LU91616I2 - Anticorps monoclonal hybride rat-souris(IgG2) soustoutes les formes couvertes par le brevet de base (REMOVAB - Catumaxomab) - Google Patents
Anticorps monoclonal hybride rat-souris(IgG2) soustoutes les formes couvertes par le brevet de base (REMOVAB - Catumaxomab)Info
- Publication number
- LU91616I2 LU91616I2 LU91616C LU91616C LU91616I2 LU 91616 I2 LU91616 I2 LU 91616I2 LU 91616 C LU91616 C LU 91616C LU 91616 C LU91616 C LU 91616C LU 91616 I2 LU91616 I2 LU 91616I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- mouse
- removab
- catumaxomab
- igg2
- monoclonal antibody
- Prior art date
Links
- 229960000419 catumaxomab Drugs 0.000 title 1
- 206010026673 Malignant Pleural Effusion Diseases 0.000 abstract 2
- 206010025538 Malignant ascites Diseases 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 102000009109 Fc receptors Human genes 0.000 abstract 1
- 108010087819 Fc receptors Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10043437A DE10043437A1 (de) | 2000-09-04 | 2000-09-04 | Verwendung von trifunktionellen bispezifischen und trispezifischen Antikörpern zur Behandlung von malignem Aszites |
PCT/EP2001/010184 WO2002020039A2 (fr) | 2000-09-04 | 2001-09-04 | Utilisation d'anticorps trifonctionnels bispecifiques et trispecifiques dans le traitement d'ascites malignes |
Publications (1)
Publication Number | Publication Date |
---|---|
LU91616I2 true LU91616I2 (fr) | 2009-12-16 |
Family
ID=7654853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU91616C LU91616I2 (fr) | 2000-09-04 | 2009-10-16 | Anticorps monoclonal hybride rat-souris(IgG2) soustoutes les formes couvertes par le brevet de base (REMOVAB - Catumaxomab) |
Country Status (10)
Country | Link |
---|---|
US (2) | US8277806B2 (fr) |
EP (1) | EP1315520B1 (fr) |
AT (1) | ATE294591T1 (fr) |
DE (3) | DE10043437A1 (fr) |
DK (1) | DK1315520T3 (fr) |
ES (1) | ES2241887T3 (fr) |
LU (1) | LU91616I2 (fr) |
NL (1) | NL300418I1 (fr) |
PT (1) | PT1315520E (fr) |
WO (1) | WO2002020039A2 (fr) |
Families Citing this family (81)
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US8066989B2 (en) * | 2004-11-30 | 2011-11-29 | Trion Pharma Gmbh | Method of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy |
WO2006114115A1 (fr) * | 2005-04-26 | 2006-11-02 | Trion Pharma Gmbh | Combinaison d'anticorps et de glucocorticoides destinee au traitement du cancer |
EP1820513A1 (fr) | 2006-02-15 | 2007-08-22 | Trion Pharma Gmbh | Destruction des cellules tumorales exprimant à un niveau bas ou moyen des antigènes cibles associés aux tumeurs, par des anticorps trifonctionels bispécifiques |
EP2033657A1 (fr) | 2007-09-04 | 2009-03-11 | Trion Pharma Gmbh | Application d'anticorps intra-opératoire trifonctionnelle pour la prophylaxie de la dissémination des cellules cancérigènes intrapéritonéales |
EP2241576A1 (fr) | 2009-04-17 | 2010-10-20 | Trion Pharma Gmbh | Utilisation des anticorps bispécifiques trifonctionnels pour le traitement des tumeurs associées aux cellules souches de cancer CD133+/EpCAM+ |
DE102009002596B4 (de) * | 2009-04-23 | 2012-11-08 | Ford Global Technologies, Llc | Verbrennungsmotor mit thermoelektrischem Generator |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
CN103052649B (zh) | 2010-07-29 | 2015-12-16 | Xencor公司 | 具有修改的等电点的抗体 |
US20140161800A1 (en) | 2011-04-22 | 2014-06-12 | John W. Blankenship | Prostate-Specific Membrane Antigen Binding Proteins and Related Compositions and Methods |
