ATE468534T1 - Verwendung von biomarkern zum nachweis von eierstockkrebs - Google Patents

Verwendung von biomarkern zum nachweis von eierstockkrebs

Info

Publication number
ATE468534T1
ATE468534T1 AT03767259T AT03767259T ATE468534T1 AT E468534 T1 ATE468534 T1 AT E468534T1 AT 03767259 T AT03767259 T AT 03767259T AT 03767259 T AT03767259 T AT 03767259T AT E468534 T1 ATE468534 T1 AT E468534T1
Authority
AT
Austria
Prior art keywords
ovarian cancer
biomarkers
detecting ovarian
subject
cancer status
Prior art date
Application number
AT03767259T
Other languages
English (en)
Inventor
Daniel Chan
Zhen Zhang
Eric Fung
Xiao-Ying Meng
Original Assignee
Univ Johns Hopkins
Ciphergen Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Ciphergen Biosystems Inc filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of ATE468534T1 publication Critical patent/ATE468534T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57545Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/807Gas detection apparatus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/967Standards, controls, materials, e.g. validation studies, buffer systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/973Simultaneous determination of more than one analyte
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/811Test for named disease, body condition or organ function
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/811Test for named disease, body condition or organ function
    • Y10S436/813Cancer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/815Test for named compound or class of compounds
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/824Immunological separation techniques
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/825Pretreatment for removal of interfering factors from sample
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03767259T 2002-08-06 2003-08-05 Verwendung von biomarkern zum nachweis von eierstockkrebs ATE468534T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40183702P 2002-08-06 2002-08-06
US44172703P 2003-01-21 2003-01-21
US46034203P 2003-04-04 2003-04-04
PCT/US2003/024659 WO2004013609A2 (en) 2002-08-06 2003-08-05 Use of biomarkers for detecting ovarian cancer

Publications (1)

Publication Number Publication Date
ATE468534T1 true ATE468534T1 (de) 2010-06-15

Family

ID=31499343

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03767259T ATE468534T1 (de) 2002-08-06 2003-08-05 Verwendung von biomarkern zum nachweis von eierstockkrebs

Country Status (15)

