ES2165052T3 - Procedimiento para la preparacion de derivados de pirimidina. - Google Patents
Procedimiento para la preparacion de derivados de pirimidina.Info
- Publication number
- ES2165052T3 ES2165052T3 ES97920966T ES97920966T ES2165052T3 ES 2165052 T3 ES2165052 T3 ES 2165052T3 ES 97920966 T ES97920966 T ES 97920966T ES 97920966 T ES97920966 T ES 97920966T ES 2165052 T3 ES2165052 T3 ES 2165052T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- preparation
- formula
- represented
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE, EN PRIMER LUGAR, A UN PROCESO PARA LA PREPARACION DE LA 5,6 - DIMETIL - 2 - (4 FLUORFENILAMINO) - 4 - (1 - METIL - 1, 2, 3, 4 TETRAHIDROISOQUINOLINA - 2 - YL) PIRIMIDINA, REPRESENTADA POR LA FORMULA (I) Y SUS SALES ACIDAS DE ADICION; EN SEGUNDO LUGAR, UN PROCESO PARA LA PREPARACION DE UN INTERMEDIO PARA LA PREPARACION DEL COMPUESTO (I), Y, EN TERCER LUGAR, UN NUEVO COMPUESTO INTERMEDIO. MAS CONCRETAMENTE, LA PRESENTE INVENCION SE REFIERE, EN PRIMER LUGAR, A UN PROCESO PARA LA PREPARACION DE LA 5,6 (DIMETIL - 2 - (4 - FLUORFENILAMINO) - 4 - (1 - METIL, 1, 2, 3, 4 - TETRAHIDROISOQUINOLINA - 2 - YL) PIRIMIDINA, REPRESENTADA POR LA FORMULA (I), Y SUS SALES ACIDAS DE ADICION, HACIENDO REACCIONAR UN DERIVADO DE LA PIRIMIDINA, REPRESENTADO POR LA FORMULA (II - A) EN LA QUE HAL REPRESENTA UN HALOGENO, CON 1 METIL - 1, 2, 3, 4 TETRAHIDROISOQUINOLINA, REPRESENTADA POR LA FORMULA (III); EN SEGUNDO LUGAR, UN PROCESO PARA PREPARAR EL DERIVADO DE LA PIRIMIDINA DE FORMULA(II - A) Y EL COMPUESTO DE FORMULA (III); Y, POR ULTIMO, UN NUEVO COMPUESTO INTERMEDIO QUE INCLUYE EL DERIVADO DE LA PIRIMIDINA DE FORMULA (II - A).
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019960014539A KR0177293B1 (ko) | 1996-05-04 | 1996-05-04 | 신규의 피리미딘 유도체 및 그의 제조방법 |
KR1019960014538A KR0177294B1 (ko) | 1996-05-04 | 1996-05-04 | 피리미딘 유도체의 제조방법 |
KR1019960049382A KR100209587B1 (ko) | 1996-10-29 | 1996-10-29 | 피리미딘 유도체의 제조방법 |
KR1019960049381A KR100193080B1 (ko) | 1996-10-29 | 1996-10-29 | (r)-피리미딘 유도체의 제조방법 |
KR1019960049380A KR0185292B1 (ko) | 1996-10-29 | 1996-10-29 | (s)-피리미딘 유도체의 제조방법 |
PCT/KR1997/000073 WO1997042186A1 (en) | 1996-05-04 | 1997-04-30 | Process for preparation of pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2165052T3 true ES2165052T3 (es) | 2002-03-01 |
Family
ID=27532197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97920966T Expired - Lifetime ES2165052T3 (es) | 1996-05-04 | 1997-04-30 | Procedimiento para la preparacion de derivados de pirimidina. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5990311A (es) |
EP (1) | EP0900214B1 (es) |
JP (2) | JP3160297B2 (es) |
CN (2) | CN1190427C (es) |
AT (1) | ATE206117T1 (es) |
AU (1) | AU712970B2 (es) |
CA (2) | CA2253906C (es) |
DE (1) | DE69706981T2 (es) |
DK (1) | DK0900214T3 (es) |
ES (1) | ES2165052T3 (es) |
HK (1) | HK1019336A1 (es) |
PT (1) | PT900214E (es) |
RU (1) | RU2174978C2 (es) |
WO (1) | WO1997042186A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN188411B (es) * | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
KR100272471B1 (ko) * | 1998-11-17 | 2000-11-15 | 김선진 | 신규의 피리미딘 유도체 및 그의 제조방법 |
US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
GB0110338D0 (en) * | 2001-04-27 | 2001-06-20 | Sb Pharmco Inc | Novel processes |
US7211590B2 (en) * | 2002-08-01 | 2007-05-01 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
US7776873B2 (en) * | 2005-12-01 | 2010-08-17 | Yuhan Corporation | Method for treating damage to gastric mucosa |
EP1965774A2 (en) * | 2005-12-30 | 2008-09-10 | Cogentus Pharmaceuticals, Inc. | Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors |
JP5844028B2 (ja) | 2006-04-04 | 2016-01-13 | ケージー アクキュイシチオン エルエルシー | 抗血小板薬及び酸阻害薬を含む経口剤形 |
CN102863423B (zh) * | 2011-07-04 | 2014-09-17 | 天津药物研究院 | 一种制备异喹啉基取代的嘧啶衍生物的方法 |
CN105601611A (zh) * | 2014-11-19 | 2016-05-25 | 江苏天士力帝益药业有限公司 | 一种盐酸洛氟普啶多晶型物及其制备方法 |
CN105669642B (zh) * | 2014-11-19 | 2020-06-09 | 江苏天士力帝益药业有限公司 | 一种盐酸洛氟普啶的制备方法 |
CN105399727A (zh) * | 2015-12-02 | 2016-03-16 | 芷威(上海)化学科技有限公司 | 盐酸瑞伐拉赞新结晶形态 |
CN106995432A (zh) * | 2016-01-25 | 2017-08-01 | 广东华南药业集团有限公司 | 一种瑞普拉生无水合物晶型及其制备方法和用途 |
CN106995431A (zh) * | 2016-01-25 | 2017-08-01 | 广东华南药业集团有限公司 | 一种瑞普拉生水合物晶型及其制备方法和用途 |
CN107759562B (zh) * | 2016-08-21 | 2020-10-23 | 常州四药制药有限公司 | 一种盐酸洛氟普啶的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4755218A (en) * | 1985-12-31 | 1988-07-05 | Monsanto Company | Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes |
US4966622A (en) * | 1988-04-12 | 1990-10-30 | Ciba-Geigy Corporation | N-phenyl-N-pyrimidin-2-ylureas |
GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
US5276186A (en) * | 1992-03-11 | 1994-01-04 | Ciba-Geigy Corporation | Process for the production of guanidine derivatives |
KR0144833B1 (ko) * | 1992-12-28 | 1998-07-15 | 김태훈 | 신규의 퀴나졸린 유도체 및 그의 제조방법 |
CA2197298C (en) * | 1994-08-13 | 1999-10-19 | Jong Wook Lee | Novel pyrimidine derivatives and processes for the preparation thereof |
-
1997
- 1997-04-30 CN CNB021247854A patent/CN1190427C/zh not_active Expired - Lifetime
- 1997-04-30 ES ES97920966T patent/ES2165052T3/es not_active Expired - Lifetime
- 1997-04-30 EP EP97920966A patent/EP0900214B1/en not_active Expired - Lifetime
- 1997-04-30 CA CA002253906A patent/CA2253906C/en not_active Expired - Fee Related
- 1997-04-30 PT PT97920966T patent/PT900214E/pt unknown
- 1997-04-30 DE DE69706981T patent/DE69706981T2/de not_active Expired - Lifetime
- 1997-04-30 DK DK97920966T patent/DK0900214T3/da active
- 1997-04-30 WO PCT/KR1997/000073 patent/WO1997042186A1/en active IP Right Grant
- 1997-04-30 US US09/171,579 patent/US5990311A/en not_active Expired - Lifetime
- 1997-04-30 JP JP53975697A patent/JP3160297B2/ja not_active Expired - Fee Related
- 1997-04-30 RU RU98121687/04A patent/RU2174978C2/ru not_active IP Right Cessation
- 1997-04-30 CA CA002358479A patent/CA2358479C/en not_active Expired - Fee Related
- 1997-04-30 AU AU27133/97A patent/AU712970B2/en not_active Ceased
- 1997-04-30 AT AT97920966T patent/ATE206117T1/de active
- 1997-04-30 CN CN97194367A patent/CN1097591C/zh not_active Expired - Lifetime
-
1999
- 1999-10-07 HK HK99104379A patent/HK1019336A1/xx not_active IP Right Cessation
-
2000
- 2000-06-30 JP JP2000198538A patent/JP2001055379A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0900214B1 (en) | 2001-09-26 |
EP0900214A1 (en) | 1999-03-10 |
DE69706981T2 (de) | 2002-06-06 |
US5990311A (en) | 1999-11-23 |
CN1425655A (zh) | 2003-06-25 |
AU712970B2 (en) | 1999-11-18 |
AU2713397A (en) | 1997-11-26 |
CA2253906C (en) | 2002-04-02 |
CA2358479A1 (en) | 1997-11-13 |
DE69706981D1 (de) | 2001-10-31 |
JPH11509237A (ja) | 1999-08-17 |
RU2174978C2 (ru) | 2001-10-20 |
JP2001055379A (ja) | 2001-02-27 |
ATE206117T1 (de) | 2001-10-15 |
WO1997042186A1 (en) | 1997-11-13 |
DK0900214T3 (da) | 2002-01-28 |
HK1019336A1 (en) | 2000-02-03 |
CA2358479C (en) | 2004-07-13 |
CN1097591C (zh) | 2003-01-01 |
PT900214E (pt) | 2002-03-28 |
CN1217722A (zh) | 1999-05-26 |
CA2253906A1 (en) | 1997-11-13 |
JP3160297B2 (ja) | 2001-04-25 |
CN1190427C (zh) | 2005-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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