HK1032966A1 - I-substituted-1-aminomethyl-cycloalkan derivatives(=gabapentin analogues), their preparation and their use in the treatment of neurological disorders. - Google Patents
I-substituted-1-aminomethyl-cycloalkan derivatives(=gabapentin analogues), their preparation and their use in the treatment of neurological disorders.Info
- Publication number
- HK1032966A1 HK1032966A1 HK01103570A HK01103570A HK1032966A1 HK 1032966 A1 HK1032966 A1 HK 1032966A1 HK 01103570 A HK01103570 A HK 01103570A HK 01103570 A HK01103570 A HK 01103570A HK 1032966 A1 HK1032966 A1 HK 1032966A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- integer
- treatment
- disorders
- cycloalkan
- aminomethyl
- Prior art date
Links
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical class OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title 2
- 208000012902 Nervous system disease Diseases 0.000 title 1
- 208000025966 Neurological disease Diseases 0.000 title 1
- 229960002870 gabapentin Drugs 0.000 title 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical group OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical group C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000006083 Hypokinesia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003483 hypokinetic effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical group 0.000 abstract 1
Classifications
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- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
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- C07D257/04—Five-membered rings
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61P25/08—Antiepileptics; Anticonvulsants
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- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07C2603/74—Adamantanes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Steroid Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6977397P | 1997-12-16 | 1997-12-16 | |
US10500598P | 1998-10-20 | 1998-10-20 | |
PCT/US1998/023918 WO1999031075A1 (en) | 1997-12-16 | 1998-11-10 | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1032966A1 true HK1032966A1 (en) | 2001-08-10 |
Family
ID=26750409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK01103570A HK1032966A1 (en) | 1997-12-16 | 2001-05-23 | I-substituted-1-aminomethyl-cycloalkan derivatives(=gabapentin analogues), their preparation and their use in the treatment of neurological disorders. |
Country Status (22)
Country | Link |
---|---|
US (1) | US6518289B1 (ko) |
EP (2) | EP1475371A1 (ko) |
JP (1) | JP2002508362A (ko) |
KR (1) | KR20010033158A (ko) |
CN (2) | CN1131855C (ko) |
AT (1) | ATE275552T1 (ko) |
AU (1) | AU765802B2 (ko) |
BR (1) | BR9814286A (ko) |
CA (1) | CA2304974C (ko) |
DE (1) | DE69826151T2 (ko) |
ES (1) | ES2227896T3 (ko) |
HK (1) | HK1032966A1 (ko) |
HU (1) | HUP0004439A3 (ko) |
IL (1) | IL135313A0 (ko) |
IS (1) | IS5435A (ko) |
NO (2) | NO317252B1 (ko) |
NZ (1) | NZ503963A (ko) |
PL (1) | PL341291A1 (ko) |
PT (1) | PT1047678E (ko) |
SI (1) | SI1047678T1 (ko) |
TR (1) | TR200001795T2 (ko) |
WO (1) | WO1999031075A1 (ko) |
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GB9901691D0 (en) | 1999-01-26 | 1999-03-17 | Cerebrus Ltd | Chemical compounds |
IL149530A0 (en) | 1999-12-01 | 2002-11-10 | Ucb Sa | A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders |
GB2362646A (en) * | 2000-05-26 | 2001-11-28 | Warner Lambert Co | Cyclic amino acid derivatives useful as pharmaceutical agents |
GB0018272D0 (en) | 2000-07-25 | 2000-09-13 | Vernalis Research Limited | Chemical compounds IV |
AU2002230398A1 (en) | 2000-10-06 | 2002-04-29 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
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US6620829B2 (en) * | 2000-10-17 | 2003-09-16 | Warner-Lambert Company | Method of treating noninflammatory cartilage damage |
GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
