HK1068810A1 - Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease - Google Patents
Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune diseaseInfo
- Publication number
- HK1068810A1 HK1068810A1 HK05101505.1A HK05101505A HK1068810A1 HK 1068810 A1 HK1068810 A1 HK 1068810A1 HK 05101505 A HK05101505 A HK 05101505A HK 1068810 A1 HK1068810 A1 HK 1068810A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antibody
- specificity
- cancer
- detection
- treatment
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
- 102000003425 Tyrosinase Human genes 0.000 abstract 4
- 108060008724 Tyrosinase Proteins 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 102000036639 antigens Human genes 0.000 abstract 4
- 102000043129 MHC class I family Human genes 0.000 abstract 3
- 108091054437 MHC class I family Proteins 0.000 abstract 3
- 108700018351 Major Histocompatibility Complex Proteins 0.000 abstract 2
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/073,301 US6992176B2 (en) | 2002-02-13 | 2002-02-13 | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
PCT/IL2003/000105 WO2003068201A2 (en) | 2002-02-13 | 2003-02-11 | High affinity antibody having a tcr-like specificity and use in detection and treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1068810A1 true HK1068810A1 (en) | 2005-05-06 |
Family
ID=27732335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05101505.1A HK1068810A1 (en) | 2002-02-13 | 2005-02-23 | Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
Country Status (11)
Country | Link |
---|---|
US (3) | US6992176B2 (xx) |
EP (3) | EP2072045B1 (xx) |
JP (1) | JP4272535B2 (xx) |
AT (1) | ATE446745T1 (xx) |
AU (3) | AU2003208582C1 (xx) |
CA (1) | CA2474782C (xx) |
DE (1) | DE60329823D1 (xx) |
ES (2) | ES2425539T3 (xx) |
HK (1) | HK1068810A1 (xx) |
IL (1) | IL193376A (xx) |
WO (1) | WO2003068201A2 (xx) |
Families Citing this family (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001060391A1 (en) * | 2000-02-15 | 2001-08-23 | Regents Of The University Of California | A universal vaccine and method for treating cancer employing telomerase reverse transcriptase |
US20040191260A1 (en) * | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US6992176B2 (en) * | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
WO2003070752A2 (en) * | 2002-02-20 | 2003-08-28 | Dyax Corporation | Mhc-peptide complex binding ligands |
US20040072262A1 (en) * | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
CA2570458C (en) * | 2004-06-09 | 2014-05-20 | Technion Research & Development Foundation Ltd. | Antibodies for selective apoptosis of cells |
WO2006009920A2 (en) * | 2004-06-17 | 2006-01-26 | Mannkind Corporation | Epitope analogs |
WO2007136778A2 (en) * | 2006-05-19 | 2007-11-29 | Teva Pharmaceutical Industries, Ltd. | Fusion proteins, uses thereof and processes for producing same |
US8361473B2 (en) * | 2007-03-29 | 2013-01-29 | Technion Research & Development Foundation Ltd. | Antibodies and their uses for diagnosis and treatment of cytomegalovirus infection and associated diseases |
EP2514766A3 (en) | 2007-03-29 | 2013-06-05 | Technion Research & Development Foundation Ltd. | Antibodies, methods and kits for diagnosing and treating melanoma |
US8747855B2 (en) * | 2008-04-09 | 2014-06-10 | Technion Research & Development Foundation Limited | Anti human immunodeficiency antibodies and uses thereof |