EP2578230A1 (fr) | 2011-10-04 | 2013-04-10 | Trion Pharma Gmbh | Élimination de cellules tumorales d'une récupération peropératoire de sang autologue |
US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
EP2589388A1 (fr) * | 2011-11-04 | 2013-05-08 | Lunamed AG | Utilisation d'acide téichoïque pour le traitement d'ascite maligne |
JP6363021B2 (ja) * | 2012-02-03 | 2018-07-25 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 抗原をトランスフェクトされたt細胞を伴う二重特異性抗体分子及び医薬におけるそれらの使用 |
US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
WO2014110601A1 (fr) | 2013-01-14 | 2014-07-17 | Xencor, Inc. | Nouvelles protéines hétérodimères |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
WO2014113510A1 (fr) | 2013-01-15 | 2014-07-24 | Xencor, Inc. | Elimination rapide de complexes antigéniques à l'aide de nouveaux anticorps |
US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
DK2970486T3 (en) | 2013-03-15 | 2018-08-06 | Xencor Inc | MODULATION OF T-CELLS WITH BISPECIFIC ANTIBODIES AND FC-FUSIONS |
US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
EP3693385A1 (fr) | 2013-07-05 | 2020-08-12 | Genmab A/S | Anticorps anti-cd3 humanisés ou chimères |
ME03666B (fr) | 2014-03-28 | 2020-10-20 | Xencor Inc | Anticorps bispécifiques se liant à cd38 et cd3 |
RU2718692C2 (ru) | 2014-05-29 | 2020-04-13 | Мэкроудженикс, Инк. | Триспецифичные связывающие молекулы, которые специфически связывают антигены множества злокачественных опухолей, и способы их применения |
EA201790173A1 (ru) | 2014-07-11 | 2017-06-30 | Генмаб А/С | Антитела, связывающие axl |
CN104592392B (zh) * | 2015-01-21 | 2018-08-28 | 武汉友芝友生物制药有限公司 | 一种双特异性抗体EpCAM×CD3的构建及应用 |
WO2016019969A1 (fr) | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Anticorps bispécifiques administrés par voie sous-cutanée, destinés à être utilisés dans le traitement du cancer |
EP3223907A2 (fr) | 2014-11-26 | 2017-10-04 | Xencor, Inc. | Anticorps hétérodimériques se liant aux antigènes cd3 et cd38 |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
KR20170084326A (ko) | 2014-11-26 | 2017-07-19 | 젠코어 인코포레이티드 | Cd3 및 종양 항원과 결합하는 이종이량체 항체 |
US10428155B2 (en) | 2014-12-22 | 2019-10-01 | Xencor, Inc. | Trispecific antibodies |
CN104788567B (zh) * | 2015-01-21 | 2019-03-26 | 武汉友芝友生物制药有限公司 | 一种靶向鼠T淋巴细胞CD3和人肿瘤抗原EpCAM的双特异性抗体制备方法及应用 |
WO2016141387A1 (fr) | 2015-03-05 | 2016-09-09 | Xencor, Inc. | Modulation de lymphocytes t avec des anticorps bispécifiques et des hybrides fc |
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EP4257613A3 (fr) | 2016-06-14 | 2023-12-13 | Xencor, Inc. | Anticorps inhibiteurs de points de contrôle bispécifiques |
EP3475304B1 (fr) | 2016-06-28 | 2022-03-23 | Xencor, Inc. | Anticorps hétérodimériques qui se lient au récepteur 2 de la somatostatine |
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CA3093745A1 (fr) | 2018-03-12 | 2019-09-19 | Genmab A/S | Anticorps |
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CA3118789A1 (fr) | 2018-11-06 | 2020-05-14 | Genmab A/S | Formulation d'anticorps |
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CN114980927A (zh) | 2020-01-16 | 2022-08-30 | 健玛保 | Cd38抗体的配制剂及其用途 |
WO2021231976A1 (fr) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Anticorps hétérodimères qui se lient à l'antigène membranaire spécifique de la prostate (psma) et cd3 |
WO2022018294A1 (fr) | 2020-07-23 | 2022-01-27 | Genmab B.V. | Combinaison d'anticorps anti-dr5 et d'un médicament à base d'imide immunomodulateur à utiliser dans le traitement du myélome multiple |
