HK1032966A1 - I-substituted-1-aminomethyl-cycloalkan derivatives(=gabapentin analogues), their preparation and their use in the treatment of neurological disorders. - Google Patents

I-substituted-1-aminomethyl-cycloalkan derivatives(=gabapentin analogues), their preparation and their use in the treatment of neurological disorders.

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Publication number
HK1032966A1
HK1032966A1 HK01103570A HK01103570A HK1032966A1 HK 1032966 A1 HK1032966 A1 HK 1032966A1 HK 01103570 A HK01103570 A HK 01103570A HK 01103570 A HK01103570 A HK 01103570A HK 1032966 A1 HK1032966 A1 HK 1032966A1
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HK
Hong Kong
Prior art keywords
integer
treatment
disorders
cycloalkan
aminomethyl
Prior art date
Application number
HK01103570A
Other languages
English (en)
Inventor
Justin Stephen Bryans
Thomas Capiris
David Christopher Horwell
Clare Octavia Kneen
David Juergen Wustrow
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HK1032966A1 publication Critical patent/HK1032966A1/xx

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    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C233/36Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
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HK01103570A 1997-12-16 2001-05-23 I-substituted-1-aminomethyl-cycloalkan derivatives(=gabapentin analogues), their preparation and their use in the treatment of neurological disorders. HK1032966A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6977397P 1997-12-16 1997-12-16
US10500598P 1998-10-20 1998-10-20
PCT/US1998/023918 WO1999031075A1 (en) 1997-12-16 1998-11-10 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders

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HK1032966A1 true HK1032966A1 (en) 2001-08-10

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SI1047678T1 (en) 2005-02-28
CA2304974A1 (en) 1999-06-24
CN1495160A (zh) 2004-05-12
NZ503963A (en) 2002-09-27
DE69826151T2 (de) 2005-01-27
BR9814286A (pt) 2000-10-03
EP1047678B1 (en) 2004-09-08
NO20003039L (no) 2000-06-14
IS5435A (is) 2000-04-07
NO317252B1 (no) 2004-09-27
WO1999031075A1 (en) 1999-06-24
NO20003039D0 (no) 2000-06-14
CN1131855C (zh) 2003-12-24
PL341291A1 (en) 2001-04-09
AU1392999A (en) 1999-07-05
TR200001795T2 (tr) 2000-11-21
HUP0004439A3 (en) 2001-12-28
DE69826151D1 (de) 2004-10-14
AU765802B2 (en) 2003-10-02
HUP0004439A2 (hu) 2001-10-28
PT1047678E (pt) 2004-12-31
ES2227896T3 (es) 2005-04-01
ATE275552T1 (de) 2004-09-15
KR20010033158A (ko) 2001-04-25
IL135313A0 (en) 2001-05-20
JP2002508362A (ja) 2002-03-19
CN1279674A (zh) 2001-01-10
CA2304974C (en) 2005-10-25
NO20041112L (no) 2000-06-14
EP1475371A1 (en) 2004-11-10
US6518289B1 (en) 2003-02-11
EP1047678A1 (en) 2000-11-02

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