HK1082752A1 - Improved secretion of neublastin - Google Patents
Improved secretion of neublastinInfo
- Publication number
- HK1082752A1 HK1082752A1 HK06105018.1A HK06105018A HK1082752A1 HK 1082752 A1 HK1082752 A1 HK 1082752A1 HK 06105018 A HK06105018 A HK 06105018A HK 1082752 A1 HK1082752 A1 HK 1082752A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- neublastin
- construct
- region
- nervous system
- nucleotide sequence
- Prior art date
Links
- 102100026376 Artemin Human genes 0.000 title abstract 7
- 101000785776 Homo sapiens Artemin Proteins 0.000 title abstract 4
- 230000028327 secretion Effects 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
- C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200300861 | 2003-06-10 | ||
US50748303P | 2003-10-02 | 2003-10-02 | |
PCT/DK2004/000411 WO2004108760A2 (en) | 2003-06-10 | 2004-06-10 | Improved secretion of neublastin |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1082752A1 true HK1082752A1 (en) | 2006-06-16 |
Family
ID=34485959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06105018.1A HK1082752A1 (en) | 2003-06-10 | 2006-04-26 | Improved secretion of neublastin |
Country Status (17)
Country | Link |
---|---|
US (1) | US7601518B2 (zh) |
EP (2) | EP1636260B1 (zh) |
JP (1) | JP5623685B2 (zh) |
KR (1) | KR20060031618A (zh) |
CN (1) | CN100475846C (zh) |
AT (2) | ATE478092T1 (zh) |
AU (1) | AU2004245175C1 (zh) |
BR (1) | BRPI0411243A (zh) |
CA (1) | CA2527914C (zh) |
DE (2) | DE602004028769D1 (zh) |
DK (2) | DK2058329T3 (zh) |
ES (2) | ES2353457T3 (zh) |
HK (1) | HK1082752A1 (zh) |
IL (1) | IL172270A (zh) |
NZ (1) | NZ544263A (zh) |
RU (1) | RU2005138368A (zh) |
WO (1) | WO2004108760A2 (zh) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
US7276580B2 (en) | 2001-03-12 | 2007-10-02 | Biogen Idec Ma Inc. | Neurotrophic factors |
JP4571776B2 (ja) * | 2002-11-05 | 2010-10-27 | Jx日鉱日石エネルギー株式会社 | 潤滑油組成物 |
EP1618179B1 (en) | 2003-04-18 | 2014-05-07 | Biogen Idec MA Inc. | Polymer-conjugated glycosylated neublastin |
EP2277996B1 (en) | 2003-05-21 | 2014-09-03 | Genzyme Corporation | Methods for producing preparations of recombinant AAV virions substantially free of empty capsids |
JP5623685B2 (ja) | 2003-06-10 | 2014-11-12 | エヌエスゲーネ・アクティーゼルスカブ | ニューブラスチンの改良された分泌 |
US7598059B2 (en) * | 2003-10-02 | 2009-10-06 | Biogen Idec Ma Inc. | Neublastin expression constructs |
US20060239966A1 (en) * | 2003-10-20 | 2006-10-26 | Tornoee Jens | In vivo gene therapy of parkinson's disease |
PT1786454E (pt) * | 2004-08-19 | 2010-08-18 | Biogen Idec Inc | Variantes de neublastina |
CN101123978B (zh) | 2004-08-19 | 2012-12-12 | 比奥根艾迪克Ma公司 | 神经胚素变体 |
JP4991705B2 (ja) | 2005-05-20 | 2012-08-01 | ロンザ・バイオロジクス・ピーエルシー | 哺乳類宿主細胞における組換え抗体の高レベル発現 |
WO2007042040A2 (en) * | 2005-10-11 | 2007-04-19 | Ns Gene A/S | TREATMENT OF RETINOPATHIES USING GFRα3 AGONISTS |
US7820195B2 (en) * | 2005-12-30 | 2010-10-26 | Neurotech Usa, Inc. | Micronized device for the delivery of biologically active molecules and methods of use thereof |
TWI501774B (zh) * | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