Country Link
US (3) US7605003B2 (de)
EP (1) EP1540010B8 (de)
JP (1) JP4644123B2 (de)
KR (2) KR20110019357A (de)
CN (3) CN100558909C (de)
AT (1) ATE468534T1 (de)
AU (3) AU2003256858B2 (de)
CA (1) CA2493817A1 (de)
DE (1) DE60332639D1 (de)
DK (1) DK1540010T3 (de)
ES (1) ES2346202T3 (de)
HK (1) HK1200915A1 (de)
IL (3) IL166118A (de)
NZ (1) NZ562192A (de)
WO (2) WO2004013609A2 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003075772A2 (en) * 2002-03-11 2003-09-18 Pawliszyn Janusz B Micro-devices and analytical procedures for investigation of biological systems
WO2017193213A1 (en) 2016-05-10 2017-11-16 Jp Scientific Limited System and method for desorbing and detecting an analyte sorbed on a solid phase microextraction device
US9870907B2 (en) 2002-03-11 2018-01-16 Jp Scientific Limited Probe for extraction of molecules of interest from a sample
US9733234B2 (en) 2002-03-11 2017-08-15 Jp Scientific Limited Probe for extraction of molecules of interest from a sample
US20090026122A1 (en) 2002-03-11 2009-01-29 Janusz Biocompatible solid-phase microextraction coatings and methods for their preparation
US8598325B2 (en) 2002-03-11 2013-12-03 Janusz B. Pawliszyn Solid-phase microextraction coatings and methods for their preparation
US7232689B2 (en) * 2002-03-11 2007-06-19 Pawliszyn Janusz B Calibration procedure for investigating biological systems
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US20050100967A1 (en) * 2003-07-11 2005-05-12 Science & Technology Corporation @ Unm Detection of endometrial pathology
ATE525478T1 (de) * 2003-12-05 2011-10-15 Univ Mcgill Serumbiomarker für morbus chagas
US7666583B2 (en) * 2004-02-19 2010-02-23 Yale University Identification of cancer protein biomarkers using proteomic techniques
WO2005098446A2 (en) * 2004-03-31 2005-10-20 The Johns Hopkins University Biomarkers for ovarian cancer
KR100624420B1 (ko) * 2004-04-10 2006-09-19 삼성전자주식회사 마이크로어레이에 대한 정보가 스팟의 형태로 저장되어있는 마이크로어레이, 그를 제조하는 방법 및 그를이용하는 방법
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
US9487575B2 (en) 2004-07-14 2016-11-08 The Regents Of The University Of California Compositions and methods for treatment of gynecologic cancers
US7670792B2 (en) 2004-07-14 2010-03-02 The Regents Of The University Of California Biomarkers for early detection of ovarian cancer
US9488655B2 (en) * 2004-07-14 2016-11-08 The Regents Of The University Of California Biomarkers for detection of early- and late-stage endometrial cancer
EP2848942B1 (de) 2004-07-14 2017-03-08 The Regents of The University of California Biomarker zur Früherkennung von Eierstockkrebs
PT1761779E (pt) * 2004-08-13 2008-02-01 Indivumed Gmbh Utilização de transtirretina como um biomarcador de adenoma colorrectal; método de detecção e sistema de teste
WO2006034032A2 (en) * 2004-09-17 2006-03-30 The Johns Hopkins University Biomarkers for breast cancer
AU2006223374B2 (en) * 2005-03-11 2011-07-21 Aspira Women’s Health Inc. Biomarkers for ovarian cancer and endometrial cancer: hepcidin
US20070087387A1 (en) * 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
EP1877795A4 (de) * 2005-05-02 2010-04-28 Brigham & Womens Hospital Diagnostische profilerstellung von serumantikörpern
JP5159619B2 (ja) * 2005-06-22 2013-03-06 ザ・ジョンズ・ホプキンス・ユニバーシティ 卵巣癌のバイオマーカー:ctap3関連タンパク質
WO2007002535A2 (en) * 2005-06-24 2007-01-04 Ciphergen Biosystems, Inc. Biomarkers for ovarian cancer
EP2993474B1 (de) * 2005-06-24 2019-06-12 Vermillion, Inc. Biomarker für ovarialkarzinom: beta-2-mikroglobulin
AT502227B1 (de) * 2005-08-08 2007-08-15 Vitateq Biotechnology Gmbh Verfahren zur diagnose von tumoren
US7972770B2 (en) * 2005-08-16 2011-07-05 Memorial Sloan-Kettering Cancer Center Methods of detection of cancer using peptide profiles
DE602006021038D1 (de) * 2005-09-15 2011-05-12 Univ Mcgill Verfahren zur diagnose eines ovarialkarzinoms
CN101473041B (zh) * 2006-01-04 2017-11-14 富士瑞必欧美国公司 He4与其它生化标记物在评估子宫内膜癌和子宫癌中的应用
WO2007084485A2 (en) * 2006-01-13 2007-07-26 Battelle Memorial Institute Markers for assessing copd-related diseases