KR102607909B1 (ko) | 2020-08-19 | 2023-12-01 | 젠코어 인코포레이티드 | 항-cd28 조성물 |
CN116472060A (zh) | 2020-09-02 | 2023-07-21 | 健玛保 | 抗体疗法 |
US20230365714A1 (en) | 2020-10-02 | 2023-11-16 | Genmab A/S | Antibodies capable of binding to ror2 and bispecific antibodies binding to ror2 and cd3 |
IL305736A (en) | 2021-03-09 | 2023-11-01 | Xencor Inc | Heterodimeric antibodies that bind CD3 and CLDN6 |
EP4305065A1 (fr) | 2021-03-10 | 2024-01-17 | Xencor, Inc. | Anticorps hétérodimères qui se lient au cd3 et au gpc3 |
KR20240051280A (ko) | 2021-09-06 | 2024-04-19 | 젠맵 에이/에스 | Cd27과 결합할 수 있는 항체, 그의 변이체 및 그의 용도 |
WO2023218046A1 (fr) | 2022-05-12 | 2023-11-16 | Genmab A/S | Agents de liaison capables de se lier à cd27 en polythérapie |
TW202409090A (zh) | 2022-05-12 | 2024-03-01 | 丹麥商珍美寶股份有限公司 | 在組合療法中能夠結合到cd27之結合劑 |
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DE19710497C2 (de) * | 1996-09-03 | 1998-07-09 | Gsf Forschungszentrum Umwelt | Verwendung Bi- und trispezifische Antikörper zur Induktion einer Tumorimmunität |
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EP1115427B1 (fr) * | 1998-09-25 | 2003-12-03 | Horst Lindhofer | Utilisation de cellules tumorales avec un decalage temporel en combinaison avec des anticorps intacts pour l'immunisation |
WO2000018806A1 (fr) * | 1998-09-25 | 2000-04-06 | Horst Lindhofer | Anticorps bispecifiques et trispecifiques reagissant de façon specifique avec des antigenes d'enveloppe pouvant etre induits, en tant que structures cibles operationnelles |
DE19859110A1 (de) * | 1998-09-25 | 2000-04-13 | Horst Lindhofer | Bispezifische und trispezifische Antikörper, die spezifisch mit induzierbaren Oberflächenantigenen als operationelle Zielstrukturen reagieren |
AU2001253426A1 (en) * | 2000-04-12 | 2001-10-30 | University Of South Florida | Regulation of systemic immune responses utilizing soluble cd40 |
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2000
- 2000-09-04 DE DE10043437A patent/DE10043437A1/de not_active Withdrawn
-
2001
- 2001-09-04 EP EP01982241A patent/EP1315520B1/fr not_active Expired - Lifetime
- 2001-09-04 DE DE50106127T patent/DE50106127D1/de not_active Expired - Lifetime
- 2001-09-04 ES ES01982241T patent/ES2241887T3/es not_active Expired - Lifetime
- 2001-09-04 DK DK01982241T patent/DK1315520T3/da active
- 2001-09-04 PT PT01982241T patent/PT1315520E/pt unknown
- 2001-09-04 WO PCT/EP2001/010184 patent/WO2002020039A2/fr active IP Right Grant
- 2001-09-04 DE DE122009000069C patent/DE122009000069I1/de active Pending
- 2001-09-04 AT AT01982241T patent/ATE294591T1/de active
-
2003
- 2003-03-03 US US10/378,218 patent/US8277806B2/en not_active Expired - Fee Related
-
2009
- 2009-10-16 LU LU91616C patent/LU91616I2/fr unknown
- 2009-10-20 NL NL300418C patent/NL300418I1/nl unknown
-
2012
- 2012-10-01 US US13/632,737 patent/US20130095106A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NL300418I1 (nl) | 2010-01-04 |
EP1315520A2 (fr) | 2003-06-04 |
EP1315520B1 (fr) | 2005-05-04 |
DE50106127D1 (de) | 2005-06-09 |
DE10043437A1 (de) | 2002-03-28 |
WO2002020039A2 (fr) | 2002-03-14 |
DK1315520T3 (da) | 2005-08-22 |
DE122009000069I1 (de) | 2010-01-21 |
ATE294591T1 (de) | 2005-05-15 |
PT1315520E (pt) | 2005-09-30 |
WO2002020039A3 (fr) | 2002-07-25 |
US20130095106A1 (en) | 2013-04-18 |
US20030223999A1 (en) | 2003-12-04 |
ES2241887T3 (es) | 2005-11-01 |
US8277806B2 (en) | 2012-10-02 |
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