HK1063788A1 - Biologically active methylene blue derivatives - Google Patents

Biologically active methylene blue derivatives

Info

Publication number
HK1063788A1
HK1063788A1 HK04106589A HK04106589A HK1063788A1 HK 1063788 A1 HK1063788 A1 HK 1063788A1 HK 04106589 A HK04106589 A HK 04106589A HK 04106589 A HK04106589 A HK 04106589A HK 1063788 A1 HK1063788 A1 HK 1063788A1
Authority
HK
Hong Kong
Prior art keywords
biologically active
methylene blue
active methylene
blue derivatives
derivatives
Prior art date
Application number
HK04106589A
Other languages
English (en)
Inventor
Stanley Beames Brown
Cassandra Claire O'grady
John Griffiths
Kirste Joanne Mellish
Richard George Tunstall
David John Howard Roberts
David Ian Vernon
Original Assignee
Photopharmica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photopharmica Ltd filed Critical Photopharmica Ltd
Publication of HK1063788A1 publication Critical patent/HK1063788A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/003—Thiazine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
    • A61L2/232—Solid substances, e.g. granules, powders, blocks, tablets layered or coated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Birds (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
HK04106589A 2001-05-30 2004-09-01 Biologically active methylene blue derivatives HK1063788A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0113121.8A GB0113121D0 (en) 2001-05-30 2001-05-30 Biologically active photosensitisers
GBGB0123945.8A GB0123945D0 (en) 2001-05-30 2001-10-05 Biologically active photosensitisers
PCT/GB2002/002278 WO2002096896A1 (en) 2001-05-30 2002-05-30 Biologically active methylene blue derivatives

Publications (1)

Publication Number Publication Date
HK1063788A1 true HK1063788A1 (en) 2005-01-14

Family

ID=26246135

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04106589A HK1063788A1 (en) 2001-05-30 2004-09-01 Biologically active methylene blue derivatives

Country Status (21)