EP2363711A1 (de) * 2006-01-27 2011-09-07 Tripath Imaging, Inc. Verfahren zur Identifizierung von Patienten mit erhöhter Wahrscheinlichkeit des Auftretens eines Ovarialkarzinoms und Zusammensetzungen dafür
AP2008004634A0 (en) * 2006-03-23 2008-10-31 Emelta De Guzman Breyer Apolipoprotein fingerprinting technique
WO2007112350A2 (en) * 2006-03-24 2007-10-04 Expression Pathology Method of assessing the metastatic status of a primary tumor
US7858389B2 (en) 2006-03-31 2010-12-28 Biodesix, Inc. Selection of non-small-cell lung cancer patients for treatment with monoclonal antibody drugs targeting EGFR pathway
US7867775B2 (en) 2006-03-31 2011-01-11 Biodesix, Inc. Selection of head and neck cancer patients for treatment with drugs targeting EGFR pathway
US7906342B2 (en) 2006-03-31 2011-03-15 Biodesix, Inc. Monitoring treatment of cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples
US7736905B2 (en) 2006-03-31 2010-06-15 Biodesix, Inc. Method and system for determining whether a drug will be effective on a patient with a disease
US7858390B2 (en) 2006-03-31 2010-12-28 Biodesix, Inc. Selection of colorectal cancer patients for treatment with drugs targeting EGFR pathway
JP2007315941A (ja) * 2006-05-26 2007-12-06 Univ Of Miyazaki 植物品種判定装置、植物品種判定方法及び植物品種判定用プログラム
WO2008060376A2 (en) * 2006-10-04 2008-05-22 The Johns Hopkins University Algorithims for multivariant models to combine a panel of biomarkers for assessing the risk of developing ovarian cancer
WO2008048508A2 (en) * 2006-10-13 2008-04-24 Vermillion, Inc. Prognostic biomarkers in patients with ovarian cancer
AU2008210207B2 (en) * 2007-02-01 2014-05-15 Med-Life Discoveries Lp Methods for the diagnosis of ovarian cancer health states and risk of ovarian cancer health states
US8518651B2 (en) 2007-02-16 2013-08-27 Shimadzu Corporation Marker for identification of tissue type of epithelial ovarian cancer, and method for determination of the occurrence of epithelial ovarian cancer based on tissue type by using the marker
US8221984B2 (en) * 2007-03-27 2012-07-17 Vermillion, Inc. Biomarkers for ovarian cancer
EP2152417B1 (de) 2007-05-04 2018-07-11 Opko Diagnostics, LLC Vorrichtung und methode für analysen in mikrofluidsysteme
US8664358B2 (en) 2007-06-29 2014-03-04 Vermillion, Inc. Predictive markers for ovarian cancer
EP2179288A4 (de) * 2007-07-20 2010-07-21 Univ Utah Res Found Identifizierung und quantifizierung von biomarkern zur evaluierung des risikos einer frühgeburt
WO2009058331A2 (en) 2007-10-29 2009-05-07 Vermilllion, Inc. Biomarkers for the detection of early stage ovarian cancer
US20090123932A1 (en) * 2007-11-09 2009-05-14 Anne-Marie Mes-Masson Quantitative test to detect disease progression markers of epithelial ovarian cancer patients
US8642347B2 (en) * 2008-01-31 2014-02-04 The Brigham And Women's Hospital, Inc. Urinary CA125 peptides as biomarkers of ovarian cancer
US8476026B2 (en) * 2008-04-01 2013-07-02 The Brigham And Women's Hospital, Inc. Biomarkers of ovarian cancer
ES2695039T3 (es) 2009-02-02 2018-12-28 Opko Diagnostics, Llc Estructuras para controlar la interacción de luz con dispositivos microfluídicos
US8704194B2 (en) * 2010-04-12 2014-04-22 Canon Kabushiki Kaisha Information acquiring apparatus and information acquiring method for acquiring mass-related information
US20120016598A1 (en) * 2010-05-21 2012-01-19 Bruker Daltonik Gmbh Normalization of mass spectra acquired by mass spectrometric imaging
WO2012019000A2 (en) * 2010-08-04 2012-02-09 On-Q-ity Biomarkers for the identification monitoring and treatment of ovarian cancer
CA2818593A1 (en) * 2010-10-22 2012-04-26 Vermillion, Inc. Prognostic biomarkers in patients with ovarian cancer
KR20140024860A (ko) * 2011-02-24 2014-03-03 버밀리언, 인코포레이티드 난소암에 대한 바이오마커 패널,진단 방법 및 시험 키트
US9057107B2 (en) 2011-03-08 2015-06-16 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
WO2013016700A1 (en) * 2011-07-27 2013-01-31 The Research Foundation Of State University Of New York Methods for generating predictive models for epithelial ovarian cancer and methods for identifying eoc
JP6078067B2 (ja) 2011-08-29 2017-02-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 炎症誘発性状態の治療および予防のためのhdl関連分子の使用