ES2450065T3 (es) * | 2006-03-01 | 2014-03-21 | Biogen Idec Ma Inc. | Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF |
CA2685686A1 (en) | 2007-05-01 | 2008-11-13 | Biogen Idec Ma Inc. | Neublastin polypeptides for use increasing vascularization in a tissue |
EP2048237A1 (en) | 2007-10-05 | 2009-04-15 | Avir Green Hills Biotechnology Research Development Trade Ag | Replication deficient Influenza virus for the expression of heterologous sequences |
RU2491344C2 (ru) * | 2007-06-29 | 2013-08-27 | Ф.Хоффманн-Ля Рош Аг | Промотор |
WO2009020964A2 (en) * | 2007-08-08 | 2009-02-12 | Biogen Idec Ma Inc. | Anti-neublastin antibodies and uses thereof |
CN105640992A (zh) * | 2008-03-21 | 2016-06-08 | 组织基因公司 | 椎间盘退化的治疗 |
EP2281047B1 (en) * | 2008-04-15 | 2020-04-08 | Genzyme Corporation | Methods to produce rod-derived cone viability factor (rdcvf) |
US20120021039A1 (en) * | 2009-01-23 | 2012-01-26 | Nsgene A/S | Expression of neuropeptides in mammalian cells |
CA2750027C (en) * | 2009-01-23 | 2020-11-10 | Nsgene A/S | Improved cell lines and their use in encapsulated cell biodelivery |
CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
WO2012170765A2 (en) | 2011-06-10 | 2012-12-13 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
JP6841507B2 (ja) * | 2015-05-07 | 2021-03-10 | ユニヴァーシティ オブ サウス フロリダ | アンジェルマン症候群の遺伝子治療法のための組み換えube3a遺伝子 |
GB201519086D0 (en) * | 2015-10-28 | 2015-12-09 | Syncona Partners Llp | Gene Therapy |
AU2017228489A1 (en) * | 2016-03-04 | 2018-09-06 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for modulating body weight |
CN108610398B (zh) * | 2018-01-15 | 2020-08-11 | 武汉海特生物制药股份有限公司 | 一段功能序列及在分泌蛋白表达中的应用 |
CN111712566A (zh) | 2018-02-08 | 2020-09-25 | 应用干细胞有限公司 | 用于筛选靶基因变体的方法 |
US20220048984A1 (en) * | 2018-12-21 | 2022-02-17 | Gloriana Therapeutics Sarl | Mammalian Cell Culture-Produced Neublastin Antibodies |
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AU6131086A (en) | 1985-07-05 | 1987-01-30 | Whitehead Institute For Biomedical Research | Epithelial cells expressing foreign genetic material |
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JP2003534787A (ja) | 2000-05-26 | 2003-11-25 | カイロン コーポレイション | レンチウイルスベクターを使用する神経細胞の形質導入の方法 |
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PL366333A1 (en) | 2000-12-22 | 2005-01-24 | Genentech, Inc. | New use of artemin, a member of the gdnf ligand family |
CN1500095B (zh) | 2001-02-01 | 2010-06-16 | 比奥根艾迪克Ma公司 | 神经胚活素的多聚体偶联物及其应用方法 |
JP4499362B2 (ja) | 2001-03-28 | 2010-07-07 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | ニューロパシーの疼痛を処置するためのニューブラスチンポリペプチドの使用 |
EP1618179B1 (en) | 2003-04-18 | 2014-05-07 | Biogen Idec MA Inc. | Polymer-conjugated glycosylated neublastin |
JP5623685B2 (ja) | 2003-06-10 | 2014-11-12 | エヌエスゲーネ・アクティーゼルスカブ | ニューブラスチンの改良された分泌 |
US7598059B2 (en) * | 2003-10-02 | 2009-10-06 | Biogen Idec Ma Inc. | Neublastin expression constructs |
