HK1086841A1 - A method for the preparation of enantiomerically pure mirtazapine - Google Patents
A method for the preparation of enantiomerically pure mirtazapineInfo
- Publication number
- HK1086841A1 HK1086841A1 HK06109133.3A HK06109133A HK1086841A1 HK 1086841 A1 HK1086841 A1 HK 1086841A1 HK 06109133 A HK06109133 A HK 06109133A HK 1086841 A1 HK1086841 A1 HK 1086841A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- preparation
- enantiomerically pure
- pure mirtazapine
- mirtazapine
- enantiomerically
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03102095 | 2003-07-10 | ||
PCT/EP2004/051357 WO2005005410A1 (en) | 2003-07-10 | 2004-07-05 | A method for the preparation of enantiomerically pure mirtazapine |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1086841A1 true HK1086841A1 (en) | 2006-09-29 |
Family
ID=34042934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06109133.3A HK1086841A1 (en) | 2003-07-10 | 2006-08-17 | A method for the preparation of enantiomerically pure mirtazapine |
Country Status (36)
Country | Link |
---|---|
US (2) | US8058436B2 (sr) |
EP (1) | EP1656365B1 (sr) |
JP (1) | JP4668184B2 (sr) |
KR (1) | KR20060056315A (sr) |
CN (1) | CN100558722C (sr) |
AR (1) | AR046494A1 (sr) |
AT (1) | ATE433965T1 (sr) |
AU (1) | AU2004255874B2 (sr) |
BR (1) | BRPI0412447A (sr) |
CA (1) | CA2531165C (sr) |
CO (1) | CO5640123A2 (sr) |
CY (1) | CY1109327T1 (sr) |
DE (1) | DE602004021605D1 (sr) |
DK (1) | DK1656365T3 (sr) |
EC (1) | ECSP066271A (sr) |
ES (1) | ES2327123T3 (sr) |
HK (1) | HK1086841A1 (sr) |
HR (1) | HRP20051019A2 (sr) |
IL (1) | IL172549A0 (sr) |
IS (1) | IS2674B (sr) |
LT (1) | LT5382B (sr) |
LV (1) | LV13441B (sr) |
MX (1) | MXPA06000325A (sr) |
NO (1) | NO20056175L (sr) |
NZ (1) | NZ544360A (sr) |
PE (1) | PE20050323A1 (sr) |
PL (1) | PL1656365T3 (sr) |
PT (1) | PT1656365E (sr) |
RS (1) | RS20050972A (sr) |
RU (1) | RU2352566C2 (sr) |
SG (1) | SG144914A1 (sr) |
SI (1) | SI1656365T1 (sr) |
TW (1) | TWI335915B (sr) |
UA (1) | UA83666C2 (sr) |
WO (1) | WO2005005410A1 (sr) |
ZA (1) | ZA200600019B (sr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5080050B2 (ja) * | 2005-09-26 | 2012-11-21 | 住友化学株式会社 | 光学活性なピペラジン化合物の製造方法 |
WO2007035003A1 (ja) * | 2005-09-26 | 2007-03-29 | Sumitomo Chemical Company, Limited | 光学活性なピペラジン化合物の製造方法 |
TW200808804A (en) * | 2006-05-22 | 2008-02-16 | Organon Nv | Mirtazapine for the treatment of neuropathic pain |
TW200815370A (en) * | 2006-06-16 | 2008-04-01 | Organon Nv | Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine |
JP5438976B2 (ja) * | 2007-02-09 | 2014-03-12 | 株式会社カネカ | 光学活性2−アリールピペラジン誘導体の製造法 |
JP5192707B2 (ja) * | 2007-03-22 | 2013-05-08 | 住友化学株式会社 | ミルタザピンの製造方法 |
MX2009010967A (es) * | 2007-04-11 | 2009-12-15 | Organon Nv | Un metodo para la preparacion de mirtazapina. |
US7994314B2 (en) | 2007-04-11 | 2011-08-09 | N.V. Organon | Method for the preparation of an enantiomerically pure benzazepine |
KR101485418B1 (ko) * | 2013-05-29 | 2015-01-26 | 주식회사 메디켐코리아 | 고순도 미르타자핀의 제조방법 |
RS62055B1 (sr) | 2015-02-27 | 2021-07-30 | Dechra Ltd | Stimulacija apetita, upravljanje gubitkom težine i lečenje anoreksije kod pasa i mačaka |
KR102540021B1 (ko) * | 2020-12-02 | 2023-06-07 | (주)유케이케미팜 | 대량 생산에 적합한 미르타자핀의 제조방법 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3959470A (en) * | 1972-11-28 | 1976-05-25 | Mikhail Davidovich Mashkovsky | Psychotropic medicinal preparation |
NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
PT95522B (pt) * | 1989-10-05 | 1997-08-29 | Sankyo Co | Processo para a preparacao de novos compostos tetraciclicos com accao anti-alergica e anti-asmatica e de composicoes farmaceuticas que os contem |
CZ296282B6 (cs) | 1997-11-14 | 2006-02-15 | Akzo Nobel N. V. | Farmaceutický prostredek |
