HK1026418A1 - Novel pyrimidine derivatives and processes for the preparation thereof - Google Patents
Novel pyrimidine derivatives and processes for the preparation thereofInfo
- Publication number
- HK1026418A1 HK1026418A1 HK00105563A HK00105563A HK1026418A1 HK 1026418 A1 HK1026418 A1 HK 1026418A1 HK 00105563 A HK00105563 A HK 00105563A HK 00105563 A HK00105563 A HK 00105563A HK 1026418 A1 HK1026418 A1 HK 1026418A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- processes
- preparation
- pyrimidine derivatives
- novel pyrimidine
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR19970010862 | 1997-03-27 | ||
KR19970010863 | 1997-03-27 | ||
PCT/KR1998/000058 WO1998043968A1 (fr) | 1997-03-27 | 1998-03-24 | Nouveaux derives de pyrimidine et procedes de preparation desdits derives |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1026418A1 true HK1026418A1 (en) | 2000-12-15 |
Family
ID=26632616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00105563A HK1026418A1 (en) | 1997-03-27 | 2000-09-05 | Novel pyrimidine derivatives and processes for the preparation thereof |
Country Status (22)
Country | Link |
---|---|
US (1) | US6352993B1 (fr) |
EP (1) | EP1015444B1 (fr) |
JP (1) | JP3176379B2 (fr) |
KR (1) | KR100278857B1 (fr) |
CN (1) | CN1118464C (fr) |
AR (1) | AR012181A1 (fr) |
AT (1) | ATE241613T1 (fr) |
AU (1) | AU720385B2 (fr) |
BR (1) | BR9808070A (fr) |
CA (1) | CA2284795C (fr) |
DE (1) | DE69815126T2 (fr) |
DK (1) | DK1015444T3 (fr) |
ES (1) | ES2200324T3 (fr) |
HK (1) | HK1026418A1 (fr) |
HU (1) | HUP0000851A3 (fr) |
IN (1) | IN188411B (fr) |
PT (1) | PT1015444E (fr) |
RU (1) | RU2203894C2 (fr) |
TR (1) | TR199902383T2 (fr) |
TW (1) | TW542831B (fr) |
UY (1) | UY24938A1 (fr) |
WO (1) | WO1998043968A1 (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100272471B1 (ko) | 1998-11-17 | 2000-11-15 | 김선진 | 신규의 피리미딘 유도체 및 그의 제조방법 |
US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
AR038368A1 (es) | 2002-02-01 | 2005-01-12 | Novartis Ag | Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento |
JP4634144B2 (ja) | 2002-08-01 | 2011-02-16 | ニコックス エスエー | ニトロソ化プロトンポンプ阻害剤、組成物および使用方法 |
WO2005009980A1 (fr) * | 2003-07-22 | 2005-02-03 | Neurogen Corporation | Analogues de pyridin-2-ylamine substitues |
CA2541989C (fr) * | 2003-10-24 | 2013-10-01 | Exelixis, Inc. | Modulateurs des p70s6 kinases et procede d'utilisation |
EP1682133A1 (fr) | 2003-11-03 | 2006-07-26 | AstraZeneca AB | Derives d'imidazo 1,2-a pydirine pour le traitement du reflux gastro-oesophagien sans douleur |
KR101122376B1 (ko) * | 2005-03-09 | 2012-03-26 | 주식회사유한양행 | 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법 |
JP2009511548A (ja) * | 2005-10-14 | 2009-03-19 | ノイロサーチ アクティーゼルスカブ | 新規ピリミジン−2,4−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用 |
US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
BRPI0917540A2 (pt) | 2008-08-05 | 2015-11-17 | Daiichi Sankyo Co Ltd | composto, sal farmacologicamente aceitavél, composição farmacêutica, e, uso de um composto ou sal farmacologicamente aceitável |
GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
WO2012065963A2 (fr) | 2010-11-15 | 2012-05-24 | Katholieke Universiteit Leuven | Nouveaux composés antiviraux |
US9850227B2 (en) | 2011-02-25 | 2017-12-26 | Yuhan Corporation | Diaminopyrimidine derivatives and processes for the preparation thereof |