BRPI0415563A (pt) | 2003-10-20 | 2007-01-02 | Nsgene As | método para o tratamento do mal de parkinson, uso de um vetor viral, vetor de expressão viral, composição farmacêutica, célula hospedeira isolada, linhagem de células de empacotamento, mamìfero não humano quimérico, dispositivo de cultura celular implantável, cápsula biocompatìvel, método para tratamento de uma doença do sistema nervoso, célula de mamìfero, e, método para produzir neurturin ou um seu equivalente funcional |
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2004
- 2004-06-10 JP JP2006515713A patent/JP5623685B2/ja not_active Expired - Fee Related
- 2004-06-10 EP EP04736510A patent/EP1636260B1/en active Active
- 2004-06-10 BR BRPI0411243-1A patent/BRPI0411243A/pt not_active IP Right Cessation
- 2004-06-10 ES ES09153016T patent/ES2353457T3/es active Active
- 2004-06-10 DE DE602004028769T patent/DE602004028769D1/de active Active
- 2004-06-10 CA CA2527914A patent/CA2527914C/en not_active Expired - Fee Related
- 2004-06-10 AU AU2004245175A patent/AU2004245175C1/en not_active Ceased
- 2004-06-10 AT AT09153016T patent/ATE478092T1/de not_active IP Right Cessation
- 2004-06-10 NZ NZ544263A patent/NZ544263A/en not_active IP Right Cessation
- 2004-06-10 US US10/864,891 patent/US7601518B2/en not_active Expired - Fee Related
- 2004-06-10 RU RU2005138368/13A patent/RU2005138368A/ru not_active Application Discontinuation
- 2004-06-10 EP EP09153016A patent/EP2058329B1/en active Active
- 2004-06-10 ES ES04736510T patent/ES2323066T3/es active Active
- 2004-06-10 DK DK09153016.2T patent/DK2058329T3/da active
- 2004-06-10 DE DE602004019524T patent/DE602004019524D1/de active Active
- 2004-06-10 KR KR1020057023631A patent/KR20060031618A/ko not_active Application Discontinuation
- 2004-06-10 CN CNB2004800229462A patent/CN100475846C/zh not_active Expired - Fee Related
- 2004-06-10 AT AT04736510T patent/ATE423134T1/de not_active IP Right Cessation
- 2004-06-10 WO PCT/DK2004/000411 patent/WO2004108760A2/en active Application Filing
- 2004-06-10 DK DK04736510T patent/DK1636260T3/da active
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Also Published As
Publication number | Publication date |
---|---|
JP5623685B2 (ja) | 2014-11-12 |
ATE478092T1 (de) | 2010-09-15 |
WO2004108760A3 (en) | 2005-04-07 |
JP2007535898A (ja) | 2007-12-13 |
WO2004108760A2 (en) | 2004-12-16 |
IL172270A (en) | 2015-04-30 |
IL172270A0 (en) | 2006-04-10 |
NZ544263A (en) | 2009-04-30 |
EP1636260A2 (en) | 2006-03-22 |
BRPI0411243A (pt) | 2006-07-11 |
CN1835971A (zh) | 2006-09-20 |
RU2005138368A (ru) | 2006-07-27 |
CN100475846C (zh) | 2009-04-08 |
KR20060031618A (ko) | 2006-04-12 |
ES2323066T3 (es) | 2009-07-06 |
DK1636260T3 (da) | 2009-06-22 |
EP1636260B1 (en) | 2009-02-18 |
DE602004019524D1 (de) | 2009-04-02 |
EP2058329A1 (en) | 2009-05-13 |
US20050089960A1 (en) | 2005-04-28 |
CA2527914A1 (en) | 2004-12-16 |
CA2527914C (en) | 2014-10-28 |
AU2004245175C1 (en) | 2010-03-18 |
DE602004028769D1 (de) | 2010-09-30 |
ES2353457T3 (es) | 2011-03-02 |
ATE423134T1 (de) | 2009-03-15 |
AU2004245175B2 (en) | 2009-10-15 |
EP2058329B1 (en) | 2010-08-18 |
DK2058329T3 (da) | 2010-12-06 |
AU2004245175A1 (en) | 2004-12-16 |
US7601518B2 (en) | 2009-10-13 |
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