HUP9903520A1 - Eljárás pirimidinszármazékok előállítására - Google Patents

Eljárás pirimidinszármazékok előállítására

Info

Publication number
HUP9903520A1
HUP9903520A1 HU9903520A HUP9903520A HUP9903520A1 HU P9903520 A1 HUP9903520 A1 HU P9903520A1 HU 9903520 A HU9903520 A HU 9903520A HU P9903520 A HUP9903520 A HU P9903520A HU P9903520 A1 HUP9903520 A1 HU P9903520A1
Authority
HU
Hungary
Prior art keywords
preparation
pyrimidine derivatives
methyl
iii
pyrimidine
Prior art date
Application number
HU9903520A
Other languages
English (en)
Inventor
You Wha Hong
Hong Bae Kim
Young Nam Lee
Original Assignee
Yuhan Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019960049382A external-priority patent/KR100209587B1/ko
Priority claimed from KR1019960049381A external-priority patent/KR100193080B1/ko
Priority claimed from KR1019960049380A external-priority patent/KR0185292B1/ko
Application filed by Yuhan Corporation filed Critical Yuhan Corporation
Publication of HUP9903520A1 publication Critical patent/HUP9903520A1/hu
Publication of HUP9903520A3 publication Critical patent/HUP9903520A3/hu
Publication of HU226752B1 publication Critical patent/HU226752B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány az ismert, fekélyellenes hatóanyagként alkalmazőtt, (I)képletű 5,6-dimetil-2-(4-flűőr-anilinő)-4-(1-metil-1,2,3,4-tetrahidrő-2-izőkinőlinil)-pirimidin és savaddíciós sói előállítási eljárásáravőnatkőzik, amelynek sőrán egy (II-A) általánős képletűpirimidinszármazékőt -, amelynek képletében Hal jelentése halőgénatőm- (III) képletű 1-metil-1,2,3,4-tetrahidrőizőkinőlinnal reagáltatnak.A találmány tárgyát képezi ezenkívül egy eljárás a (II-A) általánősképletű vegyületek, illetve egy eljárás a (III) képletű vegyületelőállítására. A találmány őltalmi körébe tartőznak tővábbá bizőnyősúj intermedierek, köztük a (II-A) általánős képletűpirimidinszármazékők. (I) (II-A) (III) ŕ
HU9903520A 1996-10-29 1997-10-27 Process for preparation of pyrimidine derivatives HU226752B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1019960049382A KR100209587B1 (ko) 1996-10-29 1996-10-29 피리미딘 유도체의 제조방법
KR1019960049381A KR100193080B1 (ko) 1996-10-29 1996-10-29 (r)-피리미딘 유도체의 제조방법
KR1019960049380A KR0185292B1 (ko) 1996-10-29 1996-10-29 (s)-피리미딘 유도체의 제조방법
PCT/KR1997/000204 WO1998018784A1 (en) 1996-10-29 1997-10-27 Process for preparation of pyrimidine derivatives

Publications (3)

Publication Number Publication Date
HUP9903520A1 true HUP9903520A1 (hu) 2000-05-28
HUP9903520A3 HUP9903520A3 (en) 2002-01-28
HU226752B1 HU226752B1 (en) 2009-09-28

Family

ID=27349413

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903520A HU226752B1 (en) 1996-10-29 1997-10-27 Process for preparation of pyrimidine derivatives

Country Status (5)

Country Link
AR (1) AR009133A1 (hu)
BR (1) BR9712392A (hu)
HU (1) HU226752B1 (hu)
TR (1) TR199900943T2 (hu)
WO (1) WO1998018784A1 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100272471B1 (ko) * 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
GB0110338D0 (en) * 2001-04-27 2001-06-20 Sb Pharmco Inc Novel processes
US7211590B2 (en) 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
US7776873B2 (en) * 2005-12-01 2010-08-17 Yuhan Corporation Method for treating damage to gastric mucosa
JP5844028B2 (ja) 2006-04-04 2016-01-13 ケージー アクキュイシチオン エルエルシー 抗血小板薬及び酸阻害薬を含む経口剤形
CN102993173B (zh) * 2012-12-28 2014-09-03 山东大学 洛氟普啶的制备方法
CN105601611A (zh) * 2014-11-19 2016-05-25 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶多晶型物及其制备方法
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
CN107759562B (zh) * 2016-08-21 2020-10-23 常州四药制药有限公司 一种盐酸洛氟普啶的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1182584A (en) * 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
TR25912A (tr) * 1989-03-22 1993-11-01 Ciba Geigy Ag 2-ANILIN-PRIMIDIN TüREVLERI BU MADDELERINELDE EDIL MELERI VE ZARARLILARA KARSI MüCADELEDE KULLANILMA- LARI
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
CA2197298C (en) * 1994-08-13 1999-10-19 Jong Wook Lee Novel pyrimidine derivatives and processes for the preparation thereof

Also Published As

Publication number Publication date
TR199900943T2 (xx) 1999-12-21
BR9712392A (pt) 2000-01-25
AR009133A1 (es) 2000-03-08
HUP9903520A3 (en) 2002-01-28
WO1998018784A1 (en) 1998-05-07
HU226752B1 (en) 2009-09-28

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees