HK1084382A1 - 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors - Google Patents
2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitorsInfo
- Publication number
- HK1084382A1 HK1084382A1 HK06102936.7A HK06102936A HK1084382A1 HK 1084382 A1 HK1084382 A1 HK 1084382A1 HK 06102936 A HK06102936 A HK 06102936A HK 1084382 A1 HK1084382 A1 HK 1084382A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- aminoaryl
- thiazoles
- aryl
- amino
- kit inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40006402P | 2002-08-02 | 2002-08-02 | |
PCT/IB2003/003685 WO2004014903A1 (fr) | 2002-08-02 | 2003-07-31 | 2-(3-aminoaryl)amino-4-aryl-thiazoles et leur utilisation en tant que inhibiteurs de c-kit |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1084382A1 true HK1084382A1 (en) | 2006-07-28 |
Family
ID=31715693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06102936.7A HK1084382A1 (en) | 2002-08-02 | 2006-03-07 | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
Country Status (20)
Country | Link |
---|---|
US (5) | US20050239852A1 (fr) |
EP (1) | EP1525200B1 (fr) |
JP (1) | JP4726486B2 (fr) |
KR (1) | KR101036866B1 (fr) |
CN (1) | CN100491374C (fr) |
AT (1) | ATE375342T1 (fr) |
BR (1) | BRPI0313165B8 (fr) |
CA (1) | CA2494695C (fr) |
CY (1) | CY1107036T1 (fr) |
DE (1) | DE60316810T2 (fr) |
DK (1) | DK1525200T3 (fr) |
ES (1) | ES2294344T3 (fr) |
HK (1) | HK1084382A1 (fr) |
IL (1) | IL166528A0 (fr) |
MX (1) | MXPA05001277A (fr) |
NO (1) | NO330608B1 (fr) |
NZ (1) | NZ538490A (fr) |
PT (1) | PT1525200E (fr) |
WO (1) | WO2004014903A1 (fr) |
ZA (1) | ZA200501331B (fr) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005507953A (ja) | 2001-03-08 | 2005-03-24 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | 抗感染剤としての表面的に両親媒性のポリマー |
JP2005500041A (ja) * | 2001-06-29 | 2005-01-06 | アブ サイエンス | 強力で選択的かつ非毒性のc−kit阻害剤 |
DK1401413T3 (da) | 2001-06-29 | 2007-03-26 | Ab Science | Anvendelse af tyrosinkinaseinhibitorer til behandling af allergiske sygdomme |
JP2004537537A (ja) | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性疾患を治療するためのチロシンキナーゼ阻害剤の使用法 |
JP3836019B2 (ja) * | 2001-11-21 | 2006-10-18 | 松下電器産業株式会社 | 受信装置、送信装置及び送信方法 |
CN100491374C (zh) | 2002-08-02 | 2009-05-27 | Ab科学公司 | 2-(3-氨基芳基)氨基-4-芳基-噻唑及其作为c-kit抑制剂的应用 |
US8450302B2 (en) * | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
US20050282814A1 (en) * | 2002-10-03 | 2005-12-22 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
WO2004076693A1 (fr) * | 2003-02-27 | 2004-09-10 | Ab Science | Traitement individualise pour differentes formes de mastocytose |
KR101241176B1 (ko) | 2003-03-17 | 2013-03-13 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 표면적으로 양쪽성인 중합체 및 올리고머 및 이의 용도 |
US20070191267A1 (en) * | 2003-04-28 | 2007-08-16 | Ab Science | Use of tyrosine kinase inhibitors for treating cerebral ischemia |
JP2007502809A (ja) * | 2003-08-15 | 2007-02-15 | アブ サイエンス | II型糖尿病を治療するためのc−kit阻害剤の使用方法 |
BRPI0418074B8 (pt) * | 2003-12-25 | 2021-05-25 | Nippon Shinyaku Co Ltd | derivado de amida, composição farmacêutica, inibidor da tirosina cinase bcr-abl e agentes terapêuticos |
WO2005072246A2 (fr) | 2004-01-23 | 2005-08-11 | The Trustees Of The University Of Pennsylvania | Polymeres et oligomeres de polyaryle et de polyarylalkynyle amphiphiles au niveau facial |
NZ548884A (en) * | 2004-01-30 | 2010-06-25 | Ab Science | 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors |
CA2567574C (fr) * | 2004-04-08 | 2013-01-08 | Targegen, Inc. | Inhibiteurs benzotriazine de kinases |
US20080146585A1 (en) * | 2004-04-20 | 2008-06-19 | Ab Science | Use Of C-Kit Inhibitors For Treating Inflammatory Muscle Disorders Including Myositis And Muscular Dystrophy |
WO2005102318A1 (fr) * | 2004-04-20 | 2005-11-03 | Ab Science | Utilisation d'inhibiteurs de c-kit dans le traitement des maladies liees au vih |
WO2005102326A2 (fr) * | 2004-04-23 | 2005-11-03 | Ab Science | Utilisation d'inhibiteurs de c-kit dans le traitement des maladies renales |
EP1742633A2 (fr) * | 2004-04-23 | 2007-01-17 | AB Science | Utilisation des inhibiteurs de c-kit pour le traitement de la fibrose |
WO2005111007A1 (fr) | 2004-05-17 | 2005-11-24 | Otsuka Pharmaceutical Co., Ltd. | Composé thiazole et utilisation de celui-ci |
EP1746990A1 (fr) * | 2004-05-18 | 2007-01-31 | AB Science | Utilisation d'inhibiteurs de mastocytes dans le traitement de patients exposes a des armes chimiques ou biologiques |
WO2005115304A2 (fr) * | 2004-05-24 | 2005-12-08 | Ab Science | Utilisation d'inhibiteurs de c-kit pour le traitement de la fibrodysplasie |
WO2005115385A1 (fr) * | 2004-05-24 | 2005-12-08 | Ab Science | Utilisation d'inhibiteurs de c-kit pour le traitement de l'acne |
CA2578283A1 (fr) | 2004-08-25 | 2006-03-02 | Targegen, Inc. | Composes heterocycliques et methodes d'utilisation |
WO2006093813A2 (fr) * | 2005-02-25 | 2006-09-08 | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA et al. | Polymeres et oligomeres a faces amphiphiles, composition a base de ceux-ci et, leur utilisation dans des procedes de traitement du cancer |
US8088806B2 (en) | 2005-05-09 | 2012-01-03 | Achillion Pharmaceuticals, Inc. | Thiazole compounds and methods of use |
WO2006133411A1 (fr) * | 2005-06-08 | 2006-12-14 | Targegen, Inc. | Methodes et preparations pour le traitement de troubles oculaires |
GB0512091D0 (en) * | 2005-06-14 | 2005-07-20 | Novartis Ag | Organic compounds |
US20080207572A1 (en) * | 2005-07-14 | 2008-08-28 | Ab Science | Use of Dual C-Kit/Fgfr3 Inhibitors for Treating Multiple Myeloma |
JP2009506125A (ja) * | 2005-08-29 | 2009-02-12 | ジェラルド・エム・ハウシー | セラミューテイン・モジュレーター |
US8133900B2 (en) * | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
BRPI0618179A2 (pt) * | 2005-11-01 | 2011-08-23 | Targegen Inc | inibidores de biaril meta pirimidina de cinases |
KR100716891B1 (ko) * | 2005-11-01 | 2007-05-09 | (주)아모레퍼시픽 | 피리딘 티아졸 카복사마이드 유도체, 이의 제조방법 및이를 함유하는 피부 미백용 조성물 |
US8604042B2 (en) * | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
US20070161645A1 (en) * | 2005-11-02 | 2007-07-12 | Targegen, Inc. | Thiazole inhibitors targeting resistant kinase mutations |
US20070135368A1 (en) * | 2005-12-09 | 2007-06-14 | Knapp Pamela E | Cell-to-cell transmission of siRNA induced gene silencing in mammalian cells |
WO2007076460A2 (fr) * | 2005-12-23 | 2007-07-05 | Kalypsys, Inc. | Nouveaux thiazole-urees substitues utiles en tant qu'inhibiteurs de proteine-kinases |
DE102005062986A1 (de) | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
DE102005062990A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Thiazole und ihre Verwendung zur Herstellung von Arzneimitteln |
CA2649755C (fr) * | 2006-04-20 | 2014-12-02 | Janssen Pharmaceutica N.V. | Procede d'inhibition de la kinase de c-kit |
US8030487B2 (en) | 2006-07-07 | 2011-10-04 | Targegen, Inc. | 2-amino—5-substituted pyrimidine inhibitors |
ES2606505T3 (es) | 2007-01-12 | 2017-03-24 | Ab Science | Tratamiento de combinación de cánceres sólidos con antimetabolitos e inhibidores de tirosina quinasa |
US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
JP5568312B2 (ja) * | 2007-02-13 | 2014-08-06 | アーべー・シオンス | キナーゼ阻害剤としての2−アミノチアゾール化合物の合成方法 |
EP1964848A1 (fr) * | 2007-03-01 | 2008-09-03 | Bayer Schering Pharma Aktiengesellschaft | Procédés de radiofluoration |
BRPI0811939A2 (pt) | 2007-05-22 | 2014-11-25 | Achillion Pharmaceuticals Inc | Tiazóis substituídos por heteroarila |
KR100885692B1 (ko) * | 2007-06-12 | 2009-02-26 | 한국화학연구원 | 2-(3-클로로-4-메톡시)아닐리노-4-아릴싸이아졸 유도체또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및이를 유효성분으로 함유하는 암 예방 및 치료용 약학적조성물 |
MX2010004718A (es) * | 2007-11-01 | 2010-07-28 | Acucela Inc | Compuestos derivados de amina para tratar enfermedades y trastornos oftalmicos. |
FR2928150A1 (fr) * | 2008-02-29 | 2009-09-04 | Vetoquinol Sa Sa | Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens |
US8106209B2 (en) | 2008-06-06 | 2012-01-31 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole prodrugs of compounds with anti-HCV activity |
EP2145891A1 (fr) * | 2008-07-09 | 2010-01-20 | Vetoquinol S.A. | Dérivés de 9-substitués-5-carboxy-oxadiazino-quinolone, leur préparation et leur application en tant qu'antibactériens |
CN102421430B (zh) * | 2009-04-06 | 2014-06-25 | 纽若泰克制药株式会社 | 用于预防或治疗烧伤的药物组合物 |
US20120302577A1 (en) * | 2010-01-28 | 2012-11-29 | Ab Science | Treatment of gist with masitinib |
TW201130830A (en) | 2010-02-01 | 2011-09-16 | Ab Science | Combined treatment of pancreatic cancer with gemcitabine and masitinib |
AR080380A1 (es) * | 2010-03-09 | 2012-04-04 | Ab Science | Tratamiento de la demencia tipo alzheimer con masitinib |
DE102010012594A1 (de) | 2010-03-23 | 2011-09-29 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an einem oder mehreren Thiazolderivaten |
TW201204360A (en) | 2010-04-20 | 2012-02-01 | Ab Science | Treatment of multiple sclerosis with MASITINIB |
TW201204719A (en) | 2010-06-02 | 2012-02-01 | Ab Science | Treatment of rheumatoid arthritis with masitinib |
US10045978B2 (en) | 2010-11-05 | 2018-08-14 | Ab Science | Treatment of mastocytosis with masitinib |
US20140147415A1 (en) * | 2010-11-05 | 2014-05-29 | Ab Science | Treatment of mastocytosis with masitinib |
AU2010363329A1 (en) | 2010-11-07 | 2013-05-09 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
US9078894B2 (en) * | 2011-02-04 | 2015-07-14 | Ab Science | Treatment of severe persistant asthma with masitinib |
EP2680846A4 (fr) * | 2011-03-01 | 2014-08-06 | Npharmakon Llc | Utilisation de n-(4-méthoxyphényl)-1-phényl-1h-pyrazol-3-amine et composés associés |
WO2012136732A1 (fr) | 2011-04-08 | 2012-10-11 | Ab Science | Traitement du myélome multiple au moyen de mastinib |
EP2736904B1 (fr) | 2011-07-27 | 2016-03-16 | AB Science | Derives d'oxazole et thiazole en tant qu'inhibiteurs selectifs de proteine kinase (c-kit) |
CN103130791B (zh) * | 2011-11-30 | 2016-05-04 | 正大天晴药业集团股份有限公司 | 一种新型苯甲酰胺类化合物 |
CN103130792B (zh) * | 2011-11-30 | 2016-05-04 | 正大天晴药业集团股份有限公司 | 一种2-氨基噻唑类化合物 |
WO2014053650A1 (fr) | 2012-10-04 | 2014-04-10 | Ab Science | Utilisation de masitinib pour le traitement du cancer chez des sous-populations de patients identifiées à l'aide de facteurs de prédiction |
TW201534597A (zh) * | 2013-06-20 | 2015-09-16 | Ab Science | 作為選擇性蛋白質激酶抑制劑之苯并咪唑衍生物 |
USD704961S1 (en) | 2013-07-03 | 2014-05-20 | Wearwell | Studded molded mat |