Country Link
US (6) US7371744B2 (ko)
EP (3) EP1790642A1 (ko)
JP (2) JP4554198B2 (ko)
KR (3) KR20090061684A (ko)
CN (2) CN101928262A (ko)
AT (1) ATE355282T1 (ko)
AU (1) AU2002256784B2 (ko)
BR (1) BR0209783A (ko)
CA (1) CA2448303C (ko)
CY (1) CY1108091T1 (ko)
DE (1) DE60218454T2 (ko)
DK (1) DK1392666T3 (ko)
ES (1) ES2280533T3 (ko)
GB (2) GB0113121D0 (ko)
HK (1) HK1063788A1 (ko)
MX (1) MXPA03010916A (ko)
NO (1) NO324321B1 (ko)
NZ (1) NZ529682A (ko)
PT (1) PT1392666E (ko)
WO (1) WO2002096896A1 (ko)
ZA (1) ZA200309215B (ko)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6283956B1 (en) 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US6887260B1 (en) 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US20060212025A1 (en) * 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
GB0113121D0 (en) 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers
US7368221B2 (en) * 2002-06-17 2008-05-06 Verification Technologies, Inc. Changing light absorption by disruption of conjugation
WO2004092335A2 (en) 2003-04-10 2004-10-28 Light Bioscience, Inc. Photomodulation methods and devices for regulating cell proliferation and gene expression
JP4739202B2 (ja) 2003-07-31 2011-08-03 ジェントルウェイブス エルエルシー 熱傷、創傷、および関連皮膚疾患の光力学治療のためのシステムおよび方法
US20050053895A1 (en) 2003-09-09 2005-03-10 The Procter & Gamble Company Attention: Chief Patent Counsel Illuminated electric toothbrushes emitting high luminous intensity toothbrush
GB0322756D0 (en) * 2003-09-29 2003-10-29 Univ Aberdeen Methods of chemical synthesis
JP2007512297A (ja) * 2003-11-28 2007-05-17 フォトファーマイカ リミテッド 生物活性メチレンブルー誘導体（２）における開発
US7326258B2 (en) 2004-06-18 2008-02-05 L'oreal S.A. Compositions comprising hydroxyalkyl direct dyes, implementation processes and uses thereof
BRPI0503921A (pt) * 2004-06-18 2006-07-18 Oreal composição cosmética, processos para tintura das fibras queratìnicas, processo para clareamento das fibras queratìnicas, dispositivo com múltiplos compartimentos, uso de composto hidroxialquilado e uso de uma composição de tintura
US8240312B2 (en) 2004-09-09 2012-08-14 Osnat Feuerstein Method and means for exerting a phototoxic effect of visible light on microorganisms
US20080166304A1 (en) * 2004-09-17 2008-07-10 The General Hospital Corpoartion Inactivation of Microorganisms With Multidrug Resistance Inhibitors and Phenothiaziniums
GB0420893D0 (en) 2004-09-20 2004-10-20 Photopharmica Ltd Photosensitisers and their uses
GB0420888D0 (en) * 2004-09-20 2004-10-20 Photopharmica Ltd Compounds and uses
PT1799662E (pt) 2004-09-23 2013-07-09 Wista Lab Ltd Métodos de síntese química e purificação de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc)
CN101084204B (zh) * 2004-09-23 2012-12-05 卫思道制药有限公司 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法
EP1810290A4 (en) * 2004-09-24 2010-04-21 Verification Technologies Inc MODIFICATION OF LIGHT ABSORPTION BY BREAK OF CONJUGATION
US7101997B2 (en) 2004-10-07 2006-09-05 Honeywell International Inc. Method for producing phenothiazinium compounds
US20060222592A1 (en) * 2005-04-05 2006-10-05 Clemens Burda Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications
GB0602125D0 (en) * 2006-02-03 2006-03-15 Univ Belfast Sensitizer-incorporated biomaterials
US20070255357A1 (en) 2006-04-28 2007-11-01 Ondine International, Ltd. Nasal decolonization of microbes
DK2057136T3 (da) 2006-07-11 2013-08-26 Wista Lab Ltd Fremgangsmåde til syntese og/eller oprensning af diaminophenothiazinium forbindelser
US20080139991A1 (en) * 2006-12-08 2008-06-12 Ondine International, Ltd. Method of wound disinfecting and tissue welding
CA2686513C (en) * 2007-04-03 2017-06-13 Prosetta Bioconformatics Inc. Diamino-benzothiazine derivatives as antiviral agents
ES2562205T3 (es) * 2007-04-17 2016-03-03 Codman & Shurtleff, Inc. Hibrídos de curcumina resveratrol
US8383865B2 (en) * 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
US20080269205A1 (en) * 2007-04-27 2008-10-30 Ondine International, Ltd. Methods to prevent vertical transmission of infectious diseases
US20090035725A1 (en) * 2007-08-02 2009-02-05 Ondine International, Ltd. Photodisinfection of oral cavity
US20090093470A1 (en) * 2007-10-08 2009-04-09 Ondine International, Ltd. Photodynamic therapy process and photosensitizer compositions therefor
KR20100138922A (ko) * 2008-02-13 2010-12-31 안드레아스 로즈 방사광 출력 패턴을 제공하는 광 전달장치
US7985776B2 (en) 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
CN102112120B (zh) * 2008-08-01 2013-01-23 恩迪尼国际有限公司 用于处理mrsa的组合物和方法
WO2010036617A1 (en) * 2008-09-23 2010-04-01 Ondine International Holdings Ltd. Portable photodynamic disinfection light delivery device for catheter disinfection
MX2011003277A (es) * 2008-10-14 2012-09-21 Salubrious Pharmaceuticals LLC Proceso para el tratamiento de la artritis reumatoide, temblores/enfermedad de parkinson, esclerosis multiple y cancer de tipo no viral.
US20100286585A1 (en) * 2009-01-26 2010-11-11 Codman & Shurtleff, Inc. Shunt Delivery of Curcumin
US7723515B1 (en) * 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
US20100256125A1 (en) * 2009-04-06 2010-10-07 Zila Pharmaceuticals, Inc. Use of improved toluidine blue in photodynamic therapy
CN102791297A (zh) * 2010-03-08 2012-11-21 诺瓦提斯公司 活性氧消毒系统及其用途
CN102958525B (zh) 2010-04-30 2017-05-24 普罗瑟塔抗病毒股份有限公司 抗病毒化合物
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
WO2012125983A1 (en) 2011-03-17 2012-09-20 Prosetta Antiviral Inc. Antiviral treatments
WO2012145567A1 (en) 2011-04-20 2012-10-26 Prosetta Antiviral Inc. Antiviral compounds
US20120301904A1 (en) 2011-04-26 2012-11-29 Prosetta Antiviral, Inc Multiprotein assemblies
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
CA2851344C (en) * 2011-09-05 2017-10-03 Hiroshi Maeda Polymer-type fluorescent molecule probe
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
AU2013341383B2 (en) 2012-11-12 2017-08-24 The Roger B. And Ann K. Mcnamee Trust U/T/A/D Systems and methods for communicating a live event to users using the internet
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
WO2016069556A2 (en) 2014-10-29 2016-05-06 University Of Maryland Methods of treating age-related symptoms in mammals and compositions therefor
CA2966010C (en) * 2014-10-31 2023-04-11 Klox Technologies Inc. Photoactivatable fibers and fabric media
JP6743041B2 (ja) * 2015-03-30 2020-08-19 タリス バイオメディカル エルエルシー 上部尿路への薬剤の局所的な送達装置及び方法
CN106901871B (zh) * 2015-12-23 2021-08-24 爱博诺德(北京)医疗科技股份有限公司 具有一个或多个附加部分的人工晶状体
CN108882981B (zh) 2016-01-29 2021-08-10 内奥瓦斯克迪亚拉公司 用于防止流出阻塞的假体瓣膜
US10189862B2 (en) 2016-06-14 2019-01-29 The Chinese University Of Hong Kong Phenothiazine-pyridine compounds and uses thereof
CN109996581B (zh) 2016-11-21 2021-10-15 内奥瓦斯克迪亚拉公司 用于快速收回经导管心脏瓣膜递送系统的方法和系统
US11413240B2 (en) 2016-12-29 2022-08-16 Board Of Regents, The University Of Texas System Methylene blue solution for the treatment of oral lesions
KR101988240B1 (ko) * 2017-02-27 2019-06-12 주식회사 디알나노 피부질환에 사용되는 메틸렌 블루 복합체 및 이의 용도
WO2019032683A2 (en) * 2017-08-08 2019-02-14 Board Of Trustees Of Michigan State University LIGHT-EMITTING ORGANIC SALTS FOR ENHANCED PHOTODYNAMIC THERAPY AND IMAGING
CA3073834A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
AU2019374743B2 (en) 2018-11-08 2022-03-03 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US11998447B2 (en) 2019-03-08 2024-06-04 Neovasc Tiara Inc. Retrievable prosthesis delivery system
US11510876B2 (en) 2019-03-29 2022-11-29 Mayo Foundation For Medical Education And Research In vivo targeting of extracellular vesicles
CA3135753C (en) 2019-04-01 2023-10-24 Neovasc Tiara Inc. Controllably deployable prosthetic valve
CA3136334A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
EP3972673A4 (en) 2019-05-20 2023-06-07 Neovasc Tiara Inc. INTRODUCER DEVICE WITH HEMOSTASIS MECHANISM
CA3143344A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
WO2023186737A1 (en) 2022-04-01 2023-10-05 Lllt Technologies Sa Photodynamic light therapy apparatus and methods for treating oral disease