EP2297200A1 (en) * | 2008-04-09 | 2011-03-23 | Technion Research & Development Foundation Ltd. | Anti influenza antibodies and uses thereof |
CN102083615B (zh) * | 2008-04-10 | 2014-08-13 | 战略系统有限公司 | 用于三维模型打印的系统和方法 |
DK2119726T5 (en) | 2008-05-14 | 2018-03-26 | Immatics Biotechnologies Gmbh | Novel and powerful MHC class II peptides derived from survivin and neurocan |
ES2536465T3 (es) | 2008-10-01 | 2015-05-25 | Immatics Biotechnologies Gmbh | Composición de péptidos tumor-asociados y relacionados con la vacuna contra el cáncer para el tratamiento de glioblastoma (GBM) y otros cánceres |
US20120077696A1 (en) | 2009-03-15 | 2012-03-29 | Technion Research And Development Foundation Ltd. | Soluble hla complexes for use in disease diagnosis |
SG177025A1 (en) | 2010-06-21 | 2012-01-30 | Agency Science Tech & Res | Hepatitis b virus specific antibody and uses thereof |
BR112013002532A2 (pt) | 2010-08-05 | 2016-05-31 | Hoffmann La Roche | proteína de fusão de citocina anti-viral do anticorpo anti-mhc |
WO2012129520A1 (en) | 2011-03-24 | 2012-09-27 | Texas Tech University System | Tcr mimic antibodies as vascular targeting tools |
JP6082997B2 (ja) * | 2011-04-01 | 2017-02-22 | メモリアル スローン−ケタリング キャンサー センター | Hla−a2により提示されるwt1ペプチドへのt細胞受容体様抗体 |
AU2012316859A1 (en) | 2011-09-29 | 2014-04-17 | Apo-T B.V. | Multi-specific binding molecules targeting aberrant cells |
WO2013105856A1 (en) * | 2012-01-13 | 2013-07-18 | Apo-T B.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
UA114108C2 (xx) | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
TWI777197B (zh) | 2013-08-05 | 2022-09-11 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(六) |
US20160310583A1 (en) * | 2013-10-03 | 2016-10-27 | Sumitomo Dainippon Pharma Co., Ltd. | Tumor antigen peptide |
GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
GB201408255D0 (en) | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
GB201411037D0 (en) | 2014-06-20 | 2014-08-06 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemai (CLL) |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
EP3193592A1 (en) | 2014-09-19 | 2017-07-26 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors |
GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
KR20170132793A (ko) | 2015-04-03 | 2017-12-04 | 유레카 쎄라퓨틱스, 인코포레이티드 | Afp 펩티드/mhc 복합체를 표적화하는 구축물 및 그의 용도 |
GB201507030D0 (en) | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
WO2016174652A1 (en) | 2015-04-30 | 2016-11-03 | Technion Research & Development Foundation Limited | Chimeric antigen receptors and methods of their use |
GB201507719D0 (en) | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
GB201511546D0 (en) | 2015-07-01 | 2015-08-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
IL308735A (en) | 2015-07-01 | 2024-01-01 | Immatics Biotechnologies Gmbh | New peptides and combinations of peptides used in immunotherapy against ovarian cancer and other types of cancer |
MX2017017148A (es) | 2015-07-06 | 2018-02-23 | Immatics Biotechnologies Gmbh | Peptidos novedosos y combinacion de peptidos para usarse en la inmunoterapia contra cancer esofagico y otros canceres. |
PL3322424T3 (pl) | 2015-07-16 | 2024-03-04 | Yeda Research And Development Co., Ltd. | Zastosowanie centralnych limfocytów t pamięci przeciwko stronie trzeciej |