WO2015082496A1 (fr) | 2013-12-02 | 2015-06-11 | Ab Science | Utilisation de masitinib pour le traitement du cancer colorectal |
EP2886543A1 (fr) | 2013-12-18 | 2015-06-24 | Sandoz Ag | Forme cristalline de masitinibe |
WO2015185958A1 (fr) | 2014-06-02 | 2015-12-10 | Ab Science | Utilisation d'un inhibiteur de l'activité kinase, en particulier le masitinib, pour le traitement du cancer de la prostate |
CN104045632B (zh) * | 2014-06-03 | 2016-09-07 | 辽宁大学 | 抗肿瘤药物苯并二氢吡喃(噻喃)酰胺类化合物及其药学上可接受的盐及制备方法和应用 |
US20160175302A1 (en) * | 2014-12-17 | 2016-06-23 | Ab Science | Masitinib for treating gastric cancer |
ES2796276T3 (es) * | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
CN106794179A (zh) * | 2015-07-29 | 2017-05-31 | 苏州晶云药物科技有限公司 | 马赛替尼甲磺酸盐的新晶型及其制备方法 |
CA3000894A1 (fr) | 2015-10-05 | 2017-04-13 | Ab Science | Traitement de la mastocytose systemique grave par le masitinib |
HUE057398T2 (hu) | 2016-03-25 | 2022-05-28 | Ab Science | A masitinib alkalmazása egy amiotrófiás laterálszklerózisos beteg alpopuláció kezelésére |
EP3601278B1 (fr) | 2017-03-31 | 2022-10-26 | Sandoz AG | Forme cristalline de masitinibe |
CN108721283A (zh) * | 2017-04-20 | 2018-11-02 | 华东理工大学 | 噻唑衍生物在治疗非淋巴细胞性白血病中的应用 |
EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021099616A1 (fr) | 2019-11-22 | 2021-05-27 | Ab Science | Masitinib pour le traitement de la drépanocytose |
EP3831384A1 (fr) | 2019-12-02 | 2021-06-09 | AB Science | Utilisation de masitinib pour le traitement de l'asthme éosinophile |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
KR20220143020A (ko) | 2020-02-20 | 2022-10-24 | 에이비 사이언스 | 다발 경화증 환자 하위집단의 치료를 위한 마시티닙 |
US20230226043A1 (en) | 2020-04-10 | 2023-07-20 | Ab Science | Use of masitinib for the treatment of coronavirus disease 2019 (covid-19) |
CA3201259A1 (fr) | 2020-12-16 | 2022-06-23 | Alain Moussy | Masitinib pour le traitement de la maladie d'alzheimer |
IL308088A (en) | 2021-05-17 | 2023-12-01 | Ab Science | Mestitinib for the treatment of castrate-resistant prostate cancer |
WO2023081923A1 (fr) | 2021-11-08 | 2023-05-11 | Frequency Therapeutics, Inc. | Inhibiteurs du récepteur du facteur de croissance dérivé des plaquettes (pdgfr) alpha et leurs utilisations |
CN114644582B (zh) * | 2022-04-11 | 2024-03-29 | 中原工学院 | 一种苯基双硫脲类化合物的制备方法 |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US590622A (en) * | 1897-09-28 | Edward mcconnell | ||
US3192225A (en) * | 1961-04-24 | 1965-06-29 | Geigy Chem Corp | 2-substituted aminothiazoles |
US3467666A (en) * | 1966-11-07 | 1969-09-16 | Geigy Chem Corp | 2-substituted aminothiazoles |
US3740420A (en) * | 1967-11-28 | 1973-06-19 | Crown Zellerbach Corp | Pharmaceutical compositions with dimethyl sulfoxide |
FR2077803B1 (fr) * | 1970-02-16 | 1973-03-16 | Innothera Lab Sa | |
US3743727A (en) * | 1970-11-16 | 1973-07-03 | Crown Zellerbach Corp | Enhancing tissue penetration of certain antimicrobial agents with dimethyl sulfoxide |
US4405616A (en) * | 1975-06-19 | 1983-09-20 | Nelson Research & Development Company | Penetration enhancers for transdermal drug delivery of systemic agents |
US3989816A (en) * | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
US4343940A (en) * | 1979-02-13 | 1982-08-10 | Mead Johnson & Company | Anti-tumor quinazoline compounds |
CA1163561A (fr) * | 1979-11-06 | 1984-03-13 | Cyril Boroda | Preparation contenant de la nitroglycerine et parfois d'autres medicaments et methode de preparation |
US4379454A (en) * | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
