 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
CN106422081B (zh) 2010-11-05 2019-06-21 斯坦福大学托管董事会 用于光遗传学方法的光的上转换
EP3486253A1 (de) 2010-11-05 2019-05-22 The Board of Trustees of The Leland Stanford Junior University Lichtaktivierte chimäre opsine und verwendungsverfahren dafür
ES2625179T3 (es) 2010-11-05 2017-07-18 The Board Of Trustees Of The Leland Stanford Junior University Control optogenético de comportamientos relacionados con la recompensa
CN103384469B (zh) 2010-11-05 2016-06-15 斯坦福大学托管董事会 光控cns功能障碍
US10086012B2 (en) 2010-11-05 2018-10-02 The Board Of Trustees Of The Leland Stanford Junior University Control and characterization of memory function
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
CA2859364C (en) 2011-12-16 2019-05-07 The Board Of Trustees Of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
ES2628006T3 (es) 2012-02-21 2017-08-01 Circuit Therapeutics, Inc. Composiciones para el tratamiento de trastornos neurogénicos del suelo pélvico
US20150355163A1 (en) * 2013-01-10 2015-12-10 Tau Therapeutics Llc T-type calcium channel inhibitors for treatment of cancer
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
ES2742492T3 (es) 2013-03-15 2020-02-14 Univ Leland Stanford Junior Control optogenético del estado conductual
US10220092B2 (en) 2013-04-29 2019-03-05 The Board Of Trustees Of The Leland Stanford Junior University Devices, systems and methods for optogenetic modulation of action potentials in target cells
JP6621747B2 (ja) 2013-08-14 2019-12-18 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 疼痛を制御するための組成物及び方法
US10568516B2 (en) 2015-06-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
WO2020193446A1 (en) * 2019-03-22 2020-10-01 Westfälische Wilhelms-Universität Münster Catsper-activity-test for determining male infertility

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US5043457A (en) * 1990-04-17 1991-08-27 Allergan, Inc. 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents
US6096514A (en) * 1988-04-04 2000-08-01 Sibia Neurosciences, Inc. Human calcium channel compositions and methods
US5851824A (en) * 1988-04-04 1998-12-22 Sibia Neurosciences, Inc. Human calcium channel α-1C/α-1D, α-2, β-1, and γsubunits and cells expressing the DNA
US5429921A (en) * 1988-04-04 1995-07-04 The Salk Institute Biotechnology/Industrial Assoc. Inc. Assays for agonists and antagonists of recombinant human calcium channels
US5876958A (en) * 1988-04-04 1999-03-02 Sibia Neurosciences, Inc. Assays of cells expressing human calcium channels containing α1 β subunits
US6090623A (en) * 1993-08-11 2000-07-18 Merck & Co., Inc. Recombinant human calcium channel β4 subunits
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US5661035A (en) 1995-06-07 1997-08-26 The Regents Of The University Of California Voltage sensing by fluorescence resonance energy transfer
US6117990A (en) * 1999-04-06 2000-09-12 Synaptic Pharmaceutical Corporation DNA encoding SNORF1 receptor
US7399599B2 (en) * 2000-07-10 2008-07-15 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods

Also Published As

Publication number Publication date
CA2501233A1 (en) 2004-04-22
EP1560915A2 (de) 2005-08-10
US20060014206A1 (en) 2006-01-19
EP1560915B1 (de) 2009-03-04
WO2004033647A3 (en) 2004-11-04
WO2004033647A2 (en) 2004-04-22
EP1560915A4 (de) 2006-11-15
DE60326482D1 (de) 2009-04-16

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