GB201513921D0 (en) | 2015-08-05 | 2015-09-23 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers |
CN115927191A (zh) | 2015-10-23 | 2023-04-07 | 优瑞科生物技术公司 | 抗体/t细胞受体嵌合构建体及其用途 |
GB201522667D0 (en) | 2015-12-22 | 2016-02-03 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers |
SG11201805420SA (en) | 2015-12-30 | 2018-07-30 | Kodiak Sciences Inc | Antibodies and conjugates thereof |
GB201602918D0 (en) | 2016-02-19 | 2016-04-06 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers |
MA54832A (fr) | 2016-03-01 | 2021-12-01 | Immatics Biotechnologies Gmbh | Peptides, combinaison de peptides et médicaments à base de cellules destinés à être utilisés en immunothérapie contre le cancer de la vessie et d'autres cancers |
CA3020162A1 (en) | 2016-04-06 | 2017-10-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against aml and other cancers |
EP3475446A1 (en) | 2016-06-27 | 2019-05-01 | Juno Therapeutics, Inc. | Method of identifying peptide epitopes, molecules that bind such epitopes and related uses |
MA45491A (fr) | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés |
TWI796299B (zh) | 2016-08-26 | 2023-03-21 | 德商英麥提克生物技術股份有限公司 | 用於頭頸鱗狀細胞癌和其他癌症免疫治療的新型肽和支架 |
WO2018057967A2 (en) * | 2016-09-23 | 2018-03-29 | Eureka Therapeutics, Inc. | Constructs targeting hiv peptide/mhc complexes and uses thereof |
US20200078400A1 (en) | 2016-12-03 | 2020-03-12 | Juno Therapeutics, Inc. | Methods for determining car-t cells dosing |
BR112019011025A2 (pt) | 2016-12-03 | 2019-10-08 | Juno Therapeutics Inc | métodos para modulação de células t car |
EP3548611A1 (en) | 2016-12-05 | 2019-10-09 | Juno Therapeutics, Inc. | Production of engineered cells for adoptive cell therapy |
CN107686522A (zh) * | 2016-12-28 | 2018-02-13 | 天津天锐生物科技有限公司 | 一种识别hla‑a2/sllmwitqc的单域抗体 |
JP7429338B2 (ja) | 2017-01-10 | 2024-02-08 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法および関連方法のエピジェネティック解析 |
IL268126B2 (en) | 2017-01-18 | 2024-02-01 | Yeda Res & Dev | Genetically engineered Veto cells and their uses in immunotherapy |
CA3050085A1 (en) | 2017-01-20 | 2018-07-26 | Juno Therapeutics Gmbh | Cell surface conjugates and related cell compositions and methods |
TWI796314B (zh) | 2017-01-27 | 2023-03-21 | 德商英麥提克生物技術股份有限公司 | 用於卵巢癌和其他癌症免疫治療的新型肽和肽組合物 |
EP3582782B1 (en) | 2017-02-17 | 2023-06-07 | Fred Hutchinson Cancer Center | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
CA3053539A1 (en) | 2017-02-27 | 2018-08-30 | Juno Therapeutics, Inc. | Compositions, articles of manufacture and methods related to dosing in cell therapy |
AU2018250336A1 (en) | 2017-04-07 | 2019-09-26 | Juno Therapeutics, Inc. | Engineered cells expressing prostate-specific membrane antigen (PSMA) or a modified form thereof and related methods |
WO2018189148A1 (en) | 2017-04-10 | 2018-10-18 | Immatics Biotechnologies Gmbh | Peptides and combination thereof for use in the immunotherapy against cancers |
EA201992416A1 (ru) | 2017-04-10 | 2020-02-25 | Имматикс Байотекнолоджиз Гмбх | Пептиды и комбинации пептидов для применения в иммунотерапии лейкозов и других видов рака |
BR112019020959A2 (pt) | 2017-04-10 | 2020-05-05 | Immatics Biotechnologies Gmbh | peptídeos e combinações dos mesmos para uso na imunoterapia contra câncer |