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579339A (en) 1967-05-23 1971-05-18 Du Pont Photopolymerizable dispersions and elements containing nonmigratory photoreducible dyes
US3641016A (en) * 1968-02-16 1972-02-08 Egyt Gyogyszervegyeszeti Gyar Thionine derivatives
US4001587A (en) * 1975-10-24 1977-01-04 Panchenkov Georgy Mitrofanovic Color indicator-dosimeter of ionizing radiation
JPS6020740B2 (ja) * 1976-07-14 1985-05-23 株式会社リコー カラ−像形成用感光材料
EP0128414A3 (en) 1983-06-06 1986-09-10 The Hilton - Davis Chemical Company Method of sanitizing toilets
US4622395A (en) * 1984-10-01 1986-11-11 Minnesota Mining And Manufacturing Company Phenoxazine and phenothiazine dyes and leuco forms thereof
DE3644369A1 (de) * 1986-12-24 1988-07-07 Basf Ag Verfahren zur uebertragung von kationischen farbstoffen in ihrer deprotonierten, elektrisch neutralen form
JPS63187154A (ja) 1987-01-29 1988-08-02 Kishida Kagaku Kk 酸素検知剤
DE3710282A1 (de) * 1987-03-28 1988-10-13 Hoechst Ag Photopolymerisierbares gemisch und daraus hergestelltes aufzeichnungsmaterial
US4844896A (en) * 1987-11-02 1989-07-04 Lim Technology Laboratories, Inc. Microencapsulated insecticidal pathogens
JP2879080B2 (ja) * 1989-03-23 1999-04-05 株式会社リコー 電界発光素子
US5270144A (en) * 1989-07-10 1993-12-14 Tomoegawa Paper Co., Ltd. Toner for developing static charge images
WO1991016911A1 (en) * 1990-05-01 1991-11-14 The American National Red Cross Decontamination of whole blood and cellular components by phenthiazin-5-ium-dyes plus light
US5545516A (en) 1990-05-01 1996-08-13 The American National Red Cross Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
US5220009A (en) * 1990-05-03 1993-06-15 Yeda Research And Development Company Limited Phenothiazinium salts and their use for disinfecting aqueous effluents
JPH05170752A (ja) * 1991-04-26 1993-07-09 Takeda Chem Ind Ltd ３，７−ビス（ジ置換アミノ）フェノチアジン誘導体およびその製造法
US5344928A (en) * 1991-04-26 1994-09-06 Takeda Chemical Industries, Ltd. Phenothiazine derivatives, their production and use
US5358876A (en) * 1991-07-17 1994-10-25 Mitsubishi Gas Chemical Company, Inc. Oxygen indicator
US5239405A (en) * 1991-09-06 1993-08-24 Donnelly Corporation Electrochemichromic solutions, processes for preparing and using the same, and devices manufactured with the same
US5611793A (en) * 1992-04-30 1997-03-18 Institute Of Dental Surgery Laser treatment
JP3690825B2 (ja) * 1993-07-26 2005-08-31 エーザイ株式会社 三環式ヘテロ環含有スルホンアミドおよびスルホン酸エステル誘導体
US5635059A (en) * 1994-10-20 1997-06-03 Aqua-Ion Systems, Inc. Method and apparatus for water treatment and purification using gas ion plasma source and disinfectant metal ion complexes
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
JPH08305026A (ja) * 1995-05-12 1996-11-22 Fuji Photo Film Co Ltd 画像記録方法
CA2214829C (en) * 1996-01-16 2002-05-14 Edwin Pomerantz Methods and compositions for in-vivo detection of oral cancers and precancerous conditions
DE19640758C2 (de) 1996-10-02 1999-11-04 Rafael Lachky Mittel zur Behandlung von Diskusfischen
CA2278245A1 (en) * 1997-01-21 1998-07-23 The American National Red Cross Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light
US20040055965A1 (en) * 1997-06-13 2004-03-25 Hubig Stephan M. Recreational water treatment employing singlet oxygen
US6251127B1 (en) * 1997-08-25 2001-06-26 Advanced Photodynamic Technologies, Inc. Dye treatment solution and photodynamic therapy and method of using same
US5811471A (en) * 1997-09-15 1998-09-22 Shanbrom Technologies Llc Disinfectant plastic sponge material
DE19750303A1 (de) 1997-11-13 1999-05-20 Henkel Kgaa Verwendung von alkylierten Phenothiazinen zum Färben von keratinhaltigen Fasern
US7229447B1 (en) * 1998-08-25 2007-06-12 Advanced Photodynamics Technologies, Inc. Photodynamic therapy utilizing a solution of photosensitizing compound and surfactant
US6562295B1 (en) * 1999-06-30 2003-05-13 Ceramoptec Industries, Inc. Bacteria resistant medical devices
JP2001124699A (ja) 1999-10-28 2001-05-11 Miura Co Ltd 溶存酸素濃度測定用指示薬
JP2003531828A (ja) * 2000-02-26 2003-10-28 アドバンスト フォトダイナミック テクノロジーズ， インコーポレイテッド 光感光性物質および界面活性剤を使用する、光力学的な細胞および無細胞生物の根絶
WO2001070699A1 (fr) 2000-03-22 2001-09-27 Bf Research Institute, Inc. Analogues d'azur a utilises comme sondes dans l'imagerie diagnostique des maladies dues a l'accumulation d'amyloide, et compositions renfermant ces analogues destinees a l'imagerie diagnostique
CA2408332C (en) * 2000-05-08 2011-02-15 The University Of British Columbia Supports for photosensitizer formulations
US6551346B2 (en) * 2000-05-17 2003-04-22 Kent Crossley Method and apparatus to prevent infections
FR2810318B1 (fr) * 2000-06-15 2005-09-23 Laurent Galey Derives de diamano-phenothiazine
WO2002089750A2 (en) * 2001-01-19 2002-11-14 Advanced Photodynamic Technologies, Inc. Apparatus and method of photodynamic eradication of organisms utilizing pyrrolnitrin
GB2373787A (en) 2001-03-08 2002-10-02 Univ Central Lancashire Phenothiazinium derivatives and their use to reduce pathogenic contaminants
GB0106953D0 (en) * 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
GB0113121D0 (en) 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers
IL159894A0 (en) * 2001-07-17 2004-06-20 Res Dev Foundation Therapeutic agents comprising pro-apoptotic proteins
US6551171B1 (en) * 2002-01-24 2003-04-22 Brian Hass Brassiere with detachable uniform pressure assembly
US7176308B2 (en) * 2002-06-17 2007-02-13 Verification Technologies, Inc. Processes for preparing novel methylene blue derivative
US6952392B2 (en) * 2002-06-17 2005-10-04 Verification Technologies, Inc. Laser reactive dyes for DVD copy protection system
GB0420888D0 (en) * 2004-09-20 2004-10-20 Photopharmica Ltd Compounds and uses
US7220879B2 (en) * 2004-10-01 2007-05-22 Rohm And Haas Company Method for inhibiting polymerization of (meth)acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor

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