US4460372A (en) * | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
US4411893A (en) * | 1981-08-14 | 1983-10-25 | Minnesota Mining And Manufacturing Company | Topical medicament preparations |
JPS5968336U (ja) | 1982-10-28 | 1984-05-09 | シャープ株式会社 | 原稿カバ−開閉検出装置 |
CA1236029A (fr) * | 1984-05-14 | 1988-05-03 | Edmund Sandborn | Solutions pharmaceutiques contenant du dimethylsulfoxyde |
US4615699A (en) * | 1985-05-03 | 1986-10-07 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
JPS6328447A (ja) | 1986-07-21 | 1988-02-06 | Toshiba Corp | 加速管 |
JP2752361B2 (ja) | 1986-11-03 | 1998-05-18 | エバレディー、バッテリー、カンパニー、インコーポレーテッド | 正極端子ピンと過塩素酸塩電解質を有する密閉された非水性電池 |
US5217999A (en) * | 1987-12-24 | 1993-06-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Styryl compounds which inhibit EGF receptor protein tyrosine kinase |
DE3815221C2 (de) * | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
GB9413975D0 (en) * | 1994-07-11 | 1994-08-31 | Fujisawa Pharmaceutical Co | New heterobicyclic derivatives |
CA2078214C (fr) | 1990-04-02 | 1995-03-28 | Robert Lee Dow | Inhibiteur de tyrosine kinase a base d'acide phenylmethanephosphonique |
US5302606A (en) * | 1990-04-16 | 1994-04-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase |
US5714493A (en) * | 1991-05-10 | 1998-02-03 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
ES2108120T3 (es) | 1991-05-10 | 1997-12-16 | Rhone Poulenc Rorer Int | Compuestos bis arilicos y heteroarilicos mono- y biciclicos que inhiben tirosina quinasa receptora de egf y/o pdgf. |
US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
JP2549583B2 (ja) | 1991-05-10 | 1996-10-30 | 明成化学工業株式会社 | セルロース繊維の反応染色における未固着染料の退色防止法 |
US6194439B1 (en) | 1991-05-29 | 2001-02-27 | Pfizer Inc. | Tricyclic polyhydroxylic tyrosine kinase inhibitors |
NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
TW225528B (fr) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
HUT71553A (en) | 1992-08-06 | 1995-12-28 | Warner Lambert Co | 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties |
US5330992A (en) * | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
GB9226855D0 (en) | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
US5656643A (en) * | 1993-11-08 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US6239172B1 (en) * | 1997-04-10 | 2001-05-29 | Nitrosystems, Inc. | Formulations for treating disease and methods of using same |
JP3728770B2 (ja) | 1995-06-01 | 2005-12-21 | ブラザー工業株式会社 | 原稿読取り装置 |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
US5906202A (en) | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
US5776020A (en) * | 1997-05-19 | 1998-07-07 | Barone; Michael A. | Tensioning device for sporting racquets |
US5883166A (en) * | 1997-06-26 | 1999-03-16 | Jennings; Thomas C. | Liquid internal mold release agents for unsaturated polyester thermosetting molding compounds |
CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
JP4333676B2 (ja) | 1997-11-21 | 2009-09-16 | オムロン株式会社 | プログラム制御装置、プログラム制御方法、およびプログラム記録媒体 |
US6291514B1 (en) * | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
EP1137415A4 (fr) * | 1998-12-07 | 2002-03-20 | Smithkline Beecham Corp | Inhibiteurs de la myt1 kinase |
JP2002533360A (ja) | 1998-12-31 | 2002-10-08 | スージェン・インコーポレーテッド | 蛋白質キナーゼ活性を調節するためおよび癌の化学療法において用いるための3−ヘテロアリーリデニル−2−インドリノン化合物 |
UA71971C2 (en) * | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
ATE414079T1 (de) | 2000-03-01 | 2008-11-15 | Janssen Pharmaceutica Nv | 2,4-disubstituierte thiazolyl derivate |