MA54103A (fr) | 2017-04-14 | 2021-09-15 | Juno Therapeutics Inc | Procédés d'évaluation de la glycosylation de surface cellulaire |
IL310182A (en) | 2017-04-26 | 2024-03-01 | Eureka Therapeutics Inc ׂ A Delaware Corp | Structures of chimeric antibody/T-cell receptor and uses thereof |
MX2019014288A (es) | 2017-06-02 | 2020-08-03 | Juno Therapeutics Inc | Articulos de manufactura y metodos relacionados a toxicidad asociada con terapia celular. |
CA3066972A1 (en) | 2017-06-14 | 2018-12-20 | Adicet Bio Inc. | Antibodies capable of binding hla-a2/tyrd in an hla restricted manner and uses thereof |
TW201906859A (zh) | 2017-07-07 | 2019-02-16 | 德商英麥提克生物技術股份有限公司 | 用於肺癌(包括 nsclc、sclc 和其他癌症)免疫治療的新型肽和肽組合物 |
WO2019007974A1 (en) | 2017-07-07 | 2019-01-10 | Immatics Biotechnologies Gmbh | NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY OF LUNG CANCER, INCLUDING NSCLC, CPPC AND OTHER CANCERS |
AU2018310452A1 (en) | 2017-07-29 | 2020-02-13 | Juno Therapeutics, Inc. | Reagents for expanding cells expressing recombinant receptors |
EP3661549A1 (en) | 2017-08-02 | 2020-06-10 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Hepatitis b nanoparticle-based vaccine for influenza virus |
BR112020001601A2 (pt) | 2017-08-09 | 2020-08-11 | Juno Therapeutics Inc | métodos e composições para preparar células geneticamente manipuladas |
US11851678B2 (en) | 2017-08-09 | 2023-12-26 | Juno Therapeutics, Inc. | Methods for producing genetically engineered cell compositions and related compositions |
MA50079A (fr) | 2017-09-07 | 2020-07-15 | Juno Therapeutics Inc | Procédés d'identification de caractéristiques cellulaires relatives à des réponses associées à une thérapie cellulaire |
WO2019089982A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
AU2018359907A1 (en) | 2017-11-06 | 2020-05-07 | Fred Hutchinson Cancer Center | Combination of a cell therapy and a gamma secretase inhibitor |
CN111989106A (zh) | 2017-12-01 | 2020-11-24 | 朱诺治疗学股份有限公司 | 基因工程化细胞的给药和调节方法 |
JP2021505615A (ja) | 2017-12-08 | 2021-02-18 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法および関連方法のための表現型マーカー |
SG11202005272SA (en) | 2017-12-08 | 2020-07-29 | Juno Therapeutics Inc | Process for producing a composition of engineered t cells |
KR20200108277A (ko) | 2017-12-08 | 2020-09-17 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포를 배양하기 위한 무혈청 배지 제형 및 이의 사용 방법 |
US20210069246A1 (en) | 2018-01-31 | 2021-03-11 | Celgene Corporation | Combination therapy using adoptive cell therapy and checkpoint inhibitor |
DE102018107224A1 (de) | 2018-02-21 | 2019-08-22 | Immatics Biotechnologies Gmbh | Peptide und Kombinationen von Peptiden nicht-kanonischen Ursprungs zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
SG11202009313VA (en) | 2018-04-05 | 2020-10-29 | Juno Therapeutics Inc | Methods of producing cells expressing a recombinant receptor and related compositions |
TW202016131A (zh) | 2018-05-16 | 2020-05-01 | 德商英麥提克生物技術股份有限公司 | 用於抗癌免疫治療的肽 |
US10925947B2 (en) | 2018-06-29 | 2021-02-23 | Immatics Biotechnologies Gmbh | A*03 restricted peptides for use in immunotherapy against cancers and related methods |
TW202019955A (zh) | 2018-07-31 | 2020-06-01 | 德商英麥提克生物技術股份有限公司 | B*07 限制肽和肽組合的抗癌免疫治療和相關方法 |
US20210163893A1 (en) | 2018-08-09 | 2021-06-03 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
