HK1050522B - Substituted 1,3,4-oxadiazole and methods for reducing TNF-α levels - Google Patents

Substituted 1,3,4-oxadiazole and methods for reducing TNF-α levels Download PDF

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Publication number
HK1050522B
HK1050522B HK03101117.3A HK03101117A HK1050522B HK 1050522 B HK1050522 B HK 1050522B HK 03101117 A HK03101117 A HK 03101117A HK 1050522 B HK1050522 B HK 1050522B
Authority
HK
Hong Kong
Prior art keywords
hydrogen
ethyl
carbon atoms
compound according
methoxyphenyl
Prior art date
Application number
HK03101117.3A
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German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1050522A1 (en
Inventor
Man Hon-Wah
Muller George
Original Assignee
Celgene Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corporation filed Critical Celgene Corporation
Publication of HK1050522A1 publication Critical patent/HK1050522A1/en
Publication of HK1050522B publication Critical patent/HK1050522B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
HK03101117.3A 1999-12-21 2000-12-19 Substituted 1,3,4-oxadiazole and methods for reducing TNF-α levels HK1050522B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/470,203 1999-12-21
US09/470,203 US6326388B1 (en) 1999-12-21 1999-12-21 Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
PCT/US2000/034457 WO2001046183A1 (en) 1999-12-21 2000-12-19 SUBSTITUTED 1,3,4-OXADIAZOLES AND A METHOD OF REDUCING TNF-α LEVELS

Publications (2)

Publication Number Publication Date
HK1050522A1 HK1050522A1 (en) 2003-06-27
HK1050522B true HK1050522B (en) 2005-09-02

Family

ID=23866662

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03101117.3A HK1050522B (en) 1999-12-21 2000-12-19 Substituted 1,3,4-oxadiazole and methods for reducing TNF-α levels

Country Status (18)

Country Link
US (1) US6326388B1 (https=)
EP (3) EP1462449B9 (https=)
JP (1) JP4806151B2 (https=)
KR (2) KR100832499B1 (https=)
CN (1) CN1413211A (https=)
AT (3) ATE489996T1 (https=)
AU (1) AU782168B2 (https=)
CA (1) CA2394615C (https=)
DE (3) DE60042902D1 (https=)
ES (3) ES2233488T3 (https=)
FI (1) FI121708B (https=)
HK (1) HK1050522B (https=)
MX (1) MXPA02006084A (https=)
NO (1) NO323449B1 (https=)
NZ (1) NZ529009A (https=)
PT (1) PT1242413E (https=)
TW (2) TW200733960A (https=)
WO (1) WO2001046183A1 (https=)

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Also Published As

Publication number Publication date
KR20020072283A (ko) 2002-09-14
NZ529009A (en) 2006-02-24
EP1510518A2 (en) 2005-03-02
ES2233488T3 (es) 2005-06-16
CA2394615C (en) 2010-03-02
NO20022937D0 (no) 2002-06-18
EP1510518A3 (en) 2006-11-22
CA2394615A1 (en) 2001-06-28
NO20022937L (no) 2002-08-15
ATE489996T1 (de) 2010-12-15
US6326388B1 (en) 2001-12-04
AU2278501A (en) 2001-07-03
EP1462449B1 (en) 2009-09-02
DE60045320D1 (de) 2011-01-13
FI20021192A0 (fi) 2002-06-19
ES2356238T3 (es) 2011-04-06
JP2003518115A (ja) 2003-06-03
DE60016029T2 (de) 2005-10-20
EP1510518B1 (en) 2010-12-01
AU782168B2 (en) 2005-07-07
ES2333011T3 (es) 2010-02-16
CN1413211A (zh) 2003-04-23
DE60042902D1 (de) 2009-10-15
TWI280961B (en) 2007-05-11
ATE282612T1 (de) 2004-12-15
HK1069581A1 (en) 2005-05-27
HK1075890A1 (en) 2005-12-30
KR100832499B1 (ko) 2008-05-26
FI20021192A7 (fi) 2002-08-21
EP1242413A1 (en) 2002-09-25
DE60016029D1 (de) 2004-12-23
HK1050522A1 (en) 2003-06-27
PT1242413E (pt) 2005-03-31
EP1242413A4 (en) 2003-04-23
EP1462449A1 (en) 2004-09-29
ATE441644T1 (de) 2009-09-15
WO2001046183A1 (en) 2001-06-28
NO323449B1 (no) 2007-05-14
FI121708B (fi) 2011-03-15
MXPA02006084A (es) 2004-10-14
EP1242413B1 (en) 2004-11-17
KR20070049688A (ko) 2007-05-11
EP1462449B9 (en) 2010-03-10
JP4806151B2 (ja) 2011-11-02
TW200733960A (en) 2007-09-16

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