JPH11222407A (ja) * | 1997-11-14 | 1999-08-17 | Sankyo Co Ltd | 新規殺菌剤 |
US20030069417A1 (en) * | 1999-04-19 | 2003-04-10 | Claude Singer | Novel synthesis and crystallization of piperazine ring-containing compounds |
IL146023A0 (en) * | 1999-04-19 | 2002-07-25 | Teva Pharma | Novel synthesis and crystallization of piperazine ring-containing compounds |
US6068695A (en) * | 1999-07-13 | 2000-05-30 | Bayer Corporation | Process for the continuous preparation of quinacridones |
AU6476300A (en) | 1999-09-30 | 2001-05-10 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a piperazine derivative |
AU6474200A (en) | 1999-12-13 | 2001-06-18 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
CA2396209C (en) | 2000-02-11 | 2009-09-01 | Akzo Nobel N.V. | The use of mirtazapine for the treatment of sleep disorders |
JP2001342188A (ja) * | 2000-03-27 | 2001-12-11 | Takeda Chem Ind Ltd | 縮合ピラゾール誘導体、その製造法および用途 |
TW200538100A (en) * | 2004-04-21 | 2005-12-01 | Akzo Nobel Nv | Mirtazapine salts |
-
2004
- 2004-05-07 UA UAA200600274A patent/UA83666C2/ru unknown
- 2004-06-28 TW TW093118845A patent/TWI335915B/zh not_active IP Right Cessation
- 2004-07-05 DK DK04741958T patent/DK1656365T3/da active
- 2004-07-05 RU RU2006103992/04A patent/RU2352566C2/ru not_active IP Right Cessation
- 2004-07-05 CA CA2531165A patent/CA2531165C/en not_active Expired - Fee Related
- 2004-07-05 RS YUP-2005/0972A patent/RS20050972A/sr unknown
- 2004-07-05 ES ES04741958T patent/ES2327123T3/es not_active Expired - Lifetime
- 2004-07-05 DE DE602004021605T patent/DE602004021605D1/de not_active Expired - Lifetime
- 2004-07-05 PL PL04741958T patent/PL1656365T3/pl unknown
- 2004-07-05 JP JP2006518216A patent/JP4668184B2/ja not_active Expired - Lifetime
- 2004-07-05 PT PT04741958T patent/PT1656365E/pt unknown
- 2004-07-05 AU AU2004255874A patent/AU2004255874B2/en not_active Expired
- 2004-07-05 BR BRPI0412447-2A patent/BRPI0412447A/pt not_active IP Right Cessation
- 2004-07-05 SG SG200805127-8A patent/SG144914A1/en unknown
- 2004-07-05 NZ NZ544360A patent/NZ544360A/en not_active IP Right Cessation
- 2004-07-05 CN CNB2004800194891A patent/CN100558722C/zh not_active Expired - Lifetime
- 2004-07-05 MX MXPA06000325A patent/MXPA06000325A/es active IP Right Grant
- 2004-07-05 KR KR1020067000511A patent/KR20060056315A/ko active IP Right Grant
- 2004-07-05 AT AT04741958T patent/ATE433965T1/de active
- 2004-07-05 EP EP04741958A patent/EP1656365B1/en not_active Expired - Lifetime
- 2004-07-05 US US10/564,193 patent/US8058436B2/en not_active Expired - Fee Related
- 2004-07-05 SI SI200431183T patent/SI1656365T1/sl unknown
- 2004-07-05 WO PCT/EP2004/051357 patent/WO2005005410A1/en active IP Right Grant
- 2004-07-07 PE PE2004000653A patent/PE20050323A1/es not_active Application Discontinuation
- 2004-07-08 AR ARP040102412A patent/AR046494A1/es not_active Application Discontinuation
-
2005
- 2005-12-12 LT LT2005107A patent/LT5382B/lt not_active IP Right Cessation
- 2005-12-13 IL IL172549A patent/IL172549A0/en not_active IP Right Cessation
- 2005-12-15 IS IS8184A patent/IS2674B/is unknown
- 2005-12-22 HR HR20051019A patent/HRP20051019A2/xx not_active Application Discontinuation
- 2005-12-23 NO NO20056175A patent/NO20056175L/no not_active Application Discontinuation
-
2006
- 2006-01-03 ZA ZA200600019A patent/ZA200600019B/en unknown
- 2006-01-09 EC EC2006006271A patent/ECSP066271A/es unknown
- 2006-01-10 CO CO06001617A patent/CO5640123A2/es not_active Application Discontinuation
- 2006-02-10 LV LVP-06-21A patent/LV13441B/en unknown
- 2006-08-17 HK HK06109133.3A patent/HK1086841A1/xx not_active IP Right Cessation
-
2008
- 2008-07-02 US US12/667,969 patent/US20100179319A1/en not_active Abandoned
-
2009
- 2009-08-25 CY CY20091100894T patent/CY1109327T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20130705 |