ES2165052T3 - Procedimiento para la preparacion de derivados de pirimidina. - Google Patents

Procedimiento para la preparacion de derivados de pirimidina.

Info

Publication number
ES2165052T3
ES2165052T3 ES97920966T ES97920966T ES2165052T3 ES 2165052 T3 ES2165052 T3 ES 2165052T3 ES 97920966 T ES97920966 T ES 97920966T ES 97920966 T ES97920966 T ES 97920966T ES 2165052 T3 ES2165052 T3 ES 2165052T3
Authority
ES
Spain
Prior art keywords
pct
preparation
formula
represented
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97920966T
Other languages
English (en)
Inventor
You Wha Hong
Young Nam Lee
Hong Bae Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019960014539A external-priority patent/KR0177293B1/ko
Priority claimed from KR1019960014538A external-priority patent/KR0177294B1/ko
Priority claimed from KR1019960049382A external-priority patent/KR100209587B1/ko
Priority claimed from KR1019960049381A external-priority patent/KR100193080B1/ko
Priority claimed from KR1019960049380A external-priority patent/KR0185292B1/ko
Application filed by Yuhan Corp filed Critical Yuhan Corp
Application granted granted Critical
Publication of ES2165052T3 publication Critical patent/ES2165052T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE, EN PRIMER LUGAR, A UN PROCESO PARA LA PREPARACION DE LA 5,6 - DIMETIL - 2 - (4 FLUORFENILAMINO) - 4 - (1 - METIL - 1, 2, 3, 4 TETRAHIDROISOQUINOLINA - 2 - YL) PIRIMIDINA, REPRESENTADA POR LA FORMULA (I) Y SUS SALES ACIDAS DE ADICION; EN SEGUNDO LUGAR, UN PROCESO PARA LA PREPARACION DE UN INTERMEDIO PARA LA PREPARACION DEL COMPUESTO (I), Y, EN TERCER LUGAR, UN NUEVO COMPUESTO INTERMEDIO. MAS CONCRETAMENTE, LA PRESENTE INVENCION SE REFIERE, EN PRIMER LUGAR, A UN PROCESO PARA LA PREPARACION DE LA 5,6 (DIMETIL - 2 - (4 - FLUORFENILAMINO) - 4 - (1 - METIL, 1, 2, 3, 4 - TETRAHIDROISOQUINOLINA - 2 - YL) PIRIMIDINA, REPRESENTADA POR LA FORMULA (I), Y SUS SALES ACIDAS DE ADICION, HACIENDO REACCIONAR UN DERIVADO DE LA PIRIMIDINA, REPRESENTADO POR LA FORMULA (II - A) EN LA QUE HAL REPRESENTA UN HALOGENO, CON 1 METIL - 1, 2, 3, 4 TETRAHIDROISOQUINOLINA, REPRESENTADA POR LA FORMULA (III); EN SEGUNDO LUGAR, UN PROCESO PARA PREPARAR EL DERIVADO DE LA PIRIMIDINA DE FORMULA(II - A) Y EL COMPUESTO DE FORMULA (III); Y, POR ULTIMO, UN NUEVO COMPUESTO INTERMEDIO QUE INCLUYE EL DERIVADO DE LA PIRIMIDINA DE FORMULA (II - A).
ES97920966T 1996-05-04 1997-04-30 Procedimiento para la preparacion de derivados de pirimidina. Expired - Lifetime ES2165052T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR1019960014539A KR0177293B1 (ko) 1996-05-04 1996-05-04 신규의 피리미딘 유도체 및 그의 제조방법
KR1019960014538A KR0177294B1 (ko) 1996-05-04 1996-05-04 피리미딘 유도체의 제조방법
KR1019960049382A KR100209587B1 (ko) 1996-10-29 1996-10-29 피리미딘 유도체의 제조방법
KR1019960049381A KR100193080B1 (ko) 1996-10-29 1996-10-29 (r)-피리미딘 유도체의 제조방법
KR1019960049380A KR0185292B1 (ko) 1996-10-29 1996-10-29 (s)-피리미딘 유도체의 제조방법
PCT/KR1997/000073 WO1997042186A1 (en) 1996-05-04 1997-04-30 Process for preparation of pyrimidine derivatives

Publications (1)

Publication Number Publication Date
ES2165052T3 true ES2165052T3 (es) 2002-03-01

Family

ID=27532197

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97920966T Expired - Lifetime ES2165052T3 (es) 1996-05-04 1997-04-30 Procedimiento para la preparacion de derivados de pirimidina.