US20130196350A1 (en) * 2012-01-31 2013-08-01 Bio-Rad Laboratories, Inc. Sensitivity and specificity for ovarian cancer
TWI596494B (zh) 2012-03-05 2017-08-21 Opko診斷法有限責任公司 預測前列腺癌風險及前列腺腺體體積之方法及裝置
WO2015039175A1 (en) * 2013-09-18 2015-03-26 Adelaide Research & Innovation Pty Ltd Autoantibody biomarkers of ovarian cancer
US20150153348A1 (en) * 2013-12-04 2015-06-04 Vermillion, Inc. BIOMARKERS FOR OVARIAN CANCER: Beta 2 MICROGLOBULIN
US12326453B2 (en) 2014-03-28 2025-06-10 Opko Diagnostics, Llc Compositions and methods for active surveillance of prostate cancer
KR102505543B1 (ko) 2014-03-28 2023-03-02 옵코 다이어그노스틱스, 엘엘씨 전립선암 진단에 관한 조성물 및 방법
CA2958745C (en) 2014-08-29 2023-09-19 Biomerieux, Inc. Maldi-tof mass spectrometers with delay time variations and related methods
PT3253800T (pt) 2015-03-27 2021-04-28 Opko Diagnostics Llc Padrões de antigénio da próstata e suas utilizações
US10392665B2 (en) 2015-06-19 2019-08-27 Sera Prognostics, Inc. Biomarker pairs for predicting preterm birth
WO2017147707A1 (en) 2016-03-02 2017-09-08 Jp Scientific Limited Solid phase microextraction coating
CN106520924A (zh) * 2016-10-14 2017-03-22 浙江大学 一种用于检测卵巢癌的引物组及检测方法
CN106544421B (zh) * 2016-10-21 2020-05-08 武汉科技大学 Spag6基因作为卵巢肿瘤诊断和治疗标志物的用途
EP4530633A3 (de) 2017-08-18 2026-03-25 Sera Prognostics, Inc. Schwangerschaftstaktproteine zur vorhersage des frühstadiums und der geburtszeit
CA3123052A1 (en) * 2019-01-16 2020-07-23 Regeneron Pharmaceuticals, Inc. Method and system of identifying and quantifying antibody fragmentation
CN117169534A (zh) 2019-08-05 2023-12-05 禧尔公司 用于样品制备、数据生成和蛋白质冠分析的系统和方法
CN113125762A (zh) * 2019-12-31 2021-07-16 瑞博奥(广州)生物科技股份有限公司 一种检测女性恶性肿瘤标志物的检测芯片及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4584278A (en) * 1982-03-19 1986-04-22 University Of Rochester Antigen derived from human ovarian tumors and radioimmunoassay using the antigen
US4921790A (en) * 1987-04-24 1990-05-01 Research Corporation Tumor specific assay for CA125 ovarian cancer antigen
WO1991002079A1 (en) * 1989-07-31 1991-02-21 The University Of British Columbia Monoclonal antibodies against a tumor-associated antigen
US5366866A (en) * 1991-07-25 1994-11-22 Duke University Method of diagnosing ovarian and endometrial cancer with monoclonal antibodies OXA and OXB
ATE242485T1 (de) * 1993-05-28 2003-06-15 Baylor College Medicine Verfahren und massenspektrometer zur desorption und ionisierung von analyten
US5800347A (en) * 1995-11-03 1998-09-01 The General Hospital Corporation ROC method for early detection of disease
US5824555A (en) * 1996-05-30 1998-10-20 The Cleveland Clinic Foundation Method of detecting gynecological carcinomas
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
AU774336B2 (en) 1999-04-27 2004-06-24 Ciphergen Biosystems, Inc. Probes for a gas phase ion spectrometer
AU1465801A (en) * 1999-11-03 2001-05-14 Oncotech, Inc. Methods for cancer prognosis and diagnosis
WO2002021133A2 (en) * 2000-09-07 2002-03-14 The Brigham And Women's Hospital, Inc. Methods of detecting cancer based on prostasin
JP2004512540A (ja) * 2000-11-01 2004-04-22 マウント・サイナイ・ホスピタル 卵巣癌の検出
EP1337845B1 (de) 2000-11-16 2012-01-04 Bio-Rad Laboratories, Inc. Methode zum analysieren von massenspektren
AU2002258518A1 (en) * 2001-03-14 2002-09-24 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
US7112408B2 (en) 2001-06-08 2006-09-26 The Brigham And Women's Hospital, Inc. Detection of ovarian cancer based upon alpha-haptoglobin levels
AU2003235749A1 (en) 2002-01-07 2003-07-24 John Hopkins University Biomarkers for detecting ovarian cancer
AU2003304434A1 (en) * 2002-08-06 2005-03-07 The Johns Hopkins University System, software and methods for biomarker identification
AU2003269618A1 (en) 2002-08-28 2004-03-19 Mount Sinai Hospital Methods for detecting breast and ovarian cancer
AU2002951346A0 (en) 2002-09-05 2002-09-26 Garvan Institute Of Medical Research Diagnosis of ovarian cancer
US7288383B2 (en) 2003-01-15 2007-10-30 The Brigham And Women's Hospital, Inc. Eosinophil-derived neurotoxin as a marker for ovarian cancer