US7087608B2 (en) | 2000-03-03 | 2006-08-08 | Robert Charles Atkins | Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy |
US6586453B2 (en) * | 2000-04-03 | 2003-07-01 | 3-Dimensional Pharmaceuticals, Inc. | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 |
US6892245B1 (en) | 2000-09-22 | 2005-05-10 | Nortel Networks Limited | Management information base for a multi-domain network address translator |
JP2002185796A (ja) | 2000-12-11 | 2002-06-28 | Canon Inc | 画像読取処理システムおよび画像読取処理方法、並びに記録媒体 |
ITTO20010110A1 (it) * | 2001-02-08 | 2002-08-08 | Rotta Research Lab | Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. |
GB0108606D0 (en) | 2001-04-05 | 2001-05-23 | Novartis Ag | Organic compounds |
EP1260876B1 (fr) | 2001-05-25 | 2013-05-22 | Ricoh Company, Ltd. | Couvercle pour la plaque d'exposition, dispositif de balayage d'images et dispositif de formation d'images avec le couvercle |
ATE343415T1 (de) | 2001-06-29 | 2006-11-15 | Ab Science | Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen |
WO2003002105A2 (fr) | 2001-06-29 | 2003-01-09 | Ab Science | Utilisation d'inhibiteurs de la tyrosine kinase dans le traitement de la perte osseuse |
JP2004537537A (ja) | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性疾患を治療するためのチロシンキナーゼ阻害剤の使用法 |
EP1471907B1 (fr) | 2001-06-29 | 2008-07-16 | AB Science | Utilisation d'inhibiteurs de c-kit destines a traiter des maladies auto-immunes |
US20050054617A1 (en) | 2001-06-29 | 2005-03-10 | Alain Moussy | Use of potent, selective and non toxic c-kit inhibitors for treating mastocytosis |
JP2005500041A (ja) | 2001-06-29 | 2005-01-06 | アブ サイエンス | 強力で選択的かつ非毒性のc−kit阻害剤 |
DK1401413T3 (da) | 2001-06-29 | 2007-03-26 | Ab Science | Anvendelse af tyrosinkinaseinhibitorer til behandling af allergiske sygdomme |
JP2005502614A (ja) | 2001-06-29 | 2005-01-27 | アブ サイエンス | 多発性硬化症(ms)を治療するためのチロシンキナーゼ阻害剤の使用方法 |
EP1401412A2 (fr) | 2001-06-29 | 2004-03-31 | AB Science | Utilisation d'inhibiteurs de materiel c, puissants, selectifs et non toxiques pour traiter l'angiogenese tumorale |
US20030091974A1 (en) | 2001-06-29 | 2003-05-15 | Alain Moussy | Method for screening compounds capable of depleting mast cells |
WO2003039550A1 (fr) | 2001-09-20 | 2003-05-15 | Ab Science | Utilisation d'inhibiteurs de tyrosine kinase pour blanchir la peau humaine et traiter des troubles associes a un dysfonctionnement des melanocytes |
US20040241226A1 (en) | 2001-09-20 | 2004-12-02 | Alain Moussy | Use of potent, selective and non-toxic c-kit inhibitors for treating bacterial infections |
ATE401078T1 (de) | 2001-09-20 | 2008-08-15 | Ab Science | Die verwendung von c-kithemmern zur förderung des haarwuchses |
JP2003134307A (ja) | 2001-10-26 | 2003-05-09 | Canon Inc | 画像読取装置 |
US20030158199A1 (en) * | 2002-01-25 | 2003-08-21 | Kylix, B.V. | Novel compounds for inhibition of Tie-2 |
CA2474322A1 (fr) | 2002-01-25 | 2003-07-31 | Kylix Pharmaceuticals B.V. | (thia-/oxa-/pyra) zoles substitues 4(hetero-) aryle pour inhibition de tie-2 |
CN100491374C (zh) * | 2002-08-02 | 2009-05-27 | Ab科学公司 | 2-(3-氨基芳基)氨基-4-芳基-噻唑及其作为c-kit抑制剂的应用 |
JP5568312B2 (ja) | 2007-02-13 | 2014-08-06 | アーべー・シオンス | キナーゼ阻害剤としての2−アミノチアゾール化合物の合成方法 |
-
2003
- 2003-07-31 CN CNB03823145XA patent/CN100491374C/zh not_active Expired - Lifetime
- 2003-07-31 CA CA2494695A patent/CA2494695C/fr not_active Expired - Lifetime
- 2003-07-31 PT PT03784419T patent/PT1525200E/pt unknown