CN112805378A (zh) | 2018-08-09 | 2021-05-14 | 朱诺治疗学股份有限公司 | 用于评估整合核酸的方法 |
BR112021004261A2 (pt) | 2018-09-11 | 2021-05-25 | Juno Therapeutics Inc | métodos para análise por espectrometria de massas de composições de células geneticamente modificadas |
US11945850B2 (en) | 2018-09-17 | 2024-04-02 | Immatics Biotechnologies Gmbh | B*44 restricted peptides for use in immunotherapy against cancers and related methods |
TW202024121A (zh) | 2018-09-18 | 2020-07-01 | 德商英麥提克生物技術股份有限公司 | A*01 限制肽和肽組合物在抗癌免疫治療中的用途和相關方法 |
EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
MX2021006238A (es) | 2018-11-30 | 2021-10-01 | Juno Therapeutics Inc | Metodos para tratamiento que usan terapia celular adoptiva. |
TW202039535A (zh) | 2018-12-18 | 2020-11-01 | 德商英麥提克生物技術股份有限公司 | B*08限制肽和肽組合物抗癌免疫治療和相關方法 |
BR112021021075A2 (pt) | 2019-05-01 | 2021-12-14 | Editas Medicine Inc | Células que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotídeos relacionados e métodos |
MX2021013223A (es) | 2019-05-01 | 2022-02-17 | Juno Therapeutics Inc | Celulas que expresan un receptor quimerico de un locus cd247 modificado, polinucleotidos relacionados y metodos. |
EP3983006A1 (en) | 2019-06-12 | 2022-04-20 | Juno Therapeutics, Inc. | Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival bcl2 family protein |
KR20220066892A (ko) | 2019-08-22 | 2022-05-24 | 주노 쎄러퓨티크스 인코퍼레이티드 | T 세포 요법 및 제스트 동족체 2의 인핸서 (ezh2) 억제제의 병용 요법 및 관련 방법 |
EP4021493A1 (en) | 2019-08-29 | 2022-07-06 | Eberhard Karls Universität Tübingen, Medizinische Fakultät | T cell epitopes of hcmv and uses of thereof |
CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
CN115427550A (zh) | 2020-01-28 | 2022-12-02 | 朱诺治疗学股份有限公司 | T细胞转导方法 |
JP2023528215A (ja) | 2020-05-13 | 2023-07-04 | ジュノー セラピューティクス インコーポレイテッド | 臨床応答に関連する特徴量の特定方法およびその使用 |
EP4171616A1 (en) | 2020-06-26 | 2023-05-03 | Juno Therapeutics GmbH | Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods |
DE102020125465A1 (de) | 2020-09-29 | 2022-03-31 | Immatics Biotechnologies Gmbh | Amidierte Peptide und ihre deamidierten Gegenstücke, die durch nicht-HLA-A*02-Moleküle präsentiert werden, zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
TW202229312A (zh) | 2020-09-29 | 2022-08-01 | 德商英麥提克生物技術股份有限公司 | 由非hla-a*02顯露以用於不同類型癌症之免疫治療的醯胺化肽及其脫醯胺化對應物 |
DE102020125457A1 (de) | 2020-09-29 | 2022-03-31 | Immatics Biotechnologies Gmbh | Amidierte Peptide und ihre deamidierten Gegenstücke, die durch HLA-A*02-Moleküle präsentiert werden, zur Verwendung in der Immuntherapie gegen verschiedene Krebsarten |
KR20230090367A (ko) | 2020-11-04 | 2023-06-21 | 주노 쎄러퓨티크스 인코퍼레이티드 | 변형된 불변 cd3 이뮤노글로불린 슈퍼패밀리 쇄 유전자좌로부터 키메라 수용체를 발현하는 세포 및 관련 폴리뉴클레오티드 및 방법 |
WO2022133030A1 (en) | 2020-12-16 | 2022-06-23 | Juno Therapeutics, Inc. | Combination therapy of a cell therapy and a bcl2 inhibitor |
TW202241925A (zh) | 2021-01-15 | 2022-11-01 | 德商英麥提克生物技術股份有限公司 | 用於不同類型癌症免疫治療的hla展示肽 |
WO2022187050A1 (en) * | 2021-03-01 | 2022-09-09 | BioLegend, Inc. | Anti-cd117 agents and compositions and methods for making and using the same |
JP2024511420A (ja) | 2021-03-22 | 2024-03-13 | ジュノー セラピューティクス インコーポレイテッド | ウイルスベクター粒子の効力を評価する方法 |
WO2022204070A1 (en) | 2021-03-22 | 2022-09-29 | Juno Therapeutics, Inc. | Methods of determining potency of a therapeutic cell composition |
US20240181052A1 (en) | 2021-03-29 | 2024-06-06 | Juno Therapeutics, Inc. | Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy |
EP4384603A1 (en) | 2021-08-10 | 2024-06-19 | Gamida-Cell Ltd. | Engineered nk cells, methods of their production and uses thereof |
WO2023147515A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Methods of manufacturing cellular compositions |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154600B (nl) * | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
NL154598B (nl) * | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
NL154599B (nl) * | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
US3901654A (en) * | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
US3853987A (en) * | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
US3867517A (en) * | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
NL171930C (nl) * | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
US3850578A (en) * | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
US6416738B1 (en) * | 1973-12-07 | 2002-07-09 | Neorx Corporation | Pretargeting methods and compounds |
US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
US4736866A (en) | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
EP0289121B1 (en) | 1987-05-01 | 1995-12-27 | Stratagene | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences |
US5591829A (en) * | 1987-05-29 | 1997-01-07 | Matsushita; Shuzo | Antibodies modified with toxic substance |
US5175385A (en) | 1987-09-03 | 1992-12-29 | Ohio University/Edison Animal Biotechnolgy Center | Virus-resistant transgenic mice |
US5221778A (en) | 1988-08-24 | 1993-06-22 | Yale University | Multiplex gene regulation |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US5175383A (en) | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
US6291160B1 (en) * | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for producing polymers having a preselected activity |
US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
FR2658197B1 (fr) * | 1990-02-14 | 1992-05-22 | Inst Nat Sante Rech Med | Anticorps monoclonaux restreints reconnaissant un peptide associe a un antigene du complexe majeur d'histocompatibilite - applications au diagnostic et au traitement. |
WO1991019810A1 (en) | 1990-06-15 | 1991-12-26 | California Biotechnology Inc. | Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5288846A (en) | 1990-10-19 | 1994-02-22 | The General Hospital Corporation | Cell specific gene regulators |
US5298422A (en) | 1991-11-06 | 1994-03-29 | Baylor College Of Medicine | Myogenic vector systems |
CA2127450C (en) | 1992-01-07 | 2007-04-17 | Samuel Wadsworth | Transgenic animal models for alzheimer's disease |
US5360735A (en) | 1992-01-08 | 1994-11-01 | Synaptic Pharmaceutical Corporation | DNA encoding a human 5-HT1F receptor, vectors, and host cells |
US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
EP0663952A4 (en) | 1992-09-11 | 1997-06-11 | Univ California | TRANSGENIC NON-HUMAN ANIMALS WITH TARGETED INTERRUPTED TRANSDUCTION GENES IN LYMPHOCYTES. |
US20030129191A1 (en) * | 1992-12-23 | 2003-07-10 | Neorx Corporation | Pretargeting methods and compounds |
WO1994023049A2 (en) | 1993-04-02 | 1994-10-13 | The Johns Hopkins University | The introduction and expression of large genomic sequences in transgenic animals |
US6664107B1 (en) | 1993-05-26 | 2003-12-16 | Ontario Cancer Institute, University Health Network | CD45 disrupted nucleic acid |
US5695928A (en) * | 1993-12-10 | 1997-12-09 | Novartis Corporation | Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic reaction |
CA2188432C (en) * | 1994-04-22 | 2011-02-01 | Yutaka Kawakami | Melanoma antigens |
GB9415492D0 (en) * | 1994-08-01 | 1994-09-21 | Celltech Ltd | Biological products |
WO1997002342A1 (en) | 1995-06-30 | 1997-01-23 | Københavns Universitet | Recombinant antibodies from a phage display library, directed against a peptide-mhc complex |
US6232445B1 (en) * | 1997-10-29 | 2001-05-15 | Sunol Molecular Corporation | Soluble MHC complexes and methods of use thereof |
CA2372053C (en) * | 1999-04-28 | 2008-09-02 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
AUPQ115499A0 (en) | 1999-06-24 | 1999-07-15 | Colocare Holdings Pty Limited | Colostomy pump device |
US6680209B1 (en) * | 1999-12-06 | 2004-01-20 | Biosite, Incorporated | Human antibodies as diagnostic reagents |
AU785493B2 (en) * | 2000-03-27 | 2008-01-03 | Technion Research & Development Foundation Ltd. | Single chain class I major histo-compatibility complexes, constructs encoding same and methods of generating same |
US20040191260A1 (en) * | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
WO2001096401A1 (fr) * | 2000-06-14 | 2001-12-20 | Medical & Biological Laboratories Co., Ltd. | Procede de construction d'un anticorps scfv fusionne a une proteine fluorescente |
EP1178116A1 (en) * | 2000-08-03 | 2002-02-06 | Hybrigenics S.A. | Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof |
US6992176B2 (en) * | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
WO2003070752A2 (en) * | 2002-02-20 | 2003-08-28 | Dyax Corporation | Mhc-peptide complex binding ligands |
US7632866B2 (en) * | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
-
2002
- 2002-02-13 US US10/073,301 patent/US6992176B2/en not_active Expired - Fee Related
-
2003
- 2003-02-11 CA CA2474782A patent/CA2474782C/en not_active Expired - Lifetime
- 2003-02-11 EP EP09001632A patent/EP2072045B1/en not_active Revoked
- 2003-02-11 EP EP10011766.2A patent/EP2329814B1/en not_active Expired - Lifetime
- 2003-02-11 AT AT03706876T patent/ATE446745T1/de not_active IP Right Cessation
- 2003-02-11 ES ES10011766T patent/ES2425539T3/es not_active Expired - Lifetime
- 2003-02-11 AU AU2003208582A patent/AU2003208582C1/en not_active Ceased
- 2003-02-11 JP JP2003567383A patent/JP4272535B2/ja not_active Expired - Fee Related
- 2003-02-11 DE DE60329823T patent/DE60329823D1/de not_active Expired - Lifetime
- 2003-02-11 EP EP03706876A patent/EP1474120B1/en not_active Expired - Lifetime
- 2003-02-11 ES ES03706876T patent/ES2332175T3/es not_active Expired - Lifetime
- 2003-02-11 WO PCT/IL2003/000105 patent/WO2003068201A2/en active Application Filing
-
2005
- 2005-02-23 HK HK05101505.1A patent/HK1068810A1/xx not_active IP Right Cessation
- 2005-08-15 US US11/203,137 patent/US20050287141A1/en not_active Abandoned
-
2008
- 2008-03-06 AU AU2008201062A patent/AU2008201062B2/en not_active Ceased
- 2008-08-11 IL IL193376A patent/IL193376A/en active IP Right Grant
-
2010
- 2010-08-26 AU AU2010214669A patent/AU2010214669B2/en not_active Ceased
-
2011
- 2011-06-19 US US13/163,701 patent/US20110318369A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2072045A3 (en) | 2010-09-22 |