Also Published As

Publication number Publication date
JP4644123B2 (ja) 2011-03-02
IL166118A0 (en) 2006-01-15
DK1540010T3 (da) 2010-07-26
KR101107765B1 (ko) 2012-01-25
DE60332639D1 (de) 2010-07-01
US20140038852A1 (en) 2014-02-06
US20110033867A1 (en) 2011-02-10
AU2003257207A1 (en) 2004-02-23
CN101692090B (zh) 2014-06-25
AU2003256858A1 (en) 2004-02-23
IL252832B (en) 2019-10-31
EP1540010A4 (de) 2007-01-17
IL252832A0 (en) 2017-08-31
US7605003B2 (en) 2009-10-20
WO2004012588A2 (en) 2004-02-12
KR20110019357A (ko) 2011-02-25
EP1540010B1 (de) 2010-05-19
KR20050062518A (ko) 2005-06-23
AU2003256858B2 (en) 2010-07-01
NZ562192A (en) 2009-07-31
CN1675372A (zh) 2005-09-28
HK1076489A1 (en) 2006-01-20
WO2004013609A2 (en) 2004-02-12
WO2004012588A3 (en) 2005-12-15
WO2004013609A3 (en) 2005-04-14
JP2006512586A (ja) 2006-04-13
CN103969449A (zh) 2014-08-06
IL220734A (en) 2017-06-29
WO2004013609A8 (en) 2005-03-10
ES2346202T3 (es) 2010-10-13
AU2010202525A1 (en) 2010-07-08
AU2003257207A8 (en) 2004-02-23
IL166118A (en) 2012-07-31
EP1540010A2 (de) 2005-06-15
CN100558909C (zh) 2009-11-11
EP1540010B8 (de) 2010-07-14
CA2493817A1 (en) 2004-02-12
HK1200915A1 (en) 2015-08-14
CN101692090A (zh) 2010-04-07
US20050059013A1 (en) 2005-03-17
CN103969449B (zh) 2016-11-23

Similar Documents

Publication Publication Date Title
ATE468534T1 (de) Verwendung von biomarkern zum nachweis von eierstockkrebs
WO2005098446A3 (en) Biomarkers for ovarian cancer
WO2004099432A3 (en) Identification of biomarkers for detecting pancreatic cancer
CA2701341A1 (en) Method of assessing colorectal cancer from a stool sample by use of the marker combination calprotectin and hemoglobin/haptoglobin complex
MX340856B (es) Sistema y metodos que determinan concentracion de analito utilizando amperometria resuelta en tiempo.
WO2007038754A3 (en) Gene expression profiling for identification monitoring and treatment of rheumatoid arthritis
ATE393240T1 (de) Verfahren zum nachweis von prostatakrebs
NZ593514A (en) p-mTOR and p-AKT as Ratio Based Biomarkers for the Prognosis and/or Diagnosis of Cancer
ATE550649T1 (de) Testvorrichtung für analyten mit vielseitiger verwendungsmöglichkeit
MX2009006205A (es) Inmunoensayo de multiples analitos.
ATE419534T1 (de) Verwendung von c3a und derivaten als biomarker für kolorektaladenom und/oder -karzinom ; nachweisverfahren und testsystem damit
ATE370414T1 (de) Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs
TW200745551A (en) Device and methods for detecting and quantifying one or more target agents
WO2003091695A3 (en) Identification of biomarkers for detecting prostate cancer
WO2005094332A3 (en) Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators in non-small cell lung cancer
WO2003057014A3 (en) Biomarkers for detecting ovarian cancer
DE602005014386D1 (de) Verwendung von cyfra 21-1 und osteopontin als marker für kolorektalkarzinome
WO2003076896A3 (en) Use of biomarkers to detect breast cancer
GB2441694A (en) A building crack monitoring device
WO2009082533A3 (en) Method of identification of petroleum compounds using frequency mixing on surfaces
DE602005013430D1 (de) Verwendung von asc als marker für kolorektalkarzinome
ATE528640T1 (de) Detektionssysteme und -verfahren für flüssigkeitsgekoppelte defekte
ATE412181T1 (de) Verbessertes verfahren zur diagnose des akuten koronarsyndroms
DE602005026587D1 (de) Verwendung eines endoplasmin-fragments und von derivaten davon als biomarker für kolorektaladenom und/oder -karzinom; nachweisverfahren und testsystem
WO2004030521A3 (en) Use of biomarkers for detecting acute renal transplant rejection

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties