HK1026418A1 - Novel pyrimidine derivatives and processes for the preparation thereof - Google Patents

Novel pyrimidine derivatives and processes for the preparation thereof

Info

Publication number
HK1026418A1
HK1026418A1 HK00105563A HK00105563A HK1026418A1 HK 1026418 A1 HK1026418 A1 HK 1026418A1 HK 00105563 A HK00105563 A HK 00105563A HK 00105563 A HK00105563 A HK 00105563A HK 1026418 A1 HK1026418 A1 HK 1026418A1
Authority
HK
Hong Kong
Prior art keywords
processes
preparation
pyrimidine derivatives
novel pyrimidine
novel
Prior art date
Application number
HK00105563A
Other languages
English (en)
Inventor
Jong Wook Lee
Bong Yong Lee
Chang Seop Kim
Seung Kyu Lee
Keun Seog Song
Song Jin Lee
Woo Jeon Shim
Man Soon Hwang
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of HK1026418A1 publication Critical patent/HK1026418A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK00105563A 1997-03-27 2000-09-05 Novel pyrimidine derivatives and processes for the preparation thereof HK1026418A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19970010863 1997-03-27
KR19970010862 1997-03-27
PCT/KR1998/000058 WO1998043968A1 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
HK1026418A1 true HK1026418A1 (en) 2000-12-15

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00105563A HK1026418A1 (en) 1997-03-27 2000-09-05 Novel pyrimidine derivatives and processes for the preparation thereof

Country Status (22)

Country Link
US (1) US6352993B1 (pt)
EP (1) EP1015444B1 (pt)
JP (1) JP3176379B2 (pt)
KR (1) KR100278857B1 (pt)
CN (1) CN1118464C (pt)
AR (1) AR012181A1 (pt)
AT (1) ATE241613T1 (pt)
AU (1) AU720385B2 (pt)
BR (1) BR9808070A (pt)
CA (1) CA2284795C (pt)
DE (1) DE69815126T2 (pt)
DK (1) DK1015444T3 (pt)
ES (1) ES2200324T3 (pt)
HK (1) HK1026418A1 (pt)
HU (1) HUP0000851A3 (pt)
IN (1) IN188411B (pt)
PT (1) PT1015444E (pt)
RU (1) RU2203894C2 (pt)
TR (1) TR199902383T2 (pt)
TW (1) TW542831B (pt)
UY (1) UY24938A1 (pt)
WO (1) WO1998043968A1 (pt)

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KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
AR038368A1 (es) 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
US7211590B2 (en) 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
AU2004259346A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
CA2541989C (en) * 2003-10-24 2013-10-01 Exelixis, Inc. P70s6 kinase modulators and method of use
EP1974730A1 (en) 2003-11-03 2008-10-01 AstraZeneca AB Imidazo[1,2-a]pyridine derivatives for use in the treatment of sleep disturbance due to silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
EP1940804A2 (en) * 2005-10-14 2008-07-09 NeuroSearch A/S Novel pyrimidine-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
KR20110039307A (ko) 2008-08-05 2011-04-15 다이이찌 산쿄 가부시키가이샤 이미다조피리딘-2-온 유도체
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
RU2013121785A (ru) 2010-11-15 2014-12-27 Католике Универзитайт Лойфен Новые противовирусные соединения
AU2012221925B2 (en) * 2011-02-25 2016-05-05 Yuhan Corporation Diaminopyrimidine derivatives and processes for the preparation thereof
AU2013221286B2 (en) * 2012-02-17 2017-06-15 Abbvie Inc. Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (RSV)
IN2014MN02314A (pt) 2012-05-29 2015-08-07 Momentive Performance Mat Inc
EA035349B1 (ru) 2012-11-21 2020-05-29 ПиТиСи ТЕРАПЬЮТИКС, ИНК. ЗАМЕЩЕННЫЕ ПИРИМИДИНОВЫЕ ОБРАТНЫЕ ИНГИБИТОРЫ Bmi-1
BR112015022545A2 (pt) 2013-03-13 2017-07-18 Constellation Pharmaceuticals Inc compostos de pirazolo e os usos disso
EA034866B1 (ru) 2013-08-30 2020-03-31 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Замещенные пиримидиновые ингибиторы bmi-1
WO2015054317A1 (en) * 2013-10-07 2015-04-16 Kadmon Corporation, Llc Rho kinase inhibitors
US10584115B2 (en) 2013-11-21 2020-03-10 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine BMI-1 inhibitors
AU2015335980A1 (en) * 2014-10-22 2017-05-18 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
SG10202009723PA (en) * 2016-01-04 2020-11-27 ObsEva SA Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
WO2018184978A1 (de) * 2017-04-05 2018-10-11 Bayer Cropscience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidinderivate und deren verwendung zur bekämpfung unerwünschten pflanzenwachstums
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

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US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4755218A (en) 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
DE3901448A1 (de) 1989-01-19 1990-07-26 Basf Ag Emulsionscopolymerisate
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GB8910722D0 (en) 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
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ATE119157T1 (de) * 1991-04-17 1995-03-15 Pfizer Pyrimidinderivate zur erhöhung der antitumoraktivität.
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
EP0640599B1 (en) 1993-08-26 1998-03-04 Ono Pharmaceutical Co., Ltd. 4-Aminopyrimidine derivatives
JP3398152B2 (ja) 1993-10-12 2003-04-21 ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
AU688087B2 (en) 1994-08-13 1998-03-05 Yuhan Corporation Novel pyrimidine derivatives and processes for the preparation thereof
ES2165052T3 (es) * 1996-05-04 2002-03-01 Yuhan Corp Procedimiento para la preparacion de derivados de pirimidina.

Also Published As

Publication number Publication date
JP2000513014A (ja) 2000-10-03
KR100278857B1 (ko) 2001-01-15
TW542831B (en) 2003-07-21
CA2284795C (en) 2004-01-20
US6352993B1 (en) 2002-03-05
JP3176379B2 (ja) 2001-06-18
CN1251586A (zh) 2000-04-26
AU6523998A (en) 1998-10-22
ATE241613T1 (de) 2003-06-15
CA2284795A1 (en) 1998-10-08
BR9808070A (pt) 2000-03-08
EP1015444B1 (en) 2003-05-28
PT1015444E (pt) 2003-10-31
EP1015444A1 (en) 2000-07-05
HUP0000851A3 (en) 2002-04-29
HUP0000851A1 (hu) 2001-04-28
WO1998043968A1 (en) 1998-10-08
AR012181A1 (es) 2000-09-27
KR19980080789A (ko) 1998-11-25
DK1015444T3 (da) 2003-08-18
ES2200324T3 (es) 2004-03-01
CN1118464C (zh) 2003-08-20
RU2203894C2 (ru) 2003-05-10
TR199902383T2 (xx) 2000-06-21
AU720385B2 (en) 2000-06-01
IN188411B (pt) 2002-09-21
DE69815126T2 (de) 2004-04-08
DE69815126D1 (de) 2003-07-03
UY24938A1 (es) 2001-01-31

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20070324