CA2864825C (fr) * | 2012-02-17 | 2021-01-26 | Abbvie Inc. | Diaminopyrimidines utilisees en tant qu'inhibiteurs du virus syncytial respiratoire (vsr) de l'homme |
WO2013181136A1 (fr) | 2012-05-29 | 2013-12-05 | Momentive Performance Materials Gmbh | Préparation d'isocyanatosilanes |
ES2821529T3 (es) | 2012-11-21 | 2021-04-26 | Ptc Therapeutics Inc | Derivados de 4,6-diamino-pirimidina como inhibidores de Bmi-1 para el tratamiento del cáncer |
MX2015011898A (es) | 2013-03-13 | 2016-05-05 | Genentech Inc | Compuestos de pirazolo y usos de los mismos. |
NZ718055A (en) * | 2013-08-30 | 2020-01-31 | Ptc Therapeutics Inc | Substituted pyrimidine bmi-1 inhibitors |
CN104903312B (zh) * | 2013-10-07 | 2019-01-29 | 卡德门企业有限公司 | Rho激酶抑制剂 |
WO2015076800A1 (fr) | 2013-11-21 | 2015-05-28 | Ptc Therapeutics, Inc. | Inhibiteurs de bmi-1 à base de pyridine et de pyrazine substituées |
AU2015335980A1 (en) * | 2014-10-22 | 2017-05-18 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof |
CN105669642B (zh) * | 2014-11-19 | 2020-06-09 | 江苏天士力帝益药业有限公司 | 一种盐酸洛氟普啶的制备方法 |
HUE058871T2 (hu) * | 2016-01-04 | 2022-09-28 | Merck Serono Sa | Hidroxipropil-tiazolidin-karboxamid származék L-valinátja, ennek sója és kristályformája |
BR112019020877A2 (pt) * | 2017-04-05 | 2020-05-12 | Bayer Cropscience Aktiengesellschaft | Derivados de 2-amino-5-oxialquil-pirimidina e seu uso para controlar o crescimento de plantas indesejadas |
CN114685369B (zh) * | 2022-05-17 | 2024-02-02 | 河南省科学院高新技术研究中心 | 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1182584A (en) | 1966-03-31 | 1970-02-25 | Ici Ltd | Pyrimidine derivates and the use thereof as fungicides |
US3980781A (en) | 1966-03-31 | 1976-09-14 | Imperial Chemical Industries Limited | Fungicidal composition and method containing 2-amino-pyrimidines |
US4000138A (en) | 1966-03-31 | 1976-12-28 | Imperial Chemical Industries Limited | Organic compounds and compositions containing them |
US4044136A (en) | 1972-09-09 | 1977-08-23 | Pfizer Inc. | Aminoquinazoline therapeutic agents |
GB1383409A (en) | 1972-09-09 | 1974-02-12 | Pfizer Ltd | Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them |
US3956495A (en) | 1973-10-30 | 1976-05-11 | Eli Lilly And Company | 2,4-Diaminoquinazolines as antithrombotic agents |
US4755218A (en) | 1985-12-31 | 1988-07-05 | Monsanto Company | Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes |
GB8621425D0 (en) * | 1986-09-05 | 1986-10-15 | Smith Kline French Lab | Compounds |
IL88507A (en) * | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
US4966622A (en) | 1988-04-12 | 1990-10-30 | Ciba-Geigy Corporation | N-phenyl-N-pyrimidin-2-ylureas |
HU206337B (en) * | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
DE3901448A1 (de) | 1989-01-19 | 1990-07-26 | Basf Ag | Emulsionscopolymerisate |
DE59010042D1 (de) | 1989-03-22 | 1996-02-22 | Ciba Geigy Ag | Schädlingsbekämpfungsmittel |
CA2015981A1 (fr) * | 1989-05-10 | 1990-11-10 | Thomas H. Brown | Composes |
GB8910722D0 (en) | 1989-05-10 | 1989-06-28 | Smithkline Beckman Intercredit | Compounds |
GB9012592D0 (en) | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
CA2095213A1 (fr) | 1990-11-06 | 1992-05-07 | Jotham W. Coe | Derives de la quinazoline pour intensifier l'activite antitumorale |
HUT65177A (en) * | 1991-04-17 | 1994-05-02 | Pfizer | Process for producing antitumor activity enhancing pyrimidine derivatives and pharmaceutical preparations containing them |