EA006396B1 (ru) | 2001-04-19 | 2005-12-29 | УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл Эл Си | Конденсированные бициклические аминокислоты |
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US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
IL159299A0 (en) | 2001-06-11 | 2004-06-01 | Xenoport Inc | Orally administered dosage forms of gaba analog prodrugs having reduced toxicity |
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JP2005521664A (ja) | 2002-01-31 | 2005-07-21 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | 耳鳴を治療するためのアルファ2デルタ・リガンド |
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WO2003080588A1 (en) | 2002-03-20 | 2003-10-02 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
AU2003243180A1 (en) | 2002-05-17 | 2003-12-12 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
BR0312240A (pt) * | 2002-06-27 | 2005-04-12 | Warner Lambert Co | Método de tratamento do distúrbio por déficit de atenção com hiperatividade |
GB0219024D0 (en) * | 2002-08-15 | 2002-09-25 | Pfizer Ltd | Synergistic combinations |
WO2004052360A1 (en) | 2002-12-11 | 2004-06-24 | Xenoport, Inc. | Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof |
WO2004054560A1 (en) | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
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AR061728A1 (es) * | 2006-06-30 | 2008-09-17 | Pfizer Prod Inc | Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1 |
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DK2125021T3 (da) | 2006-12-22 | 2011-09-19 | Recordati Ireland Ltd | Kombinationsterapi af sygdomme i de nedre urinveje med alfa2delta-ligander og NSAID'er |
JP2010513357A (ja) * | 2006-12-22 | 2010-04-30 | ノバルティス アーゲー | Dpp−iv阻害剤としての1−アミノメチル−1−フェニル−シクロヘキサン誘導体 |
WO2008155619A2 (en) * | 2007-06-21 | 2008-12-24 | Pfizer Inc. | Preparation of optically-active cyclic amino acids |
EP2192916A4 (en) * | 2007-08-23 | 2012-04-04 | Univ Leland Stanford Junior | MODULATION OF SYNAPTOGENESIS |
US8119658B2 (en) | 2007-10-01 | 2012-02-21 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
WO2009094563A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use |
ES2601852T3 (es) | 2008-01-25 | 2017-02-16 | Xenoport, Inc. | Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso |
WO2009094577A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
US20110092564A1 (en) * | 2008-02-26 | 2011-04-21 | Ernest Puil | Cyclic amino acids for the treatment of pain |
EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
US8268887B2 (en) | 2008-10-08 | 2012-09-18 | Feng Xu | Drug conjugates and methods of use thereof |
EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
EP2948139B1 (en) | 2013-01-28 | 2019-06-12 | Lopez, Hector, L. | Methods of improving tolerability, pharmacodynamics, and efficacy of b-alanine and use therefor |
WO2015091508A1 (en) | 2013-12-17 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS |
CN105873580B (zh) | 2013-12-17 | 2020-08-25 | 埃斯蒂维制药有限公司 | 加巴喷丁类化合物与σ受体配体的组合物 |
KR102031334B1 (ko) * | 2013-12-18 | 2019-10-11 | 노바쎄이 에스에이 | 통증 및 기타 장애의 치료용의 감마-아미노뷰티르산(gaba) 유사체 |
JP6271766B2 (ja) | 2014-02-03 | 2018-01-31 | クワドリガ バイオサイエンシーズ, インコーポレイテッド | 化学療法剤としてのβ置換γアミノ酸および類似体 |
MX2016010095A (es) | 2014-02-03 | 2017-02-15 | Quadriga Biosciences Inc | Beta-aminoacidos beta-sustituidos y sus analogos como agentes quimioterapeuticos. |
CN108026026B (zh) | 2015-08-03 | 2021-02-09 | 夸德里加生物科学公司 | 作为化疗剂的β-取代的β-氨基酸和类似物及其应用 |
US20210221768A1 (en) | 2018-05-14 | 2021-07-22 | Xgene Pharmaceutical Inc. | Crystalline forms of 1-(acyloxy)-alkyl carbamate drug conjugates of naproxen and pregabalin |
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NL6804065A (ko) * | 1968-03-22 | 1969-09-24 | ||
BE789025A (fr) * | 1971-09-23 | 1973-03-20 | Allen & Hanburys Ltd | Nouvelles ethylene diamines substituees |
DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
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DE3300774A1 (de) * | 1983-01-12 | 1984-07-12 | Hoechst Ag, 6230 Frankfurt | Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung |
DE3327318C1 (de) * | 1983-07-29 | 1985-03-14 | Gödecke AG, 1000 Berlin | 1-Aminomethylcyclohexylmethan-sulfonsaeure,Verfahren zu deren Herstellung und deren Verwendung |
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US5015644A (en) * | 1987-06-02 | 1991-05-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds |
US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
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FR2687402B1 (fr) * | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
CA2123728A1 (en) * | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
JPH07101929A (ja) * | 1993-10-01 | 1995-04-18 | Fujisawa Pharmaceut Co Ltd | 尿素誘導体およびその製造法 |
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ES2253782T3 (es) * | 1996-08-22 | 2006-06-01 | Warner-Lambert Company Llc | Antagonistas de receptor de bombesina no peptidicos. |
-
1998
- 1998-11-10 ES ES98957745T patent/ES2227896T3/es not_active Expired - Lifetime
- 1998-11-10 JP JP2000539002A patent/JP2002508362A/ja active Pending
- 1998-11-10 DE DE69826151T patent/DE69826151T2/de not_active Expired - Fee Related
- 1998-11-10 WO PCT/US1998/023918 patent/WO1999031075A1/en not_active Application Discontinuation
- 1998-11-10 EP EP04006036A patent/EP1475371A1/en not_active Withdrawn
- 1998-11-10 EP EP98957745A patent/EP1047678B1/en not_active Expired - Lifetime
- 1998-11-10 PT PT98957745T patent/PT1047678E/pt unknown
- 1998-11-10 HU HU0004439A patent/HUP0004439A3/hu unknown
- 1998-11-10 AU AU13929/99A patent/AU765802B2/en not_active Ceased
- 1998-11-10 IL IL13531398A patent/IL135313A0/xx unknown
- 1998-11-10 CN CN98811481XA patent/CN1131855C/zh not_active Expired - Fee Related
- 1998-11-10 BR BR9814286-0A patent/BR9814286A/pt not_active Application Discontinuation
- 1998-11-10 NZ NZ503963A patent/NZ503963A/xx unknown
- 1998-11-10 AT AT98957745T patent/ATE275552T1/de not_active IP Right Cessation
- 1998-11-10 CA CA002304974A patent/CA2304974C/en not_active Expired - Fee Related
- 1998-11-10 SI SI9830690T patent/SI1047678T1/xx unknown
- 1998-11-10 PL PL98341291A patent/PL341291A1/xx unknown
- 1998-11-10 KR KR1020007006535A patent/KR20010033158A/ko not_active Application Discontinuation
- 1998-11-10 US US09/509,905 patent/US6518289B1/en not_active Expired - Fee Related
- 1998-11-10 TR TR2000/01795T patent/TR200001795T2/xx unknown
- 1998-11-10 CN CNA2003101142270A patent/CN1495160A/zh active Pending
-
2000
- 2000-04-07 IS IS5435A patent/IS5435A/is unknown
- 2000-06-14 NO NO20003039A patent/NO317252B1/no not_active IP Right Cessation
-
2001
- 2001-05-23 HK HK01103570A patent/HK1032966A1/xx not_active IP Right Cessation
-
2004
- 2004-03-17 NO NO20041112A patent/NO20041112L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
SI1047678T1 (en) | 2005-02-28 |
CA2304974A1 (en) | 1999-06-24 |
CN1495160A (zh) | 2004-05-12 |
NZ503963A (en) | 2002-09-27 |
DE69826151T2 (de) | 2005-01-27 |
BR9814286A (pt) | 2000-10-03 |
EP1047678B1 (en) | 2004-09-08 |
NO20003039L (no) | 2000-06-14 |
IS5435A (is) | 2000-04-07 |
NO317252B1 (no) | 2004-09-27 |
WO1999031075A1 (en) | 1999-06-24 |
NO20003039D0 (no) | 2000-06-14 |
CN1131855C (zh) | 2003-12-24 |
PL341291A1 (en) | 2001-04-09 |
AU1392999A (en) | 1999-07-05 |
TR200001795T2 (tr) | 2000-11-21 |
HUP0004439A3 (en) | 2001-12-28 |
DE69826151D1 (de) | 2004-10-14 |
AU765802B2 (en) | 2003-10-02 |
HUP0004439A2 (hu) | 2001-10-28 |
PT1047678E (pt) | 2004-12-31 |
ES2227896T3 (es) | 2005-04-01 |
ATE275552T1 (de) | 2004-09-15 |
KR20010033158A (ko) | 2001-04-25 |
IL135313A0 (en) | 2001-05-20 |
JP2002508362A (ja) | 2002-03-19 |
CN1279674A (zh) | 2001-01-10 |
CA2304974C (en) | 2005-10-25 |
NO20041112L (no) | 2000-06-14 |
EP1475371A1 (en) | 2004-11-10 |
US6518289B1 (en) | 2003-02-11 |
EP1047678A1 (en) | 2000-11-02 |
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PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20081110 |