- 2003-07-31 WO PCT/IB2003/003685 patent/WO2004014903A1/fr active IP Right Grant
- 2003-07-31 IL IL16652803A patent/IL166528A0/xx active IP Right Grant
- 2003-07-31 MX MXPA05001277A patent/MXPA05001277A/es active IP Right Grant
- 2003-07-31 NZ NZ538490A patent/NZ538490A/en not_active IP Right Cessation
- 2003-07-31 JP JP2004527232A patent/JP4726486B2/ja not_active Expired - Lifetime
- 2003-07-31 US US10/523,018 patent/US20050239852A1/en not_active Abandoned
- 2003-07-31 AT AT03784419T patent/ATE375342T1/de active
- 2003-07-31 KR KR1020057001919A patent/KR101036866B1/ko active IP Right Grant
- 2003-07-31 EP EP03784419A patent/EP1525200B1/fr not_active Expired - Lifetime
- 2003-07-31 DE DE60316810T patent/DE60316810T2/de not_active Expired - Lifetime
- 2003-07-31 BR BRPI0313165A patent/BRPI0313165B8/pt not_active IP Right Cessation
- 2003-07-31 ES ES03784419T patent/ES2294344T3/es not_active Expired - Lifetime
- 2003-07-31 DK DK03784419T patent/DK1525200T3/da active
- 2003-08-01 US US10/632,101 patent/US7423055B2/en not_active Expired - Lifetime
-
2005
- 2005-02-15 ZA ZA2005/01331A patent/ZA200501331B/en unknown
- 2005-03-02 NO NO20051115A patent/NO330608B1/no not_active IP Right Cessation
-
2006
- 2006-03-07 HK HK06102936.7A patent/HK1084382A1/xx not_active IP Right Cessation
-
2007
- 2007-07-18 US US11/779,633 patent/US20080255141A1/en not_active Abandoned
- 2007-11-27 CY CY20071101517T patent/CY1107036T1/el unknown
-
2011
- 2011-01-28 US US13/015,664 patent/US8835435B2/en not_active Expired - Lifetime
-
2013
- 2013-11-26 US US14/089,946 patent/US8993573B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1084382A1 (en) | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors | |
BRPI0415467A (pt) | compostos de 2-aminoariloxazol para o tratamento de doenças | |
UA95071C2 (ru) | Замещенные производные оксазола и их применение как ингибиторов тирозинкиназы | |
NO20063861L (no) | 2-(3-substituert aryl)amin-4-arylthiazoler som tyrosinkinasehemmere | |
WO2006064375A2 (fr) | Composes heterocycliques a noyau a cinq elements a substitution aminoaryle pour le traitement de maladies | |
NO20075627L (no) | Inhibitorer av cytosolisk fosfolipase A2 | |
ATE381332T1 (de) | Tyrosinkinase-hemmer | |
CY1110663T1 (el) | 2-αμινοαρυλοξαζολικες ενωσεις ως παρεμποδιστες κινασων της τυροσινης | |
WO2007013896A3 (fr) | Composes modulant l'activite de c-kit et c-fms et utilisations | |
DE602004014117D1 (de) | Thiazole zur verwendung als inhibitoren von protein-kinasen | |
WO2004089286A3 (fr) | Nouveaux composes et compositions utilises comme inhibiteurs de la proteine kinase | |
ATE450530T1 (de) | Zusammensetzungen zur verwendung als protein- kinase-inhibitoren | |
MXPA05013224A (es) | Piridinilcarbamatos como inhibidores de lipasa sensible a hormonas. | |
DE60315146D1 (de) | Heteroarylsubstituierte biphenylderivate als inhibitoren von p38-kinase | |
IL192557A (en) | Imidazole derivatives are conserved and used as ptpase inhibitors | |
DK1401415T3 (da) | Anvendelse af N-phenyl-2-pyrimidinamin-derivater til behandling af inflammatoriske sygdomme | |
DE60307237D1 (de) | Verwendung von tyrosine-kinase inhibitoren zur behandlung von cns krankheiten | |
ATE494008T1 (de) | Verwendung eines p38-kinasehemmers zur behandlung von psychiatrischen erkrankungen | |
CU20070222A7 (es) | Derivados de oxazol sustituidos y su uso como inhibidores de tirosina quinasa |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20230727 |