AU2003208582B2 (en) | 2007-12-06 |
AU2003208582C1 (en) | 2008-08-07 |
EP2329814A1 (en) | 2011-06-08 |
US20050287141A1 (en) | 2005-12-29 |
EP2072045B1 (en) | 2012-08-15 |
AU2010214669B2 (en) | 2012-01-12 |
WO2003068201A2 (en) | 2003-08-21 |
IL193376A (en) | 2013-11-28 |
EP1474120A2 (en) | 2004-11-10 |
DE60329823D1 (de) | 2009-12-10 |
ES2332175T3 (es) | 2010-01-28 |
CA2474782A1 (en) | 2003-08-21 |
JP2005521389A (ja) | 2005-07-21 |
CA2474782C (en) | 2017-05-30 |
EP1474120A4 (en) | 2005-10-12 |
AU2010214669A1 (en) | 2010-09-16 |
IL193376A0 (en) | 2009-02-11 |
EP1474120B1 (en) | 2009-10-28 |
US20110318369A1 (en) | 2011-12-29 |
EP2329814B1 (en) | 2013-05-29 |
AU2008201062B2 (en) | 2010-10-28 |
WO2003068201A3 (en) | 2003-12-04 |
AU2008201062A1 (en) | 2008-04-03 |
AU2003208582A1 (en) | 2003-09-04 |
ATE446745T1 (de) | 2009-11-15 |
ES2425539T3 (es) | 2013-10-16 |
US20050255101A1 (en) | 2005-11-17 |
EP2072045A2 (en) | 2009-06-24 |
US6992176B2 (en) | 2006-01-31 |
JP4272535B2 (ja) | 2009-06-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1068810A1 (en) | Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease | |
EP1708752A4 (en) | THERAPEUTIC CANCER WITH POLYMER-BONDED ANTIBODY | |
MXPA03009924A (es) | Anticuerpo recombinante especifico de tumor y uso del mismo. | |
CY1117114T1 (el) | Εξανθρωπισμενα ανοσορρυθμιστικα μονοκλωνικα αντισωματα για την θεραπευτικη αγωγη νεοπλασματικης ασθενειας ή ανοσοανεπαρκειας | |
ATE382370T1 (de) | Antikörper-serumprotein hybride | |
ATE342923T1 (de) | Polyspezifische immunkonjugate und antikörper zusammensetzungen zur zielgerichteten erkennung des multidrug resistenz phenotyps | |
LU91616I2 (fr) | Anticorps monoclonal hybride rat-souris(IgG2) soustoutes les formes couvertes par le brevet de base (REMOVAB - Catumaxomab) | |
TR200001253T2 (tr) | Tümöre özel antijenler | |
DK0826696T3 (da) | Anvendelse af bi- og trispecifikke antistoffer til inducering af en tumorimmunitet | |
EA201070463A1 (ru) | Комбинированная терапия с использованием конъюгатов антитело-лекарственное средство | |
WO2007146172A8 (en) | Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same | |
HUP0202522A2 (hu) | Radioaktív jelölőkészlet és kötési mérőeljárás | |
BR0009157B1 (pt) | Conjugado antígeno transportador compreendendo um antígeno isolado de S. epidermidis, S. haemolyticus ou S. hominis | |
AU2003278002A1 (en) | Antibodies and cyclic peptides which bind cea (carcinoembryonic antigen) and their use as cancer therapeutics | |
DE69504955D1 (de) | Immunstimulierende monoklonale antikörper | |
WO2007022511A3 (en) | Listeria-induced immunorecruitment and activation, and methods of use thereof | |
IL144265A0 (en) | Use of antibodies for the vaccination against cancer | |
NO20054142D0 (no) | In vitro diagnostisk test for enterovirale infeksjoner | |
ES2187383A1 (es) | Procedimiento para la deteccion precoz de cancer colorrectal mediante la valoracion en suero o plasma humano de las glicoproteinas cd26 soluble y alfa-l-fucosidasa. | |
WO2004035003A3 (en) | Therapeutic adjuvant | |
CY1117275T1 (el) | Μεθοδοι θεραπευτικης αγωγης με τη χρηση συζευγματων αντισωματος enanti-erbb-μεϊτανσινοειδους | |
TR199902410A2 (xx) | Anti-Fas Antikorları |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20170211 |