Country Status (14)

Country Link
US (1) US5990311A (es)
EP (1) EP0900214B1 (es)
JP (2) JP3160297B2 (es)
CN (2) CN1190427C (es)
AT (1) ATE206117T1 (es)
AU (1) AU712970B2 (es)
CA (2) CA2253906C (es)
DE (1) DE69706981T2 (es)
DK (1) DK0900214T3 (es)
ES (1) ES2165052T3 (es)
HK (1) HK1019336A1 (es)
PT (1) PT900214E (es)
RU (1) RU2174978C2 (es)
WO (1) WO1997042186A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN188411B (es) * 1997-03-27 2002-09-21 Yuhan Corp
KR100272471B1 (ko) * 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
GB0110338D0 (en) * 2001-04-27 2001-06-20 Sb Pharmco Inc Novel processes
US7211590B2 (en) * 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
US7776873B2 (en) * 2005-12-01 2010-08-17 Yuhan Corporation Method for treating damage to gastric mucosa
EP1965774A2 (en) * 2005-12-30 2008-09-10 Cogentus Pharmaceuticals, Inc. Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors
JP5844028B2 (ja) 2006-04-04 2016-01-13 ケージー アクキュイシチオン エルエルシー 抗血小板薬及び酸阻害薬を含む経口剤形
CN102863423B (zh) * 2011-07-04 2014-09-17 天津药物研究院 一种制备异喹啉基取代的嘧啶衍生物的方法
CN105601611A (zh) * 2014-11-19 2016-05-25 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶多晶型物及其制备方法
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
CN105399727A (zh) * 2015-12-02 2016-03-16 芷威（上海）化学科技有限公司 盐酸瑞伐拉赞新结晶形态
CN106995432A (zh) * 2016-01-25 2017-08-01 广东华南药业集团有限公司 一种瑞普拉生无水合物晶型及其制备方法和用途
CN106995431A (zh) * 2016-01-25 2017-08-01 广东华南药业集团有限公司 一种瑞普拉生水合物晶型及其制备方法和用途
CN107759562B (zh) * 2016-08-21 2020-10-23 常州四药制药有限公司 一种盐酸洛氟普啶的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755218A (en) * 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
US4966622A (en) * 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
GB9012592D0 (en) * 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
US5276186A (en) * 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
CA2197298C (en) * 1994-08-13 1999-10-19 Jong Wook Lee Novel pyrimidine derivatives and processes for the preparation thereof

Also Published As

Publication number Publication date
EP0900214B1 (en) 2001-09-26
EP0900214A1 (en) 1999-03-10
DE69706981T2 (de) 2002-06-06
US5990311A (en) 1999-11-23
CN1425655A (zh) 2003-06-25
AU712970B2 (en) 1999-11-18
AU2713397A (en) 1997-11-26
CA2253906C (en) 2002-04-02
CA2358479A1 (en) 1997-11-13
DE69706981D1 (de) 2001-10-31
JPH11509237A (ja) 1999-08-17
RU2174978C2 (ru) 2001-10-20
JP2001055379A (ja) 2001-02-27
ATE206117T1 (de) 2001-10-15
WO1997042186A1 (en) 1997-11-13
DK0900214T3 (da) 2002-01-28
HK1019336A1 (en) 2000-02-03
CA2358479C (en) 2004-07-13
CN1097591C (zh) 2003-01-01
PT900214E (pt) 2002-03-28
CN1217722A (zh) 1999-05-26
CA2253906A1 (en) 1997-11-13
JP3160297B2 (ja) 2001-04-25
CN1190427C (zh) 2005-02-23

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