US5276186A (en) | 1992-03-11 | 1994-01-04 | Ciba-Geigy Corporation | Process for the production of guanidine derivatives |
KR0144833B1 (ko) * | 1992-12-28 | 1998-07-15 | 김태훈 | 신규의 퀴나졸린 유도체 및 그의 제조방법 |
ATE163647T1 (de) | 1993-08-26 | 1998-03-15 | Ono Pharmaceutical Co | 4-aminopyrimidin derivate |
CN1142817A (zh) | 1993-10-12 | 1997-02-12 | 杜邦麦克制药有限公司 | 1n-烷基-n-芳基嘧啶胺及其衍生物 |
DE69530989T2 (de) | 1994-08-13 | 2004-05-19 | Yuhan Corp. | Neue pyrimidinderivate und verfahren zu ihrer herstellung |
EP0900214B1 (fr) | 1996-05-04 | 2001-09-26 | Yuhan Corporation | Procede de preparation de derives de pyrimidine |
-
1998
- 1998-03-23 IN IN724DE1998 patent/IN188411B/en unknown
- 1998-03-24 WO PCT/KR1998/000058 patent/WO1998043968A1/fr active IP Right Grant
- 1998-03-24 BR BR9808070-9A patent/BR9808070A/pt not_active Application Discontinuation
- 1998-03-24 CN CN98803765A patent/CN1118464C/zh not_active Expired - Fee Related
- 1998-03-24 CA CA002284795A patent/CA2284795C/fr not_active Expired - Fee Related
- 1998-03-24 DK DK98911242T patent/DK1015444T3/da active
- 1998-03-24 TR TR1999/02383T patent/TR199902383T2/xx unknown
- 1998-03-24 JP JP54148798A patent/JP3176379B2/ja not_active Expired - Fee Related
- 1998-03-24 AU AU65239/98A patent/AU720385B2/en not_active Ceased
- 1998-03-24 PT PT98911242T patent/PT1015444E/pt unknown
- 1998-03-24 EP EP98911242A patent/EP1015444B1/fr not_active Expired - Lifetime
- 1998-03-24 US US09/381,814 patent/US6352993B1/en not_active Expired - Fee Related
- 1998-03-24 AT AT98911242T patent/ATE241613T1/de not_active IP Right Cessation
- 1998-03-24 HU HU0000851A patent/HUP0000851A3/hu unknown
- 1998-03-24 ES ES98911242T patent/ES2200324T3/es not_active Expired - Lifetime
- 1998-03-24 DE DE69815126T patent/DE69815126T2/de not_active Expired - Fee Related
- 1998-03-24 RU RU99122603/04A patent/RU2203894C2/ru not_active IP Right Cessation
- 1998-03-26 UY UY24938A patent/UY24938A1/es not_active IP Right Cessation
- 1998-03-26 AR ARP980101380A patent/AR012181A1/es unknown
- 1998-03-27 KR KR1019980010754A patent/KR100278857B1/ko not_active IP Right Cessation
- 1998-03-27 TW TW087104605A patent/TW542831B/zh not_active IP Right Cessation
-
2000
- 2000-09-05 HK HK00105563A patent/HK1026418A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100278857B1 (ko) | 2001-01-15 |
TR199902383T2 (xx) | 2000-06-21 |
EP1015444A1 (fr) | 2000-07-05 |
DK1015444T3 (da) | 2003-08-18 |
CA2284795C (fr) | 2004-01-20 |
HUP0000851A3 (en) | 2002-04-29 |
ES2200324T3 (es) | 2004-03-01 |
TW542831B (en) | 2003-07-21 |
KR19980080789A (ko) | 1998-11-25 |
HUP0000851A1 (hu) | 2001-04-28 |
UY24938A1 (es) | 2001-01-31 |
IN188411B (fr) | 2002-09-21 |
WO1998043968A1 (fr) | 1998-10-08 |
AR012181A1 (es) | 2000-09-27 |
PT1015444E (pt) | 2003-10-31 |
DE69815126D1 (de) | 2003-07-03 |
RU2203894C2 (ru) | 2003-05-10 |
ATE241613T1 (de) | 2003-06-15 |
DE69815126T2 (de) | 2004-04-08 |
EP1015444B1 (fr) | 2003-05-28 |
BR9808070A (pt) | 2000-03-08 |
AU6523998A (en) | 1998-10-22 |
CA2284795A1 (fr) | 1998-10-08 |
JP3176379B2 (ja) | 2001-06-18 |
CN1251586A (zh) | 2000-04-26 |
AU720385B2 (en) | 2000-06-01 |
JP2000513014A (ja) | 2000-10-03 |
CN1118464C (zh) | 2003-08-20 |
US6352993B1 (en) | 2002-03-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20070324 |